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Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK-signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitors.
- Published in:
- Investigational New Drugs, 2014, v. 32, n. 6, p. 1144, doi. 10.1007/s10637-014-0149-7
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- Article
Generating Patient-Derived HCC Cell Lines Suitable for Predictive In Vitro and In Vivo Drug Screening by Orthotopic Transplantation.
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- Cells (2073-4409), 2024, v. 13, n. 1, p. 82, doi. 10.3390/cells13010082
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- Article
SHIP1 Is Present but Strongly Downregulated in T-ALL, and after Restoration Suppresses Leukemia Growth in a T-ALL Xenotransplantation Mouse Model.
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- Cells (2073-4409), 2023, v. 12, n. 13, p. 1798, doi. 10.3390/cells12131798
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- Article
Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGFβ/CTGF Axis.
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- Cells (2073-4409), 2021, v. 10, n. 2, p. 430, doi. 10.3390/cells10020430
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- Article
High Sensitivity of Circulating Tumor Cells Derived from a Colorectal Cancer Patient for Dual Inhibition with AKT and mTOR Inhibitors.
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- Cells (2073-4409), 2020, v. 9, n. 9, p. 2129, doi. 10.3390/cells9092129
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- Publication type:
- Article
"Alkohol und Nikotin" - Konzept und Evaluation eines interdisziplinären Wahlfachs mit OSPE im Studienabschnitt Medizin 1.
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- GMS Zeitschrift für Medizinische Ausbildung, 2014, v. 31, n. 1, p. 1, doi. 10.3205/zma000901
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- Article
All Three AKT Isoforms Can Upregulate Oxygen Metabolism and Lactate Production in Human Hepatocellular Carcinoma Cell Lines.
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- International Journal of Molecular Sciences, 2024, v. 25, n. 4, p. 2168, doi. 10.3390/ijms25042168
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- Article
The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma Metabolism.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 3, p. 2652, doi. 10.3390/ijms24032652
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- Article
The Role of mTOR Signaling as a Therapeutic Target in Cancer.
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- International Journal of Molecular Sciences, 2021, v. 22, n. 4, p. 1743, doi. 10.3390/ijms22041743
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- Publication type:
- Article
Combined Targeting of AKT and mTOR Inhibits Proliferation of Human NF1-Associated Malignant Peripheral Nerve Sheath Tumour Cells In Vitro but not in a Xenograft Mouse Model In Vivo.
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- International Journal of Molecular Sciences, 2020, v. 21, n. 4, p. 1548, doi. 10.3390/ijms21041548
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- Article
Differential regulation of extracellular matrix proteins in three recurrent liver metastases of a single patient with colorectal cancer.
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- Clinical & Experimental Metastasis, 2020, v. 37, n. 6, p. 649, doi. 10.1007/s10585-020-10058-8
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- Publication type:
- Article
An increase in the expression and total activity of endogenous p60<sup>c-Src</sup> in several factor-independent mutants of a human GM-CSF-dependent leukemia cell line (TF-1).
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- Oncogene, 2003, v. 22, n. 46, p. 7170, doi. 10.1038/sj.onc.1206856
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- Article
The Functional Roles of the Src Homology 2 Domain-Containing Inositol 5-Phosphatases SHIP1 and SHIP2 in the Pathogenesis of Human Diseases.
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- International Journal of Molecular Sciences, 2024, v. 25, n. 10, p. 5254, doi. 10.3390/ijms25105254
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- Publication type:
- Article
Truncated O-GalNAc glycans impact on fundamental signaling pathways in pancreatic cancer.
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- Glycobiology, 2024, v. 34, n. 6, p. 1, doi. 10.1093/glycob/cwab088
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- Publication type:
- Article
Activation of CD44/PAK1/AKT signaling promotes resistance to FGFR1 inhibition in squamous-cell lung cancer.
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- NPJ Precision Oncology, 2022, v. 6, n. 1, p. 1, doi. 10.1038/s41698-022-00296-2
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- Publication type:
- Article
Up-regulation of the T cell quiescence factor KLF2 in a leukaemic T-cell line after expression of the inositol 5′-phosphatase SHIP-1.
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- British Journal of Haematology, 2005, v. 131, n. 5, p. 628, doi. 10.1111/j.1365-2141.2005.05811.x
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- Publication type:
- Article
Impact of AKT1 on cell invasion and radiosensitivity in a triple negative breast cancer cell line developing brain metastasis.
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- Frontiers in Oncology, 2023, p. 1, doi. 10.3389/fonc.2023.1129682
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- Publication type:
- Article
Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia.
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- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23752-2
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- Article
Ikaros sets the threshold for negative B-cell selection by regulation of the signaling strength of the AKT pathway.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01732-5
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- Publication type:
- Article
K-Ras(V12) differentially affects the three Akt isoforms in lung and pancreatic carcinoma cells and upregulates E-cadherin and NCAM via Akt3.
- Published in:
- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01484-2
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- Publication type:
- Article
Combined Targeting of AKT and mTOR Inhibits Tumor Formation of EpCAM + and CD90 + Human Hepatocellular Carcinoma Cells in an Orthotopic Mouse Model.
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- Cancers, 2022, v. 14, n. 8, p. 1882, doi. 10.3390/cancers14081882
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- Article
The Functional Role of Extracellular Matrix Proteins in Cancer.
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- Cancers, 2022, v. 14, n. 1, p. 238, doi. 10.3390/cancers14010238
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- Article
AKT in Bone Metastasis of Solid Tumors: A Comprehensive Review.
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- Cancers, 2021, v. 13, n. 10, p. 2287, doi. 10.3390/cancers13102287
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- Article
Modeling Spontaneous Bone Metastasis Formation of Solid Human Tumor Xenografts in Mice.
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- Cancers, 2020, v. 12, n. 2, p. 385, doi. 10.3390/cancers12020385
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- Article
Molecular analysis of Hodgkin's disease-derived cell lines.
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- 1988
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- Publication type:
- journal article
Ectopic Expression of Hematopoietic SHIP1 in Human Colorectal Cancer.
- Published in:
- Biomedicines, 2020, v. 8, n. 7, p. 215, doi. 10.3390/biomedicines8070215
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- Publication type:
- Article
Combined targeting of AKT and mTOR using MK-2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma.
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- International Journal of Cancer, 2013, v. 133, n. 9, p. 2065, doi. 10.1002/ijc.28214
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- Publication type:
- Article
Dual Targeting of Akt and mTORC1 Impairs Repair of DNA Double-Strand Breaks and Increases Radiation Sensitivity of Human Tumor Cells.
- Published in:
- PLoS ONE, 2016, v. 11, n. 5, p. 1, doi. 10.1371/journal.pone.0154745
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- Article
Downregulation of AKT3 Increases Migration and Metastasis in Triple Negative Breast Cancer Cells by Upregulating S100A4.
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- PLoS ONE, 2016, v. 11, n. 1, p. 1, doi. 10.1371/journal.pone.0146370
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- Article
Distinct functions of AKT isoforms in breast cancer: a comprehensive review.
- Published in:
- Cell Communication & Signaling, 2019, v. 17, n. 1, p. N.PAG, doi. 10.1186/s12964-019-0450-3
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- Publication type:
- Article
COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer.
- Published in:
- Molecular Cancer, 2015, v. 14, n. 1, p. 1, doi. 10.1186/s12943-015-0386-1
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- Publication type:
- Article