Works by Jin, Jin Y.

Results: 53

Quantitative Assessment of Drug Efficacy and Emergence of Resistance in Patients with Metastatic Renal Cell Carcinoma Using a Longitudinal Exposure‐Tumor Growth Inhibition Model: Apitolisib (Dual PI3K/mTORC1/2 Inhibitor) Versus Everolimus (mTORC1 Inhibitor)

Published in:

Journal of Clinical Pharmacology, 2024, v. 64, n. 9, p. 1101, doi. 10.1002/jcph.2444

By:

Moein, Anita;
Jin, Jin Y.;
Wright, Matthew R.;
Wong, Harvey

Publication type:

Article

Population Pharmacokinetics of Ranibizumab Delivered via the Port Delivery System Implanted in the Eye in Patients with Neovascular Age‐Related Macular Degeneration.

Published in:

Journal of Clinical Pharmacology, 2023, v. 63, n. 11, p. 1210, doi. 10.1002/jcph.2290

By:

Kågedal, Matts;
Alskär, Oskar;
Petersson, Klas;
Hanze, Eva;
Maia, Mauricio;
Lu, Tong;
Vakhavkar, Shweta;
Quartino, Angelica;
Willis, Jeffrey R.;
Jin, Jin Y.;
Maass, Katie F.

Publication type:

Article

Impact of Dose Delays and Alternative Dosing Regimens on Pertuzumab Pharmacokinetics.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 8, p. 1096, doi. 10.1002/jcph.1855

By:

Liu, Stephanie N.;
Lu, Tong;
Jin, Jin Y.;
Li, Chunze;
Girish, Sandhya;
Melnikov, Fjodor;
Badovinac Crnjevic, Tanja;
Machackova, Zuzana;
Restuccia, Eleonora;
Kirschbrown, Whitney P.

Publication type:

Article

Impact of Physiologically Based Pharmacokinetics, Population Pharmacokinetics and Pharmacokinetics/Pharmacodynamics in the Development of Antibody‐Drug Conjugates.

Published in:

Journal of Clinical Pharmacology, 2020, v. 60, p. S105, doi. 10.1002/jcph.1720

By:

Li, Chunze;
Chen, Shang‐Chiung;
Chen, Yuan;
Girish, Sandhya;
Kågedal, Matts;
Lu, Dan;
Lu, Tong;
Samineni, Divya;
Jin, Jin Y.

Publication type:

Article

Impact of Physiologically Based Pharmacokinetics, Population Pharmacokinetics and Pharmacokinetics/Pharmacodynamics in the Development of Antibody‐Drug Conjugates.

Published in:

Journal of Clinical Pharmacology, 2020, v. 60, p. S105, doi. 10.1002/jcph.1720

By:

Li, Chunze;
Chen, Shang‐Chiung;
Chen, Yuan;
Girish, Sandhya;
Kaagedal, Matts;
Lu, Dan;
Lu, Tong;
Samineni, Divya;
Jin, Jin Y.

Publication type:

Article

Tumor growth and overall survival modeling to support decision making in phase Ib/II trials: A comparison of the joint and two‐stage approaches.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 6, p. 1017, doi. 10.1002/psp4.13137

By:

Marchand, Mathilde;
Gonçalves, Antonio;
Mercier, François;
Chanu, Pascal;
Jin, Jin Y.;
Guedj, Jérémie;
Bruno, René

Publication type:

Article

Deep‐NCA: A deep learning methodology for performing noncompartmental analysis of pharmacokinetic data.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 5, p. 870, doi. 10.1002/psp4.13124

By:

Liu, Gengbo;
Brooks, Logan;
Canty, John;
Lu, Dan;
Jin, Jin Y.;
Lu, James

Publication type:

Article

gPKPDviz: A flexible R shiny tool for pharmacokinetic/pharmacodynamic simulations using mrgsolve.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 3, p. 341, doi. 10.1002/psp4.13096

By:

Lu, Tong;
Poon, Victor;
Brooks, Logan;
Velasquez, Erick;
Anderson, Eric;
Baron, Kyle;
Jin, Jin Y.;
Kågedal, Matts

Publication type:

Article

Comparison of two‐stage and joint TGI‐OS modeling using data from six atezolizumab clinical studies in patients with metastatic non‐small cell lung cancer.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 1, p. 68, doi. 10.1002/psp4.13057

