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MPT0B002, a novel microtubule inhibitor, downregulates T315I mutant Bcr-Abl and induces apoptosis of imatinib-resistant chronic myeloid leukemia cells.
- Published in:
- Investigational New Drugs, 2017, v. 35, n. 4, p. 427, doi. 10.1007/s10637-017-0457-9
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- Publication type:
- Article
In vitro and in vivo anti-tumour effects of MPT0B014, a novel derivative aroylquinoline, and in combination with erlotinib in human non-small-cell lung cancer cells.
- Published in:
- British Journal of Pharmacology, 2014, v. 171, n. 1, p. 122, doi. 10.1111/bph.12427
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- Publication type:
- Article
2-Methoxyestradiol attenuates phosphatidylinositol 3-kinase/Akt pathway-mediated metastasis of gastric cancer.
- Published in:
- International Journal of Cancer, 2007, v. 121, n. 11, p. 2547, doi. 10.1002/ijc.22963
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- Publication type:
- Article
Histone deacetylase 6 acts upstream of DNA damage response activation to support the survival of glioblastoma cells.
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- Cell Death & Disease, 2021, v. 12, n. 10, p. 1, doi. 10.1038/s41419-021-04182-w
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- Publication type:
- Article
The novel histone de acetylase 6 inhibitor, MPT0G211, ameliorates tau phosphorylation and cognitive deficits in an Alzheimer’s disease model.
- Published in:
- Cell Death & Disease, 2018, v. 9, n. 6, p. 1, doi. 10.1038/s41419-018-0688-5
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- Article
Evaluation of the safety and efficacy of warfarin in Taiwanese patients.
- Published in:
- International Journal of Clinical Pharmacology & Therapeutics, 2013, v. 51, n. 2, p. 106, doi. 10.5414/CP201774
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- Publication type:
- Article
Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents.
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- Molecules, 2011, v. 16, n. 3, p. 2274, doi. 10.3390/molecules16032274
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- Article
Beyond the vaccines: a glance at the small molecule and peptide-based anti-COVID19 arsenal.
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- Journal of Biomedical Science, 2022, v. 29, n. 1, p. 1, doi. 10.1186/s12929-022-00847-6
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- Publication type:
- Article
Beyond the vaccines: a glance at the small molecule and peptide-based anti-COVID19 arsenal.
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- Journal of Biomedical Science, 2022, v. 29, n. 1, p. 1, doi. 10.1186/s12929-022-00847-6
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- Publication type:
- Article
Recent developments in epigenetic cancer therapeutics: clinical advancement and emerging trends.
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- Journal of Biomedical Science, 2021, v. 28, n. 1, p. 1, doi. 10.1186/s12929-021-00721-x
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- Publication type:
- Article
Systemic and brain bioavailabilities of D-Phenylglycine-L-Dopa, a sustained dopamine-releasing prodrug.
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- Journal of Food & Drug Analysis, 2013, v. 21, n. 2, p. 136, doi. 10.1016/j.jfda.2013.05.001
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- Publication type:
- Article
Anticancer Study of a Novel Pan-HDAC Inhibitor MPT0G236 in Colorectal Cancer Cells.
- Published in:
- International Journal of Molecular Sciences, 2023, v. 24, n. 16, p. 12588, doi. 10.3390/ijms241612588
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- Publication type:
- Article
Effect of Sulfotyrosine and Negatively Charged Amino Acid of Leech‐Derived Peptides on Binding and Inhibitory Activity Against Thrombin.
- Published in:
- ChemBioChem, 2024, v. 25, n. 3, p. 1, doi. 10.1002/cbic.202300744
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- Publication type:
- Article
HDAC6 involves in regulating the lncRNA-microRNA-mRNA network to promote the proliferation of glioblastoma cells.
- Published in:
- Journal of Experimental & Clinical Cancer Research (17569966), 2022, v. 41, n. 1, p. 1, doi. 10.1186/s13046-022-02257-w
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- Publication type:
- Article
HDAC6 involves in regulating the lncRNA-microRNA-mRNA network to promote the proliferation of glioblastoma cells.
- Published in:
- Journal of Experimental & Clinical Cancer Research (17569966), 2022, v. 41, n. 1, p. 1, doi. 10.1186/s13046-022-02257-w
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- Publication type:
- Article
HDAC6 involves in regulating the lncRNA-microRNA-mRNA network to promote the proliferation of glioblastoma cells.
- Published in:
- Journal of Experimental & Clinical Cancer Research (17569966), 2022, v. 41, n. 1, p. 1, doi. 10.1186/s13046-022-02257-w
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- Publication type:
- Article
The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells.
