Works by Jaeseok Han

Results: 32

The PERK-eIF2α-ATF4 Axis Is Involved in Mediating ER-Stress-Induced Ferroptosis via DDIT4-mTORC1 Inhibition and Acetaminophen-Induced Hepatotoxicity.

Published in:

Antioxidants, 2025, v. 14, n. 3, p. 307, doi. 10.3390/antiox14030307

By:

Nghiem, Thu-Hang Thi;
Nguyen, Kim Anh;
Kusuma, Fedho;
Park, Soyoung;
Park, Jeongmin;
Joe, Yeonsoo;
Han, Jaeseok;
Chung, Hun Taeg

Publication type:

Article

Resistance switching mode transformation in SrRuO<sub>3</sub>/Cr-doped SrZrO<sub>3</sub>/Pt frameworks via a thermally activated Ti out-diffusion process.

Published in:

Scientific Reports, 2014, p. 1, doi. 10.1038/srep07354

By:

Yongcheol Jo;
Kyooho Jung;
Jongmin Kim;
Hyeonseok Woo;
Jaeseok Han;
Hyungsang Kim;
Jinpyo Hong;
Jeon-Kook Lee;
Hyunsik Im

Publication type:

Article

Vitamin D3 suppresses intestinal epithelial stemness via ER stress induction in intestinal organoids.

Published in:

Stem Cell Research & Therapy, 2021, v. 12, n. 1, p. 1, doi. 10.1186/s13287-021-02361-2

By:

Sittipo, Panida;
Kim, Hyun Kyu;
Han, Jaeseok;
Lee, Man Ryul;
Lee, Yun Kyung

Publication type:

Article

Hyperthermia Disturbs and Delays Spontaneous Differentiation of Human Embryoid Bodies.

Published in:

Biomedicines, 2020, v. 8, n. 6, p. 176, doi. 10.3390/biomedicines8060176

By:

Kwon, Ji Hyun;
Kim, Hyun Kyu;
Ha, Tae Won;
Im, Jeong Suk;
Song, Byung Hoo;
Hong, Ki Sung;
Oh, Jae Sang;
Han, Jaeseok;
Lee, Man Ryul

Publication type:

Article

Characterization of Endoplasmic Reticulum (ER) in Human Pluripotent Stem Cells Revealed Increased Susceptibility to Cell Death upon ER Stress.

Published in:

Cells (2073-4409), 2020, v. 9, n. 5, p. 1078, doi. 10.3390/cells9051078

By:

Ha, Tae Won;
Jeong, Ji Hun;
Shin, HyeonSeok;
Kim, Hyun Kyu;
Im, Jeong Suk;
Song, Byung Hoo;
Hanna, Jacob;
Oh, Jae Sang;
Woo, Dong-Hun;
Han, Jaeseok;
Lee, Man Ryul

Publication type:

Article

Modulation of Protein Synthesis by eIF2α Phosphorylation Protects Cell from Heat Stress-Mediated Apoptosis.

Published in:

Cells (2073-4409), 2018, v. 7, n. 12, p. 254, doi. 10.3390/cells7120254

By:

Park, Soyoung;
Lim, Yohan;
Lee, Duckgue;
Elvira, Rosalie;
Lee, Ji-Min;
Lee, Man Ryul;
Han, Jaeseok

Publication type:

Article

Endoplasmic Reticulum Stress in the β-Cell Pathogenesis of Type 2 Diabetes.

Published in:

Experimental Diabetes Research, 2012, p. 1, doi. 10.1155/2012/618396

By:

Sung Hoon Back;
Sang-Wook Kang;
Jaeseok Han;
Hun-Taeg Chung

Publication type:

Article

Fine Tuning of the UPR by the Ubiquitin Ligases Siah1/2.

Published in:

PLoS Genetics, 2014, v. 10, n. 5, p. 1, doi. 10.1371/journal.pgen.1004348

By:

Scortegagna, Marzia;
Kim, Hyungsoo;
Li, Jian-Liang;
Yao, Hang;
Brill, Laurence M.;
Han, Jaeseok;
Lau, Eric;
Bowtell, David;
Haddad, Gabriel;
Kaufman, Randal J.;
Ronai, Ze'ev A.

