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Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer's disease: preclinical proof of concept.
- Published in:
- 2018
- By:
- Publication type:
- journal article
Rett Syndrome Microglia Damage Dendrites and Synapses by the Elevated Release of Glutamate.
- Published in:
- Journal of Neuroscience, 2010, v. 30, n. 15, p. 5346, doi. 10.1523/JNEUROSCI.5966-09.2010
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- Publication type:
- Article
Rett Syndrome Astrocytes Are Abnormal and Spread MeCP2 Deficiency through Gap Junctions.
- Published in:
- Journal of Neuroscience, 2009, v. 29, n. 16, p. 5051, doi. 10.1523/JNEUROSCI.0324-09.2009
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- Publication type:
- Article
The ketone body β‐hydroxybutyrate shifts microglial metabolism and suppresses amyloid‐β oligomer‐induced inflammation in human microglia.
- Published in:
- FASEB Journal, 2023, v. 37, n. 11, p. 1, doi. 10.1096/fj.202301254R
- By:
- Publication type:
- Article
Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasticity.
- Published in:
- FASEB Journal, 2018, v. 32, n. 5, p. 2866, doi. 10.1096/fj.201700984RR
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- Publication type:
- Article
Reduced GABAergic synaptic transmission in the nucleus tractus solitarius in Mecp2‐null mice (1130.20).
- Published in:
- FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.1130.20
- By:
- Publication type:
- Article
Congo red and thioflavin-T analogs detect Aβ oligomers.
- Published in:
- Journal of Neurochemistry, 2008, v. 104, n. 2, p. 457, doi. 10.1111/j.1471-4159.2007.04972.x
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- Publication type:
- Article
A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-β oligomeric complexes.
- Published in:
- Journal of Neurochemistry, 2006, v. 98, n. 1, p. 57, doi. 10.1111/j.1471-4159.2006.03862.x
- By:
- Publication type:
- Article
Role of glutathione in intracellular amyloid-α precursor protein/carboxy-terminal fragment aggregation and associated cytotoxicity.
- Published in:
- Journal of Neurochemistry, 2005, v. 93, n. 4, p. 1047, doi. 10.1111/j.1471-4159.2005.03109.x
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- Publication type:
- Article
Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment-associated cytotoxicity.
- Published in:
- Journal of Neurochemistry, 2004, v. 91, n. 6, p. 1312, doi. 10.1111/j.1471-4159.2004.02818.x
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- Publication type:
- Article
Apolipoprotein E isoform-dependent dendritic recovery of hippocampal neurons following activation of innate immunity.
- Published in:
- Journal of Neuroinflammation, 2006, v. 3, p. 21, doi. 10.1186/1742-2094-3-21
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- Publication type:
- Article
Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice.
- Published in:
- Journal of Neuroinflammation, 2006, v. 3, p. 10, doi. 10.1186/1742-2094-3-10
- By:
- Publication type:
- Article
A Bifunctional Anti-Amyloid Blocks Oxidative Stress and the Accumulation of Intraneuronal Amyloid-Beta.
- Published in:
- Molecules, 2018, v. 23, n. 8, p. 2010, doi. 10.3390/molecules23082010
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- Publication type:
- Article
Cholesterol, Amyloid Beta, Fructose, and LPS Influence ROS and ATP Concentrations and the Phagocytic Capacity of HMC3 Human Microglia Cell Line.
- Published in:
- International Journal of Molecular Sciences, 2023, v. 24, n. 12, p. 10396, doi. 10.3390/ijms241210396
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- Publication type:
- Article
Repurposing the KCa3.1 inhibitor senicapoc for Alzheimer's disease.
- Published in:
- Annals of Clinical & Translational Neurology, 2019, v. 6, n. 4, p. 723, doi. 10.1002/acn3.754
- By:
- Publication type:
- Article
Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke.
- Published in:
- Annals of Clinical & Translational Neurology, 2018, v. 5, n. 2, p. 147, doi. 10.1002/acn3.513
- By:
- Publication type:
- Article
1700 nm optical coherence microscopy enables minimally invasive, label-free, in vivo optical biopsy deep in the mouse brain.
