Works by Jentsch, Thomas J.

Results: 78

Endosomal chloride/proton exchangers need inhibitory TMEM9 β-subunits for regulation and prevention of disease-causing overactivity.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-58546-3

By:

Planells-Cases, Rosa;
Vorobeva, Viktoriia;
Kar, Sumanta;
Schmitt, Franziska W.;
Schulte, Uwe;
Schrecker, Marina;
Hite, Richard K.;
Fakler, Bernd;
Jentsch, Thomas J.

Publication type:

Article

Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl- channel disruption.

Published in:

EMBO Journal, 2001, v. 20, n. 6, p. 1289, doi. 10.1093/emboj/20.6.1289

By:

Bösl, Michael R.;
Stein, Valentin;
Hübner, Christian;
Zdebik, Anselm A.;
Jordt, Sven-Eric;
Mukhopadhyay, Amal K.;
Davidoff, Michail S.;
Holstein, Adolf-Friedrich;
Jentsch, Thomas J.

Publication type:

Article

Molecular dissection of gating in the ClC-2 chloride channel.

Published in:

EMBO Journal, 1997, v. 16, n. 7, p. 1582, doi. 10.1093/emboj/16.7.1582

By:

Jordt, Sven-Eric;
Jentsch, Thomas J.

Publication type:

Article

Exome sequencing reveals new causal mutations in children with epileptic encephalopathies.

Published in:

Epilepsia (Series 4), 2013, v. 54, n. 7, p. 1270, doi. 10.1111/epi.12201

By:

Veeramah, Krishna R.;
Johnstone, Laurel;
Karafet, Tatiana M.;
Wolf, Daniel;
Sprissler, Ryan;
Salogiannis, John;
Barth ‐ Maron, Asa;
Greenberg, Michael E.;
Stuhlmann, Till;
Weinert, Stefanie;
Jentsch, Thomas J.;
Pazzi, Marjorie;
Restifo, Linda L.;
Talwar, Dinesh;
Erickson, Robert P.;
Hammer, Michael F.

Publication type:

Article

ClC-7 requires Ostm1 as a β-subunit to support bone resorption and lysosomal function.

Published in:

Nature, 2006, v. 440, n. 7081, p. 220, doi. 10.1038/nature04535

By:

Lange, Philipp F.;
Wartosch, Lena;
Jentsch, Thomas J.;
Fuhrmann, Jens C.

Publication type:

Article

Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins.

Published in:

Nature, 2005, v. 436, n. 7049, p. 424, doi. 10.1038/nature03860

By:

Scheel, Olaf;
Zdebik, Anselm A.;
Lourdel, Stéphane;
Jentsch, Thomas J.

Publication type:

Article

Chloride channel 2 gene (Clc2) maps to chromosome 16 of the mouse, extending a region of conserved synteny with human chromosome 3q.

Published in:

Genetics Research, 1995, v. 66, n. 2, p. 175, doi. 10.1017/S0016672300034522

By:

Lengeling, Andreas;
Gronemeier, Monika;
Ronsiek, Melanie;
Thiemann, Astrid;
Jentsch, Thomas J.;
Jockusch, Harald

Publication type:

Article

Ion transport mechanisms in cultured bovine corneal endothelial cells.

Published in:

Current Eye Research, 1985, v. 4, n. 4, p. 361, doi. 10.3109/02713688509025149

By:

Jentsch, Thomas J.;
Keller, Svea K.;
Wiederholt, Michael

Publication type:

Article

Place fields of single spikes in hippocampus involve Kcnq3 channel-dependent entrainment of complex spike bursts.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-24805-2

By:

Gao, Xiaojie;
Bender, Franziska;
Soh, Heun;
Chen, Changwan;
Altafi, Mahsa;
Schütze, Sebastian;
Heidenreich, Matthias;
Gorbati, Maria;
Corbu, Mihaela-Anca;
Carus-Cadavieco, Marta;
Korotkova, Tatiana;
Tzingounis, Anastasios V.;
Jentsch, Thomas J.;
Ponomarenko, Alexey

Publication type:

Article

Leukoencephalopathy upon Disruption of the Chloride Channel ClC-2.

Published in:

Journal of Neuroscience, 2007, v. 27, n. 24, p. 6581, doi. 10.1523/JNEUROSCI.0338-07.2007

By:

Blanz, Judith;
Schweizer, Michaela;
Auberson, Muriel;
Maier, Hannes;
Muenscher, Adrian;
Hübner, Christian A.;
Jentsch, Thomas J.

