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A Mode-of-Action Approach for the Identification of Genotoxic Carcinogens
Published in:
PLoS ONE, 2013, v. 8, n. 5, p. 1, doi. 10.1371/journal.pone.0064532
By:
- Hernández, Lya G.;
- van Benthem, Jan;
- Johnson, George E.
Publication type:
Article
Interlaboratory validation of the ToxTracker assay: An in vitro reporter assay for mechanistic genotoxicity assessment.
Published in:
Environmental & Molecular Mutagenesis, 2024, v. 65, n. 1/2, p. 4, doi. 10.1002/em.22592
By:
- Hendriks, Giel;
- Adriaens, Els;
- Allemang, Ashley;
- Clements, Julie;
- Cole, Gabrielle;
- Derr, Remco;
- Engel, Maria;
- Hamel, Annie;
- Kidd, Darren;
- Kellum, Stephanie;
- Kiyota, Tomomi;
- Myhre, Abby;
- Naëssens, Valerie;
- Pfuhler, Stefan;
- Roy, Marise;
- Settivari, Raja;
- Schuler, Maik;
- Zeller, Andreas;
- van Benthem, Jan;
- Vanparys, Philippe
Publication type:
Article
Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose–response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose–response data.
Published in:
Environmental & Molecular Mutagenesis, 2023, v. 64, n. 1, p. 4, doi. 10.1002/em.22517
By:
- Chepelev, Nikolai;
- Long, Alexandra S.;
- Beal, Marc;
- Barton‐Maclaren, Tara;
- Johnson, George;
- Dearfield, Kerry L.;
- Roberts, Daniel J.;
- van Benthem, Jan;
- White, Paul
Publication type:
Article
Impact of sampling time on the detection of mutations in rapidly proliferating tissues using transgenic rodent gene mutation models: A review.
Published in:
Environmental & Molecular Mutagenesis, 2022, v. 63, n. 8/9, p. 376, doi. 10.1002/em.22514
By:
- Douglas, George R.;
- Beevers, Carol;
- Gollapudi, Bhaskar;
- Keig‐Shevlin, Zena;
- Kirkland, David;
- O'Brien, Jason M.;
- van Benthem, Jan;
- Yauk, Carole L.;
- Young, Robert R.;
- Marchetti, Francesco
Publication type:
Article
Next generation testing strategy for assessment of genomic damage: A conceptual framework and considerations.
Published in:
Environmental & Molecular Mutagenesis, 2017, v. 58, n. 5, p. 264, doi. 10.1002/em.22045
By:
- Dearfield, Kerry L.;
- Gollapudi, B. Bhaskar;
- Bemis, Jeffrey C.;
- Benz, R. Daniel;
- Douglas, George R.;
- Elespuru, Rosalie K.;
- Johnson, George E.;
- Kirkland, David J.;
- LeBaron, Matthew J.;
- Li, Albert P.;
- Marchetti, Francesco;
- Pottenger, Lynn H.;
- Rorije, Emiel;
- Tanir, Jennifer Y.;
- Thybaud, Veronique;
- van Benthem, Jan;
- Yauk, Carole L.;
- Zeiger, Errol;
- Luijten, Mirjam
Publication type:
Article
Evaluation of the LacZ reporter assay in cryopreserved primary hepatocytes for In vitro genotoxicity testing.
Published in:
Environmental & Molecular Mutagenesis, 2016, v. 57, n. 9, p. 643, doi. 10.1002/em.22063
By:
- Luijten, Mirjam;
- Zwart, Edwin P.;
- Dollé, Martijn E.T.;
- de Pooter, Maaike;
- Cox, Julie A.;
- White, Paul A.;
- van Benthem, Jan
Publication type:
Article
Opportunities to integrate new approaches in genetic toxicology: An ILSI-HESI workshop report.
