Works matching AU Jamei, Masoud

Results: 58

Mechanistic Physiologically Based Pharmacokinetic Modeling of Dry Powder and Nebulized Formulations of Orally Inhaled TMEM16A Potentiator GDC‐6988.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2025, v. 14, n. 6, p. 1087, doi. 10.1002/psp4.70027

By:

Zhu, Rui;
Sorrell, Ian;
Ma, Fang;
Ning, Miaoran;
Son, Yoen‐Ju;
She, Gaohong;
De Bruyn, Tom;
Galanter, Joshua;
Kassir, Nastya;
Owen, Ryan;
Jamei, Masoud;
Gardner, Iain;
Chen, Yuan

Publication type:

Article

Cross-species translational modelling of targeted therapeutic oligonucleotides using physiologically based pharmacokinetics.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2025, v. 52, n. 4, p. 1, doi. 10.1007/s10928-025-09980-9

By:

Derbalah, Abdallah;
Stader, Felix;
Liu, Cong;
Zyla, Adriana;
Abdulla, Tariq;
Wu, Qier;
Jamei, Masoud;
Gardner, Ian;
Sepp, Armin

Publication type:

Article

Accelerating Biologics PBPK Modelling with Automated Model Building: A Tutorial.

Published in:

Pharmaceutics, 2025, v. 17, n. 5, p. 604, doi. 10.3390/pharmaceutics17050604

By:

Derbalah, Abdallah;
Abdulla, Tariq;
De Sousa Mendes, Mailys;
Wu, Qier;
Stader, Felix;
Jamei, Masoud;
Gardner, Iain;
Sepp, Armin

Publication type:

Article

Non-specific binding of compounds in in vitro metabolism assays: a comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models.

Published in:

Xenobiotica, 2022, v. 52, n. 8, p. 943, doi. 10.1080/00498254.2022.2132426

By:

Gardner, Iain;
Xu, Mandy;
Han, Chunyan;
Wang, Yi;
Jiao, Xingjin;
Jamei, Masoud;
Khalidi, Hiba;
Kilford, Peter;
Neuhoff, Sibylle;
Southall, Roz;
Turner, David B.;
Musther, Helen;
Jones, Barry;
Taylor, Simon

Publication type:

Article

Early assessment of proarrhythmic risk of drugs using the in vitro data and single-cell-based in silico models: proof of concept.

Published in:

Toxicology Mechanisms & Methods, 2017, v. 27, n. 2, p. 88, doi. 10.1080/15376516.2016.1256460

By:

Abbasi, Mitra;
Small, Ben G.;
Patel, Nikunjkumar;
Jamei, Masoud;
Polak, Sebastian

Publication type:

Article

Application of Physiologically Based Pharmacokinetic Model to Delineate the Impact of Aging and Renal Impairment on Ceftazidime Clearance.

Published in:

Antibiotics (2079-6382), 2024, v. 13, n. 9, p. 862, doi. 10.3390/antibiotics13090862

By:

Abduljalil, Khaled;
Gardner, Iain;
Jamei, Masoud

Publication type:

Article

Multi‐phase multi‐layer mechanistic dermal absorption (MPML MechDermA) model to predict local and systemic exposure of drug products applied on skin.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 8, p. 1060, doi. 10.1002/psp4.12814

By:

Patel, Nikunjkumar;
Clarke, James F.;
Salem, Farzaneh;
Abdulla, Tariq;
Martins, Frederico;
Arora, Sumit;
Tsakalozou, Eleftheria;
Hodgkinson, Arran;
Arjmandi‐Tash, Omid;
Cristea, Sinziana;
Ghosh, Priyanka;
Alam, Khondoker;
Raney, Sam G.;
Jamei, Masoud;
Polak, Sebastian

Publication type:

Article

Population PBPK modeling using parametric and nonparametric methods of the Simcyp Simulator, and Bayesian samplers.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 6, p. 755, doi. 10.1002/psp4.12787

By:

Wedagedera, Janak R.;
Afuape, Anthonia;
Chirumamilla, Siri Kalyan;
Momiji, Hiroshi;
Leary, Robert;
Dunlavey, Mike;
Matthews, Richard;
Abduljalil, Khaled;
Jamei, Masoud;
Bois, Frederic Y.

