Works by John, Chandy C

Results: 153

Elevated Levels of PDGF-BB and VEGF Are Associated With a Decreased Risk of Readmission or Death in Children With Severe Malarial Anemia.

Published in:

Journal of Infectious Diseases, 2025, v. 231, n. 5, p. 1258, doi. 10.1093/infdis/jiae527

By:

Slaughter, Mary G;
Bhumbra, Samina;
Mellencamp, Kagan A;
Namazzi, Ruth;
Opoka, Robert O;
John, Chandy C

Publication type:

Article

Post-Artesunate Delayed Hemolysis in Pediatric Malaria Patients in the United States.

Published in:

Journal of the Pediatric Infectious Diseases Society, 2024, v. 13, n. 10, p. 533, doi. 10.1093/jpids/piae080

By:

Sundararaman, Sesh A;
Villavicencio, Karen L Hanze;
Roper, Brianne;
Wang, Ziyi;
Davis, Amy K F;
Mayhew, Jonathan A;
Wang, Michelle L;
Tang, Nina L;
Soma, Vijaya L;
Shust, Gail F;
Feeney, Margaret E;
Trehan, Indi;
Weatherhead, Jill E;
John, Chandy C;
Gerber, Jeffrey S;
John, Audrey R Odom

Publication type:

Article

Subclinical Inflammation in Asymptomatic Schoolchildren With Plasmodium falciparum Parasitemia Correlates With Impaired Cognition.

Published in:

Journal of the Pediatric Infectious Diseases Society, 2024, v. 13, n. 5, p. 288, doi. 10.1093/jpids/piae025

By:

Johnson, Alexander E;
Upadhye, Aditi;
Knight, Veronicah;
Gaskin, Erik L;
Turnbull, Lindsey B;
Ayuku, David;
Nyalumbe, Mark;
Abuonji, Emily;
John, Chandy C;
McHenry, Megan S;
Tran, Tuan M;
Ayodo, George

Publication type:

Article

Retinopathy-Positive Cerebral Malaria Is Associated With Greater Inflammation, Blood-Brain Barrier Breakdown, and Neuronal Damage Than Retinopathy-Negative Cerebral Malaria.

Published in:

Journal of the Pediatric Infectious Diseases Society, 2020, v. 9, n. 5, p. 580, doi. 10.1093/jpids/piz082

By:

Villaverde, Chandler;
Namazzi, Ruth;
Shabani, Estela;
Park, Gregory S;
Datta, Dibyadyuti;
Hanisch, Benjamin;
Opoka, Robert O;
John, Chandy C

Publication type:

Article

High Postdischarge Morbidity in Ugandan Children With Severe Malarial Anemia or Cerebral Malaria.

Published in:

Journal of the Pediatric Infectious Diseases Society, 2017, v. 6, n. 3, p. e41, doi. 10.1093/jpids/piw060

By:

Opoka, Robert O.;
Hamre, Karen E. S.;
Brand, Nathan;
Bangirana, Paul;
Idro, Richard;
John, Chandy C.

Publication type:

Article

Adherence to clinical guidelines is associated with reduced inpatient mortality among children with severe anemia in Ugandan hospitals.

Published in:

PLoS ONE, 2019, v. 14, n. 1, p. 1, doi. 10.1371/journal.pone.0210982

By:

Opoka, Robert O.;
Ssemata, Andrew S.;
Oyang, William;
Nambuya, Harriet;
John, Chandy C.;
Karamagi, Charles;
Tumwine, James K.

Publication type:

Article

Community perceptions of paediatric severe anaemia in Uganda.

Published in:

PLoS ONE, 2019, v. 14, n. 01, p. 1, doi. 10.1371/journal.pone.0209476

By:

Dhabangi, Aggrey;
Idro, Richard;
John, Chandy C.;
Dzik, Walter H.;
Siu, Godfrey E.;
Opoka, Robert O.;
Ayebare, Florence;
van Hensbroek, Michael B.

