Works by Johnson, Trevor N

Results: 61

Outcomes of Cooled Radiofrequency Ablation of Lumbar Nerves as Treatment for Chronic Low Back Pain.

Published in:

Pain & Therapy, 2025, v. 14, n. 3, p. 949, doi. 10.1007/s40122-025-00717-7

By:

Abd-Elsayed, Alaa;
Johnson, Trevor N.;
Ruprecht, Kylie K.;
Argall, Tristan R.;
Henjum, Lukas J.;
Fiala, Kenneth J.

Publication type:

Article

Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice.

Published in:

Pediatric Anesthesia, 2011, v. 21, n. 3, p. 291, doi. 10.1111/j.1460-9592.2010.03323.x

By:

Johnson, Trevor N.;
Rostami-Hodjegan, Amin

Publication type:

Article

Development and Verification of a Japanese Pediatric Physiologically Based Pharmacokinetic Model with Emphasis on Drugs Eliminated by Cytochrome P450 or Renal Excretion.

Published in:

Journal of Clinical Pharmacology, 2023, v. 63, n. 10, p. 1156, doi. 10.1002/jcph.2317

By:

Johnson, Trevor N.;
Abduljalil, Khaled;
Pan, Xian;
Emoto, Chie

Publication type:

Article

Physiologically Based Pharmacokinetic Modeling and Allometric Scaling in Pediatric Drug Development: Where Do We Draw the Line?

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, p. S83, doi. 10.1002/jcph.1834

By:

Johnson, Trevor N.;
Ke, Alice B.

Publication type:

Article

Does "Birth" as an Event Impact Maturation Trajectory of Renal Clearance via Glomerular Filtration? Reexamining Data in Preterm and Full‐Term Neonates by Avoiding the Creatinine Bias.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 2, p. 159, doi. 10.1002/jcph.1725

By:

Salem, Farzaneh;
Johnson, Trevor N.;
Hodgkinson, Arran B. J.;
Ogungbenro, Kayode;
Rostami‐Hodjegan, Amin

Publication type:

Article

Precision criteria to derive sample size when designing pediatric pharmacokinetic studies: Which measure of variability should be used?

Published in:

Journal of Clinical Pharmacology, 2014, v. 54, n. 3, p. 311, doi. 10.1002/jcph.206

By:

Salem, Farzaneh;
Ogungbenro, Kayode;
Vajjah, Pavan;
Johnson, Trevor N.;
Aarons, Leon;
Rostami‐Hodjegan, Amin

Publication type:

Article

Age Related Changes in Fractional Elimination Pathways for Drugs: Assessing the Impact of Variable Ontogeny on Metabolic Drug-Drug Interactions.

Published in:

Journal of Clinical Pharmacology, 2013, v. 53, n. 8, p. 857, doi. 10.1002/jcph.100

By:

Salem, Farzaneh;
Johnson, Trevor N.;
Barter, Zoe E.;
Leeder, J. Steven;
Rostami‐Hodjegan, Amin

Publication type:

Article

Do Children Have the Same Vulnerability to Metabolic Drug-Drug Interactions as Adults? A Critical Analysis of the Literature.

Published in:

Journal of Clinical Pharmacology, 2013, v. 53, n. 5, p. 559, doi. 10.1002/jcph.13

By:

Salem, Farzaneh;
Rostami‐Hodjegan, Amin;
Johnson, Trevor N.

Publication type:

Article

Do Children Have the Same Vulnerability to Metabolic Drug-Drug Interactions as Adults? A Critical Analysis of the Literature.

Published in:

Journal of Clinical Pharmacology, 2013, v. 53, n. 4, p. 456, doi. 10.1002/jcph.13

By:

Salem, Farzaneh;
Rostami-Hodjegan, Amin;
Johnson, Trevor N.

Publication type:

Article

Pharmacodynamic studies of nasal tetracosactide with salivary glucocorticoids for a noninvasive Short Synacthen Test.

Published in:

2020

By:

Elder, Charlotte J.;
Vilela, Ruben;
Johnson, Trevor N.;
Taylor, Rosie N.;
Kemp, E. Helen;
Keevi, Brian G.;
Cross, Alexandra S.;
Ross, Richard J.;
Wright, Neil P.;
Keevil, Brian G

Publication type:

journal article

Are body surface area based estimates of liver volume applicable to children with overweight or obesity? An in vivo validation study.