By:

Gonçalves, Antonio;
Marchand, Mathilde;
Chan, Phyllis;
Jin, Jin Y.;
Guedj, Jérémie;
Bruno, René

Publication type:

Article

Modeling Alzheimer's disease progression utilizing clinical trial and ADNI data to predict longitudinal trajectory of CDR‐SB.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 7, p. 1029, doi. 10.1002/psp4.12974

By:

Jamalian, Samira;
Dolton, Michael;
Chanu, Pascal;
Ramakrishnan, Vidya;
Franco, Yesenia;
Wildsmith, Kristin;
Manser, Paul;
Teng, Edmond;
Jin, Jin Y.;
Quartino, Angelica;
Hsu, Joy C.

Publication type:

Article

Requirements, expectations, challenges and opportunities associated with training the next generation of pharmacometricians.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 7, p. 883, doi. 10.1002/psp4.12970

By:

Schmidt, Stephan;
Vozmediano, Valvanera;
Cristofoletti, Rodrigo;
Kim, Sarah;
Lin, Zhoumeng;
de Moraes, Natalia;
Azeredo, Francine;
Cicali, Brian;
Leuenberger, Hans;
Brown, Joshua D.;
Jin, Jin Y.;
Musante, Cynthia J.;
Tannenbaum, Stacey;
Wang, Yaning

Publication type:

Article

Quantitative systems pharmacology model of the amyloid pathway in Alzheimer's disease: Insights into the therapeutic mechanisms of clinical candidates.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 1, p. 62, doi. 10.1002/psp4.12876

By:

Ramakrishnan, Vidya;
Friedrich, Christina;
Witt, Colleen;
Sheehan, Robert;
Pryor, Meghan;
Atwal, Jasvinder K.;
Wildsmith, Kristin;
Kudrycki, Katherine;
Lee, Seung‐Hye;
Mazer, Norman;
Hofmann, Carsten;
Fuji, Reina N.;
Jin, Jin Y.;
Ramanujan, Saroja;
Dolton, Michael;
Quartino, Angelica

Publication type:

Article

Update to improve reproducibility and interpretability: A response to "Machine Learning for Tumor Growth Inhibition".

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 3, p. 262, doi. 10.1002/psp4.12760

By:

Chan, Phyllis;
Lu, James;
Bruno, René;
Jin, Jin Y.

Publication type:

Article

Multistate model for pharmacometric analyses of overall survival in HER2‐negative breast cancer patients treated with docetaxel.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 10, p. 1255, doi. 10.1002/psp4.12693

By:

Krishnan, Sreenath M.;
Friberg, Lena E.;
Bruno, René;
Beyer, Ulrich;
Jin, Jin Y.;
Karlsson, Mats O.

Publication type:

Article

Prediction of overall survival in patients across solid tumors following atezolizumab treatments: A tumor growth inhibition–overall survival modeling framework.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 10, p. 1171, doi. 10.1002/psp4.12686

By:

Chan, Phyllis;
Marchand, Mathilde;
Yoshida, Kenta;
Vadhavkar, Shweta;
Wang, Nina;
Lin, Alyse;
Wu, Benjamin;
Ballinger, Marcus;
Sternheim, Nitzan;
Jin, Jin Y.;
Bruno, René

Publication type:

Article

Application of Machine Learning for Tumor Growth Inhibition – Overall Survival Modeling Platform.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 1, p. 59, doi. 10.1002/psp4.12576

By:

Chan, Phyllis;
Zhou, Xiaofei;
Wang, Nina;
Liu, Qi;
Bruno, René;
Jin, Jin Y.

Publication type:

Article

Tumor Time‐Course Predicts Overall Survival in Non‐Small Cell Lung Cancer Patients Treated with Atezolizumab: Dependency on Follow‐Up Time.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2020, v. 9, n. 2, p. 115, doi. 10.1002/psp4.12489

By:

Netterberg, Ida;
Bruno, René;
Chen, Ya‐Chi;
Winter, Helen;
Li, Chi‐Chung;
Jin, Jin Y.;
Friberg, Lena E.

