Works by Isaacs, Adrian

Results: 72

Regulation of Postsynaptic Function by the Dementia-Related ESCRT-III Subunit CHMP2B.

Published in:

Journal of Neuroscience, 2015, v. 35, n. 7, p. 3155, doi. 10.1523/JNEUROSCI.0586-14.2015

By:

Chassefeyre, Romain;
Martínez-Hernández, José;
Bertaso, Federica;
Bouquier, Nathalie;
Blot, Béatrice;
Laporte, Marine;
Fraboulet, Sandrine;
Couté, Yohann;
Devoy, Anny;
Isaacs, Adrian M.;
Pernet-Gallay, Karin;
Sadoul, Rémy;
Fagni, Laurent;
Goldberg, Yves

Publication type:

Article

Transcriptome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides.

Published in:

Life Science Alliance, 2023, v. 6, n. 9, p. 1, doi. 10.26508/lsa.202201824

By:

Balendra, Rubika;
de los Mozos, Igor Ruiz;
Odeh, Hana M.;
Glaria, Idoia;
Milioto, Carmelo;
Wilson, Katherine M.;
Ule, Agnieszka M.;
Hallegger, Martina;
Masino, Laura;
Martin, Stephen;
Patani, Rickie;
Shorter, James;
Ule, Jernej;
Isaacs, Adrian M.

Publication type:

Article

Toxicity of C9orf72-associated dipeptide repeat peptides is modified by commonly used protein tags.

Published in:

Life Science Alliance, 2023, v. 6, n. 9, p. 1, doi. 10.26508/lsa.202201739

By:

Morón-Oset, Javier;
Fischer, Lilly K. S.;
Carcolé, Mireia;
Giblin, Ashling;
Pingze Zhang;
Isaacs, Adrian M.;
Grönke, Sebastian;
Partridge, Linda

Publication type:

Article

G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptome.

Published in:

FEBS Letters, 2015, v. 589, n. 14, p. 1653, doi. 10.1016/j.febslet.2015.05.003

By:

Simone, Roberto;
Fratta, Pietro;
Neidle, Stephen;
Parkinson, Gary N.;
Isaacs, Adrian M.

Publication type:

Article

A Mutation in Af4 Is Predicted to Cause Cerebellar Ataxia and Cataracts in the Robotic Mouse.

Published in:

Journal of Neuroscience, 2003, v. 23, n. 5, p. 1631, doi. 10.1523/JNEUROSCI.23-05-01631.2003

By:

Isaacs, Adrian M.;
Oliver, Peter L.;
Jones, Emma L.;
Jeans, Alexander;
Potter, Allyson;
Hovik, Berit H.;
Nolan, Patrick M.;
Vizor, Lucie;
Glenister, Peter;
Simon, A. Katharina;
Gray, Ian C.;
Spurr, Nigel H.;
Brown, Steve D.M.;
Hunter, A. Jackie;
Davies, Kay E.

Publication type:

Article

Quantitative Assessment of Eye Phenotypes for Functional Genetic Studies Using Drosophila melanogaster.

Published in:

G3: Genes | Genomes | Genetics, 2016, v. 6, n. 5, p. 1427, doi. 10.1534/g3.116.027060

By:

Iyer, Janani;
Wang, Qingyu;
Le, Thanh;
Pizzo, Lucilla;
Grönke, Sebastian;
Ambegaokar, Surendra S.;
Imai, Yuzuru;
Srivastava, Ashutosh;
Troisí, Beatriz Llamusí;
Mardon, Graeme;
Artero, Ruben;
Jackson, George R.;
Isaacs, Adrian M.;
Partridge, Linda;
Bingwei Lu;
Kumar, Justin P.;
Girirajan, Santhosh

Publication type:

Article

Six generations of CHMP2B‐mediated Frontotemporal Dementia: Clinical features, predictive testing, progression, and survival.

