Found: 55
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Bioequivalence, food effect and comparative pharmacokinetics of SUVN-1105, a novel granule formulation of abiraterone acetate, to Zytiga in healthy male subjects.
- Published in:
- Cancer Chemotherapy & Pharmacology, 2024, v. 93, n. 3, p. 253, doi. 10.1007/s00280-023-04629-1
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- Publication type:
- Article
Masupirdine (SUVN‐502) for the Potential Treatment of Agitation in Patients with Dementia of the Alzheimer's Type: Preliminary Efficacy and Phase‐3 Study Design.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 21, p. 1, doi. 10.1002/alz.074068
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- Publication type:
- Article
Role of Onset of Diabetes on Development of Cognitive Impairment in Rats.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.075193
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- Publication type:
- Article
Progress in Investigational Agents Targeting Serotonin-6 Receptors for the Treatment of Brain Disorders.
- Published in:
- Biomolecules (2218-273X), 2023, v. 13, n. 2, p. 309, doi. 10.3390/biom13020309
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- Publication type:
- Article
Effects of Masupirdine (SUVN‐502) on Agitation/Aggression and Psychosis in Patients with Probable Alzheimer's Disease: A Post Hoc Analysis.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 10, p. 1, doi. 10.1002/alz.062695
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- Publication type:
- Article
SUVN‐I7016031: A Novel M<sub>1</sub>‐receptor Positive Allosteric Modulator (M<sub>1</sub>‐PAM) for the treatment of Parkinson's Disease Associated Dementia.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 3, p. 1, doi. 10.1002/alz.062698
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- Publication type:
- Article
Effect of Concurrent Use of Memantine on the Efficacy of Masupirdine (SUVN-502): A Post Hoc Analysis of a Phase 2 Randomized Placebo-Controlled Study.
- Published in:
- Neurology & Therapy, 2022, v. 11, n. 4, p. 1583, doi. 10.1007/s40120-022-00390-4
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- Publication type:
- Article
Potential beneficial effects of masupirdine (SUVN-502) on agitation/aggression and psychosis in patients with moderate Alzheimer's disease: Exploratory post hoc analyses.
- Published in:
- 2022
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- Publication type:
- journal article
Ropanicant (SUVN-911), an α4β2 nicotinic acetylcholine receptor antagonist intended for the treatment of depressive disorders: pharmacological, behavioral, and neurochemical characterization.
- Published in:
- Psychopharmacology, 2022, v. 239, n. 7, p. 2215, doi. 10.1007/s00213-022-06108-6
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- Publication type:
- Article
1‐[2‐(1‐Cyclobutylpiperidin‐4‐yloxy)‐6,7‐dihydro‐4H‐thiazolo[5,4‐c]pyridin‐5‐yl]propan‐1‐one: a Histamine H<sub>3</sub> Receptor Inverse Agonist with Efficacy in Animal Models of Cognition
- Published in:
- ChemMedChem, 2022, v. 17, n. 3, p. 1, doi. 10.1002/cmdc.202100583
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- Publication type:
- Article
Effect of masupirdine (SUVN-502) on cognition in patients with moderate Alzheimer's disease: A randomized, double-blind, phase 2, proof-of-concept study.
- Published in:
- Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2022, v. 8, n. 1, p. 1, doi. 10.1002/trc2.12307
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- Publication type:
- Article
Masupirdine (SUVN‐502): A promising clinical candidate for the management of agitation in Alzheimer's dementia.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.051571
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- Publication type:
- Article
Metformin, a calorie restriction mimetic for the treatment of Alzheimer's disease: A preclinical investigation.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.051635
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- Publication type:
- Article
Histamine 3 receptor inverse agonist Samelisant (SUVN-G3031): Pharmacological characterization of an investigational agent for the treatment of cognitive disorders.
- Published in:
- Journal of Psychopharmacology, 2021, v. 35, n. 6, p. 713, doi. 10.1177/0269881120986418
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- Publication type:
- Article
Samelisant (SUVN-G3031), a potent, selective and orally active histamine H3 receptor inverse agonist for the potential treatment of narcolepsy: pharmacological and neurochemical characterisation.
