Works by Irwin, Nigel

Results: 74

Enzymatically stable analogue of the gut‐derived peptide xenin on beta‐cell transdifferentiation in high fat fed and insulin‐deficient Ins1Cre/+;Rosa26‐eYFP mice.
Published in:
Diabetes/Metabolism Research & Reviews, 2021, v. 37, n. 3, p. 1, doi. 10.1002/dmrr.3384
By:
- Tanday, Neil;
- Moffett, R. Charlotte;
- Gault, Victor A.;
- Flatt, Peter R.;
- Irwin, Nigel
Publication type:
Article
Exendin-4(Lys27 PAL)/gastrin/xenin-8-Gln: A novel acylated GLP-1/gastrin/xenin hybrid peptide that improves metabolic status in obese-diabetic (ob/ob) mice.
Published in:
2019
By:
- Hasib, Annie;
- Ng, Ming T.;
- Tanday, Neil;
- Craig, Sarah L.;
- Gault, Victor A.;
- Flatt, Peter R.;
- Irwin, Nigel
Publication type:
journal article
Emerging therapeutic potential for xenin and related peptides in obesity and diabetes.
Published in:
2018
By:
- Craig, Sarah L.;
- Gault, Victor A.;
- Irwin, Nigel
Publication type:
journal article
Positive effects of GLP-1 receptor activation with liraglutide on pancreatic islet morphology and metabolic control in C57BL/KsJ db/ db mice with degenerative diabetes.
Published in:
Diabetes/Metabolism Research & Reviews, 2015, v. 31, n. 3, p. 248, doi. 10.1002/dmrr.2608
By:
- Moffett, Rachel Charlotte;
- Patterson, Steven;
- Irwin, Nigel;
- Flatt, Peter R.
Publication type:
Article
Comparative Effects of GLP-1 and GLP-2 on Beta-Cell Function, Glucose Homeostasis and Appetite Regulation.
Published in:
Biomolecules (2218-273X), 2024, v. 14, n. 12, p. 1520, doi. 10.3390/biom14121520
By:
- Ali, Asif;
- Khan, Dawood;
- Dubey, Vaibhav;
- Tarasov, Andrei I.;
- Flatt, Peter R.;
- Irwin, Nigel
Publication type:
Article
Cafeteria diet compromises natural adaptations of islet cell transdifferentiation and turnover in pregnancy.
Published in:
Diabetic Medicine, 2025, v. 42, n. 1, p. 1, doi. 10.1111/dme.15434
By:
- Dubey, Vaibhav;
- Tanday, Neil;
- Irwin, Nigel;
- Tarasov, Andrei I.;
- Flatt, Peter R.;
- Moffett, R. Charlotte
Publication type:
Article
Amplifying the antidiabetic actions of glucagon‐like peptide‐1: Potential benefits of new adjunct therapies.
Published in:
Diabetic Medicine, 2021, v. 38, n. 12, p. 1, doi. 10.1111/dme.14699
By:
- Tanday, Neil;
- Flatt, Peter R.;
- Irwin, Nigel
Publication type:
Article
Short-term CFTR inhibition reduces islet area in C57BL/6 mice.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-47745-w
By:
- Khan, Dawood;
- Kelsey, Ryan;
- Maheshwari, Rashmi R.;
- Stone, Virginia M.;
- Hasib, Annie;
- Manderson Koivula, Fiona N.;
- Watson, Aoife;
- Harkin, Stephen;
- Irwin, Nigel;
- Shaw, James A.;
- McClenaghan, Neville H.;
- Venglovecz, Viktória;
- Ébert, Attila;
- Flodström-Tullberg, Malin;
- White, Michael G.;
- Kelly, Catriona
Publication type:
Article
Comparison of the subchronic antidiabetic effects of DPP IV-resistant GIP and GLP-1 analogues in obese diabetic ( ob/ob) mice.