Publication type:

Article

PKR Mediates the Mitochondrial Unfolded Protein Response through Double-Stranded RNA Accumulation under Mitochondrial Stress.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 14, p. 7738, doi. 10.3390/ijms25147738

By:

Kusuma, Fedho;
Park, Soyoung;
Nguyen, Kim Anh;
Elvira, Rosalie;
Lee, Duckgue;
Han, Jaeseok

Publication type:

Article

Activation of ERK and p38 Reduces AZD8055-Mediated Inhibition of Protein Synthesis in Hepatocellular Carcinoma HepG2 Cell Line.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 21, p. 11824, doi. 10.3390/ijms222111824

By:

Jee, Ha-yeon;
Lee, Yoon-Gyeong;
Lee, Sol;
Elvira, Rosalie;
Seo, Hye-eun;
Lee, Ji-Yeon;
Han, Jaeseok;
Lee, Kyungho

Publication type:

Article

Stress Granule Formation Attenuates RACK1-Mediated Apoptotic Cell Death Induced by Morusin.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 15, p. 5360, doi. 10.3390/ijms21155360

By:

Park, Ye-Jin;
Choi, Dong Wook;
Cho, Sang Woo;
Han, Jaeseok;
Yang, Siyoung;
Choi, Cheol Yong

Publication type:

Article

PERK-Mediated eIF2α Phosphorylation Contributes to The Protection of Dopaminergic Neurons from Chronic Heat Stress in Drosophila.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 3, p. 845, doi. 10.3390/ijms21030845

By:

Elvira, Rosalie;
Cha, Sun Joo;
Noh, Gyeong-Mu;
Kim, Kiyoung;
Han, Jaeseok

Publication type:

Article

ER Stress Induces Cell Cycle Arrest at the G2/M Phase Through eIF2α Phosphorylation and GADD45α.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 24, p. 6309, doi. 10.3390/ijms20246309

By:

Lee, Duckgue;
Hokinson, Daniel;
Park, Soyoung;
Elvira, Rosalie;
Kusuma, Fedho;
Lee, Ji-Min;
Yun, Miyong;
Lee, Seok-Geun;
Han, Jaeseok

Publication type:

Article

Cytotoxicity of Human Hepatic Intrasinusoidal CD56bright Natural Killer Cells against Hepatocellular Carcinoma Cells.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 7, p. 1564, doi. 10.3390/ijms20071564

By:

Hwang, Shin;
Song, Gi-Won;
Lee, Sung-Gyu;
Jung, Dong-Hwan;
Park, Gil-Chun;
Ahn, Chul-Soo;
Han, Jaeseok;
Baek, Ji-Seok;
Tak, Eunyoung;
Kim, Nayoung

Publication type:

Article

Mitophagy deficiency increases NLRP3 to induce brown fat dysfunction in mice.

Published in:

Autophagy, 2021, v. 17, n. 5, p. 1205, doi. 10.1080/15548627.2020.1753002

By:

Ko, Myoung Seok;
Yun, Ji Young;
Baek, In-Jeoung;
Jang, Jung Eun;
Hwang, Jung Jin;
Lee, Seung Eun;
Heo, Seung-Ho;
Bader, David A.;
Lee, Chul-Ho;
Han, Jaeseok;
Moon, Jong-Seok;
Lee, Jae Man;
Hong, Eun-Gyoung;
Lee, In-Kyu;
Kim, Seong Who;
Park, Joong Yeol;
Hartig, Sean M.;
Kang, Un Jung;
Moore, David D.;
Koh, Eun Hee

Publication type:

Article

eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet.