Publication type:

Article

Evaluation of an ultrasensitive HRP2– based rapid diagnostic test for detection of asymptomatic Plasmodium falciparum parasitaemia among children in western Kenya

Published in:

Malaria Journal, 2022, v. 21, n. 1, p. 1, doi. 10.1186/s12936-022-04351-y

By:

Turnbull, Lindsey B.;
Ayodo, George;
Knight, Veronicah;
John, Chandy C.;
McHenry, Megan S.;
Tran, Tuan M.

Publication type:

Article

Towards the use of a smartphone imaging-based tool for point-of-care detection of asymptomatic low-density malaria parasitaemia.

Published in:

Malaria Journal, 2021, v. 20, n. 1, p. 1, doi. 10.1186/s12936-021-03894-w

By:

Colbert, Ashlee J.;
Co, Katrina;
Lima-Cooper, Giselle;
Lee, Dong Hoon;
Clayton, Katherine N.;
Wereley, Steven T.;
John, Chandy C.;
Linnes, Jacqueline C.;
Kinzer-Ursem, Tamara L.

Publication type:

Article

The prevalence and density of asymptomatic Plasmodium falciparum infections among children and adults in three communities of western Kenya.

Published in:

Malaria Journal, 2021, v. 20, n. 1, p. 1, doi. 10.1186/s12936-021-03905-w

By:

Salgado, Christina;
Ayodo, George;
Macklin, Michael D.;
Gould, Meetha P.;
Nallandhighal, Srinivas;
Odhiambo, Eliud O.;
Obala, Andrew;
O'Meara, Wendy Prudhomme;
John, Chandy C.;
Tran, Tuan M.

Publication type:

Article

Blackwater fever and acute kidney injury in children hospitalized with an acute febrile illness: pathophysiology and prognostic significance.

Published in:

BMC Medicine, 2022, v. 20, n. 1, p. 1, doi. 10.1186/s12916-022-02410-4

By:

Conroy, Andrea L.;
Hawkes, Michael T.;
Leligdowicz, Aleksandra;
Mufumba, Ivan;
Starr, Michelle C.;
Zhong, Kathleen;
Namasopo, Sophie;
John, Chandy C.;
Opoka, Robert O.;
Kain, Kevin C.

Publication type:

Article

Blackwater fever and acute kidney injury in children hospitalized with an acute febrile illness: pathophysiology and prognostic significance.

Published in:

2022

By:

Conroy, Andrea L.;
Hawkes, Michael T.;
Leligdowicz, Aleksandra;
Mufumba, Ivan;
Starr, Michelle C.;
Zhong, Kathleen;
Namasopo, Sophie;
John, Chandy C.;
Opoka, Robert O.;
Kain, Kevin C.

Publication type:

journal article

Developing mentorship in a resource-limited context: a qualitative research study of the experiences and perceptions of the makerere university student and faculty mentorship programme.

Published in:

BMC Medical Education, 2017, v. 17, p. 1, doi. 10.1186/s12909-017-0962-8

By:

Ssemata, Andrew S.;
Gladding, Sophia;
John, Chandy C.;
Kiguli, Sarah

Publication type:

Article

Global research priorities for infections that affect the nervous system.

Published in:

Nature, 2015, v. 527, n. s7578, p. S178, doi. 10.1038/nature16033

By:

John, Chandy C.;
Carabin, Hélène;
Montano, Silvia M.;
Bangirana, Paul;
Zunt, Joseph R.;
Peterson, Phillip K.

Publication type:

Article

Plasmodium falciparum Histidine-Rich Protein-2 Plasma Concentrations Are Higher in Retinopathy-Negative Cerebral Malaria Than in Severe Malarial Anemia.

Published in:

Open Forum Infectious Diseases, 2017, v. 4, n. 3, p. 1, doi. 10.1093/ofid/ofx151

By:

Park, Gregory S.;
Opoka, Robert O.;
Shabani, Estela;
Wypyszynski, Alexis;
Hanisch, Benjamin;
John, Chandy C.

Publication type:

Article

The Plasmodium falciparum Antigen MB2 Induces Interferon-γ and Interleukin-10 Responses in Adults in Malaria Endemic Areas of Western Kenya.