- Published in:
- Psychopharmacology, 2021, v. 238, n. 6, p. 1495, doi. 10.1007/s00213-021-05779-x
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- Publication type:
- Article
SUVN‐I6107: A novel muscarinic M1 receptor‐positive allosteric modulator (M1‐PAM) for the treatment of cognitive deficits: Biomarkers (non‐neuroimaging)/Prognostic utility.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.039288
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- Publication type:
- Article
Masupirdine (SUVN‐502): Novel treatment option for the management of behavioral and psychological symptoms in patients with Alzheimer's disease: Human/Human trials: Other behavioral symptoms.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.039303
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- Publication type:
- Article
Masupirdine (SUVN‐502): A pure 5‐HT<sub>6</sub> receptor antagonist ameliorates aggression‐like behavior in animal models: Development of new models and analysis methods/behavioral models.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.039312
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- Publication type:
- Article
P3‐434: SUVN‐502: A PURE 5‐HT<sub>6</sub> RECEPTOR ANTAGONIST ATTENUATES MEMORY DEFICITS INDUCED BY DIVERSE CHALLENGES.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1127, doi. 10.1016/j.jalz.2019.06.3468
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- Publication type:
- Article
P2‐083: SUVN‐502: A PURE 5‐HT<sub>6</sub> RECEPTOR ANTAGONIST AMELIORATES SENILE DEMENTIA IN ANIMAL MODELS.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P604, doi. 10.1016/j.jalz.2019.06.2490
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- Publication type:
- Article
P1‐089: SUVN‐502 + DONEPEZIL + MEMANTINE (TRIPLE COMBINATION): FIRST‐IN‐CLASS AND A PROMISING NEW APPROACH FOR THE SYMPTOMATIC TREATMENT OF ALZHEIMER'S DISEASE DEMENTIA.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P269, doi. 10.1016/j.jalz.2019.06.644
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- Publication type:
- Article
P3‐273: NEUROCHEMICAL AND ELECTROPHYSIOLOGICAL CHARACTERIZATION OF SUVN‐I6107, A NOVEL MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATOR.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1182, doi. 10.1016/j.jalz.2018.06.1633
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- Publication type:
- Article
P3‐044: SUVN‐502, A PURE 5‐HT<sub>6</sub> RECEPTOR ANTAGONIST, ATTENUATES THE MEMORY DEFICIT CAUSED BY BILATERAL COMMON CAROTID ARTERY LIGATION.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1080, doi. 10.1016/j.jalz.2018.06.1399
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- Publication type:
- Article
P2‐080: SUVN‐502: A PURE 5‐HT<sub>6</sub> ANTAGONIST AMELIORATES MEMORY DEFICIT IN TWO DIFFERENTIALLY CHALLENGED SOCIAL RECOGNITION TASKS.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P698, doi. 10.1016/j.jalz.2018.06.765
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- Publication type:
- Article
P2‐094: SUVN‐502: A PURE 5‐HT<sub>6</sub> RECEPTOR ANTAGONIST ALLEVIATES POST‐MENOPAUSE ASSOCIATED DEMENTIA IN AGED MENOPAUSE WISTAR RATS.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P703, doi. 10.1016/j.jalz.2018.06.779
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- Publication type:
- Article
P1‐075: IN‐VIVO CHARACTERIZATION OF SUVN‐I2004: AN M<sub>1</sub> POSITIVE ALLOSTERIC MODULATOR (PAM) IN ANIMAL MODELS OF COGNITION AND SAFETY.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P299, doi. 10.1016/j.jalz.2018.06.077
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- Publication type:
- Article
SUVN-G3031, A SELECTIVE H3 RECEPTOR INVERSE AGONIST: ASSESSMENT OF SAFETY, TOLERABILITY AND PHARMACOKINETICS IN HEALTHY HUMAN VOLUNTEERS.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P261, doi. 10.1016/j.jalz.2017.06.130
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- Publication type:
- Article
SUVN-I6107: A NOVEL MUSCARINIC M1 RECEPTOR-POSITIVE ALLOSTERIC MODULATOR (M1-PAM) DEVOID OF CHOLINERGIC SIDE EFFECTS.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P268, doi. 10.1016/j.jalz.2017.06.146
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- Publication type:
- Article
SUVN-502 (5-HT6 ANTAGONIST) POTENTIATES THE EFFECTS OF MEMANTINE IN ANIMAL MODELS OF COGNITION.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P277, doi. 10.1016/j.jalz.2017.06.165
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- Publication type:
- Article
NOVEL OBJECT RECOGNITION TASK: A SENSITIVE AND RELEVANT ANIMAL MODEL SYSTEM FOR EVALUATING POSTMENOPAUSE-RELATED DEMENTIA.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P287, doi. 10.1016/j.jalz.2017.06.187
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- Publication type:
- Article
SUVN-D4010: A POTENT AND SELECTIVE 5-HT4 RECEPTOR PARTIAL AGONIST— ASSESSMENT OF SAFETY, TOLERABILITY AND PHARMACOKINETICS IN HEALTHY HUMAN VOLUNTEERS.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P463, doi. 10.1016/j.jalz.2017.06.476
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- Publication type:
- Article
SUVN-502 + DONEPEZIL + MEMANTINE (TRIPLE COMBINATION) REPRESENTS A PROMISING NEW APPROACH FOR SYMPTOMATIC TREATMENT OF ALZHEIMER’S DISEASE.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P617, doi. 10.1016/j.jalz.2017.06.681
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- Publication type:
- Article
SUVN-502 (A PURE 5-HT6 ANTAGONIST): PROMISING THERAPEUTIC POTENTIAL FOR PMAD (POST-MENOPAUSE-ASSOCIATED DEMENTIA) AND SMAD (SURGICAL MENOPAUSE-ASSOCIATED DEMENTIA).