- Published in:
- Light: Science & Applications, 2021, v. 10, n. 1, p. 1, doi. 10.1038/s41377-021-00586-7
- By:
- Publication type:
- Article
Metabolic flux analysis of the neural cell glycocalyx reveals differential utilization of monosaccharides.
- Published in:
- Glycobiology, 2020, v. 30, n. 11, p. 859, doi. 10.1093/glycob/cwaa038
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- Publication type:
- Article
Plasma biomarkers predict cognitive trajectories in an ethnoracially and clinically diverse cohort: Mediation with hippocampal volume.
- Published in:
- Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2022, v. 14, n. 1, p. 1, doi. 10.1002/dad2.12349
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- Publication type:
- Article
Glycosylation alterations in serum of Alzheimer's disease patients show widespread changes in N‐glycosylation of proteins related to immune function, inflammation, and lipoprotein metabolism.
- Published in:
- Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2022, v. 14, n. 1, p. 1, doi. 10.1002/dad2.12309
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- Publication type:
- Article
Dysregulation of Glutamine Transporter SNAT1 in Rett Syndrome Microglia: A Mechanism for Mitochondrial Dysfunction and Neurotoxicity.
- Published in:
- Journal of Neuroscience, 2015, v. 35, n. 6, p. 2516, doi. 10.1523/JNEUROSCI.2778-14.2015
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- Publication type:
- Article
Association of plasma abeta and tau levels in relation to cognition and brain structure in a diverse community: Biomarkers (non‐neuroimaging): Method development and validation.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.039180
- By:
- Publication type:
- Article
O5‐05‐05: REPURPOSING THE KCA3.1 INHIBITOR SENICAPOC AS A MICROGLIA‐TARGETED THERAPEUTIC CANDIDATE FOR ALZHEIMER'S DISEASE.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1656, doi. 10.1016/j.jalz.2018.06.3023
- By:
- Publication type:
- Article
KV1.3 INHIBITION REDUCES AB-INDUCED MICROGLIAL NEUROTOXICITY.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P242, doi. 10.1016/j.jalz.2016.06.434
- By:
- Publication type:
- Article
The role of potassium channel Kv1.3 in Aß-induced microglia activation
- Published in:
- 2012
- By:
- Publication type:
- Abstract
P1-010: Apolipoprotein E isoform-specific modulation of innate immune response neurotoxicity in a targeted replacement APOE mouse model
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P1-010: Apolipoprotein E isoform-specific modulation of innate immune response neurotoxicity in a targeted replacement APOE mouse model
- Published in:
- 2006
- By:
- Publication type:
- Abstract
Alterations of chaperone protein expression in presenilin mutant neurons in response to glutamate excitotoxicity.
- Published in:
- Pathology International, 2002, v. 52, n. 9, p. 551, doi. 10.1046/j.1440-1827.2002.01398.x
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- Publication type:
- Article
The Influence of Spin-Labeled Fluorene Compounds on the Assembly and Toxicity of the Aβ Peptide.
- Published in:
- PLoS ONE, 2012, v. 7, n. 4, p. 1, doi. 10.1371/journal.pone.0035443
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- Publication type:
- Article
The potassium channel KCa3.1 constitutes a pharmacological target for neuroinflammation associated with ischemia/reperfusion stroke.
- Published in:
- Journal of Cerebral Blood Flow & Metabolism, 2016, v. 36, n. 12, p. 2146, doi. 10.1177/0271678X15611434
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- Publication type:
- Article
The role of FUT8‐catalyzed core fucosylation in Alzheimer's amyloid‐β oligomer‐induced activation of human microglia.
- Published in:
- Glia, 2023, v. 71, n. 5, p. 1346, doi. 10.1002/glia.24345
- By:
- Publication type:
- Article
Biophysical basis for Kv1.3 regulation of membrane potential changes induced by P2X4‐mediated calcium entry in microglia.
- Published in:
- Glia, 2020, v. 68, n. 11, p. 2377, doi. 10.1002/glia.23847
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- Publication type:
- Article
The voltage‐gated potassium channel Kv1.3 is required for microglial pro‐inflammatory activation in vivo.
