Works by Jardin, Isaac

Results: 44

A subset of Orai1α and Orai1β subunits heteromerizes to form CRAC channels.

Published in:

Cell Communication & Signaling, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12964-025-02271-3

By:

Lopez, Jose J.;
Jardín, Isaac;
Jiménez-Velarde, Vanesa;
Alvarado, Sandra;
Macías-Díaz, Alvaro;
Nieto-Felipe, Joel;
Martín-Romero, Francisco J.;
Smani, Tarik;
Rosado, Juan A.

Publication type:

Article

Functional role of TRPC6 and STIM2 in cytosolic and endoplasmic reticulum Ca2+ content in resting estrogen receptor-positive breast cancer cells.

Published in:

Biochemical Journal, 2020, v. 477, n. 17, p. 3183, doi. 10.1042/BCJ20200560

By:

Sanchez-Collado, Jose;
Lopez, Jose J.;
Gonzalez-Gutierrez, Lucia;
Cantonero, Carlos;
Jardin, Isaac;
Salido, Ginés M.;
Rosado, Juan A.

Publication type:

Article

Physical properties of two types of calcium stores and SERCAs in human platelets.

Published in:

Molecular & Cellular Biochemistry, 2008, v. 311, n. 1/2, p. 9

By:

Alfonsas Juška;
Isaac Jardin;
Juan Rosado

Publication type:

Article

TRPC Channels in the SOCE Scenario.

Published in:

Cells (2073-4409), 2020, v. 9, n. 1, p. 1, doi. 10.3390/cells9010126

By:

Lopez, Jose J.;
Jardin, Isaac;
Sanchez-Collado, Jose;
Salido, Ginés M.;
Smani, Tarik;
Rosado, Juan A.

Publication type:

Article

Phemindole, a Synthetic Di-indole Derivative Maneuvers the Store Operated Calcium Entry (SOCE) to Induce Potent Anti-Carcinogenic Activity in Human Triple Negative Breast Cancer Cells.

Published in:

Frontiers in Pharmacology, 2016, p. 1, doi. 10.3389/fphar.2016.00114

By:

Chakraborty, Supriya;
Ghosh, Swatilekha;
Banerjee, Bhaswati;
Santra, Abhishek;
Misra, Anup K.;
Sen, Parimal C.;
Adhikary, Arghya;
Den Hollander, Petra;
Rosado Dionisio, Juan Antonio;
Jardin, Isaac

Publication type:

Article

STIM and Orai1 Variants in Store-Operated Calcium Entry.

Published in:

Frontiers in Pharmacology, 2016, v. 6, p. 1, doi. 10.3389/fphar.2015.00325

By:

Rosado, Juan A.;
Diez, Raquel;
Smani, Tarik;
Jardín, Isaac

Publication type:

Article

STIM and Orai1 variants in store-operated calcium entry.

Published in:

Frontiers in Pharmacology, 2015, v. 6, p. 1, doi. 10.3389/fphar.2015.00325

By:

Rosado, Juan A.;
Diez, Raquel;
Smani, Tarik;
Jardín, Isaac

Publication type:

Article

Homer Proteins in Ca2+ Entry.

Published in:

IUBMB Life, 2013, v. 65, n. 6, p. 497, doi. 10.1002/iub.1162

By:

Jardin, Isaac;
López, José J.;
Berna‐Erro, Alejandro;
Salido, Ginés M.;
Rosado, Juan A.

Publication type:

Article

Cholesterol modulates Orai1 channel function.

Published in:

Science Signaling, 2016, v. 9, n. 412, p. 1, doi. 10.1126/scisignal.aad7808

By:

Derler, Isabella;
Jardin, Isaac;
Stathopulos, Peter B.;
Muik, Martin;
Fahrner, Marc;
Zayats, Vasilina;
Pandey, Saurabh K.;
Poteser, Michael;
Lackner, Barbara;
Absolonova, Marketa;
Schindl, Rainer;
Groschner, Klaus;
Ettrich, Rüdiger;
Ikura, Mitsu;
Romanin, Christoph

Publication type:

Article

A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca2+ permeation and SOCE-induced gene transcription.