Published in:

Nutrition & Metabolism, 2017, v. 14, p. 1, doi. 10.1186/s12986-017-0202-6

By:

Woo-Gyun Choi;
Jaeseok Han;
Ji-Hyeon Kim;
Mi-Jeong Kim;
Jae-Woo Park;
Benbo Song;
Hee-Jeong Cha;
Hye-Seon Choi;
Hun-Taeg Chung;
In-Kyu Lee;
Tae-Sik Park;
Hatzoglou, Maria;
Hueng-Sik Choi;
Hyun Ju Yoo;
Kaufman, Randal J.;
Sung Hoon Back

Publication type:

Article

Remission of Diabetes by Insulin Gene Therapy Using a Hepatocyte-specific and Glucose-responsive Synthetic Promoter.

Published in:

Molecular Therapy, 2011, v. 19, n. 3, p. 470, doi. 10.1038/mt.2010.255

By:

Jaeseok Han;
McLane, Brienne;
Eung-Hwi Kim;
Ji-Won Yoon;
Hee-Sook Jun

Publication type:

Article

Engineered Enteroendocrine Cells Secrete Insulin in Response to Glucose and Reverse Hyperglycemia in Diabetic Mice.

Published in:

Molecular Therapy, 2007, v. 15, n. 6, p. 1195, doi. 10.1038/sj.mt.6300117

By:

Jaeseok Han;
Hyune-Hwan Lee;
Hyokjoon Kwon;
Seungjin Shin;
Ji-Won Yoon;
Hee-Sook Jun

Publication type:

Article

416. Glucose-Dependent Insulin Production by Liver-Specific, Glucose-Regulatable Synthetic Promoters Results in the Cure of Diabetes

Published in:

2005

By:

Han, Jaeseok;
McLane, Brienne;
Jun, Hee-Sook;
Yoon, Ji-Won

Publication type:

Abstract

Amelioration of hyperglycemia by intestinal overexpression of glucagon-like peptide-1 in mice.

Published in:

Journal of Molecular Medicine, 2010, v. 88, n. 4, p. 351, doi. 10.1007/s00109-009-0571-z

By:

Meng-Ju Liu;
Jaeseok Han;
Young-Sun Lee;
Mi-Sung Park;
Seungjin Shin;
Hee-Sook Jun

Publication type:

Article

Differential regulation of mammalian tRNA synthetase genes by amino acid availability (818.7).

Published in:

FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.818.7

By:

Shan, Jixiu;
Tang, Tiffany;
Han, Jaeseok;
Kaufman, Randal;
Kilberg, Michael

Publication type:

Article

Translational and post‐translational regulation of XIAP by eIF2α and ATF4 promotes ER stress‐induced cell death during the unfolded protein response (151.5).

Published in:

FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.151.5

By:

Hiramatsu, Nobuhiko;
Messah, Carissa;
Han, Jaeseok;
LaVail, Matthew;
Kaufman, Randal;
Lin, Jonathan

Publication type:

Article

Development of a Novel Reporter System to Monitor ER stress.

Published in:

FASEB Journal, 2013, v. 27, p. 834.15, doi. 10.1096/fasebj.27.1_supplement.834.15

By:

Moon, Ja Young;
Back, Sung Hoon;
Han, Jaeseok;
Kaufman, Randal

Publication type:

Article

Antioxidants Complement the Requirement for Protein Chaperone Function to Maintain β-Cell Function and Glucose Homeostasis.

Published in:

Diabetes, 2015, v. 64, n. 8, p. 2892, doi. 10.2337/db14-1357

By:

Jaeseok Han;
Benbo Song;
Jiun Kim;
Vamsi K. Kodali;
Anita Pottekat;
Miao Wang;
Justin Hassler;
Shiyu Wang;
Pennathur, Subramaniam;
Sung Hoon Back;
Katze, Michael G.;
Kaufman, Randal J.

Publication type:

Article

Remission of Type 2 Diabetes in Diabetic db/db Mice by Betacellulin Gene Therapy.