Published in:
Environmental & Molecular Mutagenesis, 2015, v. 56, n. 3, p. 277, doi. 10.1002/em.21923
By:
- Zeiger, Errol;
- Gollapudi, Bhaskar;
- Aardema, Marilyn J.;
- Auerbach, Scott;
- Boverhof, Darrell;
- Custer, Laura;
- Dedon, Peter;
- Honma, Masamitsu;
- Ishida, Seiichi;
- Kasinski, Andrea L.;
- Kim, James H.;
- Manjanatha, Mugimane G.;
- Marlowe, Jennifer;
- Pfuhler, Stefan;
- Pogribny, Igor;
- Slikker, William;
- Stankowski, Leon F.;
- Tanir, Jennifer Y.;
- Tice, Raymond;
- van Benthem, Jan
Publication type:
Article
The development of adverse outcome pathways for mutagenic effects for the organization for economic co-operation and development.
Published in:
Environmental & Molecular Mutagenesis, 2013, v. 54, n. 2, p. 79, doi. 10.1002/em.21757
By:
- Yauk, Carole L.;
- Bishop, Jack;
- Dearfield, Kerry L.;
- Douglas, George R.;
- Hales, Barbara F.;
- Luijten, Mirjam;
- O'Brien, Jason M.;
- Robaire, Bernard;
- Sram, Radim;
- van Benthem, Jan;
- Wade, Mike G.;
- White, Paul A.;
- Marchetti, Francesco
Publication type:
Article
Proliferating primary hepatocytes from the pUR288 lacZ plasmid mouse are valuable tools for genotoxicity assessment in vitro.
Published in:
Environmental & Molecular Mutagenesis, 2012, v. 53, n. 5, p. 376, doi. 10.1002/em.21700
By:
- Zwart, Edwin P.;
- Schaap, Mirjam M.;
- van den Dungen, Myrthe W.;
- Braakhuis, Hedwig M.;
- White, Paul A.;
- Steeg, Harry van;
- Benthem, Jan van;
- Luijten, Mirjam
Publication type:
Article
Can carcinogenic potency be predicted from in vivo genotoxicity data? a meta-analysis of historical data.
Published in:
Environmental & Molecular Mutagenesis, 2011, v. 52, n. 7, p. 518, doi. 10.1002/em.20651
By:
- Hernández, Lya G.;
- Slob, Wout;
- van Steeg, Harry;
- van Benthem, Jan
Publication type:
Article
Follow-up actions from positive results of in vitro genetic toxicity testing.
Published in:
Environmental & Molecular Mutagenesis, 2011, v. 52, n. 3, p. 177, doi. 10.1002/em.20617
By:
- Dearfield, Kerry L.;
- Thybaud, Véronique;
- Cimino, Michael C.;
- Custer, Laura;
- Czich, Andreas;
- Harvey, James S.;
- Hester, Susan;
- Kim, James H.;
- Kirkland, David;
- Levy, Dan D.;
- Lorge, Elisabeth;
- Moore, Martha M.;
- Ouédraogo-Arras, Gladys;
- Schuler, Maik;
- Suter, Willi;
- Sweder, Kevin;
- Tarlo, Kirk;
- van Benthem, Jan;
- van Goethem, Freddy;
- Witt, Kristine L.
Publication type:
Article
DNA Adduct Kinetics in Reproductive Tissues of DNA Repair Proficient and Deficient Male Mice After Oral Exposure to Benzo(a)pyrene.
Published in:
Environmental & Molecular Mutagenesis, 2010, v. 51, n. 2, p. 123, doi. 10.1002/em.20516
By:
- Verhofstad, Nicole;
- van Oostrom, Conny Th. M.;
- van Benthem, Jan;
- van Schooten, Frederik J.;
- van Steeg, Harry;
- Godschalk, Roger W. L.
Publication type:
Article
New methods for assessing male germ line mutations in humans and genetic risks in their offspring.