- Published in:
- Glia, 2018, v. 66, n. 9, p. 1881, doi. 10.1002/glia.23457
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- Publication type:
- Article
Differential Kv1.3, KCa3.1, and Kir2.1 expression in 'classically' and 'alternatively' activated microglia.
- Published in:
- Glia, 2017, v. 65, n. 1, p. 106, doi. 10.1002/glia.23078
- By:
- Publication type:
- Article
Dysregulated bile acid receptor-mediated signaling and IL-17A induction are implicated in diet-associated hepatic health and cognitive function.
- Published in:
- Biomarker Research, 2020, v. 8, n. 1, p. N.PAG, doi. 10.1186/s40364-020-00239-8
- By:
- Publication type:
- Article
High-Density Lipoprotein Changes in Alzheimer's Disease Are APOE Genotype-Specific.
- Published in:
- Biomedicines, 2022, v. 10, n. 7, p. N.PAG, doi. 10.3390/biomedicines10071495
- By:
- Publication type:
- Article
Transcriptomic and glycomic analyses highlight pathway-specific glycosylation alterations unique to Alzheimer's disease.
- Published in:
- Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-34787-4
- By:
- Publication type:
- Article
Elevated lipopolysaccharide binding protein in Alzheimer's disease patients with APOE3/E3 but not APOE3/E4 genotype.
- Published in:
- Frontiers in Neurology, 2024, p. 01, doi. 10.3389/fneur.2024.1408220
- By:
- Publication type:
- Article
MeCP2 modulates gene expression pathways in astrocytes.
- Published in:
- Molecular Autism, 2013, v. 4, n. 1, p. 1, doi. 10.1186/2040-2392-4-3
- By:
- Publication type:
- Article
Neuropathologic features in the hippocampus and cerebellum of three older men with fragile X syndrome.
- Published in:
- Molecular Autism, 2011, v. 2, n. 1, p. 1, doi. 10.1186/2040-2392-2-2
- By:
- Publication type:
- Article
Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK.
- Published in:
- FASEB Journal, 2006, v. 20, n. 6, p. 797, doi. 10.1096/fj.05-5423fje
- By:
- Publication type:
- Article
Novel tricyclic pyrone compounds prevent intracellular APP C99-induced cell death.
- Published in:
- Journal of Molecular Neuroscience, 2002, v. 19, n. 1/2, p. 57, doi. 10.1007/s12031-002-0011-9
- By:
- Publication type:
- Article
Advanced glycation endproduct precursor alters intracellular amyloid- β/AβPP carboxy-terminal fragment aggregation and cytotoxicity.
- Published in:
- Journal of Alzheimer's Disease, 2003, v. 5, n. 6, p. 467
- By:
- Publication type:
- Article
Ketogenic diet and BHB rescue the fall of long-term potentiation in an Alzheimer's mouse model and stimulates synaptic plasticity pathway enzymes.
- Published in:
- Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-05860-z
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- Publication type:
- Article
High‐density lipoprotein particle size distribution among patients with Alzheimer's disease, mild cognitive impairment, and age‐matched controls.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.076822
- By:
- Publication type:
- Article
Multi‐omics approach reveals disturbances in brain phosphatidylcholine metabolism in Alzheimer's Disease.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079431
- By:
- Publication type:
- Article
The role of FUT8‐catalyzed core fucosylation in Alzheimer's amyloid‐β oligomer‐induced activation of human microglia.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.065303
- By:
- Publication type:
- Article
Cell‐type deconvolution analysis of RNAseq data reveals cell‐specific glycosylation changes in the brains of Alzheimer's Disease patients.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.060726
- By:
- Publication type:
- Article
Alzheimer's Disease Patients, Especially ApoE4 Carriers, Have Significantly Reduced High‐density Lipoprotein Particle Size Revealed by Negative‐stained Transmission Electron Microscopy.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.063375
- By:
- Publication type:
- Article
Amyloid‐β plus cholesterol treatment impairs the ability of microglia to efflux excess cholesterol.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 3, p. 1, doi. 10.1002/alz.067436
- By:
- Publication type:
- Article