Publication type:

Article

Analysis of Longitudinal‐Ordered Categorical Data for Muscle Spasm Adverse Event of Vismodegib: Comparison Between Different Pharmacometric Models.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2020, v. 9, n. 2, p. 96, doi. 10.1002/psp4.12487

By:

Lu, Tong;
Yang, Yujie;
Jin, Jin Y.;
Kågedal, Matts

Publication type:

Article

Time‐to‐Event Modeling of Peripheral Neuropathy: Platform Analysis of Eight Valine‐Citrulline‐Monomethylauristatin E Antibody–Drug Conjugates.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2019, v. 8, n. 8, p. 606, doi. 10.1002/psp4.12442

By:

Kågedal, Matts;
Samineni, Divya;
Gillespie, William R.;
Lu, Dan;
Fine, Bernard M.;
Girish, Sandhya;
Li, Chunze;
Jin, Jin Y.

Publication type:

Article

Combining 'Bottom-up' and 'Top-down' Approaches to Assess the Impact of Food and Gastric pH on Pictilisib (GDC-0941) Pharmacokinetics.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2017, v. 6, n. 11, p. 747, doi. 10.1002/psp4.12228

By:

Lu, Tong;
Fraczkiewicz, Grazyna;
Salphati, Laurent;
Budha, Nageshwar;
Dalziel, Gena;
Smelick, Gillian S.;
Morrissey, Kari M.;
Davis, John D.;
Jin, Jin Y.;
Ware, Joseph A.

Publication type:

Article

Quantitative characterization of the effects of fulvestrant alone or in combination with taselisib (PI3Kinase inhibitor) on longitudinal tumor growth in patients with estrogen receptor-positive, HER2-negative, PIK3CA-mutant, advanced or metastatic breast cancer

Published in:

Cancer Chemotherapy & Pharmacology, 2024, v. 94, n. 3, p. 421, doi. 10.1007/s00280-024-04690-4

By:

Moein, Anita;
Jin, Jin Y.;
Wright, Matthew R.;
Wong, Harvey

Publication type:

Article

Assessment of cytochrome P450 3A4-mediated drug–drug interactions for ipatasertib using a fit-for-purpose physiologically based pharmacokinetic model.

Published in:

Cancer Chemotherapy & Pharmacology, 2022, v. 89, n. 5, p. 707, doi. 10.1007/s00280-022-04434-2

By:

Jing, Jing;
Chen, Yuan;
Musib, Luna;
Jin, Jin Y.;
Cheung, Kit Wun Kathy;
Yoshida, Kenta;
Sane, Rucha

Publication type:

Article

Time-dependent population PK models of single-agent atezolizumab in patients with cancer.

Published in:

Cancer Chemotherapy & Pharmacology, 2021, v. 88, n. 2, p. 211, doi. 10.1007/s00280-021-04276-4

By:

Marchand, Mathilde;
Zhang, Rong;
Chan, Phyllis;
Quarmby, Valerie;
Ballinger, Marcus;
Sternheim, Nitzan;
Wu, Benjamin;
Jin, Jin Y.;
Bruno, René

Publication type:

Article

Pharmacokinetics of polatuzumab vedotin in combination with R/G-CHP in patients with B-cell non-Hodgkin lymphoma.

Published in:

2020

By:

Shemesh, Colby S.;
Agarwal, Priya;
Lu, Tong;
Lee, Calvin;
Dere, Randall C.;
Li, Xiaobin;
Li, Chunze;
Jin, Jin Y.;
Girish, Sandhya;
Miles, Dale;
Lu, Dan

Publication type:

journal article

Alternative dosing regimens for atezolizumab: an example of model-informed drug development in the postmarketing setting.

Published in:

2019

By:

Morrissey, Kari M.;
Marchand, Mathilde;
Patel, Hina;
Zhang, Rong;
Wu, Benjamin;
Phyllis Chan, H.;
Mecke, Almut;
Girish, Sandhya;
Jin, Jin Y.;
Winter, Helen R.;
Bruno, René

Publication type:

journal article

Population pharmacokinetic and covariate analyses of intravenous trastuzumab (Herceptin<sup>®</sup>), a HER2-targeted monoclonal antibody, in patients with a variety of solid tumors.