Published in:

Acta Neurologica Scandinavica, 2022, v. 145, n. 5, p. 529, doi. 10.1111/ane.13578

By:

Roos, Peter;
Johannsen, Peter;
Lindquist, Suzanne G.;
Brown, Jeremy M.;
Waldemar, Gunhild;
Duno, Morten;
Nielsen, Troels T.;
Budtz‐Jørgensen, Esben;
Gydesen, Susanne;
Holm, Ida E.;
Collinge, John;
Isaacs, Adrian M.;
Nielsen, Jørgen E.;
Gade, Anders;
Stokholm, Jette;
Thusgaard, Tove;
Fisher, Elizabeth M.C.;
Englund, Elisabet

Publication type:

Article

A novel exon 2 I27V VCP variant is associated with dissimilar clinical syndromes.

Published in:

Journal of Neurology, 2011, v. 258, n. 8, p. 1494, doi. 10.1007/s00415-011-5966-4

By:

Rohrer, Jonathan D.;
Warren, Jason D.;
Reiman, David;
Uphill, James;
Beck, Jonathan;
Collinge, John;
Rossor, Martin N.;
Isaacs, Adrian M.;
Mead, Simon

Publication type:

Article

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease.

Published in:

Journal of Cell Biology, 2007, v. 179, n. 3, p. 485, doi. 10.1083/jcb.200702115

By:

Filimonenko, Maria;
Stuffers, Susanne;
Raiborg, Camilla;
Yamamoto, Ai;
Malerød, Lene;
Fisher, Elizabeth M. C.;
Isaacs, Adrian;
Brech, Andreas;
Stenmark, Harald;
Simonsen, Anne

Publication type:

Article

Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUS.

Published in:

Acta Neuropathologica Communications, 2019, v. 7, n. 1, p. N.PAG, doi. 10.1186/s40478-019-0673-y

By:

Gittings, Lauren M.;
Foti, Sandrine C.;
Benson, Bridget C.;
Gami-Patel, Priya;
Isaacs, Adrian M.;
Lashley, Tammaryn

Publication type:

Article

Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration.

Published in:

Acta Neuropathologica Communications, 2017, v. 5, p. 1, doi. 10.1186/s40478-017-0432-x

By:

Mizielinska, Sarah;
Ridler, Charlotte E.;
Balendra, Rubika;
Thoeng, Annora;
Woodling, Nathan S.;
Grässer, Friedrich A.;
Plagnol, Vincent;
Lashley, Tammaryn;
Partridge, Linda;
Isaacs, Adrian M.

Publication type:

Article

Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.58565

By:

Atilano, Magda L.;
Grönke, Sebastian;
Niccoli, Teresa;
Kempthorne, Liam;
Hahn, Oliver;
Morón-Oset, Javier;
Hendrich, Oliver;
Dyson, Miranda;
Adams, Mirjam Lisette;
Hull, Alexander;
Salcher-Konrad, Marie-Therese;
Monaghan, Amy;
Bictash, Magda;
Glaria, Idoia;
Isaacs, Adrian M.;
Partridge, Linda

Publication type:

Article

CHMP2B C-truncating mutations in frontotemporal lobar degeneration are associated with an aberrant endosomal phenotype in vitro.

Published in:

Human Molecular Genetics, 2008, v. 17, n. 2, p. 313, doi. 10.1093/hmg/ddm309

By:

van der Zee, Julie;
Urwin, Hazel;
Engelborghs, Sebastiaan;
Bruyland, Marc;
Vandenberghe, Rik;
Dermaut, Bart;
De Pooter, Tim;
Peeters, Karin;
Santens, Patrick;
De Deyn, Peter P.;
Fisher, Elizabeth M.;
Collinge, John;
Isaacs, Adrian M.;
Van Broeckhoven, Christine

Publication type:

Article

Identification of two new Pmp22 mouse mutants using large-scale mutagenesis and a novel rapid mapping strategy.

Published in:

Human Molecular Genetics, 2000, v. 9, n. 12, p. 1865, doi. 10.1093/hmg/9.12.1865

By:

Isaacs, Adrian M.

Publication type:

Article

Localization of frontotemporal dementia with parkinsonism in an Australian kindred to chromosome 17q21-22.

Published in:

Annals of Neurology, 1997, v. 42, n. 5, p. 794, doi. 10.1002/ana.410420516

By:

Baker, Matt;
Kwok, John B. J.;
Kucera, Steve;
Crook, Richard;
Farrer, Matthew;
Houlden, Henry;
Isaacs, Adrian;
Lincoln, Sarah;
Onstead, Luisa;
Hardy, John;
Wittenberg, Leonie;
Dodd, Peter;
Webb, Sonja;
Hayward, Nick;
Tannenberg, Tony;
Andreadis, Athena;
Hallupp, Marianne;
Schofield, Peter;
Dark, Frances;
Hutton, Michael

Publication type:

Article

C9orf72 ALS/FTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation.

