Found: 12

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  • Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo.

    Published in:
    Angewandte Chemie International Edition, 2012, v. 51, n. 34, p. 8529, doi. 10.1002/anie.201203263
    By:
    • Jayaraman, Muthusamy;
    • Ansell, Steven M.;
    • Mui, Barbara L.;
    • Tam, Ying K.;
    • Chen, Jianxin;
    • Du, Xinyao;
    • Butler, David;
    • Eltepu, Laxman;
    • Matsuda, Shigeo;
    • Narayanannair, Jayaprakash K.;
    • Rajeev, Kallanthottathil G.;
    • Hafez, Ismail M.;
    • Akinc, Akin;
    • Maier, Martin A.;
    • Tracy, Mark A.;
    • Cullis, Pieter R.;
    • Madden, Thomas D.;
    • Manoharan, Muthiah;
    • Hope, Michael J.
    Publication type:
    Article

  • Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics.

    Published in:
    Molecular Therapy, 2013, v. 21, n. 8, p. 1570, doi. 10.1038/mt.2013.124
    By:
    • Maier, Martin A;
    • Jayaraman, Muthusamy;
    • Matsuda, Shigeo;
    • Liu, Ju;
    • Barros, Scott;
    • Querbes, William;
    • Tam, Ying K;
    • Ansell, Steven M;
    • Kumar, Varun;
    • Qin, June;
    • Zhang, Xuemei;
    • Wang, Qianfan;
    • Panesar, Sue;
    • Hutabarat, Renta;
    • Carioto, Mary;
    • Hettinger, Julia;
    • Kandasamy, Pachamuthu;
    • Butler, David;
    • Rajeev, Kallanthottathil G;
    • Pang, Bo
    Publication type:
    Article

  • Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms.

    Published in:
    Molecular Therapy, 2010, v. 18, n. 7, p. 1357, doi. 10.1038/mt.2010.85
    By:
    • Akinc, Akin;
    • Querbes, William;
    • De, Soma;
    • Qin, June;
    • Frank-Kamenetsky, Maria;
    • Jayaprakash, K. Narayanannair;
    • Jayaraman, Muthusamy;
    • Rajeev, Kallanthottathil G;
    • Cantley, William L.;
    • Dorkin, J. Robert;
    • Butler, James S.;
    • Qin, LiuLiang;
    • Racie, Timothy;
    • Sprague, Andrew;
    • Fava, Eugenio;
    • Zeigerer, Anja;
    • Hope, Michael J.;
    • Zerial, Marino;
    • Sah, Dinah W. Y.;
    • Fitzgerald, Kevin
    Publication type:
    Article

  • Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver.

    Published in:
    Molecular Therapy, 2009, v. 17, n. 5, p. 872, doi. 10.1038/mt.2009.36
    By:
    • Akinc, Akin;
    • Goldberg, Michael;
    • Qin, June;
    • Dorkin, J. Robert;
    • Gamba-Vitalo, Christina;
    • Maier, Martin;
    • Jayaprakash, K. Narayanannair;
    • Jayaraman, Muthusamy;
    • Rajeev, Kallanthottathil G.;
    • Manoharan, Muthiah;
    • Koteliansky, Victor;
    • Röhl, Ingo;
    • Leshchiner, Elizaveta S.;
    • Langer, Robert;
    • Anderson, Daniel G.
    Publication type:
    Article

  • Rational design of cationic lipids for siRNA delivery.

    Published in:
    Nature Biotechnology, 2010, v. 28, n. 2, p. 172, doi. 10.1038/nbt.1602
    By:
    • Semple, Sean C.;
    • Akinc, Akin;
    • Chen, Jianxin;
    • Sandhu, Ammen P.;
    • Mui, Barbara L.;
    • Cho, Connie K.;
    • Sah, Dinah W. Y.;
    • Stebbing, Derrick;
    • Crosley, Erin J.;
    • Yaworski, Ed;
    • Hafez, Ismail M.;
    • Dorkin, J. Robert;
    • Qin, June;
    • Lam, Kieu;
    • Rajeev, Kallanthottathil G.;
    • Wong, Kim F.;
    • Jeffs, Lloyd B.;
    • Nechev, Lubomir;
    • Eisenhardt, Merete L.;
    • Jayaraman, Muthusamy
    Publication type:
    Article

  • A combinatorial library of lipid-like materials for delivery of RNAi therapeutics.

    Published in:
    Nature Biotechnology, 2008, v. 26, n. 5, p. 561, doi. 10.1038/nbt1402
    By:
    • Akinc, Akin;
    • Zumbuehl, Andreas;
    • Goldberg, Michael;
    • Leshchiner, Elizaveta S;
    • Busini, Valentina;
    • Hossain, Naushad;
    • Bacallado, Sergio A;
    • Nguyen, David N;
    • Fuller, Jason;
    • Alvarez, Rene;
    • Borodovsky, Anna;
    • Borland, Todd;
    • Constien, Rainer;
    • de Fougerolles, Antonin;
    • Dorkin, J Robert;
    • Narayanannair Jayaprakash, K;
    • Jayaraman, Muthusamy;
    • John, Matthias;
    • Koteliansky, Victor;
    • Manoharan, Muthiah
    Publication type:
    Article

  • Mechanisms and optimization of in vivo delivery of lipophilic siRNAs.