Published in:

2019

By:

Quartino, Angelica L.;
Li, Hanbin;
Kirschbrown, Whitney P.;
Mangat, Ranvir;
Wada, D. Russell;
Garg, Amit;
Jin, Jin Y.;
Lum, Bert

Publication type:

journal article

Pharmacokinetic and exposure-response analyses of pertuzumab in combination with trastuzumab and docetaxel during neoadjuvant treatment of HER2+ early breast cancer.

Published in:

2017

By:

Quartino, Angelica;
Li, Hanbin;
Jin, Jin;
Wada, D.;
Benyunes, Mark;
McNally, Virginia;
Viganò, Lucia;
Nijem, Ihsan;
Lum, Bert;
Garg, Amit;
Quartino, Angelica L;
Jin, Jin Y;
Wada, D Russell;
Benyunes, Mark C;
Viganò, Lucia;
Lum, Bert L

Publication type:

journal article

Ethnic sensitivity assessment of the antibody-drug conjugate trastuzumab emtansine (T-DM1) in patients with HER2-positive locally advanced or metastatic breast cancer.

Published in:

2016

By:

Li, Chunze;
Wang, Bei;
Lu, Dan;
Jin, Jin;
Gao, Yuying;
Matsunaga, Kiyoshi;
Igawa, Yuriko;
Nijem, Ihsan;
Lu, Michael;
Strasak, Alexander;
Chernyukhin, Nataliya;
Girish, Sandhya;
Jin, Jin Y

Publication type:

journal article

Population pharmacokinetic and exposure-response analysis for trastuzumab administered using a subcutaneous "manual syringe" injection or intravenously in women with HER2-positive early breast cancer.

Published in:

2016

By:

Quartino, Angelica;
Hillenbach, Carina;
Li, Jing;
Li, Hanbin;
Wada, Russell;
Visich, Jennifer;
Li, Chunze;
Heinzmann, Dominik;
Jin, Jin;
Lum, Bert;
Quartino, Angelica L;
Wada, Russell D;
Jin, Jin Y;
Lum, Bert L

Publication type:

journal article

Population pharmacokinetics and dosing implications for cobimetinib in patients with solid tumors.

Published in:

2015

By:

Han, Kelong;
Jin, Jin;
Marchand, Mathilde;
Eppler, Stephen;
Choong, Nicholas;
Hack, Stephen;
Tikoo, Nalin;
Bruno, Rene;
Dresser, Mark;
Musib, Luna;
Budha, Nageshwar;
Jin, Jin Y;
Hack, Stephen P;
Budha, Nageshwar R

Publication type:

journal article

Short-Term Efficacy Reliably Predicts Long-Term Clinical Benefit in Rheumatoid Arthritis Clinical Trials as Demonstrated by Model-Based Meta-Analysis.

Published in:

Journal of Clinical Pharmacology, 2016, v. 56, n. 7, p. 835, doi. 10.1002/jcph.668

By:

Wang, Yehong;
Zhu, Rui;
Xiao, Jim;
Davis, John C.;
Mandema, Jaap W.;
Jin, Jin Y.;
Tang, Meina T.

Publication type:

Article

Development of a pediatric physiologically-based pharmacokinetic model to support recommended dosing of atezolizumab in children with solid tumors.

Published in:

Frontiers in Pharmacology, 2022, v. 13, p. 01, doi. 10.3389/fphar.2022.974423

By:

Weize Huang;
Stader, Felix;
Chan, Phyllis;
Shemesh, Colby S.;
Yuan Chen;
Gill, Katherine L.;
Jones, Hannah M.;
Linzhong Li;
Rossato, Gianluca;
Wu, Benjamin;
Jin Y. Jin;
Chanu, Pascal

Publication type:

Article

Retrospective Assessment of Translational Pharmacokinetic–Pharmacodynamic Modeling Performance: A Case Study with Apitolisib, a Dual PI3K/mTOR Inhibitor.

Published in:

Drugs in R&D, 2024, v. 24, n. 2, p. 155, doi. 10.1007/s40268-024-00459-5

By:

Moein, Anita;
Jin, Jin Y.;
Wright, Matthew R.;
Alicke, Bruno;
Wong, Harvey

Publication type:

Article

Toward Progress in Quantitative Translational Medicine: A Call to Action.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 1, p. 85, doi. 10.1002/cpt.1687

By:

Venkatakrishnan, Karthik;
Zheng, Songmao;
Musante, Cynthia J.;
Jin, Jin Y.;
Riggs, Matthew M.;
Krishnaswami, Sriram;
Visser, Sandra A.G.