Published in:
Journal of Peptide Science, 2007, v. 13, n. 6, p. 400, doi. 10.1002/psc.861
By:
- Irwin, Nigel;
- McClean, Paula L.;
- Flatt, Peter R.
Publication type:
Article
Gut-Derived Peptide Hormone Analogues and Potential Treatment of Bone Disorders in Obesity and Diabetes Mellitus.
Published in:
Clinical Medicine Insights: Endocrinology & Diabetes, 2024, p. 1, doi. 10.1177/11795514241238059
By:
- Ali, Asif;
- Flatt, Peter R;
- Irwin, Nigel
Publication type:
Article
Potential Therapeutic Role for Apelin and Related Peptides in Diabetes: An Update.
Published in:
Clinical Medicine Insights: Endocrinology & Diabetes, 2022, p. 1, doi. 10.1177/11795514221074679
By:
- Palmer, Ethan S;
- Irwin, Nigel;
- O'Harte, Finbarr PM
Publication type:
Article
Potential Therapeutic Role for Apelin and Related Peptides in Diabetes: An Update.
Published in:
Clinical Medicine Insights: Endocrinology & Diabetes, 2022, v. 15, p. 1, doi. 10.1177/11795514221074679
By:
- Palmer, Ethan S.;
- Irwin, Nigel;
- O'Harte, Finbarr P. M.
Publication type:
Article
Xenin and Related Peptides: Potential Therapeutic Role in Diabetes and Related Metabolic Disorders.
Published in:
Clinical Medicine Insights: Endocrinology & Diabetes, 2021, p. 1, doi. 10.1177/11795514211043868
By:
- Craig, Sarah L;
- Irwin, Nigel;
- Gault, Victor A
Publication type:
Article
Therapeutic Potential of Peptides Derived from Animal Venoms: Current Views and Emerging Drugs for Diabetes.
Published in:
Clinical Medicine Insights: Endocrinology & Diabetes, 2021, p. 1, doi. 10.1177/11795514211006071
By:
- Coulter-Parkhill, Aimee;
- McClean, Stephen;
- Gault, Victor A;
- Irwin, Nigel
Publication type:
Article
Nonclassical Islet Peptides: Pancreatic and Extrapancreatic Actions.
Published in:
Clinical Medicine Insights: Endocrinology & Diabetes, 2019, v. 12, p. N.PAG, doi. 10.1177/1179551419888871
By:
- English, Andrew;
- Irwin, Nigel
Publication type:
Article
Effects of 2 Novel PYY(1-36) Analogues, (P 3 L 31 P 34)PYY(1-36) and PYY(1-36)(Lys 12 PAL), on Pancreatic Beta-Cell Function, Growth, and Survival.
Published in:
Clinical Medicine Insights: Endocrinology & Diabetes, 2019, v. 12, p. N.PAG, doi. 10.1177/1179551419855626
By:
- Lafferty, Ryan A;
- Gault, Victor A;
- Flatt, Peter R;
- Irwin, Nigel
Publication type:
Article
Effects of 2 Novel PYY(1-36) Analogues, (P 3 L 31 P 34)PYY(1-36) and PYY(1-36)(Lys 12 PAL), on Pancreatic Beta-Cell Function, Growth, and Survival.
Published in:
Clinical Medicine Insights: Endocrinology & Diabetes, 2019, v. 12, p. N.PAG, doi. 10.1177/1179551419855626
By:
- Lafferty, Ryan A;
- Gault, Victor A;
- Flatt, Peter R;
- Irwin, Nigel
Publication type:
Article
A novel neurotensin/xenin fusion peptide enhances ß-cell function and exhibits antidiabetic efficacy in high-fat fed mice.
Published in:
Bioscience Reports, 2021, v. 41, n. 8, p. 1, doi. 10.1042/BSR20211275
By:
- Perry, Rachele A.;
- Craig, Sarah. L.;
- Gault, Victor A.;
- Flatt, Peter R.;
- Irwin, Nigel
Publication type:
Article
Stable Incretin Mimetics Counter Rapid Deterioration of Bone Quality in Type 1 Diabetes Mellitus.