Published in:
Mutagenesis, 2008, v. 23, n. 4, p. 241, doi. 10.1093/mutage/gen022
By:
- Nicole Verhofstad;
- Joost O. Linschooten;
- Jan van Benthem;
- Yuri E. Dubrova;
- Harry van Steeg;
- Frederik J. van Schooten;
- Roger W. L. Godschalk
Publication type:
Article
ECVAM retrospective validation of in vitro micronucleus test (MNT).
Published in:
Mutagenesis, 2008, v. 23, n. 4, p. 271, doi. 10.1093/mutage/gen010
By:
- Raffaella Corvi;
- Silvio Albertini;
- Thomas Hartung;
- Sebastian Hoffmann;
- Daniela Maurici;
- Stefan Pfuhler;
- Jan van Benthem;
- Philippe Vanparys
Publication type:
Article
In vivo cytokinesis blocked micronucleus assay with carbendazim in rat fibroblasts and comparison with in vitro assays.
Published in:
Mutagenesis, 2000, v. 15, n. 2, p. 155, doi. 10.1093/mutage/15.2.155
By:
- de Stoppelaar, Joyce M.;
- van de Kuil, Ton;
- Verharen, Henny W.;
- Hokse, Harro;
- Opperhuizen, Antoon;
- Mohn, Georges R.;
- van Benthem, Jan;
- Hoebee, Barbara
Publication type:
Article
Increased frequencies of diploid sperm detected by multicolour FISH after treatment of rats with carbendazim without micronucleus induction in peripheral blood erythrocytes.
Published in:
Mutagenesis, 1999, v. 14, n. 6, p. 621, doi. 10.1093/mutage/14.6.621
By:
- de Stoppelaar, Joyce M.;
- van de Kuil, Ton;
- Bedaf, Mirjam;
- Verharen, Henny W.;
- Slob, Wout;
- Mohn, Georges R.;
- Hoebee, Barbara;
- van Benthem, Jan
Publication type:
Article
Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.
Published in:
Archives of Toxicology, 2011, v. 85, n. 5, p. 367, doi. 10.1007/s00204-011-0693-2
By:
- Adler, Sarah;
- Basketter, David;
- Creton, Stuart;
- Pelkonen, Olavi;
- van Benthem, Jan;
- Zuang, Valérie;
- Andersen, Klaus Ejner;
- Angers-Loustau, Alexandre;
- Aptula, Aynur;
- Bal-Price, Anna;
- Benfenati, Emilio;
- Bernauer, Ulrike;
- Bessems, Jos;
- Bois, Frederic Y.;
- Boobis, Alan;
- Brandon, Esther;
- Bremer, Susanne;
- Broschard, Thomas;
- Casati, Silvia;
- Coecke, Sandra
Publication type:
Article
Evaluation of the Xpa-Deficient Transgenic Mouse Model for Short-Term Carcinogenicity Testing: 9-Month Studies with Haloperidol, Reserpine, Phenacetin, and D -Mannitol.
Published in:
Toxicologic Pathology, 2004, v. 32, n. 2, p. 192, doi. 10.1080/01926230490274344
By:
- Lina, Ben A. R.;
- Woutersen, Ruud A.;
- Bruijntjes, Joost P.;
- Van Benthem, Jan;
- Van Den Berg, Jolanda A. H.;
- Monbaliu, Johan;
- Thoolen, Bob J. J. M.;
- Beems, Rudolf B.;
- Van Kreijl, Coen F.
Publication type:
Article
DNA Repair-Deficient Xpa and Xpa/p53[sup +/-] Knock-Out Mice: Nature of the Models.
Published in:
Toxicologic Pathology, 2001, v. 29, p. 109, doi. 10.1080/019262301753178519
By:
- van Steeg, Harry;
- de Vries, Annemieke;
- van Oostrom, Conny TH. M.;
- Van Benthem, Jan;
- Beems, Rudolf B.;
- van Kreijl, Coen F.
Publication type:
Article
DNA Repair—Deficient Xpa and Xpa/p53+/- Knock-Out Mice: Nature of the Models.