Publication type:

Article

Structural Determinants of M-Type KCNQ (Kv7) K+ Channel Assembly.

Published in:

Journal of Neuroscience, 2006, v. 26, n. 14, p. 3757, doi. 10.1523/JNEUROSCI.5017-05.2006

By:

Schwake, Michael;
Athanasiadu, Despina;
Beimgraben, Christian;
Blanz, Judith;
Beck, Christian;
Jentsch, Thomas J.;
Saftig, Paul;
Friedrich, Thomas

Publication type:

Article

Molecular Determinants of KCNQ (Kv7) K+ Channel Sensitivity to the Anticonvulsant Retigabine.

Published in:

Journal of Neuroscience, 2005, v. 25, n. 20, p. 5051, doi. 10.1523/JNEUROSCI.0128-05.2005

By:

Schenzer, Anne;
Friedrich, Thomas;
Pusch, Michael;
Saftig, Paul;
Jentsch, Thomas J.;
Grötzinger, Joachim;
Schwake, Michael

Publication type:

Article

No evidence for a role of CLCN2 variants in idiopathic generalized epilepsy.

Published in:

2010

By:

Niemeyer, María I.;
Cid, L. Pablo;
Sepúlveda, Francisco V.;
Blanz, Judith;
Auberson, Muriel;
Jentsch, Thomas J.

Publication type:

Letter

Mutations in CAV3 cause mechanical hyperirritability of skeletal muscle in rippling muscle disease.

Published in:

Nature Genetics, 2001, v. 28, n. 3, p. 218, doi. 10.1038/90050

By:

Betz, Regina C.;
Schoser, Benedikt G. H.;
Kasper, Dagmar;
Ricker, Kenneth;
Ramírez, Alfredo;
Stein, Valentin;
Torbergsen, Torberg;
Lee, Young-Ae;
Nöthen, Markus M.;
Wienker, Thomas F.;
Malin, Jean-Pierre;
Propping, Peter;
Reis, André;
Mortier, Wilhelm;
Jentsch, Thomas J.;
Vorgerd, Matthias;
Kubisch, Christian

Publication type:

Article

In Vivo Evidence for Lysosome Depletion and Impaired Autophagic Clearance in Hereditary Spastic Paraplegia Type SPG11.

Published in:

PLoS Genetics, 2015, v. 11, n. 8, p. 1, doi. 10.1371/journal.pgen.1005454

By:

Varga, Rita-Eva;
Khundadze, Mukhran;
Damme, Markus;
Nietzsche, Sandor;
Hoffmann, Birgit;
Stauber, Tobias;
Koch, Nicole;
Hennings, J. Christopher;
Franzka, Patricia;
Huebner, Antje K.;
Kessels, Michael M.;
Biskup, Christoph;
Jentsch, Thomas J.;
Qualmann, Britta;
Braulke, Thomas;
Kurth, Ingo;
Beetz, Christian;
Hübner, Christian A.

Publication type:

Article

Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice.

Published in:

2007

By:

Rust, Marco B.;
Alper, Seth L.;
Rudhard, York;
Shmukler, Boris E.;
Vicente, Rubén;
Brugnara, Carlo;
Trudel, Marie;
Jentsch, Thomas J.;
Hübner, Christian A.;
Vicente, Rubén;
Hübner, Christian A

Publication type:

journal article

Chloride channel diseases resulting from impaired transepithelial transport or vesicular function.

Published in:

Journal of Clinical Investigation, 2005, v. 115, n. 8, p. 2039, doi. 10.1172/JCI25470

By:

Jentsch, Thomas J.;
Maritzen, Tanja;
Zdebik, Anselm A.

Publication type:

Article

Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation.

Published in:

Communications Biology, 2020, v. 3, n. 1, p. 1, doi. 10.1038/s42003-020-0951-z

By:

Nakamura, Ryoki;
Numata, Tomohiro;
Kasuya, Go;
Yokoyama, Takeshi;
Nishizawa, Tomohiro;
Kusakizako, Tsukasa;
Kato, Takafumi;
Hagino, Tatsuya;
Dohmae, Naoshi;
Inoue, Masato;
Watanabe, Kengo;
Ichijo, Hidenori;
Kikkawa, Masahide;
Shirouzu, Mikako;
Jentsch, Thomas J.;
Ishitani, Ryuichiro;
Okada, Yasunobu;
Nureki, Osamu

Publication type:

Article

A carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly.

