Works by Ismaili, Lhassane

Results: 33

New method for the synthesis of 4-aryl-3,4-dihydro-2H-benzo[g]chromene-2,5,10-triones.

Published in:

Synthetic Communications, 2019, v. 49, n. 21, p. 2834, doi. 10.1080/00397911.2019.1646286

By:

Choura, Emna;
Ncir, Marwa;
Maalej, Emna;
Marco-Contelles, José;
Ismaili, Lhassane;
Chabchoub, Fakher

Publication type:

Article

Facile one-pot synthesis of new [1,2,4]triazolo[1,5- a ]pyridine derivatives by ultrasonic irradiation.

Published in:

Synthetic Communications, 2017, v. 47, n. 21, p. 1934, doi. 10.1080/00397911.2017.1357078

By:

Zribi, Lazhar;
Zribi, Fathi;
Marco-Contelles, José;
Chabchoub, Fakher;
Ismaili, Lhassane

Publication type:

Article

Tacrines as Therapeutic Agents for Alzheimer's Disease. V. Recent Developments.

Published in:

Chemical Record, 2021, v. 21, n. 1, p. 162, doi. 10.1002/tcr.202000107

By:

Bautista‐Aguilera, Óscar M.;
Ismaili, Lhassane;
Iriepa, Isabel;
Diez‐Iriepa, Daniel;
Chabchoub, Fakher;
Marco‐Contelles, José;
Pérez, Marta

Publication type:

Article

Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca 2+ Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties.

Published in:

Pharmaceutics, 2024, v. 16, n. 1, p. 121, doi. 10.3390/pharmaceutics16010121

By:

Pachón-Angona, Irene;
Bernard, Paul J.;
Simakov, Alexey;
Maj, Maciej;
Jozwiak, Krzysztof;
Novotna, Anna;
Lemke, Carina;
Gütschow, Michael;
Martin, Helene;
Oset-Gasque, María-Jesús;
Contelles, José-Marco;
Ismaili, Lhassane

Publication type:

Article

Synthesis and Biological Evaluation of New Benzochromenopyrimidines for the Therapy of Colon and Lung Cancer.

Published in:

ChemistrySelect, 2024, v. 9, n. 2, p. 1, doi. 10.1002/slct.202303632

By:

Choura, Emna;
El Ghali, Fares;
Bernard, Paul J;
Marco‐Contelles, José;
Aifa, Sami;
Ismaili, Lhassane;
Chabchoub, Fakher

Publication type:

Article

Design, Synthesis, in Silico and Biological Evaluation of Novel 4‐Aminopyrimidine‐5‐carbonitriles.

Published in:

ChemistrySelect, 2023, v. 8, n. 31, p. 1, doi. 10.1002/slct.202302207

By:

Maalej, Emna;
Abdelmalek, Dorra;
Msalbi, Dhouha;
Aifa, Sami;
Ismaili, Lhassane;
Marco‐Contelles, José;
Chabchoub, Fakher

Publication type:

Article

Synthesis and Biological Assessment of PyrimidoTacrines as Promising Agents for Alzheimer's Disease Therapy.

Published in:

ChemistrySelect, 2021, v. 6, n. 37, p. 9975, doi. 10.1002/slct.202102363

By:

Dakhlaoui, Imen;
Maalej, Emna;
Martin, Helene;
Lucht, Aurélia;
Iriepa, Isabel;
Moraleda, Ignacio;
Marco‐Contelles, Jose;
Chabchoub, Fakher;
Ismaili, Lhassane

Publication type:

Article

Synthesis and Fluorescence of (E)‐3‐Aryl‐2‐(5‐aryl‐4H‐1,2,4‐triazol‐3‐yl) Acrylonitriles.

Published in:

ChemistrySelect, 2021, v. 6, n. 25, p. 6360, doi. 10.1002/slct.202100571

By:

Zribi, Lazhar;
Ismaili, Lhassane;
Vieira‐Ferreira, Luís F.;
Ferreira‐Machado, Isabel L.;
Marco‐Contelles, José;
Chabchoub, Fakher

Publication type:

Article

Regioselective Synthesis of Novel [1,2,4]Triazolo[1,5‐a]pyridine Derivatives.