- Published in:
- Clinical Epigenetics, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13148-018-0595-8
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- Publication type:
- Article
Pharmacokinetics and protein binding of MPT0B292.
- Published in:
- Biopharmaceutics & Drug Disposition, 2017, v. 38, n. 5, p. 340, doi. 10.1002/bdd.2067
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- Publication type:
- Article
Intermediary Metabolite Precursor Dimethyl-2-Ketoglutarate Stabilizes Hypoxia-Inducible Factor-1α by Inhibiting Prolyl-4-Hydroxylase PHD2.
- Published in:
- PLoS ONE, 2014, v. 9, n. 11, p. 1, doi. 10.1371/journal.pone.0113865
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- Publication type:
- Article
A Novel Synthetic Microtubule Inhibitor, MPT0B214 Exhibits Antitumor Activity in Human Tumor Cells through Mitochondria-Dependent Intrinsic Pathway.
- Published in:
- PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0058953
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- Publication type:
- Article
Anticancer Activity of MPT0E028, a Novel Potent Histone Deacetylase Inhibitor, in Human Colorectal Cancer HCT116 Cells In Vitroand In Vivo.
- Published in:
- PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0043645
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- Publication type:
- Article
Anti-Arthritic Effects of Magnolol in Human Interleukin 1β-Stimulated Fibroblast-Like Synoviocytes and in a Rat Arthritis Model.
- Published in:
- PLoS ONE, 2012, v. 7, n. 2, p. 1, doi. 10.1371/journal.pone.0031368
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- Publication type:
- Article
Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivo.
- Published in:
- Scientific Reports, 2017, p. 42291, doi. 10.1038/srep42291
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- Publication type:
- Article
MPT0G066, a novel anti-mitotic drug, induces JNK-independent mitotic arrest, JNK-mediated apoptosis, and potentiates antineoplastic effect of cisplatin in ovarian cancer.
- Published in:
- Scientific Reports, 2016, p. 31664, doi. 10.1038/srep31664
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- Publication type:
- Article
LTP-1, a novel antimitotic agent and Stat3 inhibitor, inhibits human pancreatic carcinomas in vitro and in vivo.
- Published in:
- Scientific Reports, 2016, p. 27794, doi. 10.1038/srep27794
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- Publication type:
- Article
Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status.
- Published in:
- Clinical Epigenetics, 2019, v. 11, n. 1, p. N.PAG, doi. 10.1186/s13148-019-0681-6
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- Publication type:
- Article
2-Amino-3,4,5-Trimethoxybenzophenones as Potent Tubulin Polymerization Inhibitors.
- Published in:
- ChemMedChem, 2011, v. 6, n. 3, p. 450, doi. 10.1002/cmdc.201000479
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- Publication type:
- Article
Synthesis and Structure-Activity Relationships of 1-Benzyl-4,5,6-trimethoxyindoles as a Novel Class of Potent Antimitotic Agents.
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- ChemMedChem, 2009, v. 4, n. 4, p. 588, doi. 10.1002/cmdc.200800405
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- Publication type:
- Article
Structure-Activity Relationship Studies of 3-Aroylindoles as Potent Antimitotic Agents.
- Published in:
- ChemMedChem, 2006, v. 1, n. 10, p. 1106, doi. 10.1002/cmdc.200600125
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- Publication type:
- Article
MPT0G413, A Novel HDAC6-Selective Inhibitor, and Bortezomib Synergistically Exert Anti-tumor Activity in Multiple Myeloma Cells.
- Published in:
- Frontiers in Oncology, 2019, p. N.PAG, doi. 10.3389/fonc.2019.00249
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- Publication type:
- Article
Novel microtubule inhibitor MPT0B098 inhibits hypoxia-induced epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma.
- Published in:
- Journal of Biomedical Science, 2018, v. 25, p. 1, doi. 10.1186/s12929-018-0432-6
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- Publication type:
- Article
Suberoylanilide hydroxamic acid represses glioma stem-like cells.
- Published in:
- Journal of Biomedical Science, 2016, v. 23, p. 1, doi. 10.1186/s12929-016-0296-6
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- Publication type:
- Article
1-Arylsulfonyl-5-( N-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors.
- Published in:
- ChemBioChem, 2013, v. 14, n. 10, p. 1248, doi. 10.1002/cbic.201300201
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- Publication type:
- Article
Inside Cover: 1-Arylsulfonyl-5-( N-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors (ChemBioChem 10/2013).