Published in:

EMBO Journal, 2022, v. 41, n. 1, p. 1, doi. 10.15252/embj.2020105026

By:

Licata, Nausicaa V;
Cristofani, Riccardo;
Salomonsson, Sally;
Wilson, Katherine M;
Kempthorne, Liam;
Vaizoglu, Deniz;
D'Agostino, Vito G;
Pollini, Daniele;
Loffredo, Rosa;
Pancher, Michael;
Adami, Valentina;
Bellosta, Paola;
Ratti, Antonia;
Viero, Gabriella;
Quattrone, Alessandro;
Isaacs, Adrian M;
Poletti, Angelo;
Provenzani, Alessandro

Publication type:

Article

Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoids.

Published in:

Acta Neuropathologica Communications, 2024, p. 1, doi. 10.1186/s40478-024-01857-1

By:

van der Geest, Astrid T.;
Jakobs, Channa E.;
Ljubikj, Tijana;
Huffels, Christiaan F. M.;
Cañizares Luna, Marta;
Vieira de Sá, Renata;
Adolfs, Youri;
de Wit, Marina;
Rutten, Daan H.;
Kaal, Marthe;
Zwartkruis, Maria M.;
Carcolé, Mireia;
Groen, Ewout J. N.;
Hol, Elly M.;
Basak, Onur;
Isaacs, Adrian M.;
Westeneng, Henk-Jan;
van den Berg, Leonard H.;
Veldink, Jan H.;
Schlegel, Domino K.

Publication type:

Article

Repeat length of C9orf72-associated glycine–alanine polypeptides affects their toxicity.

Published in:

Acta Neuropathologica Communications, 2023, v. 11, n. 1, p. 1, doi. 10.1186/s40478-023-01634-6

By:

Morón-Oset, Javier;
Fischer, Lilly Katharina Sophie;
Jauré, Nathalie;
Zhang, Pingze;
Jahn, Annika Julia;
Supèr, Tessa;
Pahl, André;
Isaacs, Adrian M.;
Grönke, Sebastian;
Partridge, Linda

Publication type:

Article

Adult polyglucosan body disease with GBE1 haploinsufficiency and concomitant frontotemporal lobar degeneration.

Published in:

Neuropathology & Applied Neurobiology, 2014, v. 40, n. 6, p. 778, doi. 10.1111/nan.12144

By:

Bit‐Ivan, Esther N.;
Lee, Kyung‐Hwa;
Gitelman, Darren;
Weintraub, Sandra;
Mesulam, Marsel;
Rademakers, Rosa;
Isaacs, Adrian M.;
Hatanpaa, Kimmo J.;
White, Charles L.;
Mao, Qinwen;
Akman, Orhan;
DiMauro, Salvatore;
Bigio, Eileen H.

Publication type:

Article

Specific biomarkers for C9orf72 FTD/ ALS could expedite the journey towards effective therapies.

Published in:

EMBO Molecular Medicine, 2017, v. 9, n. 7, p. 853, doi. 10.15252/emmm.201707848

By:

Balendra, Rubika;
Moens, Thomas G;
Isaacs, Adrian M

Publication type:

Article

A novel synaptopathy‐defective synaptic vesicle protein trafficking in the mutant CHMP2B mouse model of frontotemporal dementia.

Published in:

Journal of Neurochemistry, 2022, v. 160, n. 3, p. 412, doi. 10.1111/jnc.15551

By:

Clayton, Emma L.;
Bonnycastle, Katherine;
Isaacs, Adrian M.;
Cousin, Michael A.;
Schorge, Stephanie

Publication type:

Article

Reversal of pathology in CHMP2B-mediated frontotemporal dementia patient cells using RNA interference.

Published in:

Journal of Gene Medicine, 2012, v. 14, n. 8, p. 521, doi. 10.1002/jgm.2649

By:

Nielsen, Troels Tolstrup;
Mizielinska, Sarah;
Hasholt, Lis;
Isaacs, Adrian M.;
Nielsen, Jørgen E.