Published in:

ChemistrySelect, 2021, v. 6, n. 5, p. 945, doi. 10.1002/slct.202004577

By:

Hassen, Manel Ben;
Masmoudi, Fatma;
Zribi, Lazhar;
Trigui, Mohamed;
Ismaili, Lhassane;
Marco‐Contelles, José;
Chabchoub, Fakher

Publication type:

Article

Automated Synthesis of New Quinoxalinetacrines.

Published in:

ChemistrySelect, 2020, v. 5, n. 21, p. 6491, doi. 10.1002/slct.202001593

By:

Bautista‐Aguilera, Óscar M.;
Ismaili, Lhassane;
Chioua, Mourad;
Iriepa, Isabel;
Ángeles Martinez‐Grau, Marìa;
Beadle, Christopher D.;
Vetman, Tatiana;
López‐Muñoz, Francisco;
Marco‐Contelles, José

Publication type:

Article

Synthesis of (±)‐cis‐1‐Aryl‐3‐oxo‐2,3‐dihydro‐1H‐benzo[f]chromene‐2‐carbonitriles and (±)‐trans‐4‐Aryl‐2‐oxo‐3,4‐dihydro‐2H‐benzo[h]chromene‐3‐carbonitriles

Published in:

ChemistrySelect, 2019, v. 4, n. 44, p. 12902, doi. 10.1002/slct.201903982

By:

Mkaouar, Kamar;
Iriepa, Isabel;
Diez‐Iriepa, Daniel;
Marco‐Contelles, José;
Ismaili, Lhassane;
Chabchoub, Fakher

Publication type:

Article

Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer's disease therapy.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2019, v. 34, n. 1, p. 479, doi. 10.1080/14756366.2018.1545766

By:

Pachón-Angona, Irene;
Refouvelet, Bernard;
Andrýs, Rudolf;
Martin, Helène;
Luzet, Vincent;
Iriepa, Isabel;
Moraleda, Ignacio;
Diez-Iriepa, Daniel;
Oset-Gasque, María-Jesús;
Marco-Contelles, José;
Musilek, Kamil;
Ismaili, Lhassane

Publication type:

Article

Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2019, v. 34, n. 1, p. 163, doi. 10.1080/14756366.2018.1538136

By:

Dgachi, Youssef;
Martin, Hélène;
Malek, Rim;
Jun, Daniel;
Janockova, Jana;
Sepsova, Vendula;
Soukup, Ondrej;
Iriepa, Isabel;
Moraleda, Ignacio;
Maalej, Emna;
Carreiras, M. Carmo;
Refouvelet, Bernard;
Chabchoub, Fakher;
Marco-Contelles, José;
Ismaili, Lhassane

Publication type:

Article

The Proof-of-Concept of MBA121, a Tacrine–Ferulic Acid Hybrid, for Alzheimer's Disease Therapy.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 15, p. 12254, doi. 10.3390/ijms241512254

By:

Rodríguez-Ruiz, Emelina R.;
Herrero-Labrador, Raquel;
Fernández-Fernández, Ana P.;
Serrano-Masa, Julia;
Martínez-Montero, José A.;
González-Nieto, Daniel;
Hana-Vaish, Mayuri;
Benchekroun, Mohamed;
Ismaili, Lhassane;
Marco-Contelles, José;
Martínez-Murillo, Ricardo

Publication type:

Article

Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer's Disease Treatment.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 11, p. 9742, doi. 10.3390/ijms24119742

By:

Dakhlaoui, Imen;
Bernard, Paul J.;
Pietrzak, Diana;
Simakov, Alexey;
Maj, Maciej;
Refouvelet, Bernard;
Béduneau, Arnaud;
Cornu, Raphaël;
Jozwiak, Krzysztof;
Chabchoub, Fakher;
Iriepa, Isabel;
Martin, Helene;
Marco-Contelles, José;
Ismaili, Lhassane

Publication type:

Article

Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 20, p. 7652, doi. 10.3390/ijms21207652

By:

Pachón Angona, Irene;
Martin, Helene;
Daniel, Solene;
Moraleda, Ignacio;
Bonet, Alexandre;
Wnorowski, Artur;
Maj, Maciej;
Jozwiak, Krzysztof;
Iriepa, Isabel;
Refouvelet, Bernard;
Marco-Contelles, José;
Ismaili, Lhassane

Publication type:

Article

Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer's Disease Therapy.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 11, p. 3913, doi. 10.3390/ijms21113913

By:

Bautista-Aguilera, Óscar M.;
Ismaili, Lhassane;
Chioua, Mourad;
Andrys, Rudolf;
Schmidt, Monika;
Bzonek, Petr;
Martínez-Grau, María Ángeles;
Beadle, Christopher D.;
Vetman, Tatiana;
López-Muñoz, Francisco;
Iriepa, Isabel;
Refouvelet, Bernard;
Musilek, Kamil;
Marco-Contelles, José

Publication type:

Article

ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy.