Published in:

CTS: Clinical & Translational Science, 2021, v. 14, n. 5, p. 2008, doi. 10.1111/cts.13059

By:

Hosey‐Cojocari, Chelsea;
Chan, Sherwin S.;
Friesen, Chance S.;
Robinson, Amie;
Williams, Veronica;
Swanson, Erica;
O'Toole, Daniel;
Radford, Jansynn;
Mardis, Neil;
Johnson, Trevor N.;
Leeder, J. Steven;
Shakhnovich, Valentina

Publication type:

Article

Pediatric Pharmacokinetics and Dose Predictions: A Report of a Satellite Meeting to the 10th Juvenile Toxicity Symposium.

Published in:

CTS: Clinical & Translational Science, 2021, v. 14, n. 1, p. 29, doi. 10.1111/cts.12843

By:

Groen, Bianca D.;
Pilla Reddy, Venkatesh;
Badée, Justine;
Olivares‐Morales, Andrés;
Johnson, Trevor N.;
Nicolaï, Johan;
Annaert, Pieter;
Smits, Anne;
Wildt, Saskia N.;
Knibbe, Catherijne A. J.;
Zwart, Loeckie

Publication type:

Article

A guide to developing population files for physiologically‐based pharmacokinetic modeling in the Simcyp Simulator.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 9, p. 1429, doi. 10.1002/psp4.13202

By:

Curry, Liam;
Alrubia, Sarah;
Bois, Frederic Y.;
Clayton, Ruth;
El‐Khateeb, Eman;
Johnson, Trevor N.;
Faisal, Muhammad;
Neuhoff, Sibylle;
Wragg, Kris;
Rostami‐Hodjegan, Amin

Publication type:

Article

Combining data on the bioavailability of midazolam and physiologically‐based pharmacokinetic modeling to investigate intestinal CYP3A4 ontogeny.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 9, p. 1570, doi. 10.1002/psp4.13192

By:

Johnson, Trevor N.;
Batchelor, Hannah K.;
Goelen, Jan;
Horniblow, Richard D.;
Dinh, Jean

Publication type:

Article

Development and application of a pediatric mechanistic kidney model.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 7, p. 854, doi. 10.1002/psp4.12798

By:

Salem, Farzaneh;
Small, Ben G.;
Johnson, Trevor N.

Publication type:

Article

Increasing application of pediatric physiologically based pharmacokinetic models across academic and industry organizations.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 3, p. 373, doi. 10.1002/psp4.12764

By:

Johnson, Trevor N.;
Small, Ben G.;
Rowland Yeo, Karen

Publication type:

Article

A best practice framework for applying physiologically‐based pharmacokinetic modeling to pediatric drug development.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 9, p. 967, doi. 10.1002/psp4.12678

By:

Johnson, Trevor N.;
Small, Ben G.;
Berglund, Eva Gil;
Rowland Yeo, Karen

Publication type:

Article

A Theoretical Physiologically‐Based Pharmacokinetic Approach to Ascertain Covariates Explaining the Large Interpatient Variability in Tacrolimus Disposition.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2019, v. 8, n. 5, p. 273, doi. 10.1002/psp4.12392

By:

Emoto, Chie;
Johnson, Trevor N.;
Hahn, David;
Christians, Uwe;
Alloway, Rita R.;
Vinks, Alexander A.;
Fukuda, Tsuyoshi

Publication type:

Article

PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 7, p. 464, doi. 10.1002/psp4.12306

By:

Emoto, Chie;
Johnson, Trevor N.;
Neuhoff, Sibylle;
Hahn, David;
Vinks, Alexander A.;
Fukuda, Tsuyoshi

Publication type:

Article

Using a Vancomycin PBPK Model in Special Populations to Elucidate Case‐Based Clinical PK Observations.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 4, p. 237, doi. 10.1002/psp4.12279

By:

Emoto, Chie;
Johnson, Trevor N.;
McPhail, Brooks T.;
Vinks, Alexander A.;
Fukuda, Tsuyoshi

Publication type:

Article

Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 3, p. 175, doi. 10.1002/psp4.12273

By:

Calvier, Elisa A. M.;
Krekels, Elke H. J.;
Yu, Huixin;
Välitalo, Pyry A. J.;
Johnson, Trevor N.;
Rostami‐Hodjegan, Amin;
Tibboel, Dick;
van der Graaf, Piet H.;
Danhof, Meindert;
Knibbe, Catherijne A. J.