Published in:

Journal of Global Infectious Diseases, 2013, v. 5, n. 4, p. 131, doi. 10.4103/0974-777X.122001

By:

Ochola, Lyticia A.;
Ng'wena, Gideon M.;
Noland, Gregory S.;
Ondigo, Bartholomew N.;
Ayodo, George;
John, Chandy C.

Publication type:

Article

Artemisinin Partial Resistance in Ugandan Children—Reply.

Published in:

JAMA: Journal of the American Medical Association, 2025, v. 333, n. 16, p. 1456, doi. 10.1001/jama.2025.0016

By:

Namazzi, Ruth;
John, Chandy C.;
Sutherland, Colin

Publication type:

Article

Artemisinin Partial Resistance in Ugandan Children With Complicated Malaria.

Published in:

JAMA: Journal of the American Medical Association, 2025, v. 333, n. 1, p. 83, doi. 10.1001/jama.2024.22343

By:

Henrici, Ryan C.;
Namazzi, Ruth;
Lima-Cooper, Giselle;
Kato, Charles;
Aliwuya, Sadati;
Dombrowski, Jamille G.;
Pratt, Sade;
Campino, Susana;
Conroy, Andrea L.;
Sutherland, Colin J.;
John, Chandy C.;
Opoka, Robert O.

Publication type:

Article

Azithromycin for Prevention of Mortality in African Children: More Data, More Questions.

Published in:

JAMA: Journal of the American Medical Association, 2024, v. 331, n. 6, p. 475, doi. 10.1001/jama.2023.27329

By:

John, Chandy C.;
Namazzi, Ruth;
Schneider, Jack G.

Publication type:

Article

Vitamin D Insufficiency Is Common in Ugandan Children and Is Associated with Severe Malaria.

Published in:

PLoS ONE, 2014, v. 9, n. 12, p. 1, doi. 10.1371/journal.pone.0113185

By:

Cusick, Sarah E.;
Opoka, Robert O.;
Lund, Troy C.;
John, Chandy C.;
Polgreen, Lynda E.

Publication type:

Article

Changes in B Cell Populations and Merozoite Surface Protein-1-Specific Memory B Cell Responses after Prolonged Absence of Detectable <i>P. falciparum</i> Infection.

Published in:

PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0067230

By:

Ayieko, Cyrus;
Maue, Alexander C.;
Jura, Walter G. Z. O.;
Noland, Gregory S.;
Ayodo, George;
Rochford, Rosemary;
John, Chandy C.

Publication type:

Article

The Association between Cognition and Academic Performance in Ugandan Children Surviving Malaria with Neurological Involvement.

Published in:

PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0055653

By:

Bangirana, Paul;
Menk, Jeremiah;
John, Chandy C.;
Boivin, Michael J.;
Hodges, James S.

Publication type:

Article

Recurrent Plasmodium falciparum Malaria Infections in Kenyan Children Diminish T-Cell Immunity to Epstein Barr Virus Lytic but Not Latent Antigens.

Published in:

PLoS ONE, 2012, v. 7, n. 3, p. 1, doi. 10.1371/journal.pone.0031753

By:

Snider, Cynthia J.;
Cole, Stephen R.;
Chelimo, Kiprotich;
Sumba, Peter Odada;
MacDonald, Pia D. M.;
John, Chandy C.;
Meshnick, Steven R.;
Moormann, Ann M.

Publication type:

Article

Serum Angiopoietin-1 and -2 Levels Discriminate Cerebral Malaria from Uncomplicated Malaria and Predict Clinical Outcome in African Children.

Published in:

PLoS ONE, 2009, v. 4, n. 3, p. 1, doi. 10.1371/journal.pone.0004912

By:

Lovegrove, Fiona E.;
Tangpukdee, Noppadon;
Opoka, Robert O.;
Lafferty, Erin I.;
Rajwans, Nimerta;
Hawkes, Michael;
Krudsood, Srivicha;
Looareesuwan, Sornchai;
John, Chandy C.;
Liles, W. Conrad;
Kain, Kevin C.