Publication type:

Article

Presymptomatic Generalized Brain Atrophy in Frontotemporal Dementia Caused by CHMP2B Mutation.

Published in:

Dementia & Geriatric Cognitive Disorders, 2009, v. 27, n. 2, p. 182, doi. 10.1159/000200466

By:

Rohrer, Jonathan D.;
Ahsan, R. Laila;
Isaacs, Adrian M.;
Nielsen, Jorgen E.;
Ostergaard, Leif;
Scahill, Rachael;
Warren, Jason D.;
Rossor, Martin N.;
Fox, Nick C.;
Johannsen, Peter

Publication type:

Article

SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits.

Published in:

Nature Communications, 2017, v. 8, n. 7, p. 16063, doi. 10.1038/ncomms16063

By:

Hautbergue, Guillaume M.;
Castelli, Lydia M.;
Ferraiuolo, Laura;
Sanchez-Martinez, Alvaro;
Cooper-Knock, Johnathan;
Higginbottom, Adrian;
Lin, Ya-Hui;
Bauer, Claudia S.;
Dodd, Jennifer E.;
Myszczynska, Monika A.;
Alam, Sarah M.;
Garneret, Pierre;
Chandran, Jayanth S.;
Karyka, Evangelia;
Stopford, Matthew J.;
Smith, Emma F.;
Kirby, Janine;
Meyer, Kathrin;
Kaspar, Brian K.;
Isaacs, Adrian M.

Publication type:

Article

G2C4 targeting antisense oligonucleotides potently mitigate TDP-43 dysfunction in human C9orf72 ALS/FTD induced pluripotent stem cell derived neurons.

Published in:

Acta Neuropathologica, 2024, v. 147, n. 1, p. 1, doi. 10.1007/s00401-023-02652-3

By:

Rothstein, Jeffrey D.;
Baskerville, Victoria;
Rapuri, Sampath;
Mehlhop, Emma;
Jafar-Nejad, Paymaan;
Rigo, Frank;
Bennett, Frank;
Mizielinska, Sarah;
Isaacs, Adrian;
Coyne, Alyssa N.

Publication type:

Article

Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR phase separation and toxicity.

Published in:

Acta Neuropathologica, 2020, v. 139, n. 2, p. 407, doi. 10.1007/s00401-019-02104-x

By:

Gittings, Lauren M.;
Boeynaems, Steven;
Lightwood, Daniel;
Clargo, Alison;
Topia, Sarfaraj;
Nakayama, Lisa;
Troakes, Claire;
Mann, David M. A.;
Gitler, Aaron D.;
Lashley, Tammaryn;
Isaacs, Adrian M.

Publication type:

Article

C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A.

Published in:

Acta Neuropathologica, 2019, v. 137, n. 3, p. 487, doi. 10.1007/s00401-018-1946-4

By:

Moens, Thomas G.;
Niccoli, Teresa;
Wilson, Katherine M.;
Atilano, Magda L.;
Birsa, Nicol;
Gittings, Lauren M.;
Holbling, Benedikt V.;
Dyson, Miranda C.;
Thoeng, Annora;
Neeves, Jacob;
Glaria, Idoia;
Yu, Lu;
Bussmann, Julia;
Storkebaum, Erik;
Pardo, Mercedes;
Choudhary, Jyoti S.;
Fratta, Pietro;
Partridge, Linda;
Isaacs, Adrian M.

Publication type:

Article

Sense and antisense RNA are not toxic in <italic>Drosophila</italic> models of <italic>C9orf72</italic>-associated ALS/FTD.

Published in:

Acta Neuropathologica, 2018, v. 135, n. 3, p. 445, doi. 10.1007/s00401-017-1798-3

By:

Moens, Thomas G.;
Mizielinska, Sarah;
Niccoli, Teresa;
Mitchell, Jamie S.;
Thoeng, Annora;
Ridler, Charlotte E.;
Grönke, Sebastian;
Esser, Jacqueline;
Heslegrave, Amanda;
Zetterberg, Henrik;
Partridge, Linda;
Isaacs, Adrian M.

Publication type:

Article

A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism.