Published in:

Science Signaling, 2015, v. 8, n. 408, p. 1, doi. 10.1126/scisignal.aab1901

By:

Frischauf, Irene;
Zayats, Vasilina;
Deix, Michael;
Hochreiter, Anna;
Jardin, Isaac;
Muik, Martin;
Lackner, Barbara;
Svobodová, Barbora;
Pammer, Teresa;
Litviňuková, Monika;
Sridhar, Amrutha Arumbakam;
Derler, Isabella;
Bogeski, Ivan;
Romanin, Christoph;
Ettrich, Rüdiger H.;
Schindl, Rainer

Publication type:

Article

Identification and Function of Exchange Proteins Activated Directly by Cyclic AMP (Epac) in Mammalian Spermatozoa.

Published in:

PLoS ONE, 2012, v. 7, n. 5, p. 1, doi. 10.1371/journal.pone.0037713

By:

Miro-Moran, Alvaro;
Jardin, Isaac;
Ortega-Ferrusola, Cristina;
Salido, Gines M.;
Peña, Fernando J.;
Tapia, Jose A.;
Aparicio, Ines M.

Publication type:

Article

Orai1α and Orai1β support calcium entry and mammosphere formation in breast cancer stem cells.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-46946-8

By:

Jardin, Isaac;
Alvarado, Sandra;
Jimenez-Velarde, Vanesa;
Nieto-Felipe, Joel;
Lopez, Jose J.;
Salido, Gines M.;
Smani, Tarik;
Rosado, Juan A.

Publication type:

Article

The TRPV1 ion channel is expressed in human but not mouse platelets.

Published in:

Platelets, 2014, v. 25, n. 5, p. 390, doi. 10.3109/09537104.2013.777952

By:

Sage, Stewart O.;
Jarvis, Gavin E.;
Jardín, Isaac;
Rosado, Juan A.;
Harper, Alan G. S.

Publication type:

Article

The STIM1/Orai signaling machinery.

Published in:

Channels (19336950), 2013, v. 7, n. 5, p. 1, doi. 10.4161/chan.26742

By:

Fahrner, Marc;
Derler, Isabella;
Jardin, Isaac;
Romanin, Christoph

Publication type:

Article

Description of a new quantitative method to assess mitochondrial distribution pattern in mature equine oocytes.

Published in:

Veterinary Research Communications, 2024, v. 48, n. 3, p. 1867, doi. 10.1007/s11259-024-10325-z

By:

Luis-Calero, Marcos;
Fernández-Hernández, Pablo;
Ortiz-Rodríguez, José Manuel;
Muñoz-García, Carmen Cristina;
Jardin, Isaac;
Macías-García, Beatriz;
González-Fernández, Lauro

Publication type:

Article

The Ca 2+ Sensor STIM in Human Diseases.

Published in:

Biomolecules (2218-273X), 2023, v. 13, n. 9, p. 1284, doi. 10.3390/biom13091284

By:

Berna-Erro, Alejandro;
Sanchez-Collado, Jose;
Nieto-Felipe, Joel;
Macias-Diaz, Alvaro;
Redondo, Pedro C.;
Smani, Tarik;
Lopez, Jose J.;
Jardin, Isaac;
Rosado, Juan A.

Publication type:

Article

Secretion of Interleukin 6 in Human Skeletal Muscle Cultures Depends on Ca 2+ Signalling.

Published in:

Biology (2079-7737), 2023, v. 12, n. 7, p. 968, doi. 10.3390/biology12070968

By:

Calle-Ciborro, Blanca;
Espin-Jaime, Teresa;
Santos, Francisco J.;
Gomez-Martin, Ana;
Jardin, Isaac;
Pozo, Maria J.;
Rosado, Juan A.;
Camello, Pedro J.;
Camello-Almaraz, Cristina

Publication type:

Article

TRPs in Pain Sensation.

Published in:

Frontiers in Physiology, 2017, p. 1, doi. 10.3389/fphys.2017.00392

By:

Jardín, Isaac;
López, José J.;
Diez, Raquel;
Sánchez-Collado, José;
Cantonero, Carlos;
Albarrán, Letizia;
Woodard, Geoffrey E.;
Redondo, Pedro C.;
Salido, Ginés M.;
Smani, Tarik;
Rosado, Juan A.

Publication type:

Article

Extended Synaptotagmins 1 and 2 Are Required for Store-Operated Calcium Entry, Cell Migration and Viability in Breast Cancer Cells.

