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Neratinib, a pan ERBB/HER inhibitor, restores sensitivity of PTEN-null, BRAFV600E melanoma to BRAF/MEK inhibition.
- Published in:
- Frontiers in Oncology, 2024, p. 1, doi. 10.3389/fonc.2024.1191217
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- Publication type:
- Article
Identification of 4‐Anilinoquin(az)oline as a Cell‐Active Protein Kinase Novel 3 (PKN3) Inhibitor Chemotype**.
- Published in:
- ChemMedChem, 2022, v. 17, n. 12, p. 1, doi. 10.1002/cmdc.202200161
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- Article
Synthesis and Evaluation of Novel 1,2,6-Thiadiazinone Kinase Inhibitors as Potent Inhibitors of Solid Tumors.
- Published in:
- Molecules, 2021, v. 26, n. 19, p. 5911, doi. 10.3390/molecules26195911
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- Publication type:
- Article
High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy.
- Published in:
- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-96227-5
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- Article
Limited inhibition of multiple nodes in a driver network blocks metastasis.
- Published in:
- eLife, 2021, p. 1, doi. 10.7554/eLife.59696
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- Publication type:
- Article
SOX4 and SMARCA4 cooperatively regulate PI3k signaling through transcriptional activation of TGFBR2.
- Published in:
- NPJ Breast Cancer, 2021, v. 7, n. 1, p. 1, doi. 10.1038/s41523-021-00248-2
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- Publication type:
- Article
Inhibition of Aurora A Kinase in Combination with Chemotherapy Induces Synthetic Lethality and Overcomes Chemoresistance in Myc-Overexpressing Lymphoma.
- Published in:
- 2019
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- Publication type:
- journal article
proteasome-resistant fragment of NIK mediates oncogenic NF- κ B signaling in schwannomas.
- Published in:
- Human Molecular Genetics, 2019, v. 28, n. 4, p. 572, doi. 10.1093/hmg/ddy361
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- Article
Far away from the lamppost.
- Published in:
- PLoS Biology, 2018, v. 16, n. 12, p. 1, doi. 10.1371/journal.pbio.3000067
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- Article
EPH receptor signaling as a novel therapeutic target in NF2-deficient meningioma.
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- Neuro-Oncology, 2018, v. 20, n. 9, p. 1185, doi. 10.1093/neuonc/noy046
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- Article
Traditional and systems biology based drug discovery for the rare tumor syndrome neurofibromatosis type 2.
- Published in:
- PLoS ONE, 2018, v. 13, n. 6, p. 1, doi. 10.1371/journal.pone.0197350
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- Publication type:
- Article
Identification and Optimization of 4‐Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase.
- Published in:
- ChemMedChem, 2018, v. 13, n. 1, p. 48, doi. 10.1002/cmdc.201700663
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- Publication type:
- Article
Effects of the kinase inhibitor sorafenib on heart, muscle, liver and plasma metabolism in vivo using non-targeted metabolomics analysis.
- Published in:
- 2017
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- Publication type:
- journal article
Measuring Kinase Activity-A Global Challenge.
- Published in:
- Journal of Cellular Biochemistry, 2017, v. 118, n. 11, p. 3595, doi. 10.1002/jcb.26103
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- Publication type:
- Article
Combined kinase inhibitors of MEK1/2 and either PI3K or PDGFR are efficacious in intracranial triple-negative breast cancer.
- Published in:
- Neuro-Oncology, 2017, v. 19, n. 11, p. 1481, doi. 10.1093/neuonc/nox052
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- Publication type:
- Article
Kinome and Transcriptome Profiling Reveal Broad and Distinct Activities of Erlotinib, Sunitinib, and Sorafenib n the Mouse Heart and Suggest Cardiotoxicity From Combined Signal Transducer and Activator of Transcription and Epidermal Growth Factor Receptor Inhibition.