Publication type:

Article

Development of physiologically‐based pharmacokinetic models for standard of care and newer tuberculosis drugs.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 11, p. 1382, doi. 10.1002/psp4.12707

By:

Humphries, Helen;
Almond, Lisa;
Berg, Alexander;
Gardner, Iain;
Hatley, Oliver;
Pan, Xian;
Small, Ben;
Zhang, Mian;
Jamei, Masoud;
Romero, Klaus

Publication type:

Article

Prediction of drug concentrations in milk during breastfeeding, integrating predictive algorithms within a physiologically‐based pharmacokinetic model.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 8, p. 878, doi. 10.1002/psp4.12662

By:

Abduljalil, Khaled;
Pansari, Amita;
Ning, Jia;
Jamei, Masoud

Publication type:

Article

Where Do PBPK Models Stand in Pharmacometrics and Systems Pharmacology?

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2020, v. 9, n. 2, p. 75, doi. 10.1002/psp4.12493

By:

Jamei, Masoud

Publication type:

Article

Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability.

Published in:

Frontiers in Pharmacology, 2014, v. 5, p. 1, doi. 10.3389/fphar.2014.00258

By:

Chetty, Manoranjenni;
Rose, Rachel H.;
Abduljalil, Khaled;
Patel, Nikunjkumar;
Gaohua Lu;
Cain, Theresa;
Jamei, Masoud;
Rostami-Hodjegan, Amin;
Bruno, Valeria;
Hempel, Georg

Publication type:

Article

A Physiologically Based Pharmacokinetic Model Relates the Subcutaneous Bioavailability of Monoclonal Antibodies to the Saturation of FcRn-Mediated Recycling in Injection-Site-Draining Lymph Nodes.

Published in:

Antibodies (2073-4468), 2024, v. 13, n. 3, p. 70, doi. 10.3390/antib13030070

By:

Stader, Felix;
Liu, Cong;
Derbalah, Abdallah;
Momiji, Hiroshi;
Pan, Xian;
Gardner, Iain;
Jamei, Masoud;
Sepp, Armin

Publication type:

Article

Physiologically-based pharmacokinetic modeling to predict drug-drug interaction of enzalutamide with combined P-gp and CYP3A substrates.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2023, v. 50, n. 5, p. 365, doi. 10.1007/s10928-023-09867-7

By:

Otsuka, Yukio;
Poondru, Srinivasu;
Bonate, Peter L.;
Rose, Rachel H.;
Jamei, Masoud;
Ushigome, Fumihiko;
Minematsu, Tsuyoshi

Publication type:

Article

Prediction of maternal pharmacokinetics using physiologically based pharmacokinetic models: assessing the impact of the longitudinal changes in the activity of CYP1A2, CYP2D6 and CYP3A4 enzymes during pregnancy.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2020, v. 47, n. 4, p. 361, doi. 10.1007/s10928-020-09711-2

By:

Abduljalil, Khaled;
Pansari, Amita;
Jamei, Masoud

Publication type:

Article

Quantitative approach for cardiac risk assessment and interpretation in tuberculosis drug development.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2018, v. 45, n. 3, p. 457, doi. 10.1007/s10928-018-9580-2

By:

Polak, Sebastian;
Romero, Klaus;
Berg, Alexander;
Patel, Nikunjkumar;
Jamei, Masoud;
Hermann, David;
Hanna, Debra

Publication type:

Article

Accelerating the Progress of Kinase Inhibitors in Oncology.

Published in:

Applied Clinical Trials, 2024, v. 33, n. 5, p. 16

By:

Jones, Hannah;
Jamei, Masoud

Publication type:

Article

Implications of mechanism-based inhibition of CYP2D6 for the pharmacokinetics and toxicity of MDMA.

Published in:

Journal of Psychopharmacology, 2006, v. 20, n. 6, p. 842, doi. 10.1177/0269881106065907

By:

Jiansong Yang;
Jamei, Masoud;
Heydari, Amir;
Yeo, Karen R.;
De la Torre, Rafael;
Farré, Magí;
Tucker, Geoffrey T.;
Rostami-Hodjegan, Amin

Publication type:

Article

The role of automation in enhancing reproducibility and interoperability of PBPK models.

Published in:

2025

By:

Derbalah, Abdallah;
Jamei, Masoud;
Gardner, Iain;
Sepp, Armin

Publication type:

Letter to the Editor

A pregnancy physiologically based pharmacokinetic (p- PBPK) model for disposition of drugs metabolized by CYP1A2, CYP2D6 and CYP3A4.