Published in:

Cancers, 2024, v. 16, n. 14, p. 2518, doi. 10.3390/cancers16142518

By:

Redondo, Pedro C.;
Lopez, Jose J.;
Alvarado, Sandra;
Jardin, Isaac;
Nieto-Felipe, Joel;
Macias-Diaz, Alvaro;
Jimenez-Velarde, Vanesa;
Salido, Gines M.;
Rosado, Juan A.

Publication type:

Article

Correction: Sanchez-Collado et al. Orai2 Modulates Store-Operated Ca 2+ Entry and Cell Cycle Progression in Breast Cancer Cells. Cancers 2021, 14 , 114.

Published in:

2023

By:

Sanchez-Collado, Jose;
Lopez, Jose J.;
Cantonero, Carlos;
Jardin, Isaac;
Regodón, Sergio;
Redondo, Pedro C.;
Gordillo, Juan;
Smani, Tarik;
Salido, Gines M.;
Rosado, Juan A.

Publication type:

Correction Notice

Store-Operated Calcium Entry in Breast Cancer Cells Is Insensitive to Orai1 and STIM1 N-Linked Glycosylation.

Published in:

Cancers, 2023, v. 15, n. 1, p. 203, doi. 10.3390/cancers15010203

By:

Sanchez-Collado, Jose;
Nieto-Felipe, Joel;
Jardin, Isaac;
Bhardwaj, Rajesh;
Berna-Erro, Alejandro;
Salido, Gines M.;
Smani, Tarik;
Hediger, Matthias A;
Lopez, Jose J.;
Rosado, Juan A.

Publication type:

Article

Orai2 Modulates Store-Operated Ca 2+ Entry and Cell Cycle Progression in Breast Cancer Cells.

Published in:

Cancers, 2022, v. 14, n. 1, p. 114, doi. 10.3390/cancers14010114

By:

Sanchez-Collado, Jose;
Lopez, Jose J.;
Cantonero, Carlos;
Jardin, Isaac;
Regodón, Sergio;
Redondo, Pedro C.;
Gordillo, Juan;
Smani, Tarik;
Salido, Gines M.;
Rosado, Juan A.

Publication type:

Article

SARAF and EFHB Modulate Store-Operated Ca 2+ Entry and Are Required for Cell Proliferation, Migration and Viability in Breast Cancer Cells.

Published in:

Cancers, 2021, v. 13, n. 16, p. 4160, doi. 10.3390/cancers13164160

By:

Jardin, Isaac;
Nieto-Felipe, Joel;
Alvarado, Sandra;
Diez-Bello, Raquel;
Lopez, Jose J.;
Salido, Ginés M.;
Smani, Tarik;
Rosado, Juan A.

Publication type:

Article

Adenylyl Cyclase Type 8 Overexpression Impairs Phosphorylation-Dependent Orai1 Inactivation and Promotes Migration in MDA-MB-231 Breast Cancer Cells.

Published in:

Cancers, 2019, v. 11, n. 11, p. 1624, doi. 10.3390/cancers11111624

By:

Sanchez-Collado, Jose;
Lopez, Jose J.;
Jardin, Isaac;
Camello, Pedro J.;
Falcon, Debora;
Regodon, Sergio;
Salido, Gines M.;
Smani, Tarik;
Rosado, Juan A.

Publication type:

Article

TRPC6 Channels Are Required for Proliferation, Migration and Invasion of Breast Cancer Cell Lines by Modulation of Orai1 and Orai3 Surface Exposure.

Published in:

Cancers, 2018, v. 10, n. 9, p. 331, doi. 10.3390/cancers10090331

By:

Jardin, Isaac;
Diez-Bello, Raquel;
Lopez, Jose J.;
Redondo, Pedro C.;
Salido, Ginés M.;
Smani, Tarik;
Rosado, Juan A.

Publication type:

Article

Ca2++ leakage rate from agonist-sensitive intracellular pools is altered in platelets from patients with type 2 diabetes.

Published in:

Platelets, 2011, v. 22, n. 4, p. 284, doi. 10.3109/09537104.2010.528813

By:

Zbidi, Hanene;
Jardin, Isaac;
Bartegi, Aghleb;
Salido, Gines M;
Rosado, Juan A

Publication type:

Article

Endogenously generated reactive oxygen species reduce PMCA activity in platelets from patients with non-insulin-dependent diabetes mellitus.