- Published in:
- Journal of the American Heart Association, 2017, v. 6, n. 10, p. 1, doi. 10.1161/JAHA.117.006635
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- Publication type:
- Article
Non-Targeted Metabolomics Analysis of the Effects of Tyrosine Kinase Inhibitors Sunitinib and Erlotinib on Heart, Muscle, Liver and Serum Metabolism In Vivo.
- Published in:
- Metabolites (2218-1989), 2017, v. 7, n. 3, p. 31, doi. 10.3390/metabo7030031
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- Publication type:
- Article
Ambulatory care pharmacy: Realizing the potential for patient access and operational excellence.
- Published in:
- American Journal of Health-System Pharmacy, 2017, v. 74, n. 13, p. 1013, doi. 10.2146/ajhp160802
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- Publication type:
- Article
Targeting the Breast Cancer Kinome.
- Published in:
- Journal of Cellular Physiology, 2017, v. 232, n. 1, p. 53, doi. 10.1002/jcp.25427
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- Publication type:
- Article
Weight loss reduces basal-like breast cancer through kinome reprogramming.
- Published in:
- Cancer Cell International, 2016, v. 16, p. 1, doi. 10.1186/s12935-016-0300-y
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- Publication type:
- Article
Big changes ahead.
- Published in:
- 2015
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- Publication type:
- Letter to the Editor
Proving The Negative: On The Admissibility Of The Lack Of Prior Accidents In A Products Liability Case.
- Published in:
- Defense Counsel Journal, 2015, v. 82, n. 2, p. 131, doi. 10.12690/0161-8202-82.2.131
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- Publication type:
- Article
Assessing adaptation of the cancer kinome in response to targeted therapies.
- Published in:
- Biochemical Society Transactions, 2014, v. 42, n. 4, p. 765, doi. 10.1042/BST20130274
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- Publication type:
- Article
Col-F, a fluorescent probe for ex vivo confocal imaging of collagen and elastin in animal tissues.
- Published in:
- Cytometry. Part A, 2013, v. 83A, n. 6, p. 533, doi. 10.1002/cyto.a.22264
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- Publication type:
- Article
Application of Multiplexed Kinase Inhibitor Beads to Study Kinome Adaptations in Drug-Resistant Leukemia.
- Published in:
- PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0066755
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- Publication type:
- Article
The dynamic nature of the kinome.
- Published in:
- Biochemical Journal, 2013, v. 450, n. 1, p. 1, doi. 10.1042/BJ20121456
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- Publication type:
- Article
Cerebral cavernous malformation is a vascular disease associated with activated RhoA signaling.
- Published in:
- Biological Chemistry, 2013, v. 394, n. 1, p. 35, doi. 10.1515/hsz-2012-0243
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- Publication type:
- Article
Pointed in the RIGHT DIRECTION.
- Published in:
- Quality Progress, 2012, v. 45, n. 9, p. 16
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- Publication type:
- Article
Optimizing 340B purchasing practices.
- Published in:
- American Journal of Health-System Pharmacy, 2012, v. 69, n. 16, p. 1366, doi. 10.2146/ajhp110626
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- Publication type:
- Article
Defining the expressed breast cancer kinome.
- Published in:
- Cell Research, 2012, v. 22, n. 4, p. 620, doi. 10.1038/cr.2012.25
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- Publication type:
- Article
Efficiently identifying genome-wide changes with next-generation sequencing data.
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- Nucleic Acids Research, 2011, v. 39, n. 19, p. e130, doi. 10.1093/nar/gkr592
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- Article
The Practical Art: On the Archaeology and Architecture of Liability Insurance Contracts.
- Published in:
- Defense Counsel Journal, 2011, v. 78, n. 2, p. 143
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- Publication type:
- Article
Defining the Functional Domain of Programmed Cell Death 10 through Its Interactions with Phosphatidylinositol-3,4,5-Trisphosphate.
- Published in:
- PLoS ONE, 2010, v. 5, n. 7, p. 1, doi. 10.1371/journal.pone.0011740
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- Publication type:
- Article
Commentary: Harry Truman's Lessons for Lawyers.
- Published in:
- 2010
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- Publication type:
- Opinion
Coordination of Rho GTPase activities during cell protrusion.