Publication type:

Article

Prospective validation of pediatric disease severity scores to predict mortality in Ugandan children presenting with malaria and non-malaria febrile illness.

Published in:

Critical Care, 2015, v. 19, n. 1, p. 1, doi. 10.1186/s13054-015-0773-4

By:

Conroy, Andrea L.;
Hawkes, Michael;
Hayford, Kyla;
Namasopo, Sophie;
Opoka, Robert O.;
John, Chandy C.;
Liles, W. Conrad;
Kain, Kevin C.

Publication type:

Article

Prospective validation of pediatric disease severity scores to predict mortality in Ugandan children presenting with malaria and non-malaria febrile illness.

Published in:

2015

By:

Conroy, Andrea L;
Hawkes, Michael;
Hayford, Kyla;
Namasopo, Sophie;
Opoka, Robert O;
John, Chandy C;
Liles, W Conrad;
Kain, Kevin C

Publication type:

journal article

Malaria chemoprevention with monthly dihydroartemisinin-piperaquine for the post-discharge management of severe anaemia in children aged less than 5 years in Uganda and Kenya: study protocol for a multi-centre, two-arm, randomised, placebo-controlled, superiority trial.

Published in:

2018

By:

Kwambai, Titus K.;
Dhabangi, Aggrey;
Idro, Richard;
Opoka, Robert;
Kariuki, Simon;
Samuels, Aaron M.;
Desai, Meghna;
van Hensbroek, Michael Boele;
John, Chandy C.;
Robberstad, Bjarne;
Wang, Duolao;
Phiri, Kamija;
ter Kuile, Feiko O.

Publication type:

journal article

Perceived benefits and risks of participation in a clinical trial for Ugandan children with sickle cell anemia.

Published in:

2020

By:

Carman, Aubri S.;
Sautter, Casey;
Anyanwu, Juliana N.;
Ssemata, Andrew S.;
Opoka, Robert O.;
Ware, Russell E.;
Rujumba, Joseph;
John, Chandy C.

Publication type:

journal article

Lack of mortality in 22 children with sickle cell anemia and severe malarial anemia.

Published in:

2018

By:

Opoka, Robert O.;
Bangirana, Paul;
Idro, Richard;
Shabani, Estela;
Namazzi, Ruth;
John, Chandy C.

Publication type:

journal article

Decline in Childhood Iron Deficiency After Interruption of Malaria Transmission in Highland Kenya.

Published in:

FASEB Journal, 2013, v. 27, p. 845.23, doi. 10.1096/fasebj.27.1_supplement.845.23

By:

Cusick, Sarah Eastman;
Frosch, Anne E. P.;
Ondigo, Bartholomew N.;
Ayodo, George A.;
John, Chandy C.

Publication type:

Article

Cerebral malaria is associated with long-term mental health disorders: a cross sectional survey of a long-term cohort.

Published in:

Malaria Journal, 2016, v. 15, p. 1, doi. 10.1186/s12936-016-1233-6

By:

Idro, Richard;
Kakooza-Mwesige, Angelina;
Asea, Benjamin;
Ssebyala, Keron;
Bangirana, Paul;
Opoka, Robert O.;
Lubowa, Samson K.;
Semrud-Clikeman, Margaret;
John, Chandy C.;
Nalugya, Joyce

Publication type:

Article

Sensitivity of fever for diagnosis of clinical malaria in a Kenyan area of unstable, low malaria transmission.

Published in:

Malaria Journal, 2014, v. 13, n. 1, p. 1, doi. 10.1186/1475-2875-13-163

By:

Mutanda, Albino L.;
Cheruiyot, Priscah;
Hodges, James S.;
Ayodo, George;
Odero, Wilson;
John, Chandy C.

Publication type:

Article

Use of a three-band HRP2/pLDH combination rapid diagnostic test increases diagnostic specificity for falciparum malaria in Ugandan children.

Published in:

Malaria Journal, 2014, v. 13, n. 1, p. 1, doi. 10.1186/1475-2875-13-43

By:

Hawkes, Michael;
Conroy, Andrea L.;
Opoka, Robert O.;
Namasopo, Sophie;
Liles, W. Conrad;
John, Chandy C.;
Kain, Kevin C.