Publication type:

Article

Proceedings of a Workshop: US Food and Drug Administration‐International Society of Pharmacometrics Model‐Informed Drug Development in Oncology.

Published in:

Clinical Pharmacology & Therapeutics, 2019, v. 106, n. 1, p. 81, doi. 10.1002/cpt.1421

By:

Bruno, Rene;
Jin, Jin Y.;
Maxfield, Kimberly;
Milligan, Lauren;
Liu, Chao;
Wang, Yaning;
McKee, Amy E.;
Zineh, Issam

Publication type:

Article

Pharmacokinetics and pharmacodynamic effect of crenezumab on plasma and cerebrospinal fluid beta-amyloid in patients with mild-to-moderate Alzheimer's disease.

Published in:

Alzheimer's Research & Therapy, 2020, v. 12, n. 1, p. 1, doi. 10.1186/s13195-020-0580-2

By:

Yoshida, Kenta;
Moein, Anita;
Bittner, Tobias;
Ostrowitzki, Susanne;
Lin, Helen;
Honigberg, Lee;
Jin, Jin Y.;
Quartino, Angelica

Publication type:

Article

Tumor Growth Inhibition-Overall Survival (TGI-OS) Model for Subgroup Analysis Based on Post-Randomization Factors: Application for Anti-drug Antibody (ADA) Subgroup Analysis of Atezolizumab in the IMpower150 Study.

Published in:

AAPS Journal, 2022, v. 24, n. 3, p. 1, doi. 10.1208/s12248-022-00710-4

By:

Yoshida, Kenta;
Chan, Phyllis;
Marchand, Mathilde;
Zhang, Rong;
Wu, Benjamin;
Ballinger, Marcus;
Sternheim, Nitzan;
Jin, Jin Y.;
Bruno, René

Publication type:

Article

A Physiologically Based Pharmacokinetic Model of Vismodegib: Deconvoluting the Impact of Saturable Plasma Protein Binding, pH-Dependent Solubility and Nonsink Permeation.

Published in:

AAPS Journal, 2020, v. 22, n. 5, p. 1, doi. 10.1208/s12248-020-00503-7

By:

Dolton, Michael J.;
Chiang, Po-Chang;
Ma, Fang;
Jin, Jin Y.;
Chen, Yuan

Publication type:

Article

A Pharmacometric Analysis of Patient-Reported Outcomes in Breast Cancer Patients Through Item Response Theory.

Published in:

Pharmaceutical Research, 2018, v. 35, n. 6, p. 1, doi. 10.1007/s11095-018-2403-8

By:

Schindler, Emilie;
Friberg, Lena E.;
Lum, Bertram L.;
Bei Wang;
Quartino, Angelica;
Chunze Li;
Girish, Sandhya;
Jin, Jin Y.;
Karlsson, Mats O.

Publication type:

Article

A disease model predicting placebo response and remission status of patients with ulcerative colitis using modified Mayo score.

Published in:

CTS: Clinical & Translational Science, 2023, v. 16, n. 11, p. 2310, doi. 10.1111/cts.13632

By:

Moein, Anita;
Langenhorst, Jurgen;
Plan, Elodie L.;
Jin, Jin Y.;
Kågedal, Matts;
Kassir, Nastya

Publication type:

Article

Systems‐based digital twins to help characterize clinical dose–response and propose predictive biomarkers in a Phase I study of bispecific antibody, mosunetuzumab, in NHL.

Published in:

CTS: Clinical & Translational Science, 2023, v. 16, n. 7, p. 1134, doi. 10.1111/cts.13501

By:

Susilo, Monica E.;
Li, Chi‐Chung;
Gadkar, Kapil;
Hernandez, Genevive;
Huw, Ling‐Yuh;
Jin, Jin Y.;
Yin, Shen;
Wei, Michael C.;
Ramanujan, Saroja;
Hosseini, Iraj

Publication type:

Article

Challenges and Opportunities in Dose Finding in Oncology and Immuno‐oncology.