- Published in:
- Nature, 2009, v. 461, n. 7260, p. 99, doi. 10.1038/nature08242
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- Publication type:
- Article
Inhibitors paradoxically prime kinases.
- Published in:
- Nature Chemical Biology, 2009, v. 5, n. 7, p. 448, doi. 10.1038/nchembio.f.11
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- Publication type:
- Article
Data-driven modeling of cellular stimulation, signaling and output response in RAW 264.7 cells.
- Published in:
- Journal of Molecular Signaling, 2008, v. 3, p. 1, doi. 10.1186/1750-2187-3-11
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- Publication type:
- Article
Integrated activation of MAP3Ks balances cell fate in response to stress.
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- Journal of Cellular Biochemistry, 2007, v. 102, n. 4, p. 848, doi. 10.1002/jcb.21522
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- Publication type:
- Article
CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis.
- Published in:
- Human Molecular Genetics, 2005, v. 14, n. 17, p. 2521, doi. 10.1093/hmg/ddi256
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- Publication type:
- Article
MEKK1 regulates the AP-1 dimer repertoire via control of JunB transcription and Fra-2 protein stability.
- Published in:
- Oncogene, 2005, v. 24, n. 5, p. 801, doi. 10.1038/sj.onc.1208239
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- Publication type:
- Article
Wiring diagrams of MAPK regulation by MEKK1, 2, and 3.
- Published in:
- Biochemistry & Cell Biology, 2004, v. 82, n. 6, p. 658, doi. 10.1139/O04-114
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- Publication type:
- Article
MEKK2 regulates the coordinate activation of ERK5 and JNK in response to FGF-2 in fibroblasts (Kamala Kesavan and Katherine Lobel-Rice contributed equally to this work.).
- Published in:
- Journal of Cellular Physiology, 2004, v. 199, n. 1, p. 140, doi. 10.1002/jcp.10457
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- Publication type:
- Article
Rac--MEKK3--MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock.
- Published in:
- Nature Cell Biology, 2003, v. 5, n. 12, p. 1104, doi. 10.1038/ncb1071
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- Publication type:
- Article
MEF2C regulates c-Jun but not TNF-α gene expression in stimulated mast cells.
- Published in:
- European Journal of Immunology, 2003, v. 33, n. 10, p. 2903, doi. 10.1002/eji.200324127
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- Publication type:
- Article
MEKK1-induced apoptosis requires TRAIL death receptor activation and is inhibited by AKT/PKB through inhibition of MEKK1 cleavage.
- Published in:
- Oncogene, 2002, v. 21, n. 43, p. 6649, doi. 10.1038/sj.onc.1205819
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- Publication type:
- Article
Signalling: Mixed-lineage kinase control of JNK and p38 MAPK pathways.
- Published in:
- Nature Reviews Molecular Cell Biology, 2002, v. 3, n. 9, p. 663, doi. 10.1038/nrm906
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- Publication type:
- Article
TRAIL and inhibitors of apoptosis are opposing determinants for NF-KB-dependent, genotoxin-induced apoptosis of cancer cells.
- Published in:
- Oncogene, 2002, v. 21, n. 2, p. 260, doi. 10.1038/sj.onc.1205048
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- Publication type:
- Article
Caspase 8-dependent sensitization of cancer cells to TRAIL-induced apoptosis following reovirus-infection.
- Published in:
- Oncogene, 2001, v. 20, n. 47, p. 6910, doi. 10.1038/sj.onc.1204842
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- Publication type:
- Article
MEKK2 gene disruption causes loss of cytokine production in response to IgE and c‐Kit ligand stimulation of ES cell‐derived mast cells.
- Published in:
- EMBO Journal, 2000, v. 19, n. 20, p. 5387, doi. 10.1093/emboj/19.20.5387
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- Publication type:
- Article
MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells.
- Published in:
- EMBO Journal, 2000, v. 19, n. 20, p. 5387, doi. 10.1093/emboj/19.20.5387
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- Publication type:
- Article