Works matching AU Jin, Jin Y
Results: 53
A physiologically based pharmacokinetic (PBPK) approach to evaluate pharmacokinetics in patients with cancer.
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- Biopharmaceutics & Drug Disposition, 2013, v. 34, n. 3, p. 141, doi. 10.1002/bdd.1830
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- Publication type:
- Article
Application of IVIVE and PBPK modeling in prospective prediction of clinical pharmacokinetics: strategy and approach during the drug discovery phase with four case studies.
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- Biopharmaceutics & Drug Disposition, 2012, v. 33, n. 2, p. 85, doi. 10.1002/bdd.1769
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- Article
Support to early clinical decisions in drug development and personalised medicine with checkpoint inhibitors using dynamic biomarker-overall survival models.
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- British Journal of Cancer, 2023, v. 129, n. 9, p. 1383, doi. 10.1038/s41416-023-02190-5
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- Publication type:
- Article
Pharmacokinetics and pharmacodynamic effect of crenezumab on plasma and cerebrospinal fluid beta-amyloid in patients with mild-to-moderate Alzheimer's disease.
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- Alzheimer's Research & Therapy, 2020, v. 12, n. 1, p. 1, doi. 10.1186/s13195-020-0580-2
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- Article
Quantitative characterization of the effects of fulvestrant alone or in combination with taselisib (PI3Kinase inhibitor) on longitudinal tumor growth in patients with estrogen receptor-positive, HER2-negative, PIK3CA-mutant, advanced or metastatic breast cancer
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- Cancer Chemotherapy & Pharmacology, 2024, v. 94, n. 3, p. 421, doi. 10.1007/s00280-024-04690-4
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- Article
Combining 'Bottom-up' and 'Top-down' Approaches to Assess the Impact of Food and Gastric pH on Pictilisib (GDC-0941) Pharmacokinetics.
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- CPT: Pharmacometrics & Systems Pharmacology, 2017, v. 6, n. 11, p. 747, doi. 10.1002/psp4.12228
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- Article
Short-Term Efficacy Reliably Predicts Long-Term Clinical Benefit in Rheumatoid Arthritis Clinical Trials as Demonstrated by Model-Based Meta-Analysis.
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- Journal of Clinical Pharmacology, 2016, v. 56, n. 7, p. 835, doi. 10.1002/jcph.668
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- Article
A disease model predicting placebo response and remission status of patients with ulcerative colitis using modified Mayo score.
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- CTS: Clinical & Translational Science, 2023, v. 16, n. 11, p. 2310, doi. 10.1111/cts.13632
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- Article
Systems‐based digital twins to help characterize clinical dose–response and propose predictive biomarkers in a Phase I study of bispecific antibody, mosunetuzumab, in NHL.
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- CTS: Clinical & Translational Science, 2023, v. 16, n. 7, p. 1134, doi. 10.1111/cts.13501
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- Article
Challenges and Opportunities in Dose Finding in Oncology and Immuno‐oncology.
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- 2018
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- Publication type:
- Proceeding
Tumor growth and overall survival modeling to support decision making in phase Ib/II trials: A comparison of the joint and two‐stage approaches.
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- CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 6, p. 1017, doi. 10.1002/psp4.13137
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- Publication type:
- Article
Deep‐NCA: A deep learning methodology for performing noncompartmental analysis of pharmacokinetic data.
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- CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 5, p. 870, doi. 10.1002/psp4.13124
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- Publication type:
- Article
gPKPDviz: A flexible R shiny tool for pharmacokinetic/pharmacodynamic simulations using mrgsolve.
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- CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 3, p. 341, doi. 10.1002/psp4.13096
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- Publication type:
- Article
Comparison of two‐stage and joint TGI‐OS modeling using data from six atezolizumab clinical studies in patients with metastatic non‐small cell lung cancer.
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- CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 1, p. 68, doi. 10.1002/psp4.13057
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- Article
Modeling Alzheimer's disease progression utilizing clinical trial and ADNI data to predict longitudinal trajectory of CDR‐SB.
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- CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 7, p. 1029, doi. 10.1002/psp4.12974
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- Article
Requirements, expectations, challenges and opportunities associated with training the next generation of pharmacometricians.
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- CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 7, p. 883, doi. 10.1002/psp4.12970
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- Publication type:
- Article
Quantitative systems pharmacology model of the amyloid pathway in Alzheimer's disease: Insights into the therapeutic mechanisms of clinical candidates.