Published in:

Frontiers in Neuroscience, 2016, p. 1, doi. 10.3389/fnins.2016.00294

By:

Marco-Contelles, José;
Unzeta, Mercedes;
Bolea, Irene;
Esteban, Gerard;
Ramsay, Rona R.;
Romero, Alejandro;
Martínez-Murillo, Ricard;
Carreiras, M. Carmo;
Ismaili, Lhassane;
Meneses, Alfredo;
Parsons, Christopher Graham

Publication type:

Article

Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Aβ1−42 Aggregation Inhibitors for Alzheimer's Disease Therapy.

Published in:

ChemMedChem, 2016, v. 11, n. 12, p. 1318, doi. 10.1002/cmdc.201500539

By:

Dgachi, Youssef;
Ismaili, Lhassane;
Knez, Damijan;
Benchekroun, Mohamed;
Martin, Hélène;
Szałaj, Natalia;
Wehle, Sarah;
Bautista‐Aguilera, Oscar M.;
Luzet, Vincent;
Bonnet, Alexandre;
Malawska, Barbara;
Gobec, Stanislav;
Chioua, Mourad;
Decker, Michael;
Chabchoub, Fakher;
Marco‐Contelles, José

Publication type:

Article

Synthesis of new pyrazolo[4,3- c]quinolin-3-one derivatives and some oxazolo[4,5- c]quinoline-2,4-diones.

Published in:

Journal of Heterocyclic Chemistry, 1999, v. 36, n. 3, p. 719, doi. 10.1002/jhet.5570360323

By:

Ismaïli, Lhassane;
Refouvelet, Bernard;
Robert, Jean François

Publication type:

Article

Multipotente Liganden mit kombinierter Cholinesterase- und Monoaminooxidase-Inhibition sowie Histamin-H3R-Antagonismus bei neurodegenerativen Erkrankungen.

Published in:

Angewandte Chemie, 2017, v. 129, n. 41, p. 12939, doi. 10.1002/ange.201706072

By:

Bautista ‐ Aguilera, Óscar M.;
Hagenow, Stefanie;
Palomino ‐ Antolin, Alejandra;
Farré ‐ Alins, Víctor;
Ismaili, Lhassane;
Joffrin, Pierre ‐ Louis;
Jimeno, María L.;
Soukup, Ondřej;
Janočková, Jana;
Kalinowsky, Lena;
Proschak, Ewgenij;
Iriepa, Isabel;
Moraleda, Ignacio;
Schwed, Johannes S.;
Romero Martínez, Alejandro;
López ‐ Muñoz, Francisco;
Chioua, Mourad;
Egea, Javier;
Ramsay, Rona R.;
Marco ‐ Contelles, José

Publication type:

Article

Efficient Two-Step Synthesis of Novel Pyrimido[4,5- d ] Pyrimidines with Potent Neuroprotective, Antioxidant, and A β Anti-Aggregation Properties.

Published in:

Chemistry (2624-8549), 2024, v. 6, n. 4, p. 695, doi. 10.3390/chemistry6040041

By:

Ben Ameur, Ghada;
Maalej, Emna;
Martin, Helene;
Jacquinot, Anne-Sophie;
Barbanneau, Nadine;
Bernard, Paul J.;
Marco-Contelles, José;
Chabchoub, Fakher;
Ismaili, Lhassane

Publication type:

Article

Pharmacophore Modelling and Synthesis of Quinoline-3-Carbohydrazide as Antioxidants.

Published in:

International Journal of Medicinal Chemistry, 2011, p. 1, doi. 10.1155/2011/592879

By:

Bakkali, Mustapha El;
Ismaili, Lhassane;
Tomassoli, Isabelle;
Nicod, Laurence;
Pudlo, Marc;
Refouvelet, Bernard

Publication type:

Article

Calcium channel blockers' contribution to overcoming Current drug discovery challenges in Alzheimer's disease.