Published in:
Journal of Cellular Physiology, 2015, v. 230, n. 12, p. 3009, doi. 10.1002/jcp.25033
By:
- Mansur, Sity Aishah;
- Mieczkowska, Aleksandra;
- Bouvard, Béatrice;
- Flatt, Peter R.;
- Chappard, Daniel;
- Irwin, Nigel;
- Mabilleau, Guillaume
Publication type:
Article
[P3]PP, a stable, long‐acting pancreatic polypeptide analogue, evokes weight lowering and pancreatic beta‐cell‐protective effects in obesity‐associated diabetes.
Published in:
Diabetes, Obesity & Metabolism, 2024, v. 26, n. 11, p. 4945, doi. 10.1111/dom.15897
By:
- Tanday, Neil;
- Zhu, Wuyun;
- Tarasov, Andrei I.;
- Flatt, Peter R.;
- Irwin, Nigel
Publication type:
Article
Sustained metabolic benefits of ΔTRTX‐Ac1, a tarantula venom‐derived peptide, when administered together with exenatide in high‐fat fed mice.
Published in:
Diabetes, Obesity & Metabolism, 2024, v. 26, n. 1, p. 329, doi. 10.1111/dom.15319
By:
- Coulter‐Parkhill, Aimee;
- Tanday, Neil;
- Cobice, Diego;
- McLaughlin, Christopher M.;
- McClean, Stephen;
- Gault, Victor A.;
- Irwin, Nigel
Publication type:
Article
Pancreatic islet cell plasticity: Pathogenic or therapeutically exploitable?
Published in:
Diabetes, Obesity & Metabolism, 2024, v. 26, n. 1, p. 16, doi. 10.1111/dom.15300
By:
- Tanday, Neil;
- Tarasov, Andrei I.;
- Moffett, R. Charlotte;
- Flatt, Peter R.;
- Irwin, Nigel
Publication type:
Article
Beneficial metabolic effects of recurrent periods of beta‐cell rest and stimulation using stable neuropeptide Y1 and glucagon‐like peptide‐1 receptor agonists.
Published in:
Diabetes, Obesity & Metabolism, 2022, v. 24, n. 12, p. 2353, doi. 10.1111/dom.14821
By:
- Tanday, Neil;
- Lafferty, Ryan A.;
- Flatt, Peter R.;
- Irwin, Nigel
Publication type:
Article
Weight‐reducing, lipid‐lowering and antidiabetic activities of a novel arginine vasopressin analogue acting at the V1a and V1b receptors in high‐fat‐fed mice.
Published in:
Diabetes, Obesity & Metabolism, 2021, v. 23, n. 10, p. 2215, doi. 10.1111/dom.14462
By:
- Mohan, Shruti;
- Flatt, Peter R.;
- Irwin, Nigel;
- Moffett, R. Charlotte
Publication type:
Article
Beneficial actions of a long‐acting apelin analogue in diabetes are related to positive effects on islet cell turnover and transdifferentiation.
Published in:
Diabetes, Obesity & Metabolism, 2020, v. 22, n. 12, p. 2468, doi. 10.1111/dom.14177
By:
- Tanday, Neil;
- Irwin, Nigel;
- Moffett, R. Charlotte;
- Flatt, Peter R.;
- O'Harte, Finbarr P. M.
Publication type:
Article
Peptide YY (1–36) peptides from phylogenetically ancient fish targeting mammalian neuropeptide Y1 receptors demonstrate potent effects on pancreatic β‐cell function, growth and survival.