Published in:

Acta Neuropathologica, 2018, v. 135, n. 3, p. 427, doi. 10.1007/s00401-017-1796-5

By:

Swinnen, Bart;
Bento-Abreu, Andre;
Gendron, Tania F.;
Boeynaems, Steven;
Bogaert, Elke;
Nuyts, Rik;
Timmers, Mieke;
Scheveneels, Wendy;
Hersmus, Nicole;
Wang, Jiou;
Mizielinska, Sarah;
Isaacs, Adrian M.;
Petrucelli, Leonard;
Lemmens, Robin;
Van Damme, Philip;
Van Den Bosch, Ludo;
Robberecht, Wim

Publication type:

Article

A 30-unit hexanucleotide repeat expansion in C9orf72 induces pathological lesions with dipeptide-repeat proteins and RNA foci, but not TDP-43 inclusions and clinical disease.

Published in:

2015

By:

Gami, Priya;
Murray, Christina;
Holton, Janice;
Revesz, Tamas;
Lashley, Tammaryn;
Schottlaender, Lucia;
Bettencourt, Conceição;
Houlden, Henry;
Pablo Fernandez, Eduardo;
Mudanohwo, Ese;
Polke, James;
Mizielinska, Sarah;
Isaacs, Adrian

Publication type:

Letter

Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology.

Published in:

Acta Neuropathologica, 2015, v. 130, n. 4, p. 511, doi. 10.1007/s00401-015-1475-3

By:

Holm, Ida;
Nielsen, Jørgen;
Collinge, John;
Clayton, Emma;
Mizielinska, Sarah;
Marshall, Sarah;
Norona, Frances;
Robbins, Miranda;
Damirji, Hana;
Isaacs, Adrian;
Edgar, James;
Nielsen, Troels;
Johannsen, Peter;
Asante, Emmanuel

Publication type:

Article

C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci.

Published in:

Acta Neuropathologica, 2013, v. 126, n. 6, p. 845, doi. 10.1007/s00401-013-1200-z

By:

Mizielinska, Sarah;
Lashley, Tammaryn;
Norona, Frances E.;
Clayton, Emma L.;
Ridler, Charlotte E.;
Fratta, Pietro;
Isaacs, Adrian M.

Publication type:

Article

Homozygosity for the C9orf72 GGGGCC repeat expansion in frontotemporal dementia.

Published in:

Acta Neuropathologica, 2013, v. 126, n. 3, p. 401, doi. 10.1007/s00401-013-1147-0

By:

Fratta, Pietro;
Poulter, Mark;
Lashley, Tammaryn;
Rohrer, Jonathan;
Polke, James;
Beck, Jon;
Ryan, Natalie;
Hensman, Davina;
Mizielinska, Sarah;
Waite, Adrian;
Lai, Mang-Ching;
Gendron, Tania;
Petrucelli, Leonard;
Fisher, Elizabeth;
Revesz, Tamas;
Warren, Jason;
Collinge, John;
Isaacs, Adrian;
Mead, Simon

Publication type:

Article

Absence of FUS-immunoreactive pathology in frontotemporal dementia linked to chromosome 3 (FTD-3) caused by mutation in the CHMP2B gene.

Published in:

2009

By:

Holm, Ida Elisabeth;
Isaacs, Adrian M.;
Mackenzie, Ian R. A.

Publication type:

Letter

Failure of C9orf72 sense repeat-targeting antisense oligonucleotides: lessons learned and the path forward.

Published in:

Brain: A Journal of Neurology, 2024, v. 147, n. 8, p. 2607, doi. 10.1093/brain/awae168

By:

Cammack, Alexander J;
Balendra, Rubika;
Isaacs, Adrian M

Publication type:

Article

Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown.

Published in:

2018

By:

Clayton, Emma L;
Milioto, Carmelo;
Muralidharan, Bhavana;
Norona, Frances E;
Edgar, James R;
Soriano, Armand;
Jafar-nejad, Paymaan;
Rigo, Frank;
Collinge, John;
Isaacs, Adrian M

Publication type:

journal article

The snowball effect of RNA binding protein dysfunction in amyotrophic lateral sclerosis.

Published in:

2018

By:

Fratta, Pietro;
Isaacs, Adrian M.