Published in:

2003

By:

Schwake, Michael;
Jentsch, Thomas J.;
Friedrich, Thomas

Publication type:

Report

Kv7 channels: interaction with dopaminergic and serotonergic neurotransmission in the CNS.

Published in:

Journal of Physiology, 2008, v. 586, n. 7, p. 1823, doi. 10.1113/jphysiol.2007.149450

By:

Hansen, Henrik H.;
Waroux, Olivier;
Seutin, Vincent;
Jentsch, Thomas J.;
Aznar, Susana;
Mikkelsen, Jens D.

Publication type:

Article

Chloride and the endosomal–lysosomal pathway: emerging roles of CLC chloride transporters.

Published in:

Journal of Physiology, 2007, v. 578, n. 3, p. 633, doi. 10.1113/jphysiol.2006.124719

By:

Jentsch, Thomas J.

Publication type:

Article

Functional and structural conservation of CBS domains from CLC chloride channels.

Published in:

Journal of Physiology, 2004, v. 557, n. 2, p. 363, doi. 10.1113/jphysiol.2003.058453

By:

Estévez, Raúl;
Pusch, Michael;
Ferrer-Costa, Caries;
Orozco, Modesto;
Jentsch, Thomas J.

Publication type:

Article

Chloride dependence of hyperpolarization-activated chloride channel gates.

Published in:

Journal of Physiology, 1999, v. 515, n. 2, p. 341, doi. 10.1111/j.1469-7793.1999.341ac.x

By:

Pusch, Michael;
Jordt, Sven-Eric;
Stein, Valentin;
Jentsch, Thomas J.

Publication type:

Article

Ion channel diseases.

Published in:

Human Molecular Genetics, 2002, v. 11, n. 20, p. 2435, doi. 10.1093/hmg/11.20.2435

By:

Hübner, Christian A.;
Jentsch, Thomas J.

Publication type:

Article

ClC-1 chloride channel mutations in myotonia congenita: variable penetrance of mutations shifting the voltage dependence.

Published in:

Human Molecular Genetics, 1998, v. 7, n. 11, p. 1753, doi. 10.1093/hmg/7.11.1753

By:

Kubisch, Christian;
Schmidt‐Rose, Thomas;
Fontaine, Bertrand;
Bretag, Allan H.;
Jentsch, Thomas J.

Publication type:

Article

Pathophysiological Mechanisms of Dominant and Recessive KvLQT1 K+ Channel Mutations Found in Inherited Cardiac Arrhythmias.

Published in:

Human Molecular Genetics, 1997, v. 6, n. 11, p. 1943, doi. 10.1093/hmg/6.11.1943

By:

Wollnik, Bernd;
Schroeder, Björn C.;
Kubisch, Christian;
Esperer, Hans D.;
Wieacker, Peter;
Jentsch, Thomas J.

Publication type:

Article

Characterisation of Renal Chloride Channel, CLCN5, Mutations in Hypercalciuric Nephrolithiasis (Kidney Stones) Disorders.

Published in:

Human Molecular Genetics, 1997, v. 6, n. 8, p. 1233, doi. 10.1093/hmg/6.8.1233

By:

Lloyd, Sarah E.;
Günther, Willy;
Pearce, Simon H.S.;
Thomson, Amelia;
Bianchi, Maria L.;
Bosio, Maurizio;
Craig, Ian W.;
Fisher, Simon E.;
Scheinman, Steven J.;
Wrong, Oliver;
Jentsch, Thomas J.;
Thakker, Rajesh V.

Publication type:

Article

NKCC1-Dependent GABAergic Excitation Drives Synaptic Network Maturation during Early Hippocampal Development.

Published in:

Journal of Neuroscience, 2009, v. 29, n. 11, p. 3419, doi. 10.1523/JNEUROSCI.1377-08.2009

By:

Pfeffer, Carsten K.;
Stein, Valentin;
Keating, Damien J.;
Maier, Hannes;
Rinke, Ilka;
Rudhard, York;
Hentschke, Moritz;
Rune, Gabriele M.;
Jentsch, Thomas J.;
Hübner, Christian A.

Publication type:

Article

Role of the Vesicular Chloride Transporter ClC-3 in Neuroendocrine Tissue.

Published in:

Journal of Neuroscience, 2008, v. 28, n. 42, p. 10587, doi. 10.1523/JNEUROSCI.3750-08.2008

By:

Maritzen, Tanja;
Keating, Damien J.;
Neagoe, Ioana;
Zdebik, Anselm A.;
Jentsch, Thomas J.