Publication type:

Article

Standardization and validation of a cytometric bead assay to assess antibodies to multiple Plasmodium falciparum recombinant antigens.

Published in:

Malaria Journal, 2012, v. 11, n. 1, p. 427, doi. 10.1186/1475-2875-11-427

By:

Ondigo, Bartholomew N.;
Park, Gregory S.;
Gose, Severin O.;
Ho, Benjamin M.;
Ochola, Lyticia A.;
Ayodo, George O.;
Ofulla, Ayub V.;
John, Chandy C.

Publication type:

Article

Local topographic wetness indices predict household malaria risk better than land-use and land-cover in the western Kenya highlands.

Published in:

Malaria Journal, 2010, v. 9, p. 328, doi. 10.1186/1475-2875-9-328

By:

Cohen, Justin M.;
Ernst, Kacey C.;
Lindblade, Kim A.;
Vulule, John M.;
John, Chandy C.;
Wilson, Mark L.

Publication type:

Article

Topography-derived wetness indices are associated with household-level malaria risk in two communities in the western Kenyan highlands.

Published in:

Malaria Journal, 2008, v. 7, p. 1, doi. 10.1186/1475-2875-7-40

By:

Cohen, Justin M.;
Ernst, Kacey C.;
Lindblade, Kim A.;
Vulule, John M.;
John, Chandy C.;
Wilson, Mark L.

Publication type:

Article

Malaria hotspot areas in a highland Kenya site are consistent in epidemic and non-epidemic years and are associated with ecological factors.

Published in:

Malaria Journal, 2006, v. 5, p. 78, doi. 10.1186/1475-2875-5-78

By:

Ernst, Kacey C.;
Adoka, Samson O.;
Kowuor, Dickens O.;
Wilson, Mark L.;
John, Chandy C.

Publication type:

Article

Interferon-gamma responses to Plasmodium falciparum liver-stage antigen-1 and merozoite-surface protein-1 increase with age in children in a malaria holoendemic area of western Kenya.

Published in:

Malaria Journal, 2003, v. 2, p. 1

By:

Chelimo, Kiprotich;
Sumba, Peter O.;
Kazura, James W.;
Ofula, Ayub V.;
John, Chandy C.

Publication type:

Article

Methemoglobin and nitric oxide therapy in Ugandan children hospitalized for febrile illness: results from a prospective cohort study and randomized double-blind placebo-controlled trial.

Published in:

BMC Pediatrics, 2016, v. 16, p. 1, doi. 10.1186/s12887-016-0719-2

By:

Conroy, Andrea L.;
Hawkes, Michael;
Hayford, Kyla;
Hermann, Laura;
McDonald, Chloe R.;
Sharma, Suparna;
Namasopo, Sophie;
Opoka, Robert O.;
John, Chandy C.;
Liles, W. Conrad;
Miller, Christopher;
Kain, Kevin C.

Publication type:

Article

Methods to estimate baseline creatinine and define acute kidney injury in lean Ugandan children with severe malaria: a prospective cohort study.

Published in:

2020

By:

Batte, Anthony;
Starr, Michelle C.;
Schwaderer, Andrew L.;
Opoka, Robert O.;
Namazzi, Ruth;
Phelps Nishiguchi, Erika S.;
Ssenkusu, John M.;
John, Chandy C.;
Conroy, Andrea L.

Publication type:

journal article

Blood biomarkers of neuronal injury in paediatric cerebral malaria and severe malarial anaemia.

Published in:

Brain Communications, 2023, v. 5, n. 6, p. 1, doi. 10.1093/braincomms/fcad323

By:

Datta, Dibyadyuti;
Gopinadhan, Adnan;
Soto, Alejandro;
Bangirana, Paul;
Opoka, Robert O.;
Conroy, Andrea L.;
Saykin, Andrew J.;
Keisuke Kawata;
John, Chandy C.