- Published in:
- ChemBioChem, 2013, v. 14, n. 10, p. 1150, doi. 10.1002/cbic.201390034
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- Publication type:
- Article
MPT0B169, a New Tubulin Inhibitor, Inhibits Cell Growth and Induces G2/M Arrest in Nonresistant and Paclitaxel-Resistant Cancer Cells.
- Published in:
- Pharmacology, 2013, v. 92, n. 1/2, p. 90, doi. 10.1159/000351852
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- Publication type:
- Article
A novel dual HDAC and HSP90 inhibitor, MPT0G449, downregulates oncogenic pathways in human acute leukemia in vitro and in vivo.
- Published in:
- Oncogenesis, 2021, v. 10, n. 5, p. 1, doi. 10.1038/s41389-021-00331-0
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- Publication type:
- Article
Combining an Autophagy Inhibitor, MPT0L145, with Abemaciclib Is a New Therapeutic Strategy in GBM Treatment.
- Published in:
- Cancers, 2021, v. 13, n. 23, p. 6117, doi. 10.3390/cancers13236117
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- Publication type:
- Article
Targeting Autophagy by MPT0L145, a Highly Potent PIK3C3 Inhibitor, Provides Synergistic Interaction to Targeted or Chemotherapeutic Agents in Cancer Cells.
- Published in:
- Cancers, 2019, v. 11, n. 9, p. 1345, doi. 10.3390/cancers11091345
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- Publication type:
- Article
Denbinobin upregulates miR-146a expression and attenuates IL-1β-induced upregulation of ICAM-1 and VCAM-1 expressions in osteoarthritis fibroblast-like synoviocytes.
- Published in:
- Journal of Molecular Medicine, 2014, v. 92, n. 11, p. 1147, doi. 10.1007/s00109-014-1192-8
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- Publication type:
- Article
A Novel Dual HDAC6 and Tubulin Inhibitor, MPT0B451, Displays Anti-tumor Ability in Human Cancer Cells in Vitro and in Vivo.
- Published in:
- Frontiers in Pharmacology, 2018, p. 1, doi. 10.3389/fphar.2018.00205
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- Publication type:
- Article
HDAC inhibitor protects chronic cerebral hypoperfusion and oxygen‐glucose deprivation injuries via H3K14 and H4K5 acetylation‐mediated BDNF expression.
- Published in:
- Journal of Cellular & Molecular Medicine, 2020, v. 24, n. 12, p. 6966, doi. 10.1111/jcmm.15358
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- Article
Erratum to: A novel tubulin polymerization inhibitor, MPT0B206, downregulates Bcr-Abl expression and induces apoptosis in imatinib-sensitive and imatinib-resistant CML cells.
- Published in:
- 2017
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- Publication type:
- Erratum
A novel tubulin polymerization inhibitor, MPT0B206, downregulates Bcr-Abl expression and induces apoptosis in imatinib-sensitive and imatinib-resistant CML cells.
- Published in:
- Apoptosis, 2016, v. 21, n. 9, p. 1008, doi. 10.1007/s10495-016-1264-z
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- Publication type:
- Article
Increased activation of HDAC1/2/6 and Sp1 underlies therapeutic resistance and tumor growth in glioblastoma.
- Published in:
- Neuro-Oncology, 2020, v. 22, n. 10, p. 1439, doi. 10.1093/neuonc/noaa103
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- Publication type:
- Article
Optimization and Development of Selective Histone Deacetylase Inhibitor (MPT0B291)-Loaded Albumin Nanoparticles for Anticancer Therapy.
- Published in:
- Pharmaceutics, 2021, v. 13, n. 10, p. 1728, doi. 10.3390/pharmaceutics13101728
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- Publication type:
- Article
The synergic effect of vincristine and vorinostat in leukemia in vitro and in vivo.
- Published in:
- Journal of Hematology & Oncology, 2015, v. 8, n. 1, p. 1, doi. 10.1186/s13045-015-0176-7
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- Publication type:
- Article
MPT0B098, a Microtubule Inhibitor, Suppresses JAK2/STAT3 Signaling Pathway through Modulation of SOCS3 Stability in Oral Squamous Cell Carcinoma.
- Published in:
- PLoS ONE, 2016, v. 11, n. 7, p. 1, doi. 10.1371/journal.pone.0158440
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- Publication type:
- Article
MT-4 Suppresses Resistant Ovarian Cancer Growth through Targeting Tubulin and HSP27.
- Published in:
- PLoS ONE, 2015, v. 10, n. 4, p. 1, doi. 10.1371/journal.pone.0123819
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- Article