Published in:

2018

By:

Ji, Yan;
Jin, Jin Y.;
Hyman, David M.;
Kim, Geoffrey;
Suri, Ajit

Publication type:

Proceeding

Nonlinear multilevel joint model for individual lesion kinetics and survival to characterize intra‐individual heterogeneity in patients with advanced cancer.

Published in:

Biometrics, 2023, v. 79, n. 4, p. 3752, doi. 10.1111/biom.13912

By:

Kerioui, Marion;
Beaulieu, Maxime;
Desmée, Solène;
Bertrand, Julie;
Mercier, François;
Jin, Jin Y.;
Bruno, René;
Guedj, Jérémie

Publication type:

Article

Support to early clinical decisions in drug development and personalised medicine with checkpoint inhibitors using dynamic biomarker-overall survival models.

Published in:

British Journal of Cancer, 2023, v. 129, n. 9, p. 1383, doi. 10.1038/s41416-023-02190-5

By:

Bruno, René;
Chanu, Pascal;
Kågedal, Matts;
Mercier, Francois;
Yoshida, Kenta;
Guedj, Jérémie;
Li, Chunze;
Beyer, Ulrich;
Jin, Jin Y.

Publication type:

Article

Applications of Advanced Natural Language Processing for Clinical Pharmacology.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 4, p. 786, doi. 10.1002/cpt.3161

By:

Hsu, Joy C.;
Wu, Michael;
Kim, Chloe;
Vora, Bianca;
Lien, Yi Ting;
Jindal, Ashutosh;
Yoshida, Kenta;
Kawakatsu, Sonoko;
Gore, Jeremy;
Jin, Jin Y.;
Lu, Christina;
Chen, Bingyuan;
Wu, Benjamin

Publication type:

Article

Artificial Intelligence: From Buzzword to Useful Tool in Clinical Pharmacology.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 4, p. 698, doi. 10.1002/cpt.3083

By:

Shahin, Mohamed H.;
Barth, Aline;
Podichetty, Jagdeep T.;
Liu, Qi;
Goyal, Navin;
Jin, Jin Y.;
Ouellet, Daniele

Publication type:

Article

Challenging the Norm: A Multidisciplinary Perspective on Intravenous to Subcutaneous Bridging Strategies for Biologics.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 3, p. 412, doi. 10.1002/cpt.3133

By:

Ait‐Oudhia, Sihem;
Wang, Yow‐Ming;
Dosne, Anne‐Gaelle;
Roy, Amit;
Jin, Jin Y.;
Shen, Jun;
Kagan, Leonid;
Musuamba, Flora T.;
Zhang, Lucia;
Kijima, Shinichi;
Gastonguay, Marc R.;
Ouellet, Daniele

Publication type:

Article

Early Decision Making in a Randomized Phase II Trial of Atezolizumab in Biliary Tract Cancer Using a Tumor Growth Inhibition‐Survival Modeling Framework.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 3, p. 644, doi. 10.1002/cpt.2953

By:

Shemesh, Colby S.;
Chan, Phyllis;
Marchand, Mathilde;
Gonçalves, Antonio;
Vadhavkar, Shweta;
Wu, Benjamin;
Li, Chunze;
Jin, Jin Y.;
Hack, Stephen P.;
Bruno, Rene

Publication type:

Article

Opportunities and Challenges of Disease Progression Modeling in Drug Development – An IQ Perspective.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 2, p. 266, doi. 10.1002/cpt.2873

By:

Goteti, Kosalaram;
Hanan, Nathan;
Magee, Mindy;
Wojciechowski, Jessica;
Mensing, Sven;
Lalovic, Bojan;
Hang, Yaming;
Solms, Alexander;
Singh, Indrajeet;
Singh, Rajendra;
Rieger, Theodore Robert;
Jin, Jin Y.

Publication type:

Article

Multistate Pharmacometric Model to Define the Impact of Second‐Line Immunotherapies on the Survival Outcome of the IMpower131 Study.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 113, n. 4, p. 851, doi. 10.1002/cpt.2838

By:

Krishnan, Sreenath M.;
Friberg, Lena E.;
Mercier, François;
Zhang, Rong;
Wu, Ben;
Jin, Jin Y.;
Hoang, Tien;
Ballinger, Marcus;
Bruno, René;
Karlsson, Mats O.

Publication type:

Article