Published in:

Expert Opinion on Drug Discovery, 2024, v. 19, n. 1, p. 21, doi. 10.1080/17460441.2023.2266994

By:

Bernard, Paul J;
Bellili, Djamila;
Ismaili, Lhassane

Publication type:

Article

Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer1s Disease Therapy.

Published in:

Molecules, 2016, v. 21, n. 4, p. 400, doi. 10.3390/molecules21040400

By:

Boulebd, Houssem;
Ismaili, Lhassane;
Bartolini, Manuela;
Bouraiou, Abdelmalek;
Andrisano, Vincenza;
Martin, Helene;
Bonet, Alexandre;
Moraleda, Ignacio;
Iriepa, Isabel;
Chioua, Mourad;
Belfaitah, Ali;
Marco-Contelles, José

Publication type:

Article

Synthesis and Anti‐Inflammatory Activity of Spiropyrimido[4,5‐d]pyrimidine Derivatives.

Published in:

ChemistrySelect, 2025, v. 10, n. 15, p. 1, doi. 10.1002/slct.202500270

By:

Maalej, Emna;
Ziri, Olfa Kallech;
Ayadi, Wiem;
Bernard, Paul J.;
López‐Muñoz, Francisco;
Marco‐Contelles, J.;
Chabchoub, Fakher;
Refouvelet, Bernard;
Ismaili, Lhassane

Publication type:

Article

Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3R Antagonism for Neurodegenerative Diseases.

Published in:

Angewandte Chemie International Edition, 2017, v. 56, n. 41, p. 12765, doi. 10.1002/anie.201706072

By:

Bautista‐Aguilera, Óscar M.;
Hagenow, Stefanie;
Palomino‐Antolin, Alejandra;
Farré‐Alins, Víctor;
Ismaili, Lhassane;
Joffrin, Pierre‐Louis;
Jimeno, María L.;
Soukup, Ondřej;
Janočková, Jana;
Kalinowsky, Lena;
Proschak, Ewgenij;
Iriepa, Isabel;
Moraleda, Ignacio;
Schwed, Johannes S.;
Romero Martínez, Alejandro;
López‐Muñoz, Francisco;
Chioua, Mourad;
Egea, Javier;
Ramsay, Rona R.;
Marco‐Contelles, José

Publication type:

Article

Nrf2 Activation and Antioxidant Properties of Chromone-Containing MTDLs for Alzheimer's Disease Treatment.

Published in:

Molecules, 2025, v. 30, n. 9, p. 2048, doi. 10.3390/molecules30092048

By:

Simakov, Alexey;
Chhor, Stecy;
Ismaili, Lhassane;
Martin, Hélène

Publication type:

Article

Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca 2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation.

Published in:

Molecules, 2023, v. 28, n. 1, p. 71, doi. 10.3390/molecules28010071

By:

Malek, Rim;
Simakov, Alexey;
Davis, Audrey;
Maj, Maciej;
Bernard, Paul J.;
Wnorowski, Artur;
Martin, Helene;
Marco-Contelles, José;
Chabchoub, Fakher;
Dallemagne, Patrick;
Rochais, Christophe;
Jozwiak, Krzysztof;
Ismaili, Lhassane

Publication type:

Article

Benzochromenopyrimidines: Synthesis, Antiproliferative Activity against Colorectal Cancer and Physicochemical Properties.

Published in:

Molecules, 2022, v. 27, n. 22, p. 7878, doi. 10.3390/molecules27227878

By:

Choura, Emna;
Elghali, Fares;
Bernard, Paul J.;
Msalbi, Dhouha;
Marco-Contelles, José;
Aifa, Sami;
Ismaili, Lhassane;
Chabchoub, Fakher

Publication type:

Article

Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer's Disease Therapy.

Published in:

Molecules, 2020, v. 25, n. 14, p. 3190, doi. 10.3390/molecules25143190

By:

Zribi, Lazhar;
Pachòn-Angona, Irene;
Bautista-Aguilera, Òscar M.;
Diez-Iriepa, Daniel;
Marco-Contelles, José;
Ismaili, Lhassane;
Iriepa, Isabel;
Chabchoub, Fakher;
Branco, Paula Sério

Publication type:

Article

Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels.

