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Decitabine cytotoxicity is promoted by dCMP deaminase DCTD and mitigated by SUMO-dependent E3 ligase TOPORS.
- Published in:
- EMBO Journal, 2024, v. 43, n. 12, p. 2397, doi. 10.1038/s44318-024-00108-2
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- Article
Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity.
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- EMBO Journal, 2023, v. 42, n. 18, p. 1, doi. 10.15252/embj.2022113190
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- Article
Clinical prospects of WRN inhibition as a treatment for MSI tumours.
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- NPJ Precision Oncology, 2022, v. 6, n. 1, p. 1, doi. 10.1038/s41698-022-00319-y
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- Article
SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling.
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- EMBO Journal, 2022, v. 41, n. 21, p. 1, doi. 10.15252/embj.2022111338
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- Article
SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination.
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- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-31287-3
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- Article
Microarray screening reveals two non-conventional SUMO-binding modules linked to DNA repair by non-homologous end-joining.
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- Nucleic Acids Research, 2022, v. 50, n. 8, p. 4732, doi. 10.1093/nar/gkac237
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- Article
Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress.
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- Nucleic Acids Research, 2021, v. 49, n. 15, p. 8665, doi. 10.1093/nar/gkab628
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- Article
Mutagenic mechanisms of cancer-associated DNA polymerase ϵ alleles.
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- Nucleic Acids Research, 2021, v. 49, n. 7, p. 3919, doi. 10.1093/nar/gkab160
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- Article
Myocardial Fibrosis in Heart Failure: Anti-Fibrotic Therapies and the Role of Cardiovascular Magnetic Resonance in Drug Trials.
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- Cardiology & Therapy, 2020, v. 9, n. 2, p. 363, doi. 10.1007/s40119-020-00199-y
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- Article
PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1.
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- Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-14563-y
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- Article
Chronic irradiation of human cells reduces histone levels and deregulates gene expression.
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- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-59163-4
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- Article
MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance.
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- Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-12929-5
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- Article
Derivation and maintenance of mouse haploid embryonic stem cells.
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- Nature Protocols, 2019, v. 14, n. 7, p. 1991, doi. 10.1038/s41596-019-0169-z
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Predicting the mutations generated by repair of Cas9-induced double-strand breaks.
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- Nature Biotechnology, 2019, v. 37, n. 1, p. 64, doi. 10.1038/nbt.4317
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Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway.
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- Science Signaling, 2018, v. 11, n. 537, p. 1, doi. 10.1126/scisignal.aar5401
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- Article
Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48.
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- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04649-z
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- Article
Validating the concept of mutational signatures with isogenic cell models.
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- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04052-8
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- Article
Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome.
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- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03770-3
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- Article
Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia.
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- Nature Communications, 2017, v. 8, n. 11, p. 1, doi. 10.1038/s41467-017-01439-x
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- Article
Chromatin determinants impart camptothecin sensitivity.
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- EMBO Reports, 2017, v. 18, n. 6, p. 1000, doi. 10.15252/embr.201643560
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- Article
Corrigendum: Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks.
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- Nature Communications, 2017, v. 8, n. 6, p. 1, doi. 10.1038/ncomms15917
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- Article
Prelamin A impairs 53 BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient.
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- Aging Cell, 2016, v. 15, n. 6, p. 1039, doi. 10.1111/acel.12506
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- Article
Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks.
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- Nature Communications, 2016, v. 7, n. 9, p. 12889, doi. 10.1038/ncomms12889
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- Article
CRISPR-Cas9<sup>D10A</sup> nickase-based genotypic and phenotypic screening to enhance genome editing.
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- Scientific Reports, 2016, p. 24356, doi. 10.1038/srep24356
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- Article
Single-stranded DNA oligomers stimulate error-prone alternative repair of DNA double-strand breaks through hijacking Ku protein.
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- Nucleic Acids Research, 2015, v. 43, n. 21, p. 10264, doi. 10.1093/nar/gkv894
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- Article
Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair.
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- Nature Cell Biology, 2015, v. 17, n. 11, p. 1458, doi. 10.1038/ncb3260
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- Article
Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing’s Sarcoma.
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- PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0140988
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- Article
A flow cytometry-based method to simplify the analysis and quantification of protein association to chromatin in mammalian cells.