Published in:
Diabetes, Obesity & Metabolism, 2020, v. 22, n. 3, p. 404, doi. 10.1111/dom.13908
By:
- Lafferty, Ryan A.;
- Tanday, Neil;
- McCloskey, Andrew;
- Bompada, Pradeep;
- De Marinis, Yang;
- Flatt, Peter R.;
- Irwin, Nigel
Publication type:
Article
Development of a First‐in‐Class Unimolecular Dual GIP/GLP‐2 Analogue, GL‐0001, for the Treatment of Bone Fragility.
Published in:
Journal of Bone & Mineral Research, 2023, v. 38, n. 5, p. 733, doi. 10.1002/jbmr.4792
By:
- Gobron, Benoit;
- Couchot, Malory;
- Irwin, Nigel;
- Legrand, Erick;
- Bouvard, Béatrice;
- Mabilleau, Guillaume
Publication type:
Article
Enteroendocrine K Cells Exert Complementary Effects to Control Bone Quality and Mass in Mice.
Published in:
Journal of Bone & Mineral Research, 2020, v. 35, n. 7, p. 1363, doi. 10.1002/jbmr.4004
By:
- Gobron, Benoît;
- Bouvard, Béatrice;
- Vyavahare, Sagar;
- Blom, Liv VV;
- Pedersen, Kristian K;
- Windeløv, Johanne A;
- Boer, Geke A;
- Harada, Norio;
- Zhang, Sheng;
- Shimazu‐Kuwahara, Satoko;
- Wice, Burton;
- Inagaki, Nobuya;
- Legrand, Erick;
- Flatt, Peter R;
- Chappard, Daniel;
- Hartmann, Bolette;
- Holst, Jens J;
- Rosenkilde, Mette M;
- Irwin, Nigel;
- Mabilleau, Guillaume
Publication type:
Article
Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro3)GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-related diabetes.
Published in:
2005
By:
- Gault VA;
- Irwin N;
- Green BD;
- McCluskey JT;
- Greer B;
- Bailey CJ;
- Harriott P;
- O'Harte FPM;
- Flatt PR;
- Gault, Victor A;
- Irwin, Nigel;
- Green, Brian D;
- McCluskey, Jane T;
- Greer, Brett;
- Bailey, Clifford J;
- Harriott, Patrick;
- O'harte, Finbarr P M;
- Flatt, Peter R
Publication type:
journal article
Chemical Ablation of Gastric Inhibitory Polypeptide Receptor Action by Daily (Pro3)GIP Administration Improves Glucose Tolerance and Ameliorates Insulin Resistance and Abnormalities of Islet Structure in Obesity-Related Diabetes.
Published in:
Diabetes, 2005, v. 54, n. 8, p. 2436, doi. 10.2337/diabetes.54.8.2436
By:
- Gault, Victor A.;
- Irwin, Nigel;
- Green, Brian D.;
- McCluskey, Jane T.;
- Greer, Brett;
- Bailey, Clifford J.;
- Harriott, Patrick;
- O'Harte, Finbarr P. M.;
- Flatt, Peter R.
Publication type:
Article
Individual and combined effects of GIP and xenin on differentiation, glucose uptake and lipolysis in 3T3-L1 adipocytes.
Published in:
Biological Chemistry, 2020, v. 401, n. 11, p. 1293, doi. 10.1515/hsz-2020-0195
By:
- English, Andrew;
- Craig, Sarah L.;
- Flatt, Peter R.;
- Irwin, Nigel
Publication type:
Article
Locally produced xenin and the neurotensinergic system in pancreatic islet function and β-cell survival.
Published in:
Biological Chemistry, 2018, v. 399, n. 1, p. 79, doi. 10.1515/hsz-2017-0136
By:
- Khan, Dawood;
- Vasu, Srividya;
- Moffett, R. Charlotte;
- Gault, Victor A.;
- Flatt, Peter R.;
- Irwin, Nigel
Publication type:
Article
Effects of short-term chemical ablation of glucagon signalling by peptide-based glucagon receptor antagonists on insulin secretion and glucose homeostasis in mice.