Publication type:

Article

Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.

Published in:

EMBO Journal, 2020, v. 39, n. 9, p. 1, doi. 10.15252/embj.2019103358

By:

Weinert, Stefanie;
Gimber, Niclas;
Deuschel, Dorothea;
Stuhlmann, Till;
Puchkov, Dmytro;
Farsi, Zohreh;
Ludwig, Carmen F;
Novarino, Gaia;
López‐Cayuqueo, Karen I;
Planells‐Cases, Rosa;
Jentsch, Thomas J

Publication type:

Article

Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs.

Published in:

EMBO Journal, 2015, v. 34, n. 24, p. 2993, doi. 10.15252/embj.201592409

By:

Planells‐Cases, Rosa;
Lutter, Darius;
Guyader, Charlotte;
Gerhards, Nora M;
Ullrich, Florian;
Elger, Deborah A;
Kucukosmanoglu, Asli;
Xu, Guotai;
Voss, Felizia K;
Reincke, S Momsen;
Stauber, Tobias;
Blomen, Vincent A;
Vis, Daniel J;
Wessels, Lodewyk F;
Brummelkamp, Thijn R;
Borst, Piet;
Rottenberg, Sven;
Jentsch, Thomas J

Publication type:

Article

Departure gate of acidic Ca2+ confirmed.

Published in:

EMBO Journal, 2015, v. 34, n. 13, p. 1737, doi. 10.15252/embj.201591884

By:

Jentsch, Thomas J;
Hoegg‐Beiler, Maja B;
Vogt, Janis

Publication type:

Article

REVIEW ■ : Chloride Channel Myotonias.

Published in:

Neuroscientist, 1996, v. 2, n. 4, p. 225, doi. 10.1177/107385849600200411

By:

Steinmeyer, Klaus;
Jentsch, Thomas J.

Publication type:

Article

KCNQ4 K+ channels tune mechanoreceptors for normal touch sensation in mouse and man.

Published in:

Nature Neuroscience, 2012, v. 15, n. 1, p. 138, doi. 10.1038/nn.2985

By:

Heidenreich, Matthias;
Lechner, Stefan G;
Vardanyan, Vitya;
Wetzel, Christiane;
Cremers, Cor W;
De Leenheer, Els M;
Aránguez, Gracia;
Moreno-Pelayo, Miguel Ángel;
Jentsch, Thomas J;
Lewin, Gary R

Publication type:

Article

Ca2+-activated Cl− currents are dispensable for olfaction.

Published in:

Nature Neuroscience, 2011, v. 14, n. 6, p. 763, doi. 10.1038/nn.2821

By:

Billig, Gwendolyn M;
Pál, Balázs;
Fidzinski, Pawel;
Jentsch, Thomas J.

Publication type:

Article

Genomic organization of the human muscle chloride channel CIC-1 and analysis of novel mutations leading to Becker-type myotonia.

Published in:

Human Molecular Genetics, 1994, v. 3, n. 6, p. 941

By:

Lorenz, Claudius;
Meyer-Kleine, Christof;
Steinmeyer, Klaus;
Koch, Manuela C.;
Jentsch, Thomas J.

Publication type:

Article

Chloride channels: An emerging molecular picture.

Published in:

BioEssays, 1997, v. 19, n. 2, p. 117, doi. 10.1002/bies.950190206

By:

Jentsch, Thomas J.;
Gunther, Willy

Publication type:

Article

A mouse model for distal renal tubular acidosis reveals a previously unrecognized role of the V-ATPase a4 subunit in the proximal tubule.

Published in:

EMBO Molecular Medicine, 2012, v. 4, n. 10, p. 1057, doi. 10.1002/emmm.201201527

By:

Hennings, J. Christopher;
Picard, Nicolas;
Huebner, Antje K.;
Stauber, Tobias;
Maier, Hannes;
Brown, Dennis;
Jentsch, Thomas J.;
Vargas-Poussou, Rosa;
Eladari, Dominique;
Hübner, Christian A.

Publication type:

Article

Expression of the KCl cotransporter KCC2 parallels neuronal maturation and the emergence of low intracellular chloride.

Published in:

Journal of Comparative Neurology, 2004, v. 468, n. 1, p. 57, doi. 10.1002/cne.10983

By:

Valentin Stein;
Irm Hermans-Borgmeyer;
Thomas J. Jentsch

Publication type:

Article

Molecular diagnosis of McArdle disease: Revised genomic structure of the myophosphorylase gene and identification of a novel mutation.