Published in:

Molecules, 2020, v. 25, n. 6, p. 1329, doi. 10.3390/molecules25061329

By:

Pachòn Angona, Irene;
Daniel, Solene;
Martin, Helene;
Bonet, Alexandre;
Wnorowski, Artur;
Maj, Maciej;
Jóźwiak, Krzysztof;
Silva, Tiago Barros;
Refouvelet, Bernard;
Borges, Fernanda;
Marco-Contelles, José;
Ismaili, Lhassane;
Romanelli, Maria Novella;
Dei, Silvia

Publication type:

Article

Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer’s Disease.

Published in:

Molecules, 2016, v. 21, n. 5, p. 634, doi. 10.3390/molecules21050634

By:

Dgachi, Youssef;
Bautista-Aguilera, Oscar M.;
Benchekroun, Mohamed;
Martin, Hélène;
Bonet, Alexandre;
Knez, Damijan;
Godyń, Justyna;
Malawska, Barbara;
Gobec, Stanislav;
Chioua, Mourad;
Janockova, Jana;
Soukup, Ondrej;
Chabchoub, Fakher;
Marco-Contelles, José;
Ismaili, Lhassane

Publication type:

Article

Works by Ismaili, Lhassane

New method for the synthesis of 4-aryl-3,4-dihydro-2H-benzo[g]chromene-2,5,10-triones.

Facile one-pot synthesis of new [1,2,4]triazolo[1,5- a ]pyridine derivatives by ultrasonic irradiation.

Tacrines as Therapeutic Agents for Alzheimer's Disease. V. Recent Developments.

Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca 2+ Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties.

Synthesis and Biological Evaluation of New Benzochromenopyrimidines for the Therapy of Colon and Lung Cancer.

Design, Synthesis, in Silico and Biological Evaluation of Novel 4‐Aminopyrimidine‐5‐carbonitriles.

Synthesis and Biological Assessment of PyrimidoTacrines as Promising Agents for Alzheimer's Disease Therapy.

Synthesis and Fluorescence of (E)‐3‐Aryl‐2‐(5‐aryl‐4H‐1,2,4‐triazol‐3‐yl) Acrylonitriles.

Regioselective Synthesis of Novel [1,2,4]Triazolo[1,5‐a]pyridine Derivatives.

Automated Synthesis of New Quinoxalinetacrines.

Synthesis of (±)‐cis‐1‐Aryl‐3‐oxo‐2,3‐dihydro‐1H‐benzo[f]chromene‐2‐carbonitriles and (±)‐trans‐4‐Aryl‐2‐oxo‐3,4‐dihydro‐2H‐benzo[h]chromene‐3‐carbonitriles

Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer's disease therapy.

Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy.

The Proof-of-Concept of MBA121, a Tacrine–Ferulic Acid Hybrid, for Alzheimer's Disease Therapy.

Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer's Disease Treatment.

Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives.

Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer's Disease Therapy.

ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy.

Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Aβ<sub>1−42</sub> Aggregation Inhibitors for Alzheimer's Disease Therapy.

Synthesis of new pyrazolo[4,3- c]quinolin-3-one derivatives and some oxazolo[4,5- c]quinoline-2,4-diones.

Multipotente Liganden mit kombinierter Cholinesterase- und Monoaminooxidase-Inhibition sowie Histamin-H<sub>3</sub>R-Antagonismus bei neurodegenerativen Erkrankungen.

Efficient Two-Step Synthesis of Novel Pyrimido[4,5- d ] Pyrimidines with Potent Neuroprotective, Antioxidant, and A β Anti-Aggregation Properties.

Pharmacophore Modelling and Synthesis of Quinoline-3-Carbohydrazide as Antioxidants.

Calcium channel blockers' contribution to overcoming Current drug discovery challenges in Alzheimer's disease.

Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer1s Disease Therapy.

Synthesis and Anti‐Inflammatory Activity of Spiropyrimido[4,5‐d]pyrimidine Derivatives.

Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H<sub>3</sub>R Antagonism for Neurodegenerative Diseases.

Nrf2 Activation and Antioxidant Properties of Chromone-Containing MTDLs for Alzheimer's Disease Treatment.

Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca 2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation.

Benzochromenopyrimidines: Synthesis, Antiproliferative Activity against Colorectal Cancer and Physicochemical Properties.

Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer's Disease Therapy.

Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels.

Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer’s Disease.