Published in:
Biological Chemistry, 2014, v. 395, n. 4, p. 433, doi. 10.1515/hsz-2013-0224
By:
- Franklin, Zara J.;
- O'Harte, Finbarr P.M.;
- Irwin, Nigel
Publication type:
Article
Insulin modulates glucose-dependent insulinotropic polypeptide (GIP) secretion from enteroendocrine K cells in rats.
Published in:
Biological Chemistry, 2011, v. 392, n. 10, p. 909, doi. 10.1515/BC.2011.176
By:
- Irwin, Nigel;
- Francis, Jacqueline M.E.;
- Flatt, Peter R.
Publication type:
Article
Metabolic responses and benefits of glucagon‐like peptide‐1 (GLP‐1) receptor ligands.
Published in:
British Journal of Pharmacology, 2022, v. 179, n. 4, p. 526, doi. 10.1111/bph.15485
By:
- Tanday, Neil;
- Flatt, Peter R.;
- Irwin, Nigel
Publication type:
Article
The GLP-1 Receptor Agonist Exenatide Ameliorates Bone Composition and Tissue Material Properties in High Fat Fed Diabetic Mice.
Published in:
Frontiers in Endocrinology, 2019, p. N.PAG, doi. 10.3389/fendo.2019.00051
By:
- Mansur, Sity Aishah;
- Mieczkowska, Aleksandra;
- Flatt, Peter R.;
- Chappard, Daniel;
- Irwin, Nigel;
- Mabilleau, Guillaume
Publication type:
Article
Biological Activity and Antidiabetic Potential of C-Terminal Octapeptide Fragments of the Gut-Derived Hormone Xenin.
Published in:
PLoS ONE, 2016, v. 11, n. 3, p. 1, doi. 10.1371/journal.pone.0152818
By:
- Martin, Christine M.;
- Parthsarathy, Vadivel;
- Hasib, Annie;
- Ng, Ming T.;
- McClean, Stephen;
- Flatt, Peter R.;
- Gault, Victor A.;
- Irwin, Nigel
Publication type:
Article
Gastric Inhibitory Polypeptide (GIP) Is Selectively Decreased in the Roux-Limb of Dietary Obese Mice after RYGB Surgery.
Published in:
PLoS ONE, 2015, v. 10, n. 8, p. 1, doi. 10.1371/journal.pone.0134728
By:
- Zhou, Jiaqiang;
- Hao, Zheng;
- Irwin, Nigel;
- Berthoud, Hans-Rudolf;
- Ye, Jianping
Publication type:
Article
Dopamine signalling in pancreatic islet cells and role in adaptations to metabolic stress.
Published in:
Journal of Pharmacy & Pharmacology, 2024, v. 76, n. 7, p. 861, doi. 10.1093/jpp/rgae049
By:
- Sridhar, Ananyaa;
- Flatt, Peter R;
- Draper, Matthew;
- Tarasov, Andrei I;
- Moffett, R Charlotte;
- Irwin, Nigel;
- Khan, Dawood
Publication type:
Article
Effects of artemether on pancreatic islet morphology, islet cell turnover and α-cell transdifferentiation in insulin-deficient GluCreERT2;ROSA26-eYFP diabetic mice.
Published in:
Journal of Pharmacy & Pharmacology, 2022, v. 74, n. 12, p. 1758, doi. 10.1093/jpp/rgac075
By:
- Sarnobat, Dipak;
- Lafferty, Ryan A;
- Charlotte Moffett, R;
- Tarasov, Andrei I;
- Flatt, Peter R;
- Irwin, Nigel
Publication type:
Article
Benefits of Sustained Upregulated Unimolecular GLP-1 and CCK Receptor Signalling in Obesity-Diabetes.
Published in:
Frontiers in Endocrinology, 2022, v. 13, p. 1, doi. 10.3389/fendo.2021.674704
By:
- Tanday, Neil;
- English, Andrew;
- Lafferty, Ryan A.;
- Flatt, Peter R.;
- Irwin, Nigel
Publication type:
Article
Proglucagon-Derived Peptides as Therapeutics.
