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Inhibition of NF-κB with an Analog of Withaferin-A Restores TDP-43 Homeostasis and Proteome Profiles in a Model of Sporadic ALS.
- Published in:
- Biomedicines, 2024, v. 12, n. 5, p. 1017, doi. 10.3390/biomedicines12051017
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- Article
Neuronal dysfunction caused by FUSR521G promotes ALS-associated phenotypes that are attenuated by NF-κB inhibition.
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- Acta Neuropathologica Communications, 2023, v. 11, n. 1, p. 1, doi. 10.1186/s40478-023-01671-1
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- Article
Transactive response DNA-binding protein 43 is enriched at the centrosome in human cells.
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- Brain: A Journal of Neurology, 2023, v. 146, n. 9, p. 3624, doi. 10.1093/brain/awad228
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- Article
Emerging Trends in the Field of Inflammation and Proteinopathy in ALS/FTD Spectrum Disorder.
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- Biomedicines, 2023, v. 11, n. 6, p. 1599, doi. 10.3390/biomedicines11061599
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- Publication type:
- Article
A New Mouse Model of Giant Axonal Neuropathy with Overt Phenotypes and Neurodegeneration Driven by Neurofilament Disorganization.
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- Journal of Neuroscience, 2023, v. 43, n. 22, p. 4174, doi. 10.1523/JNEUROSCI.1959-22.2023
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- Publication type:
- Article
Distinct Plasma Immune Profile in ALS Implicates sTNFR-II in pAMPK/Leptin Homeostasis.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 6, p. 5065, doi. 10.3390/ijms24065065
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- Article
Noise-induced hearing loss vulnerability in type III intermediate filament peripherin gene knockout mice.
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- Frontiers in Neurology, 2022, v. 13, p. 1, doi. 10.3389/fneur.2022.962227
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- Article
Induction of autophagy mitigates TDP-43 pathology and translational repression of neurofilament mRNAs in mouse models of ALS/FTD.
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- Molecular Neurodegeneration, 2021, v. 16, n. 1, p. 1, doi. 10.1186/s13024-020-00420-5
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- Article
Neurofilaments: neurobiological foundations for biomarker applications.
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- 2020
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- journal article
Mitigation of ALS Pathology by Neuron-Specific Inhibition of Nuclear Factor Kappa B Signaling.
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- Journal of Neuroscience, 2020, v. 40, n. 26, p. 5137, doi. 10.1523/JNEUROSCI.0536-20.2020
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- Article
Transmission of ALS pathogenesis by the cerebrospinal fluid.
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- Acta Neuropathologica Communications, 2020, v. 8, n. 1, p. 1, doi. 10.1186/s40478-020-00943-4
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- Article
Key role of UBQLN2 in pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia.
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- Acta Neuropathologica Communications, 2019, v. 7, n. 1, p. N.PAG, doi. 10.1186/s40478-019-0758-7
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- Publication type:
- Article
Neuronal Expression of UBQLN2<sup>P497H</sup> Exacerbates TDP-43 Pathology in TDP-43<sup>G348C</sup> Mice through Interaction with Ubiquitin.
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- Molecular Neurobiology, 2019, v. 56, n. 7, p. 4680, doi. 10.1007/s12035-018-1411-3
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- Article
Virus-mediated delivery of antibody targeting TAR DNA-binding protein-43 mitigates associated neuropathology.
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- 2019
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- Publication type:
- journal article
Local Acceleration of Neurofilament Transport at Nodes of Ranvier.
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- Journal of Neuroscience, 2019, v. 39, n. 4, p. 663, doi. 10.1523/JNEUROSCI.2272-18.2018
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- Publication type:
- Article
Misfolded SOD1 pathology in sporadic Amyotrophic Lateral Sclerosis.
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- Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-31773-z
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- Article
Neurofilament light interaction with GluN1 modulates neurotransmission and schizophrenia-associated behaviors.
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- Translational Psychiatry, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41398-018-0194-7
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- Article
Exosome secretion is a key pathway for clearance of pathological TDP-43.
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- 2016
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- Publication type:
- journal article
Sex-dependent effects of chromogranin B P413L allelic variant as disease modifier in amyotrophic lateral sclerosis.
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- Human Molecular Genetics, 2016, v. 25, n. 21, p. 4771, doi. 10.1093/hmg/ddw304
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- Article
Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression.
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- 2016
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- Publication type:
- journal article
From animal models to human disease: a genetic approach for personalized medicine in ALS.
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- Acta Neuropathologica Communications, 2016, v. 4, p. 1, doi. 10.1186/s40478-016-0340-5
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- Publication type:
- Article
THE PATHOLOGICAL ROLE OF TDP-43 AND NF-KB IN MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASE.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P1053, doi. 10.1016/j.jalz.2016.06.2197
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- Article
Neurofilament depletion improves microtubule dynamics via modulation of Stat3/stathmin signaling.
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- Acta Neuropathologica, 2016, v. 132, n. 1, p. 93, doi. 10.1007/s00401-016-1564-y
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- Article
MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis.
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- 2016
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- Publication type:
- journal article
Ubiquilin-2 drives NF-κB activity and cytosolic TDP-43 aggregation in neuronal cells.
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- Molecular Brain, 2015, v. 8, p. 1, doi. 10.1186/s13041-015-0162-6
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- Article
Inflammation Induces TDP-43 Mislocalization and Aggregation.
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- PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0140248
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- Article
Dissociation of Axonal Neurofilament Content from Its Transport Rate.
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- PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0133848
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- Publication type:
- Article
Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier.