Publication type:

Article

Use of a physiologically based pharmacokinetic–pharmacodynamic model for initial dose prediction and escalation during a paediatric clinical trial.

Published in:

British Journal of Clinical Pharmacology, 2021, v. 87, n. 3, p. 1378, doi. 10.1111/bcp.14528

By:

Johnson, Trevor N.;
Abduljalil, Khaled;
Nicolas, Jean‐Marie;
Muglia, Pierandrea;
Chanteux, Hugues;
Nicolai, Johan;
Gillent, Eric;
Cornet, Miranda;
Sciberras, David

Publication type:

Article

Development of a physiologically based pharmacokinetic model for mefloquine and its application alongside a clinical effectiveness model to select an optimal dose for prevention of malaria in young Caucasian children.

Published in:

British Journal of Clinical Pharmacology, 2019, v. 85, n. 1, p. 100, doi. 10.1111/bcp.13764

By:

Johnson, Trevor N.;
Cleary, Yumi;
Parrott, Neil;
Reigner, Bruno;
Smith, James R.;
Toovey, Stephen

Publication type:

Article

Development of a physiologically based pharmacokinetic model of actinomycin D in children with cancer.

Published in:

British Journal of Clinical Pharmacology, 2016, v. 81, n. 5, p. 989, doi. 10.1111/bcp.12878

By:

Walsh, Christopher;
Bonner, Jennifer J.;
Johnson, Trevor N.;
Neuhoff, Sibylle;
Ghazaly, Essam A.;
Gribben, John G.;
Boddy, Alan V.;
Veal, Gareth J.

Publication type:

Article

A pregnancy physiologically based pharmacokinetic (p- PBPK) model for disposition of drugs metabolized by CYP1A2, CYP2D6 and CYP3A4.

Published in:

British Journal of Clinical Pharmacology, 2012, v. 74, n. 5, p. 873, doi. 10.1111/j.1365-2125.2012.04363.x

By:

Gaohua, Lu;
Abduljalil, Khaled;
Jamei, Masoud;
Johnson, Trevor N.;
Rostami-Hodjegan, Amin

Publication type:

Article

Modelling approaches to dose estimation in children.

Published in:

British Journal of Clinical Pharmacology, 2005, v. 59, n. 6, p. 663, doi. 10.1111/j.1365-2125.2005.02429.x

By:

Johnson, Trevor N.

Publication type:

Article

Authors' Reply to Völler et al: "Comment on: Preterm Physiologically Based Pharmacokinetic Model, Part I and Part II".

Published in:

2021

By:

Abduljalil, Khaled;
Pan, Xian;
Pansari, Amita;
Jamei, Masoud;
Johnson, Trevor N.

Publication type:

Letter

Fetal Physiologically Based Pharmacokinetic Models: Systems Information on Fetal Blood Components and Binding Proteins.

Published in:

2020

By:

Abduljalil, Khaled;
Jamei, Masoud;
Johnson, Trevor N.

Publication type:

journal article

Preterm Physiologically Based Pharmacokinetic Model. Part II: Applications of the Model to Predict Drug Pharmacokinetics in the Preterm Population.

Published in:

2020

By:

Abduljalil, Khaled;
Pan, Xian;
Pansari, Amita;
Jamei, Masoud;
Johnson, Trevor N.

Publication type:

journal article

A Preterm Physiologically Based Pharmacokinetic Model. Part I: Physiological Parameters and Model Building.

Published in:

2020

By:

Abduljalil, Khaled;
Pan, Xian;
Pansari, Amita;
Jamei, Masoud;
Johnson, Trevor N.

Publication type:

journal article

Fetal Physiologically Based Pharmacokinetic Models: Systems Information on the Growth and Composition of Fetal Organs.

Published in:

2019

By:

Abduljalil, Khaled;
Jamei, Masoud;
Johnson, Trevor N.

Publication type:

journal article

Fetal Physiologically-Based Pharmacokinetic Models: Systems Information on Fetal Biometry and Gross Composition.