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- Nature Protocols, 2015, v. 10, n. 9, p. 1297, doi. 10.1038/nprot.2015.066
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- Article
Synthetic viability genomic screening defines Sae2 function in DNA repair.
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- EMBO Journal, 2015, v. 34, n. 11, p. 1509, doi. 10.15252/embj.201590973
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- Article
CtIP tetramer assembly is required for DNA-end resection and repair.
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- Nature Structural & Molecular Biology, 2015, v. 22, n. 2, p. 150, doi. 10.1038/nsmb.2937
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- Article
A high-throughput in vivo micronucleus assay for genome instability screening in mice.
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- Nature Protocols, 2015, v. 10, n. 1, p. 205, doi. 10.1038/nprot.2015.010
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- Article
Confinement and Deformation of Single Cells and Their Nuclei Inside Size-Adapted Microtubes.
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- Advanced Healthcare Materials, 2014, v. 3, n. 11, p. 1753, doi. 10.1002/adhm.201300678
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- Article
Cell Microenvironment: Confinement and Deformation of Single Cells and Their Nuclei Inside Size-Adapted Microtubes (Adv. Healthcare Mater. 11/2014).
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- Advanced Healthcare Materials, 2014, v. 3, n. 11, p. 1932, doi. 10.1002/adhm.201470059
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- Article
Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity.
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- Nature Cell Biology, 2014, v. 16, n. 10, p. 1016, doi. 10.1038/ncb3028
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Keeping 53BP1 out of focus in mitosis.
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- Cell Research, 2014, v. 24, n. 7, p. 781, doi. 10.1038/cr.2014.62
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Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks.
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- Nature Structural & Molecular Biology, 2014, v. 21, n. 4, p. 366, doi. 10.1038/nsmb.2796
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KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling.
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- Nature, 2013, v. 498, n. 7452, p. 70, doi. 10.1038/nature12201
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Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination.
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- Nucleic Acids Research, 2013, v. 41, n. 3, p. 1669
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- Article
A high-throughput, flow cytometry-based method to quantify DNA-end resection in mammalian cells.
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- Cytometry. Part A, 2012, v. 81A, n. 10, p. 922, doi. 10.1002/cyto.a.22155
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Chromothripsis and cancer: causes and consequences of chromosome shattering.
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- Nature Reviews Cancer, 2012, v. 12, n. 10, p. 663, doi. 10.1038/nrc3352
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Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.
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- Nature Structural & Molecular Biology, 2012, v. 19, n. 7, p. 693, doi. 10.1038/nsmb.2323
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- Article
CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination.
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- EMBO Reports, 2012, v. 13, n. 6, p. 561, doi. 10.1038/embor.2012.58
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- Article
Small-molecule-induced DNA damage identifies alternative DNA structures in human genes.
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- Nature Chemical Biology, 2012, v. 8, n. 3, p. 301, doi. 10.1038/nchembio.780
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- Article
CtIP Mutations Cause Seckel and Jawad Syndromes.
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- PLoS Genetics, 2011, v. 7, n. 10, p. 1, doi. 10.1371/journal.pgen.1002310
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Regulation of Rad51 function by phosphorylation.
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- EMBO Reports, 2011, v. 12, n. 8, p. 833, doi. 10.1038/embor.2011.127
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- Article
A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1.
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- Genome Biology, 2011, v. 12, n. 8, p. 1, doi. 10.1186/gb-2011-12-8-r78
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Structure-Specific DNA Endonuclease Mus81/Eme1 Generates DNA Damage Caused by Chk1 Inactivation.
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- PLoS ONE, 2011, v. 6, n. 8, p. 1, doi. 10.1371/journal.pone.0023517
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- Article
Replication stress induces 53BP1-containing OPT domains in G1 cells.
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- Journal of Cell Biology, 2011, v. 193, n. 1, p. 97, doi. 10.1083/jcb.201011083
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- Article
Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4.
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- EMBO Journal, 2010, v. 29, n. 18, p. 3130, doi. 10.1038/emboj.2010.188
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- Article
Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining.
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- Nature Structural & Molecular Biology, 2010, v. 17, n. 9, p. 1144, doi. 10.1038/nsmb.1899
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- Article