Published in:

British Journal of Clinical Pharmacology, 2012, v. 74, n. 5, p. 873, doi. 10.1111/j.1365-2125.2012.04363.x

By:

Gaohua, Lu;
Abduljalil, Khaled;
Jamei, Masoud;
Johnson, Trevor N.;
Rostami-Hodjegan, Amin

Publication type:

Article

Considerations and Caveats when Applying Global Sensitivity Analysis Methods to Physiologically Based Pharmacokinetic Models.

Published in:

AAPS Journal, 2020, v. 22, n. 5, p. N.PAG, doi. 10.1208/s12248-020-00480-x

By:

Liu, Dan;
Li, Linzhong;
Rostami-Hodjegan, Amin;
Bois, Frederic Y.;
Jamei, Masoud

Publication type:

Article

Development and Application of a Physiologically-Based Pharmacokinetic Model to Predict the Pharmacokinetics of Therapeutic Proteins from Full-term Neonates to Adolescents.

Published in:

AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00460-1

By:

Pan, Xian;
Stader, Felix;
Abduljalil, Khaled;
Gill, Katherine L.;
Johnson, Trevor N.;
Gardner, Iain;
Jamei, Masoud

Publication type:

Article

What Does it Take to Make Model-Informed Precision Dosing Common Practice? Report from the 1st Asian Symposium on Precision Dosing.

Published in:

AAPS Journal, 2019, v. 21, n. 2, p. 1, doi. 10.1208/s12248-018-0286-6

By:

Polasek, Thomas M.;
Rostami-Hodjegan, Amin;
Yim, Dong-Seok;
Jamei, Masoud;
Lee, Howard;
Kimko, Holly;
Kim, Jae Kyoung;
Nguyen, Phuong Thi Thu;
Darwich, Adam S.;
Shin, Jae-Gook

Publication type:

Article

Real Patient and its Virtual Twin: Application of Quantitative Systems Toxicology Modelling in the Cardiac Safety Assessment of Citalopram.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0155-8

By:

Patel, Nikunjkumar;
Wiśniowska, Barbara;
Jamei, Masoud;
Polak, Sebastian

Publication type:

Article

Incorporation of the Time-Varying Postprandial Increase in Splanchnic Blood Flow into a PBPK Model to Predict the Effect of Food on the Pharmacokinetics of Orally Administered High-Extraction Drugs.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 1205, doi. 10.1208/s12248-017-0099-z

By:

Rose, Rachel;
Turner, David;
Neuhoff, Sibylle;
Jamei, Masoud

Publication type:

Article

Examining the Use of a Mechanistic Model to Generate an In Vivo/ In Vitro Correlation: Journey Through a Thought Process.

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1144, doi. 10.1208/s12248-016-9930-1

By:

Mistry, Bipin;
Patel, Nikunjkumar;
Jamei, Masoud;
Rostami-Hodjegan, Amin;
Martinez, Marilyn

Publication type:

Article

A Bottom-Up Whole-Body Physiologically Based Pharmacokinetic Model to Mechanistically Predict Tissue Distribution and the Rate of Subcutaneous Absorption of Therapeutic Proteins.

Published in:

AAPS Journal, 2016, v. 18, n. 1, p. 156, doi. 10.1208/s12248-015-9819-4

By:

Gill, Katherine;
Gardner, Iain;
Li, Linzhong;
Jamei, Masoud

Publication type:

Article

Are Physiologically Based Pharmacokinetic Models Reporting the Right C? Central Venous Versus Peripheral Sampling Site.

Published in:

AAPS Journal, 2015, v. 17, n. 5, p. 1268, doi. 10.1208/s12248-015-9796-7

By:

Musther, Helen;
Gill, Katherine;
Chetty, Manoranjenni;
Rostami-Hodjegan, Amin;
Rowland, Malcolm;
Jamei, Masoud

Publication type:

Article

Simulation of Monoclonal Antibody Pharmacokinetics in HumansUsing a Minimal Physiologically Based Model.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 1097, doi. 10.1208/s12248-014-9640-5

By:

Li, Linzhong;
Gardner, Iain;
Dostalek, Miroslav;
Jamei, Masoud

Publication type:

Article

Changes in Individual Drug-Independent System Parameters during Virtual Paediatric Pharmacokinetic Trials: Introducing Time-Varying Physiology into a Paediatric PBPK Model.

Published in:

AAPS Journal, 2014, v. 16, n. 3, p. 568, doi. 10.1208/s12248-014-9592-9

By:

Abduljalil, Khaled;
Jamei, Masoud;
Rostami-Hodjegan, Amin;
Johnson, Trevor N.

Publication type:

Article

Population-Based Mechanistic Prediction of Oral Drug Absorption.