Published in:

Human Mutation, 1998, v. 12, n. 1, p. 27, doi. 10.1002/(SICI)1098-1004(1998)12:1<27::AID-HUMU4>3.0.CO;2-#

By:

Kubisch, Christian;
Wicklein, Eva M.;
Jentsch, Thomas J.

Publication type:

Article

Physiological roles of CLC Cl−/H+ exchangers in renal proximal tubules.

Published in:

Pflügers Archiv: European Journal of Physiology, 2009, v. 458, n. 1, p. 23, doi. 10.1007/s00424-008-0597-z

By:

Plans, Vanessa;
Rickheit, Gesa;
Jentsch, Thomas J.

Publication type:

Article

The ClC-5 chloride channel knock-out mouse – an animal model for Dent's disease.

Published in:

Pflügers Archiv: European Journal of Physiology, 2003, v. 445, n. 4, p. 456, doi. 10.1007/s00424-002-0950-6

By:

Günther, Willy;
Piwon, Nils;
Jentsch, Thomas J.

Publication type:

Article

Trinity of cation channels.

Published in:

Nature, 1994, v. 367, n. 6462, p. 412, doi. 10.1038/367412a0

By:

Jentsch, Thomas J.

Publication type:

Article

ClC-7 drives intraphagosomal chloride accumulation to support hydrolase activity and phagosome resolution.

Published in:

Journal of Cell Biology, 2023, v. 222, n. 6, p. 1, doi. 10.1083/jcb.202208155

By:

Jing Ze Wu;
Zeziulia, Mariia;
Whijin Kwon;
Jentsch, Thomas J.;
Grinstein, Sergio;
Freeman, Spencer A.

Publication type:

Article

A cation counterflux supports lysosomal acidification.

Published in:

Journal of Cell Biology, 2010, v. 189, n. 7, p. 1171, doi. 10.1083/jcb.200911083

By:

Steinberg, Benjamin E.;
Huynh, Kassidy K.;
Brodovitch, Alexandre;
Jabs, Sabrina;
Stauber, Tobias;
Jentsch, Thomas J.;
Grinstein, Sergio

Publication type:

Article

K2P TASK‐2 and KCNQ1–KCNE3 K+ channels are major players contributing to intestinal anion and fluid secretion.

Published in:

Journal of Physiology, 2018, v. 596, n. 3, p. 393, doi. 10.1113/JP275178

By:

Julio‐Kalajzić, Francisca;
Villanueva, Sandra;
Burgos, Johanna;
Ojeda, Margarita;
Cid, L. Pablo;
Jentsch, Thomas J.;
Sepúlveda, Francisco V.

Publication type:

Article

Discovery of CLC transport proteins: cloning, structure, function and pathophysiology.

Published in:

Journal of Physiology, 2015, v. 593, n. 18, p. 4091, doi. 10.1113/JP270043

By:

Jentsch, Thomas J.

Publication type:

Article

Impaired Autophagic Clearance with a Gain-of-Function Variant of the Lysosomal Cl − /H + Exchanger ClC-7.

Published in:

Biomolecules (2218-273X), 2023, v. 13, n. 12, p. 1799, doi. 10.3390/biom13121799

By:

Bose, Shroddha;
de Heus, Cecilia;
Kennedy, Mary E.;
Wang, Fan;
Jentsch, Thomas J.;
Klumperman, Judith;
Stauber, Tobias

Publication type:

Article

Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination.

Published in:

Nature Communications, 2016, v. 7, n. 7, p. 12043, doi. 10.1038/ncomms12043

By:

Gödde, Kathrin;
Gschwend, Olivier;
Puchkov, Dmytro;
Pfeffer, Carsten K.;
Carleton, Alan;
Jentsch, Thomas J.

Publication type:

Article

KCNQ5 K+ channels control hippocampal synaptic inhibition and fast network oscillations.

Published in:

Nature Communications, 2015, v. 6, n. 2, p. 6254, doi. 10.1038/ncomms7254

By:

Fidzinski, Pawel;
Korotkova, Tatiana;
Heidenreich, Matthias;
Maier, Nikolaus;
Schuetze, Sebastian;
Kobler, Oliver;
Zuschratter, Werner;
Schmitz, Dietmar;
Ponomarenko, Alexey;
Jentsch, Thomas J.

Publication type:

Article