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- CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 1, p. 62, doi. 10.1002/psp4.12876
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- Publication type:
- Article
Update to improve reproducibility and interpretability: A response to "Machine Learning for Tumor Growth Inhibition".
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- CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 3, p. 262, doi. 10.1002/psp4.12760
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- Article
Multistate model for pharmacometric analyses of overall survival in HER2‐negative breast cancer patients treated with docetaxel.
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- CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 10, p. 1255, doi. 10.1002/psp4.12693
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- Publication type:
- Article
Prediction of overall survival in patients across solid tumors following atezolizumab treatments: A tumor growth inhibition–overall survival modeling framework.
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- CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 10, p. 1171, doi. 10.1002/psp4.12686
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- Publication type:
- Article
Application of Machine Learning for Tumor Growth Inhibition – Overall Survival Modeling Platform.
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- CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 1, p. 59, doi. 10.1002/psp4.12576
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- Publication type:
- Article
Tumor Time‐Course Predicts Overall Survival in Non‐Small Cell Lung Cancer Patients Treated with Atezolizumab: Dependency on Follow‐Up Time.
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- CPT: Pharmacometrics & Systems Pharmacology, 2020, v. 9, n. 2, p. 115, doi. 10.1002/psp4.12489
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- Article
Analysis of Longitudinal‐Ordered Categorical Data for Muscle Spasm Adverse Event of Vismodegib: Comparison Between Different Pharmacometric Models.
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- CPT: Pharmacometrics & Systems Pharmacology, 2020, v. 9, n. 2, p. 96, doi. 10.1002/psp4.12487
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- Publication type:
- Article
Time‐to‐Event Modeling of Peripheral Neuropathy: Platform Analysis of Eight Valine‐Citrulline‐Monomethylauristatin E Antibody–Drug Conjugates.
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- CPT: Pharmacometrics & Systems Pharmacology, 2019, v. 8, n. 8, p. 606, doi. 10.1002/psp4.12442
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- Publication type:
- Article
Development of a pediatric physiologically-based pharmacokinetic model to support recommended dosing of atezolizumab in children with solid tumors.
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- Frontiers in Pharmacology, 2022, v. 13, p. 01, doi. 10.3389/fphar.2022.974423
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- Publication type:
- Article
Evaluation of Cytochrome P450 3A4-Mediated Drug-Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation.
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- 2016
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- Publication type:
- journal article
Assessment of cytochrome P450 3A4-mediated drug–drug interactions for ipatasertib using a fit-for-purpose physiologically based pharmacokinetic model.
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- Cancer Chemotherapy & Pharmacology, 2022, v. 89, n. 5, p. 707, doi. 10.1007/s00280-022-04434-2
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- Publication type:
- Article
Time-dependent population PK models of single-agent atezolizumab in patients with cancer.
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- Cancer Chemotherapy & Pharmacology, 2021, v. 88, n. 2, p. 211, doi. 10.1007/s00280-021-04276-4
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- Publication type:
- Article
Pharmacokinetics of polatuzumab vedotin in combination with R/G-CHP in patients with B-cell non-Hodgkin lymphoma.
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- 2020
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- Publication type:
- journal article
Alternative dosing regimens for atezolizumab: an example of model-informed drug development in the postmarketing setting.
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- 2019
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- Publication type:
- journal article
Population pharmacokinetic and covariate analyses of intravenous trastuzumab (Herceptin<sup>®</sup>), a HER2-targeted monoclonal antibody, in patients with a variety of solid tumors.
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- 2019
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- Publication type:
- journal article
Pharmacokinetic and exposure-response analyses of pertuzumab in combination with trastuzumab and docetaxel during neoadjuvant treatment of HER2+ early breast cancer.
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- 2017
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- Publication type:
- journal article
Ethnic sensitivity assessment of the antibody-drug conjugate trastuzumab emtansine (T-DM1) in patients with HER2-positive locally advanced or metastatic breast cancer.
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- 2016
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- Publication type:
- journal article
Population pharmacokinetic and exposure-response analysis for trastuzumab administered using a subcutaneous "manual syringe" injection or intravenously in women with HER2-positive early breast cancer.
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- 2016
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- Publication type:
- journal article
Population pharmacokinetics and dosing implications for cobimetinib in patients with solid tumors.