Published in:

2018

By:

Abduljalil, Khaled;
Johnson, Trevor N.;
Rostami-Hodjegan, Amin

Publication type:

journal article

How Biosimulation Can Predict Drug Success.

Published in:

Applied Clinical Trials, 2016, v. 25, n. 4/5, p. 18

By:

Marier, J.F.;
Johnson, Trevor N.;
Minton, Suzanne

Publication type:

Article

Can Population Modelling Principles be Used to Identify Key PBPK Parameters for Paediatric Clearance Predictions? An Innovative Application of Optimal Design Theory.

Published in:

Pharmaceutical Research, 2018, v. 35, n. 11, p. 1, doi. 10.1007/s11095-018-2487-1

By:

Calvier, Elisa A. M.;
Nguyen, Thu Thuy;
Johnson, Trevor N.;
Rostami-Hodjegan, Amin;
Tibboel, Dick;
Krekels, Elke H. J.;
Knibbe, Catherijne A. J.

Publication type:

Article

Incorporation and Performance Verification of Hepatic Portal Blood Flow Shunting in Minimal and Full PBPK Models of Liver Cirrhosis.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 6, p. 1264, doi. 10.1002/cpt.3032

By:

Small, Ben G.;
Hatley, Oliver;
Jamei, Masoud;
Gardner, Iain;
Johnson, Trevor N.

Publication type:

Article

Another Step Toward Qualification of Pediatric Physiologically Based Pharmacokinetic Models to Facilitate Inclusivity and Diversity in Pediatric Clinical Studies.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 113, n. 3, p. 735, doi. 10.1002/cpt.2777

By:

Small, Ben G.;
Johnson, Trevor N.;
Rowland Yeo, Karen

Publication type:

Article

Physiologically‐Based Pharmacokinetic Modeling to Investigate the Effect of Maturation on Buprenorphine Pharmacokinetics in Newborns with Neonatal Opioid Withdrawal Syndrome.

Published in:

Clinical Pharmacology & Therapeutics, 2022, v. 111, n. 2, p. 496, doi. 10.1002/cpt.2458

By:

van Hoogdalem, Matthijs W.;
Johnson, Trevor N.;
McPhail, Brooks T.;
Kamatkar, Suyog;
Wexelblatt, Scott L.;
Ward, Laura P.;
Christians, Uwe;
Akinbi, Henry T.;
Vinks, Alexander A.;
Mizuno, Tomoyuki

Publication type:

Article

Chloroquine Dosing Recommendations for Pediatric COVID‐19 Supported by Modeling and Simulation.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 108, n. 2, p. 248, doi. 10.1002/cpt.1864

By:

Verscheijden, Laurens F. M.;
Zanden, Tjitske M.;
Bussel, Lianne P. M.;
Hoop‐Sommen, Marika;
Russel, Frans G. M.;
Johnson, Trevor N.;
Wildt, Saskia N.

Publication type:

Article

Predictive Performance of Physiologically Based Pharmacokinetic (PBPK) Modeling of Drugs Extensively Metabolized by Major Cytochrome P450s in Children.

Published in:

Clinical Pharmacology & Therapeutics, 2018, v. 104, n. 1, p. 188, doi. 10.1002/cpt.905

By:

Bui, Khanh H.;
Li, Jianguo;
Xu, Hongmei;
Al‐Huniti, Nidal;
Zhou, Diansong;
Zhou, Wangda;
Johnson, Trevor N.;
Cheung, S. Y. Amy

Publication type:

Article

Prediction of liver volume - a population-based approach to meta-analysis of paediatric, adult and geriatric populations - an update.

Published in:

Biopharmaceutics & Drug Disposition, 2017, v. 38, n. 4, p. 290, doi. 10.1002/bdd.2063

By:

Small, Ben G.;
Wendt, Bernd;
Jamei, Masoud;
Johnson, Trevor N.

Publication type:

Article

Does age affect gastric emptying time? A model-based meta-analysis of data from premature neonates through to adults.

Published in:

Biopharmaceutics & Drug Disposition, 2015, v. 36, n. 4, p. 245, doi. 10.1002/bdd.1937

By:

Bonner, Jennifer J.;
Vajjah, Pavan;
Abduljalil, Khaled;
Jamei, Masoud;
Rostami‐Hodjegan, Amin;
Tucker, Geoffrey T.;
Johnson, Trevor N.