Published in:

Platelets, 2006, v. 17, n. 5, p. 283, doi. 10.1080/09537100600745187

By:

Jardín, Isaac;
Redondo, Pedro C.;
Salido, Ginés M.;
Pariente, José A.;
Rosado, Juan A.

Publication type:

Article

Melatonin, as an adjuvant-like agent, enhances platelet responsiveness.

Published in:

Journal of Pineal Research, 2009, v. 46, n. 3, p. 275, doi. 10.1111/j.1600-079X.2008.00658.x

By:

Regodón, Sergio;
Del Prado Míguez, María;
Jardín, Isaac;
López, José J.;
Ramos, Asunción;
Paredes, Sergio D.;
Rosado, Juan A.

Publication type:

Article

Involvement of stanniocalcins in the deregulation of glycaemia in obese mice and type 2 diabetic patients.

Published in:

Journal of Cellular & Molecular Medicine, 2018, v. 22, n. 1, p. 684, doi. 10.1111/jcmm.13355

By:

López, José Javier;
Jardín, Isaac;
Cantonero Chamorro, Carlos;
Duran, Manuel Luis;
Tarancón Rubio, María José;
Reyes Panadero, Maria;
Jiménez, Francisca;
Montero, Rocio;
González, María José;
Martínez, Manuel;
Hernández, María Jose;
Brull, José María;
Corbacho, Antonio Jesús;
Delgado, Elena;
Granados, María Purificación;
Gómez‐Gordo, Luis;
Rosado, Juan Antonio;
Redondo, Pedro Cosme

Publication type:

Article

Role of STIM2 in cell function and physiopathology.

Published in:

Journal of Physiology, 2017, v. 595, n. 10, p. 3111, doi. 10.1113/JP273889

By:

Berna‐Erro, Alejandro;
Jardin, Isaac;
Salido, Gines M.;
Rosado, Juan A.

Publication type:

Article

Store-Operated Calcium Entry and Its Implications in Cancer Stem Cells.

Published in:

Cells (2073-4409), 2022, v. 11, n. 8, p. 1332, doi. 10.3390/cells11081332

By:

Jardin, Isaac;
Lopez, Jose J.;
Sanchez-Collado, Jose;
Gomez, Luis J.;
Salido, Gines M.;
Rosado, Juan A.

Publication type:

Article

Urtica dioica extract reduces platelet hyperaggregability in type 2 diabetes mellitus by inhibition of oxidant production, Ca2+ mobilization and protein tyrosine phosphorylation.

Published in:

Journal of Applied Biomedicine, 2007, v. 5, n. 2, p. 105, doi. 10.32725/jab.2007.015

By:

El Haouari, Mohammed;
Jardin, Isaac;
Mekhfi, Hasane;
Rosado, Juan A.;
Salido, Ginés M.

Publication type:

Article

Similarities and Differences between the Orai1 Variants: Orai1α and Orai1β.

Published in:

2022

By:

Jardin, Isaac;
Berna-Erro, Alejandro;
Nieto-Felipe, Joel;
Macias, Alvaro;
Sanchez-Collado, Jose;
Lopez, Jose J.;
Salido, Gines M.;
Rosado, Juan A.

Publication type:

Literature Review

A Fibrin Coating Method of Polypropylene Meshes Enables the Adhesion of Menstrual Blood-Derived Mesenchymal Stromal Cells: A New Delivery Strategy for Stem Cell-Based Therapies.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 24, p. 13385, doi. 10.3390/ijms222413385

By:

Marinaro, Federica;
Silva, Joana M.;
Barros, Alexandre A.;
Aroso, Ivo M.;
Gómez-Blanco, Juan C.;
Jardin, Isaac;
Lopez, Jose J.;
Pulido, María;
de Pedro, María Ángeles;
Reis, Rui L.;
Sánchez-Margallo, Francisco Miguel;
Casado, Javier G.;
López, Esther

Publication type:

Article

Role of Orai3 in the Pathophysiology of Cancer.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 21, p. 11426, doi. 10.3390/ijms222111426

By:

Sanchez-Collado, Jose;
Jardin, Isaac;
López, Jose J.;
Ronco, Victor;
Salido, Gines M.;
Dubois, Charlotte;
Prevarskaya, Natalia;
Rosado, Juan A.

Publication type:

Article

Store-Operated Ca2+ Entry in Breast Cancer Cells: Remodeling and Functional Role.