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- Nature Communications, 2015, v. 6, n. 5, p. 7115, doi. 10.1038/ncomms8115
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- Publication type:
- Article
Early and Persistent Abnormal Decoding by Glial Cells at the Neuromuscular Junction in an ALS Model.
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- Journal of Neuroscience, 2015, v. 35, n. 2, p. 689, doi. 10.1523/JNEUROSCI.1379-14.2015
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- Publication type:
- Article
Interaction of transactive response DNA binding protein 43 with nuclear factor κB in mild cognitive impairment with episodic memory deficits.
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- Acta Neuropathologica Communications, 2014, v. 2, n. 1, p. 1, doi. 10.1186/2051-5960-2-37
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- Article
Loss of Glial Neurofascin 155 Delays Developmental Synapse Elimination at the Neuromuscular Junction.
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- Journal of Neuroscience, 2014, v. 34, n. 38, p. 12904, doi. 10.1523/JNEUROSCI.1725-14.2014
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- Publication type:
- Article
Adeno-associated Virus-mediated Delivery of a Recombinant Single-chain Antibody Against Misfolded Superoxide Dismutase for Treatment of Amyotrophic Lateral Sclerosis.
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- Molecular Therapy, 2014, v. 22, n. 3, p. 498, doi. 10.1038/mt.2013.239
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- Article
Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1.
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- 2013
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- Abstract
Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1.
- Published in:
- Human Molecular Genetics, 2013, v. 22, n. 19, p. 3947, doi. 10.1093/hmg/ddt249
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- Publication type:
- Article
Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation.
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- Journal of Clinical Investigation, 2013, v. 123, n. 5, p. 1964, doi. 10.1172/JCI66387
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- Article
Axonal transport deficits and neurodegenerative diseases.
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- Nature Reviews Neuroscience, 2013, v. 14, n. 3, p. 161, doi. 10.1038/nrn3380
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- Article
Abnormal Regenerative Responses and Impaired Axonal Outgrowth after Nerve Crush in TDP-43 Transgenic Mouse Models of Amyotrophic Lateral Sclerosis.
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- Journal of Neuroscience, 2012, v. 32, n. 50, p. 18186, doi. 10.1523/JNEUROSCI.2267-12.2012
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- Article
Peripherin Is a Subunit of Peripheral Nerve Neurofilaments: Implications for Differential Vulnerability of CNS and Peripheral Nervous System Axons.
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- Journal of Neuroscience, 2012, v. 32, n. 25, p. 8501, doi. 10.1523/JNEUROSCI.1081-12.2012
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- Publication type:
- Article
Ablation of Proliferating Cells in the CNS Exacerbates Motor Neuron Disease Caused by Mutant Superoxide Dismutase.
- Published in:
- PLoS ONE, 2012, v. 7, n. 4, p. 1, doi. 10.1371/journal.pone.0034932
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- Publication type:
- Article
Normal role of the low-molecular-weight neurofilament protein in mitochondrial dynamics and disruption in Charcot-Marie-Tooth disease.
- Published in:
- FASEB Journal, 2012, v. 26, n. 3, p. 1194, doi. 10.1096/fj.11-196345
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- Article
Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments.
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- Brain: A Journal of Neurology, 2011, v. 134, n. 9, p. 2610, doi. 10.1093/brain/awr159
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- Article
Technical advances to genetically engineering human embryonic stem cells.
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- Integrative Biology, 2011, v. 3, n. 7, p. 717, doi. 10.1039/c1ib00019e
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- Publication type:
- Article
Misfolded SOD1 Associated with Motor Neuron Mitochondria Alters Mitochondrial Shape and Distribution Prior to Clinical Onset.
- Published in:
- PLoS ONE, 2011, v. 6, n. 7, p. 1, doi. 10.1371/journal.pone.0022031
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- Publication type:
- Article
Neuronal over-expression of chromogranin A accelerates disease onset in a mouse model of ALS S. A. Ezzi et al. Chromogranins and ALS pathogenesis.
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- Journal of Neurochemistry, 2010, v. 115, n. 5, p. 1102, doi. 10.1111/j.1471-4159.2010.06979.x
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- Publication type:
- Article
Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS.
- Published in:
- Nature Neuroscience, 2010, v. 13, n. 11, p. 1396, doi. 10.1038/nn.2660
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- Article
Reversal of neuropathy phenotypes in conditional mouse model of Charcot–Marie–Tooth disease type 2E.
- Published in:
- Human Molecular Genetics, 2010, v. 19, n. 13, p. 2616, doi. 10.1093/hmg/ddq149
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- Article
Intracerebroventricular infusion of monoclonal antibody or its derived Fab fragment against misfolded forms of SOD1 mutant delays mortality in a mouse model of ALS.
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- Journal of Neurochemistry, 2010, v. 113, n. 5, p. 1188, doi. 10.1111/j.1471-4159.2010.06683.x
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- Publication type:
- Article
Extracellular mutant SOD1 induces microglial-mediated motoneuron injury.
- Published in:
- Glia, 2010, v. 58, n. 2, p. 231, doi. 10.1002/glia.20919
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- Publication type:
- Article
Real-time imaging reveals defects of fast axonal transport induced by disorganization of intermediate filaments.
- Published in:
- FASEB Journal, 2009, v. 23, n. 9, p. 3213, doi. 10.1096/fj.09-129585
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- Publication type:
- Article
Preoperative chemotherapy is safe in early breast cancer, even after 10 years of follow-up; clinical and translational results from the EORTC trial 10902.
- Published in:
- Breast Cancer Research & Treatment, 2009, v. 115, n. 1, p. 101, doi. 10.1007/s10549-008-0050-1
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- Article