Publication type:

Article

Development of physiologically based pharmacokinetic model to evaluate the relative systemic exposure to quetiapine after administration of IR and XR formulations to adults, children and adolescents.

Published in:

Biopharmaceutics & Drug Disposition, 2014, v. 35, n. 6, p. 341, doi. 10.1002/bdd.1899

By:

Johnson, Trevor N.;
Zhou, Diansong;
Bui, Khanh H.

Publication type:

Article

An indirect response model of homocysteine suppression by betaine: optimising the dosage regimen of betaine in homocystinuria.

Published in:

British Journal of Clinical Pharmacology, 2002, v. 54, n. 2, p. 140, doi. 10.1046/j.1365-2125.2002.01620.x

By:

Matthews, Angela;
Johnson, Trevor N.;
Rostami-Hodjegan, Amin;
Chakrapani, Anupam;
Wraith, J. Edward;
Moat, Stuart J.;
Bonham, James R.;
Tucker, Geoffrey T.

Publication type:

Article

Complementary therapies for pharmacists.

Published in:

2002

By:

Johnson, Trevor N.

Publication type:

Book Review

Enterocytic CYP3A4 in a paediatric population: developmental changes and the effect of coeliac disease and cystic fibrosis.

Published in:

British Journal of Clinical Pharmacology, 2001, v. 51, n. 5, p. 451, doi. 10.1046/j.1365-2125.2001.01370.x

By:

Johnson, Trevor N.;
Tanner, M. Stuart;
Taylor, Christopher J.;
Tucker, Geoffrey T.

Publication type:

Article

Anatomical, physiological and metabolic changes with gestational age during normal pregnancy: a database for parameters required in physiologically based pharmacokinetic modelling.

Published in:

2012

By:

Abduljalil K;
Furness P;
Johnson TN;
Rostami-Hodjegan A;
Soltani H;
Abduljalil, Khaled;
Furness, Penny;
Johnson, Trevor N;
Rostami-Hodjegan, Amin;
Soltani, Hora

Publication type:

journal article

Anatomical, Physiological and Metabolic Changes with Gestational Age during Normal Pregnancy.

Published in:

Clinical Pharmacokinetics, 2012, v. 51, n. 6, p. 365, doi. 10.2165/11597440-000000000-00000

By:

Abduljalil, Khaled;
Furness, Penny;
Johnson, Trevor N.;
Rostami-Hodjegan, Amin;
Soltani, Hora

Publication type:

Article

Application of a systems approach to the bottom-up assessment of pharmacokinetics in obese patients: expected variations in clearance.

Published in:

2011

By:

Ghobadi C;
Johnson TN;
Aarabi M;
Almond LM;
Allabi AC;
Rowland-Yeo K;
Jamei M;
Rostami-Hodjegan A;
Ghobadi, Cyrus;
Johnson, Trevor N;
Aarabi, Mohsen;
Almond, Lisa M;
Allabi, Aurel Constant;
Rowland-Yeo, Karen;
Jamei, Masoud;
Rostami-Hodjegan, Amin

Publication type:

journal article

Application of a Systems Approach to the Bottom-Up Assessment of Pharmacokinetics in Obese Patients.

Published in:

Clinical Pharmacokinetics, 2011, v. 50, n. 12, p. 809, doi. 10.2165/11594420-000000000-00000

By:

Ghobadi, Cyrus;
Johnson, Trevor N.;
Aarabi, Mohsen;
Almond, Lisa M.;
Allabi, Aurel Constant;
Rowland-Yeo, Karen;
Jamei, Masoud;
Rostami-Hodjegan, Amin

Publication type:

Article

A Semi-Mechanistic Model to Predict the Effects of Liver Cirrhosis on Drug Clearance.

Published in:

Clinical Pharmacokinetics, 2010, v. 49, n. 3, p. 189, doi. 10.2165/11318160-000000000-00000

By:

Johnson, Trevor N.;
Boussery, Koen;
Rowland-Yeo, Karen;
Tucker, Geoffrey T.;
Rostami-Hodjegan, Amin

Publication type:

Article