Published in:

AAPS Journal, 2009, v. 11, n. 2, p. 225, doi. 10.1208/s12248-009-9099-y

By:

Jamei, Masoud;
Turner, David;
Yang, Jiansong;
Neuhoff, Sibylle;
Polak, Sebastian;
Rostami-Hodjegan, Amin;
Tucker, Geoffrey

Publication type:

Article

Predicting Nonlinear Pharmacokinetics of Omeprazole Enantiomers and Racemic Drug Using Physiologically Based Pharmacokinetic Modeling and Simulation: Application to Predict Drug/Genetic Interactions.

Published in:

Pharmaceutical Research, 2014, v. 31, n. 8, p. 1919, doi. 10.1007/s11095-013-1293-z

By:

Wu, Fang;
Gaohua, Lu;
Zhao, Ping;
Jamei, Masoud;
Huang, Shiew-Mei;
Bashaw, Edward;
Lee, Sue-Chih

Publication type:

Article

Prediction of the pharmacokinetics, pharmacodynamics, and efficacy of a monoclonal antibody, using a physiologically based pharmacokinetic FcRn model.

Published in:

Frontiers in Immunology, 2015, v. 5, p. 1, doi. 10.3389/fimmu.2014.00670

By:

Chetty, Manoranjenni;
Linzhong Li;
Rose, Rachel;
Machavaram, Krishna;
Jamei, Masoud;
Rostami-Hodjegan, Amin;
Gardner, Iain;
Frenkel, Dan;
Olive, Daniel

Publication type:

Article

Pharmacokinetics under the COVID‐19 storm.

Published in:

British Journal of Clinical Pharmacology, 2023, v. 89, n. 1, p. 158, doi. 10.1111/bcp.14668

By:

Pilla Reddy, Venkatesh;
El‐Khateeb, Eman;
Jo, Heeseung;
Giovino, Natalie;
Lythgoe, Emily;
Sharma, Shringi;
Tang, Weifeng;
Jamei, Masoud;
Rastomi‐Hodjegan, Amin

Publication type:

Article

Postpartum changes in maternal physiology and milk composition: a comprehensive database for developing lactation physiologically-based pharmacokinetic models.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1517069

By:

Deferm, Neel;
Dinh, Jean;
Pansari, Amita;
Jamei, Masoud;
Abduljalil, Khaled

Publication type:

Article

Application of Physiologically Based Pharmacokinetic (PBPK) Modeling Within a Bayesian Framework to Identify Poor Metabolizers of Efavirenz (PM), Using a Test Dose of Efavirenz.

Published in:

Frontiers in Pharmacology, 2018, p. 1, doi. 10.3389/fphar.2018.00247

By:

Chetty, Manoranjenni;
Cain, Theresa;
Wedagedera, Janak;
Rostami-Hodjegan, Amin;
Jamei, Masoud

Publication type:

Article

A mechanistic pharmacokinetic model to assess modified oral drug bioavailability post bariatric surgery in morbidly obese patients: interplay between CYP3A gut wall metabolism, permeability and dissolution.

Published in:

Journal of Pharmacy & Pharmacology, 2012, v. 64, n. 7, p. 1008, doi. 10.1111/j.2042-7158.2012.01538.x

By:

Darwich, Adam S.;
Pade, Devendra;
Ammori, Basil J.;
Jamei, Masoud;
Ashcroft, Darren M.;
Rostami-Hodjegan, Amin

Publication type:

Article

An Application of a Physiologically Based Pharmacokinetic Approach to Predict Ceftazidime Pharmacokinetics in a Pregnant Population.

Published in:

Pharmaceutics, 2024, v. 16, n. 4, p. 474, doi. 10.3390/pharmaceutics16040474

By:

Abduljalil, Khaled;
Gardner, Iain;
Jamei, Masoud

Publication type:

Article

Mechanistic PBPK Modelling to Predict the Advantage of the Salt Form of a Drug When Dosed with Acid Reducing Agents.

Published in:

Pharmaceutics, 2021, v. 13, n. 8, p. 1169, doi. 10.3390/pharmaceutics13081169

By:

Chirumamilla, Siri Kalyan;
Banala, Venkatesh Teja;
Jamei, Masoud;
Turner, David B.

Publication type:

Article

Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling to Predict the Impact of CYP2C9 Genetic Polymorphisms, Co-Medication and Formulation on the Pharmacokinetics and Pharmacodynamics of Flurbiprofen.