Publication type:

Article

Xanthine oxidase levels and immune dysregulation are independently associated with anemia in Plasmodium falciparum malaria.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-41764-4

By:

Vasquez, Marilyn;
Sica, Margaux;
Namazzi, Ruth;
Opoka, Robert O.;
Sherman, Julian;
Datta, Dibyadyuti;
Duran-Frigola, Miquel;
Ssenkusu, John M.;
John, Chandy C.;
Conroy, Andrea L.;
Rodriguez, Ana

Publication type:

Article

Hepatitis A Screening for Internationally Adopted Children From Hepatitis A Endemic Countries.

Published in:

Clinical Pediatrics, 2014, v. 53, n. 1, p. 31, doi. 10.1177/0009922813505903

By:

Raabe, Vanessa N.;
Sautter, Casey;
Chesney, Mary;
Eckerle, Judith K.;
Howard, Cynthia R.;
John, Chandy C.

Publication type:

Article

Essential Factors for the Development of a Residency Global Health Track.

Published in:

Clinical Pediatrics, 2012, v. 51, n. 9, p. 862, doi. 10.1177/0009922812450507

By:

Campagna, Ann M.;
St. Clair, Nicole E.;
Gladding, Sophia P.;
Wagner, Sabrina M.;
John, Chandy C.

Publication type:

Article

Cost-Effectiveness of Hydroxyurea for Sickle Cell Anemia in a Low-Income African Setting: A Model-Based Evaluation of Two Dosing Regimens.

Published in:

PharmacoEconomics, 2023, v. 41, n. 12, p. 1603, doi. 10.1007/s40273-023-01294-3

By:

Teigen, David;
Opoka, Robert O.;
Kasirye, Phillip;
Nabaggala, Catherine;
Hume, Heather A.;
Blomberg, Bjørn;
John, Chandy C.;
Ware, Russell E.;
Robberstad, Bjarne

Publication type:

Article

Improving the diagnosis of severe malaria in African children using platelet counts and plasma PfHRP2 concentrations.

Published in:

Science Translational Medicine, 2022, v. 14, n. 654, p. 1, doi. 10.1126/scitranslmed.abn5040

By:

Watson, James A.;
Uyoga, Sophie;
Wanjiku, Perpetual;
Makale, Johnstone;
Nyutu, Gideon M.;
Mturi, Neema;
George, Elizabeth C.;
Woodrow, Charles J.;
Day, Nicholas P. J.;
Bejon, Philip;
Opoka, Robert O.;
Dondorp, Arjen M.;
John, Chandy C.;
Maitland, Kathryn;
Williams, Thomas N.;
White, Nicholas J.

Publication type:

Article

Toward a Better Malaria Vaccine: Understanding How Antibodies to Malaria Protect Against Disease.

Published in:

2015

By:

John, Chandy C.

Publication type:

Editorial

Severe Hemolysis as a Potential Contributing Factor in the Pathophysiology of Cerebral Malaria.

Published in:

2015

By:

Shabani, Estela;
Vercellotti, Gregory M.;
John, Chandy C.

Publication type:

Letter to the Editor

High Plasma Erythropoietin Levels are Associated With Prolonged Coma Duration and Increased Mortality in Children With Cerebral Malaria.

Published in:

Clinical Infectious Diseases, 2015, v. 60, n. 1, p. 27, doi. 10.1093/cid/ciu735

By:

Shabani, Estela;
Opoka, Robert O.;
Idro, Richard;
Schmidt, Robert;
Park, Gregory S.;
Bangirana, Paul;
Vercellotti, Gregory M.;
Hodges, James S.;
Widness, John A.;
John, Chandy C.

Publication type:

Article

Severe Malarial Anemia is Associated With Long-term Neurocognitive Impairment.

Published in:

Clinical Infectious Diseases, 2014, v. 59, n. 3, p. 336, doi. 10.1093/cid/ciu293

By:

Bangirana, Paul;
Opoka, Robert O.;
Boivin, Michael J.;
Idro, Richard;
Hodges, James S.;
Romero, Regilda A.;
Shapiro, Elsa;
John, Chandy C.

Publication type:

Article