Published in:

International Journal of Molecular Sciences, 2018, v. 19, n. 12, p. 4053, doi. 10.3390/ijms19124053

By:

Jardin, Isaac;
Lopez, Jose J.;
Salido, Gines M.;
Rosado, Juan A.

Publication type:

Article

Feedback modulation of Orai1α and Orai1β protein content mediated by STIM proteins.

Published in:

Journal of Cellular Physiology, 2025, v. 240, n. 1, p. 1, doi. 10.1002/jcp.31450

By:

Nieto‐Felipe, Joel;
Macias‐Díaz, Alvaro;
Jimenez‐Velarde, Vanesa;
Lopez, Jose J.;
Salido, Gines M.;
Smani, Tarik;
Jardin, Isaac;
Rosado, Juan A.

Publication type:

Article

Functional differences in agonist‐induced plasma membrane expression of Orai1α and Orai1β.

Published in:

Journal of Cellular Physiology, 2023, v. 238, n. 9, p. 2050, doi. 10.1002/jcp.31055

By:

Jardin, Isaac;
Alvarado, Sandra;
Sanchez‐Collado, Jose;
Nieto‐Felipe, Joel;
Lopez, Jose J.;
Salido, Gines M.;
Rosado, Juan A.

Publication type:

Article

Role of Orai‐family channels in the activation and regulation of transcriptional activity.

Published in:

Journal of Cellular Physiology, 2023, v. 238, n. 4, p. 714, doi. 10.1002/jcp.30971

By:

Nieto‐Felipe, Joel;
Macias‐Diaz, Alvaro;
Sanchez‐Collado, Jose;
Berna‐Erro, Alejandro;
Jardin, Isaac;
Salido, Gines M.;
Lopez, Jose J.;
Rosado, Juan A.

Publication type:

Article

Role of Oxidant Scavengers in the Prevention of Ca2+ Homeostasis Disorders.

Published in:

Molecules, 2010, v. 15, n. 10, p. 7167, doi. 10.3390/molecules15107167

By:

Galan, Carmen;
Jardín, Isaac;
Dionisio, Natalia;
Salido, Ginés;
Rosado, Juan A.

Publication type:

Article

EFHB is a Novel Cytosolic Ca2+ Sensor That Modulates STIM1-SARAF Interaction.

Published in:

Cellular Physiology & Biochemistry (Karger AG), 2018, v. 51, n. 3, p. 1164, doi. 10.1159/000495494

By:

Albarran, Letizia;
Lopez, Jose J.;
Jardin, Isaac;
Sanchez-Collado, Jose;
Berna-Erro, Alejandro;
Smani, Tarik;
Camello, Pedro J.;
Salido, Gines M.;
Rosado, Juan A.

Publication type:

Article

Homers regulate calcium entry and aggregation in human platelets: a role for Homers in the association between STIM1 and Orai1.

Published in:

Biochemical Journal, 2012, v. 445, n. 1, p. 29, doi. 10.1042/BJ20120471

By:

JARDIN, Isaac;
ALBARRÁN, Letizia;
BERMEJO, Nuria;
SALIDO, Ginés M.;
ROSADO, Juan A.

Publication type:

Article

Postbiotics of Lacticaseibacillus paracaseiCECT 9610 and Lactiplantibacillus plantarumCECT 9608 attenuates store‐operated calcium entry and FAK phosphorylation in colorectal cancer cells.

Published in:

Molecular Oncology, 2024, v. 18, n. 5, p. 1123, doi. 10.1002/1878-0261.13629

By:

Macias‐Diaz, Alvaro;
Lopez, Jose J.;
Bravo, Maria;
Jardín, Isaac;
Garcia‐Jimenez, Waldo Luis;
Blanco‐Blanco, Francisco J.;
Cerrato, Rosario;
Rosado, Juan A.

Publication type:

Article

Orai1α, but not Orai1β, co-localizes with TRPC1 and is required for its plasma membrane location and activation in HeLa cells.

Published in:

Cellular & Molecular Life Sciences, 2022, v. 79, n. 1, p. 1, doi. 10.1007/s00018-021-04098-w

By:

Sanchez-Collado, Jose;
Lopez, Jose J.;
Jardin, Isaac;
Berna-Erro, Alejandro;
Camello, Pedro J.;
Cantonero, Carlos;
Smani, Tarik;
Salido, Gines M.;
Rosado, Juan A.

Publication type:

Article