Publication type:

journal article

Humanized mutant FUS drives progressive motor neuron degeneration without aggregation in 'FUSDelta14' knockin mice.

Published in:

2017

By:

Devoy, Anny;
Kalmar, Bernadett;
Stewart, Michelle;
Park, Heesoon;
Burke, Beverley;
Noy, Suzanna J.;
Redhead, Yushi;
Humphrey, Jack;
Lo, Kitty;
Jaeger, Julian;
Mejia Maza, Alan;
Sivakumar, Prasanth;
Bertolin, Cinzia;
Soraru, Gianni;
Plagno, Vincent;
Greensmith, Linda;
Arozena, Abraham Acevedo;
Isaacs, Adrian M.;
Davies, Benjamin;
Fratta, Pietro

Publication type:

journal article

Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice.

Published in:

Brain: A Journal of Neurology, 2012, v. 135, n. 3, p. 819, doi. 10.1093/brain/aws006

By:

Ghazi-Noori, Shabnam;
Froud, Kristina E.;
Mizielinska, Sarah;
Powell, Caroline;
Smidak, Michelle;
Fernandez de Marco, Mar;
O’Malley, Catherine;
Farmer, Michael;
Parkinson, Nick;
Fisher, Elizabeth M. C.;
Asante, Emmanuel A.;
Brandner, Sebastian;
Collinge, John;
Isaacs, Adrian M.

Publication type:

Article

Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration.

Published in:

Brain: A Journal of Neurology, 2011, v. 134, n. 9, p. 2565, doi. 10.1093/brain/awr198

By:

Rohrer, Jonathan D.;
Lashley, Tammaryn;
Schott, Jonathan M.;
Warren, Jane E.;
Mead, Simon;
Isaacs, Adrian M.;
Beck, Jonathan;
Hardy, John;
de Silva, Rohan;
Warrington, Elizabeth;
Troakes, Claire;
Al-Sarraj, Safa;
King, Andrew;
Borroni, Barbara;
Clarkson, Matthew J.;
Ourselin, Sebastien;
Holton, Janice L.;
Fox, Nick C.;
Revesz, Tamas;
Rossor, Martin N.

Publication type:

Article

A comparative clinical, pathological, biochemical and genetic study of fused in sarcoma proteinopathies.

Published in:

Brain: A Journal of Neurology, 2011, v. 134, n. 9, p. 2548, doi. 10.1093/brain/awr160

By:

Lashley, Tammaryn;
Rohrer, Jonathan D.;
Bandopadhyay, Rina;
Fry, Charles;
Ahmed, Zeshan;
Isaacs, Adrian M.;
Brelstaff, Jack H.;
Borroni, Barbara;
Warren, Jason D.;
Troakes, Claire;
King, Andrew;
Al-Saraj, Safa;
Newcombe, Jia;
Quinn, Niall;
Ostergaard, Karen;
Schrøder, Henrik Daa;
Bojsen-Møller, Marie;
Braendgaard, Hans;
Fox, Nick C.;
Rossor, Martin N.

Publication type:

Article

Very early-onset frontotemporal dementia with no family history predicts underlying fused in sarcoma pathology.

Published in:

Brain: A Journal of Neurology, 2010, v. 133, n. 12, p. e158, doi. 10.1093/brain/awq186

By:

Loy, Clement T.;
McCusker, Elizabeth;
Kril, Jillian J.;
Kwok, John B.;
Brooks, William S.;
McCann, Heather;
Isaacs, Adrian M.;
Halliday, Glenda M.

Publication type:

Article

A distinct clinical, neuropsychological and radiological phenotype is associated with progranulin gene mutations in a large UK series.

Published in:

Brain: A Journal of Neurology, 2008, v. 131, n. 3, p. 706, doi. 10.1093/brain/awm320

By:

Jonathan Beck;
Jonathan D. Rohrer;
Tracy Campbell;
Adrian Isaacs;
Karen E. Morrison;
Emily F. Goodall;
Elizabeth K. Warrington;
John Stevens;
Tamas Revesz;
Janice Holton;
Safa Al-Sarraj;
Andrew King;
Rachael Scahill;
Jason D. Warren;
Nick C. Fox;
Martin N. Rossor;
John Collinge;
Simon Mead

Publication type:

Article

Novel Types of Frontotemporal Lobar Degeneration: Beyond Tau and TDP-43.