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- 2015
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- Publication type:
- journal article
Retrospective Assessment of Translational Pharmacokinetic–Pharmacodynamic Modeling Performance: A Case Study with Apitolisib, a Dual PI3K/mTOR Inhibitor.
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- Drugs in R&D, 2024, v. 24, n. 2, p. 155, doi. 10.1007/s40268-024-00459-5
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- Publication type:
- Article
Quantitative Assessment of Drug Efficacy and Emergence of Resistance in Patients with Metastatic Renal Cell Carcinoma Using a Longitudinal Exposure‐Tumor Growth Inhibition Model: Apitolisib (Dual PI3K/mTORC1/2 Inhibitor) Versus Everolimus (mTORC1 Inhibitor)
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- Journal of Clinical Pharmacology, 2024, v. 64, n. 9, p. 1101, doi. 10.1002/jcph.2444
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- Publication type:
- Article
Population Pharmacokinetics of Ranibizumab Delivered via the Port Delivery System Implanted in the Eye in Patients with Neovascular Age‐Related Macular Degeneration.
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- Journal of Clinical Pharmacology, 2023, v. 63, n. 11, p. 1210, doi. 10.1002/jcph.2290
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- Publication type:
- Article
Impact of Dose Delays and Alternative Dosing Regimens on Pertuzumab Pharmacokinetics.
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- Journal of Clinical Pharmacology, 2021, v. 61, n. 8, p. 1096, doi. 10.1002/jcph.1855
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- Publication type:
- Article
Impact of Physiologically Based Pharmacokinetics, Population Pharmacokinetics and Pharmacokinetics/Pharmacodynamics in the Development of Antibody‐Drug Conjugates.
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- Journal of Clinical Pharmacology, 2020, v. 60, p. S105, doi. 10.1002/jcph.1720
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- Publication type:
- Article
Impact of Physiologically Based Pharmacokinetics, Population Pharmacokinetics and Pharmacokinetics/Pharmacodynamics in the Development of Antibody‐Drug Conjugates.
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- Journal of Clinical Pharmacology, 2020, v. 60, p. S105, doi. 10.1002/jcph.1720
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- Publication type:
- Article
Tumor Growth Inhibition-Overall Survival (TGI-OS) Model for Subgroup Analysis Based on Post-Randomization Factors: Application for Anti-drug Antibody (ADA) Subgroup Analysis of Atezolizumab in the IMpower150 Study.
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- AAPS Journal, 2022, v. 24, n. 3, p. 1, doi. 10.1208/s12248-022-00710-4
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- Publication type:
- Article
A Physiologically Based Pharmacokinetic Model of Vismodegib: Deconvoluting the Impact of Saturable Plasma Protein Binding, pH-Dependent Solubility and Nonsink Permeation.
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- AAPS Journal, 2020, v. 22, n. 5, p. 1, doi. 10.1208/s12248-020-00503-7
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- Publication type:
- Article
A Pharmacometric Analysis of Patient-Reported Outcomes in Breast Cancer Patients Through Item Response Theory.
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- Pharmaceutical Research, 2018, v. 35, n. 6, p. 1, doi. 10.1007/s11095-018-2403-8
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- Publication type:
- Article
Nonlinear multilevel joint model for individual lesion kinetics and survival to characterize intra‐individual heterogeneity in patients with advanced cancer.
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- Biometrics, 2023, v. 79, n. 4, p. 3752, doi. 10.1111/biom.13912
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- Publication type:
- Article
Applications of Advanced Natural Language Processing for Clinical Pharmacology.
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- Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 4, p. 786, doi. 10.1002/cpt.3161
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- Publication type:
- Article
Artificial Intelligence: From Buzzword to Useful Tool in Clinical Pharmacology.
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- Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 4, p. 698, doi. 10.1002/cpt.3083
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- Article
Challenging the Norm: A Multidisciplinary Perspective on Intravenous to Subcutaneous Bridging Strategies for Biologics.
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- Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 3, p. 412, doi. 10.1002/cpt.3133
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- Publication type:
- Article
Early Decision Making in a Randomized Phase II Trial of Atezolizumab in Biliary Tract Cancer Using a Tumor Growth Inhibition‐Survival Modeling Framework.
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- Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 3, p. 644, doi. 10.1002/cpt.2953
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- Publication type:
- Article
Opportunities and Challenges of Disease Progression Modeling in Drug Development – An IQ Perspective.
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- Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 2, p. 266, doi. 10.1002/cpt.2873
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- Article