Published in:

Diabetes, 2007, v. 56, p. A454

By:

Shin, Seungjin;
Kim, Jinsil;
Lim, Yong;
Han, Jaeseok;
Jun, Heesook

Publication type:

Article

Glucagon-Like Peptide-1 Gene Therapy in Obese Diabetic Mice Results in Long-Term Cure of Diabetes by Improving Insulin Sensitivity and Reducing Hepatic Gluconeogenesis.

Published in:

Diabetes, 2007, v. 56, n. 6, p. 1671, doi. 10.2337/db06-1182

By:

Lee, Young-Sun;
Shin, Seungjin;
Shigihara, Toshikatsu;
Hahm, Eunsil;
Liu, Meng-Ju;
Han, Jaeseok;
Yoon, Ji-Won;
Jun, Hee-Sook

Publication type:

Article

Transplantation of reversibly immortalized insulin-secreting human hepatocytes controls diabetes in pancreatectomized pigs.

Published in:

2004

By:

Okitsu, Teru;
Kobayashi, Naoya;
Totsugawa, Toshinori;
Tanaka, Noriaki;
Jun, Hee-Sook;
Shin, Seungjin;
Kim, Su-Jin;
Han, Jaeseok;
Kwon, Hyokjoon;
Yoon, Ji-Won;
Sakaguchi, Masakiyo;
Kohara, Michinori;
Westerman, Karen A.;
Leboulch, Philippe

Publication type:

journal article

Biallelic mutations in ABCB1 display recurrent reversible encephalopathy.

Published in:

Annals of Clinical & Translational Neurology, 2020, v. 7, n. 8, p. 1443, doi. 10.1002/acn3.51125

By:

Seo, Jieun;
Lee, Cho‐Rong;
Paeng, Jin Chul;
Kwon, Hyun W.;
Lee, Duckgue;
Kim, Soon‐Chan;
Han, Jaeseok;
Ku, Ja‐Lok;
Chae, Jong Hee;
Lim, Byung Chan;
Choi, Murim

Publication type:

Article

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.

Published in:

Nature Cell Biology, 2013, v. 15, n. 5, p. 481, doi. 10.1038/ncb2738

By:

Han, Jaeseok;
Back, Sung Hoon;
Hur, Junguk;
Lin, Yu-Hsuan;
Gildersleeve, Robert;
Shan, Jixiu;
Yuan, Celvie L.;
Krokowski, Dawid;
Wang, Shiyu;
Hatzoglou, Maria;
Kilberg, Michael S.;
Sartor, Maureen A.;
Kaufman, Randal J.

Publication type:

Article

TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-17802-4

By:

Kim, Hyun-Kyoung;
Bhattarai, Kashi Raj;
Junjappa, Raghu Patil;
Ahn, Jin Hee;
Pagire, Suvarna H.;
Yoo, Hyun Ju;
Han, Jaeseok;
Lee, Duckgue;
Kim, Kyung-Woon;
Kim, Hyung-Ryong;
Chae, Han-Jung

Publication type:

Article

Eukaryotic translation initiation factor 2 α phosphorylation as a therapeutic target in diabetes.

Published in:

Expert Review of Endocrinology & Metabolism, 2014, v. 9, n. 4, p. 345, doi. 10.1586/17446651.2014.927309

By:

Yong, Jing;
Grankvist, Nina;
Han, Jaeseok;
Kaufman, Randal J

Publication type:

Article

The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells.

Published in:

PLoS Biology, 2015, v. 13, n. 10, p. 1, doi. 10.1371/journal.pbio.1002277

By:

Hassler, Justin R.;
Scheuner, Donalyn L.;
Wang, Shiyu;
Han, Jaeseok;
Kodali, Vamsi K.;
Li, Philip;
Nguyen, Julie;
George, Jenny S.;
Davis, Cory;
Wu, Shengyang P.;
Bai, Yongsheng;
Sartor, Maureen;
Cavalcoli, James;
Malhi, Harmeet;
Baudouin, Gregory;
Zhang, Yaoyang;
Yates III, John R.;
Itkin-Ansari, Pamela;
Volkmann, Niels;
Kaufman, Randal J.

Publication type:

Article