Published in:

Journal of Molecular Neuroscience, 2011, v. 45, n. 3, p. 402, doi. 10.1007/s12031-011-9551-1

By:

Mackenzie, Ian;
Neumann, Manuela;
Cairns, Nigel;
Munoz, David;
Isaacs, Adrian

Publication type:

Article

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17.

Published in:

Nature, 1998, v. 393, n. 6686, p. 702, doi. 10.1038/31508

By:

Hutton, Mike;
Lendon, Corinne L.;
Rizzu, Patrizia;
Baker, Matt;
Froelich, Susanne;
Houlden, Henry;
Pickering-Brown, Stuart;
Chakraverty, Sumi;
Isaacs, Adrian;
Grover, Andrew;
Hackett, Jennifer;
Adamson, Jennifer;
Lincoln, Sarah;
Dickson, Dennis;
Davies, Peter;
Petersen, Ronald C.;
Stevens, Martijn;
de Graaff, Esther;
Wauters, Erwin;
van Baren, Jeltje

Publication type:

Article

Humoral response to neurofilaments and dipeptide repeats in ALS progression.

Published in:

Annals of Clinical & Translational Neurology, 2021, v. 8, n. 9, p. 1831, doi. 10.1002/acn3.51428

By:

Puentes, Fabiola;
Lombardi, Vittoria;
Lu, Ching‐Hua;
Yildiz, Ozlem;
Fratta, Pietro;
Isaacs, Adrian;
Bobeva, Yoana;
Wuu, Joanne;
Benatar, Michael;
Malaspina, Andrea

Publication type:

Article

Evolution of the Aging Brain Transcriptome and Synaptic Regulation.

Published in:

PLoS ONE, 2008, v. 3, n. 10, p. 1, doi. 10.1371/journal.pone.0003329

By:

Loerch, Patrick M.;
Tao Lu;
Dakin, Kelly A.;
Vann, James M.;
Isaacs, Adrian;
Geula, Chengiz;
Jianbin Wang;
Ying Pan;
Gabuzda, Dana H.;
Cheng Li;
Prolla, Tomas A.;
Yankner, Bruce A.

Publication type:

Article

Dysregulation in Subcellular Localization of Myelin Basic Protein mRNA Does Not Result in Altered Myelination in Amyotrophic Lateral Sclerosis.

Published in:

Frontiers in Neuroscience, 2021, v. 15, p. 1, doi. 10.3389/fnins.2021.705306

By:

Barton, Samantha K.;
Gregory, Jenna M.;
Selvaraj, Bhuvaneish T.;
McDade, Karina;
Henstridge, Christopher M.;
Spires-Jones, Tara L.;
James, Owen G.;
Mehta, Arpan R.;
Story, David;
Burr, Karen;
Magnani, Dario;
Isaacs, Adrian M.;
Smith, Colin;
Chandran, Siddharthan

Publication type:

Article

Opinion: more mouse models and more translation needed for ALS.

Published in:

Molecular Neurodegeneration, 2023, v. 18, n. 1, p. 1, doi. 10.1186/s13024-023-00619-2

By:

Fisher, Elizabeth M.C.;
Greensmith, Linda;
Malaspina, Andrea;
Fratta, Pietro;
Hanna, Michael G.;
Schiavo, Giampietro;
Isaacs, Adrian M.;
Orrell, Richard W.;
Cunningham, Thomas J.;
Arozena, Abraham Acevedo

Publication type:

Article

A monocarboxylate transporter rescues frontotemporal dementia and Alzheimer's disease models.

Published in:

PLoS Genetics, 2023, v. 19, n. 9, p. 1, doi. 10.1371/journal.pgen.1010893

By:

Xu, Dongwei;
Vincent, Alec;
González-Gutiérrez, Andrés;
Aleyakpo, Benjamin;
Anoar, Sharifah;
Giblin, Ashling;
Atilano, Magda L.;
Adams, Mirjam;
Shen, Dunxin;
Thoeng, Annora;
Tsintzas, Elli;
Maeland, Marie;
Isaacs, Adrian M.;
Sierralta, Jimena;
Niccoli, Teresa

Publication type:

Article