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P637, doi. 10.1016/j.jalz.2017.06.731
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- Publication type:
- Article
SUVN-502, POTENT AND PURE 5-HT6 RECEPTOR ANTAGONIST: PROOF-OF-CONCEPT STUDY DESIGN IN MODERATE ALZHEIMER’S DISEASE PATIENTS.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P434, doi. 10.1016/j.jalz.2016.06.833
- By:
- Publication type:
- Article
SUVN-G3031, A POTENT AND SELECTIVE H3 RECEPTOR INVERSE AGONIST: SAFETY, TOLERABILITY AND PHARMACOKINETICS IN HUMANS.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P618, doi. 10.1016/j.jalz.2016.06.1230
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- Publication type:
- Article
THE AMNESIC EFFECT OF PRE- AND POST-TRIAL ADMINISTRATION OF SCOPOLAMINE AND ITS REVERSAL PATTERN BY DIFFERENT COGNITION ENHANCERS IN FEAR CONDITIONING TASK.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P627, doi. 10.1016/j.jalz.2016.06.1256
- By:
- Publication type:
- Article
SUVN-D4010, A POTENT AND SELECTIVE 5-HT4 RECEPTOR PARTIAL AGONIST: SAFETY, TOLERABILITY AND PHARMACOKINETICS IN HUMANS.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P823, doi. 10.1016/j.jalz.2016.06.1673
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- Publication type:
- Article
5-ht6 antagonist SUVN-502 potentiates the procognitive and neurochemical effects of donepezil and memantine.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P472, doi. 10.1016/j.jalz.2015.06.517
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- Publication type:
- Article
The 5-ht6 antagonist SUVN-502 potentiates the effects of acetylcholinesterase inhibitors on extracellular acetylcholine levels and in animal models of cognition.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P475, doi. 10.1016/j.jalz.2015.06.526
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- Publication type:
- Article
Safety, tolerability, and pharmacokinetics of a potent and selective 5-ht6 receptor antagonist, SUVN-502, following multiple ascending doses in healthy elderly subjects, and effect of gender and food on single-dose pharmacokinetics.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P748, doi. 10.1016/j.jalz.2015.06.1669
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- Publication type:
- Article
Effect of gender and food on the single-dose pharmacokinetics of SUVN-502, a potent and selective 5-HT6 receptor antagonist.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2014, v. 10, p. P772, doi. 10.1016/j.jalz.2014.05.1484
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- Publication type:
- Article
Influence of chronic pain on cognitive function: 5-HT6 antagonist improves the behavioral outcome and attenuates the side effects of Gabapentin.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2014, v. 10, p. P865, doi. 10.1016/j.jalz.2014.05.1727
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- Publication type:
- Article
Pharmacokinetic-pharmacodynamic relationships of amnesic effects of scopolamine in rats
- Published in:
- 2012
- By:
- Publication type:
- Abstract
SUVN-D1104010: Novel 5-HT4 receptor partial agonist for the treatment of Alzheimer's disease
- Published in:
- 2012
- By:
- Publication type:
- Abstract
Effect of various cognitive enhancers in acquisition task of radial maze
- Published in:
- 2011
- By:
- Publication type:
- Abstract
SUVN-502: A potent and selective 5-HT6 antagonist, potential drug for the treatment of Alzheimer's disease
- Published in:
- 2011
- By:
- Publication type:
- Abstract
SUVN-G1031, a novel selective H3 receptor antagonist in animal models of cognitive deficits
- Published in:
- 2011
- By:
- Publication type:
- Abstract
SUVN-90716: A Selective 5-HT<sub>6</sub> Antagonist for the Potential Treatment of Alzheimer's Disease
- Published in:
- 2010
- By:
- Publication type:
- Abstract
SUVN-91052: A potent and selective 5-HT<sub>4</sub> agonist for the treatment of Alzheimer's disease
- Published in:
- 2010
- By:
- Publication type:
- Abstract
SUVN-90121: A selective nicotinic acetylcholine receptor (nAChR) ligand for the treatment of cognitive impairment and depression
- Published in:
- 2010
- By:
- Publication type:
- Abstract