Published in:
Toxicologic Pathology, 2001, v. 29, n. 1S, p. 109, doi. 10.1080/019262301753178519
By:
- Van Steeg, Harry;
- De Vries, Annemieke;
- Van Oostrom, Conny TH. M.;
- Van Benthem, Jan;
- Beems, Rudolf B.;
- Van Kreijl, Coen F.
Publication type:
Article
Benzo(a)pyrene induces similar gene expression changes in testis of DNA repair proficient and deficient mice.
Published in:
BMC Genomics, 2010, v. 11, p. 333, doi. 10.1186/1471-2164-11-333
By:
- Verhofstad, Nicole;
- Pennings, Jeroen L. A.;
- van Oostrom, Conny ThM;
- van Benthem, Jan;
- van Schooten, Frederik J.;
- van Steeg, Harry;
- Godschalk, Roger W. L.
Publication type:
Article
Comparison of clastogen-induced gene expression profiles in wild-type and DNA repair-deficient Rad54/Rad54B cells.
Published in:
BMC Genomics, 2010, v. 11, p. 1, doi. 10.1186/1471-2164-11-24
By:
- Mahabir, Anuska G;
- Schaap, Mirjam M;
- Pennings, Jeroen LA;
- Benthem, Jan van;
- Hendriksen, Coenraad FM;
- Steeg, Harry van
Publication type:
Article
Paternal Exposure to Environmental Chemical Stress Affects Male Offspring's Hepatic Mitochondria.
Published in:
Toxicological Sciences, 2018, v. 162, n. 1, p. 241, doi. 10.1093/toxsci/kfx246
By:
- Godschalk, Roger;
- Remels, Alex;
- Hoogendoorn, Camiel;
- Benthem, Jan van;
- Luijten, Mirjam;
- Duale, Nur;
- Brunborg, Gunnar;
- Olsen, Ann-Karin;
- Bouwman, Freek G;
- Munnia, Armelle
Publication type:
Article
Transgenic Animal Models in Toxicology: Historical Perspectives and Future Outlook.
Published in:
Toxicological Sciences, 2011, v. 121, n. 2, p. 207, doi. 10.1093/toxsci/kfr075
By:
- Boverhof, Darrell R.;
- Chamberlain, Mark P;
- Elcombe, Clifford R.;
- Gonzalez, Frank J.;
- Heflich, Robert H.;
- Hernández, Lya G.;
- Jacobs, Abigail C.;
- Jacobson-Kram, David;
- Luijten, Mirjam;
- Maggi, Adriana;
- Manjanatha, Mugimane G.;
- Benthem, Jan van;
- Gollapudi, B. Bhaskar
Publication type:
Article
Evaluation of Benzo(a)pyrene-Induced Gene Mutations in Male Germ Cells.
Published in:
Toxicological Sciences, 2011, v. 119, n. 1, p. 218, doi. 10.1093/toxsci/kfq325
By:
- Verhofstad, Nicole;
- van Oostrom, Conny Th. M.;
- Zwart, Edwin;
- Maas, Lou M.;
- van Benthem, Jan;
- van Schooten, Frederik J.;
- van Steeg, Harry;
- Godschalk, Roger W.L.
Publication type:
Article
Finding maximal transcriptome differences between reprotoxic and non-reprotoxic phthalate responses in rat testis.
Published in:
Journal of Applied Toxicology, 2011, v. 31, n. 5, p. 421, doi. 10.1002/jat.1601
By:
- Yuan, Xiaolian;
- Jonker, Martijs J.;
- de Wilde, Jillian;
- Verhoef, Aart;
- Wittink, Floyd R.A.;
- van Benthem, Jan;
- Bessems, Jos G.;
- Hakkert, Betty C.;
- Kuiper, Raoul V.;
- van Steeg, Harry;
- Breit, Timo M.;
- Luijten, Mirjam
Publication type:
Article

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