    Published in:
    Nature Biotechnology, 2007, v. 25, n. 10, p. 1149, doi. 10.1038/nbt1339
    By:
    • Wolfrum, Christian;
    • Shuanping Shi;
    • Jayaprakash, K. Narayanannair;
    • Jayaraman, Muthusamy;
    • Gang Wang;
    • Pandey, Rajendra K.;
    • Rajeev, Kallanthottathil G.;
    • Nakayama, Tomoko;
    • Charrise, Klaus;
    • Ndungo, Esther M.;
    • Zimmermann, Tracy;
    • Koteliansky, Victor;
    • Manoharan, Muthiah;
    • Stoffel, Markus
    Publication type:
    Article

  • Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo.

    Published in:
    Angewandte Chemie, 2012, v. 124, n. 34, p. 8657, doi. 10.1002/ange.201203263
    By:
    • Jayaraman, Muthusamy;
    • Ansell, Steven M.;
    • Mui, Barbara L.;
    • Tam, Ying K.;
    • Chen, Jianxin;
    • Du, Xinyao;
    • Butler, David;
    • Eltepu, Laxman;
    • Matsuda, Shigeo;
    • Narayanannair, Jayaprakash K.;
    • Rajeev, Kallanthottathil G.;
    • Hafez, Ismail M.;
    • Akinc, Akin;
    • Maier, Martin A.;
    • Tracy, Mark A.;
    • Cullis, Pieter R.;
    • Madden, Thomas D.;
    • Manoharan, Muthiah;
    • Hope, Michael J.
    Publication type:
    Article

  • Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery.

    Published in:
    Nature Nanotechnology, 2012, v. 7, n. 6, p. 389, doi. 10.1038/nnano.2012.73
    By:
    • Lee, Hyukjin;
    • Lytton-Jean, Abigail K. R.;
    • Chen, Yi;
    • Love, Kevin T.;
    • Park, Angela I.;
    • Karagiannis, Emmanouil D.;
    • Sehgal, Alfica;
    • Querbes, William;
    • Zurenko, Christopher S.;
    • Jayaraman, Muthusamy;
    • Peng, Chang G.;
    • Charisse, Klaus;
    • Borodovsky, Anna;
    • Manoharan, Muthiah;
    • Donahoe, Jessica S.;
    • Truelove, Jessica;
    • Nahrendorf, Matthias;
    • Langer, Robert;
    • Anderson, Daniel G.
    Publication type:
    Article

  • Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates.

    Published in:
    Nucleic Acids Research, 2020, v. 48, n. 21, p. 11827, doi. 10.1093/nar/gkaa670
    By:
    • Brown, Christopher R;
    • Gupta, Swati;
    • Qin, June;
    • Racie, Timothy;
    • He, Guo;
    • Lentini, Scott;
    • Malone, Ryan;
    • Yu, Mikyung;
    • Matsuda, Shigeo;
    • Shulga-Morskaya, Svetlana;
    • Nair, Anil V;
    • Theile, Christopher S;
    • Schmidt, Karyn;
    • Shahraz, Azar;
    • Goel, Varun;
    • Parmar, Rubina G;
    • Zlatev, Ivan;
    • Schlegel, Mark K;
    • Nair, Jayaprakash K;
    • Jayaraman, Muthusamy
    Publication type:
    Article

  • Cover Picture: Hepatocyte-Specific Delivery of siRNAs Conjugated to Novel Non-nucleosidic Trivalent N-Acetylgalactosamine Elicits Robust Gene Silencing in Vivo (ChemBioChem 6/2015).

    Published in:
    ChemBioChem, 2015, v. 16, n. 6, p. 873, doi. 10.1002/cbic.201590012
    By:
    • Rajeev, Kallanthottathil G.;
    • Nair, Jayaprakash K.;
    • Jayaraman, Muthusamy;
    • Charisse, Klaus;
    • Taneja, Nate;
    • O'Shea, Jonathan;
    • Willoughby, Jennifer L. S.;
    • Yucius, Kristina;
    • Nguyen, Tuyen;
    • Shulga‐Morskaya, Svetlana;
    • Milstein, Stuart;
    • Liebow, Abigail;
    • Querbes, William;
    • Borodovsky, Anna;
    • Fitzgerald, Kevin;
    • Maier, Martin A.;
    • Manoharan, Muthiah
    Publication type:
    Article

  • Hepatocyte-Specific Delivery of siRNAs Conjugated to Novel Non-nucleosidic Trivalent N-Acetylgalactosamine Elicits Robust Gene Silencing in Vivo.

    Published in:
    ChemBioChem, 2015, v. 16, n. 6, p. 903, doi. 10.1002/cbic.201500023
    By:
    • Rajeev, Kallanthottathil G.;
    • Nair, Jayaprakash K.;
    • Jayaraman, Muthusamy;
    • Charisse, Klaus;
    • Taneja, Nate;
    • O'Shea, Jonathan;
    • Willoughby, Jennifer L. S.;
    • Yucius, Kristina;
    • Nguyen, Tuyen;
    • Shulga‐Morskaya, Svetlana;
    • Milstein, Stuart;
    • Liebow, Abigail;
    • Querbes, William;
    • Borodovsky, Anna;
    • Fitzgerald, Kevin;
    • Maier, Martin A.;
    • Manoharan, Muthiah
    Publication type:
    Article