Published in:

Pharmaceutics, 2020, v. 12, n. 11, p. 1049, doi. 10.3390/pharmaceutics12111049

By:

Loisios-Konstantinidis, Ioannis;
Cristofoletti, Rodrigo;
Jamei, Masoud;
Turner, David;
Dressman, Jennifer

Publication type:

Article

Developing Clinically Relevant Dissolution Specifications for Oral Drug Products—Industrial and Regulatory Perspectives.

Published in:

Pharmaceutics, 2020, v. 12, n. 1, p. 19, doi. 10.3390/pharmaceutics12010019

By:

McAllister, Mark;
Flanagan, Talia;
Boon, Karin;
Pepin, Xavier;
Tistaert, Christophe;
Jamei, Masoud;
Abend, Andreas;
Kotzagiorgis, Evangelos;
Mackie, Claire

Publication type:

Article

Cytokine Dynamics in Action: A Mechanistic Approach to Assess Interleukin 6 Related Therapeutic Protein‐Drug–Disease Interactions.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1369, doi. 10.1002/cpt.3560

By:

Pan, Xian;
Gill, Katherine L.;
Pansari, Amita;
Hatley, Oliver;
Curry, Liam;
Jamei, Masoud;
Gardner, Iain

Publication type:

Article

Incorporation and Performance Verification of Hepatic Portal Blood Flow Shunting in Minimal and Full PBPK Models of Liver Cirrhosis.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 6, p. 1264, doi. 10.1002/cpt.3032

By:

Small, Ben G.;
Hatley, Oliver;
Jamei, Masoud;
Gardner, Iain;
Johnson, Trevor N.

Publication type:

Article

Prediction of basic drug exposure in milk using a lactation model algorithm integrated within a physiologically based pharmacokinetic model.

Published in:

Biopharmaceutics & Drug Disposition, 2022, v. 43, n. 5, p. 201, doi. 10.1002/bdd.2334

By:

Pansari, Amita;
Faisal, Muhammad;
Jamei, Masoud;
Abduljalil, Khaled

Publication type:

Article

Prediction of liver volume - a population-based approach to meta-analysis of paediatric, adult and geriatric populations - an update.

Published in:

Biopharmaceutics & Drug Disposition, 2017, v. 38, n. 4, p. 290, doi. 10.1002/bdd.2063

By:

Small, Ben G.;
Wendt, Bernd;
Jamei, Masoud;
Johnson, Trevor N.

Publication type:

Article

Does age affect gastric emptying time? A model-based meta-analysis of data from premature neonates through to adults.

Published in:

Biopharmaceutics & Drug Disposition, 2015, v. 36, n. 4, p. 245, doi. 10.1002/bdd.1937

By:

Bonner, Jennifer J.;
Vajjah, Pavan;
Abduljalil, Khaled;
Jamei, Masoud;
Rostami‐Hodjegan, Amin;
Tucker, Geoffrey T.;
Johnson, Trevor N.

Publication type:

Article

Static Versus Dynamic Model Predictions of Competitive Inhibitory Metabolic Drug–Drug Interactions via Cytochromes P450: One Step Forward and Two Steps Backwards: Static versus Dynamic Models to Predict DDIs via CYP: I. Tiryannik et al.

Published in:

Clinical Pharmacokinetics, 2025, v. 64, n. 1, p. 155, doi. 10.1007/s40262-024-01457-1

By:

Tiryannik, Ivan;
Heikkinen, Aki T.;
Gardner, Iain;
Onasanwo, Anthonia;
Jamei, Masoud;
Polasek, Thomas M.;
Rostami-Hodjegan, Amin

Publication type:

Article

Prediction of Maternal and Fetal Acyclovir, Emtricitabine, Lamivudine, and Metformin Concentrations during Pregnancy Using a Physiologically Based Pharmacokinetic Modeling Approach.

Published in:

2022

By:

Abduljalil, Khaled;
Pansari, Amita;
Ning, Jia;
Jamei, Masoud

Publication type:

journal article

Authors' Reply to Völler et al: "Comment on: Preterm Physiologically Based Pharmacokinetic Model, Part I and Part II".

Published in:

2021

By:

Abduljalil, Khaled;
Pan, Xian;
Pansari, Amita;
Jamei, Masoud;
Johnson, Trevor N.

Publication type:

Letter

Fetal Physiologically Based Pharmacokinetic Models: Systems Information on Fetal Blood Components and Binding Proteins.

Published in:

2020

By:

Abduljalil, Khaled;
Jamei, Masoud;
Johnson, Trevor N.

Publication type:

journal article