Published in:
Frontiers in Endocrinology, 2021, v. 11, p. N.PAG, doi. 10.3389/fendo.2021.689678
By:
- Lafferty, Ryan A.;
- O'Harte, Finbarr P. M.;
- Irwin, Nigel;
- Gault, Victor A.;
- Flatt, Peter R.
Publication type:
Article
Benefits of Sustained Upregulated Unimolecular GLP-1 and CCK Receptor Signalling in Obesity-Diabetes.
Published in:
Frontiers in Endocrinology, 2021, v. 11, p. N.PAG, doi. 10.3389/fendo.2021.674704
By:
- Tanday, Neil;
- English, Andrew;
- Lafferty, Ryan A.;
- Flatt, Peter R.;
- Irwin, Nigel
Publication type:
Article
(D-Ser2)Oxm[Lys38-γ-glu-PAL] improves hippocampal gene expression and cognition in a mouse model of type 1 diabetes.
Published in:
Journal of Experimental & Integrative Medicine, 2016, v. 6, n. 1, p. 1, doi. 10.5455/jeim.050216.br.027
By:
- Pathak, Nupur Madhur;
- Irwin, Nigel;
- Pathak, Varun;
- Gault, Victor Alan;
- Flatt, Peter Raymond
Publication type:
Article
Novel enzyme‐resistant pancreatic polypeptide analogs evoke pancreatic beta‐cell rest, enhance islet cell turnover, and inhibit food intake in mice.
Published in:
Biofactors, 2024, v. 50, n. 6, p. 1101, doi. 10.1002/biof.2059
By:
- Zhu, Wuyun;
- Tanday, Neil;
- Lafferty, Ryan A.;
- Flatt, Peter R.;
- Irwin, Nigel
Publication type:
Article
Synthesis and Evaluation of a Series of Long-Acting Glucagon-Like Peptide-1 (GLP-1) Pentasaccharide Conjugates for the Treatment of Type 2 Diabetes.
Published in:
ChemMedChem, 2015, v. 10, n. 8, p. 1424, doi. 10.1002/cmdc.201500140
By:
- Irwin, Nigel;
- Patterson, Steven;
- de Kort, Martin;
- Moffett, R. Charlotte;
- Wisse, Jeffry A. J.;
- Dokter, Wim H. A.;
- Bos, Ebo S.;
- Miltenburg, André M. M.;
- Flatt, Peter R.
Publication type:
Article
Comparison of the anti-diabetic effects of GIP- and GLP-1-receptor activation in obese diabetic ( ob/ob) mice: studies with DPP IV resistant N-AcGIP and exendin(1-39)amide.
Published in:
Diabetes/Metabolism Research & Reviews, 2007, v. 23, n. 7, p. 572, doi. 10.1002/dmrr.729
By:
- Irwin, Nigel;
- McClean, Paula L.;
- Cassidy, Roslyn S.;
- O'Harte, Finbarr P. M.;
- Green, Brian D.;
- Gault, Victor A.;
- Harriott, Patrick;
- Flatt, Peter R.
Publication type:
Article
Effect of poly(ethylene glycol) content and formulation parameters on particulate properties and intraperitoneal delivery of insulin from PLGA nanoparticles prepared using the double-emulsion evaporation procedure.
Published in:
Pharmaceutical Development & Technology, 2018, v. 23, n. 4, p. 370, doi. 10.1080/10837450.2017.1295066
By:
- Haggag, Yusuf A.;
- Faheem, Ahmed M.;
- Tambuwala, Murtaza M.;
- Osman, Mohamed A.;
- El-Gizawy, Sanaa A.;
- O’Hagan, Barry;
- Irwin, Nigel;
- McCarron, Paul A.
Publication type:
Article
Positive Effects of NPY1 Receptor Activation on Islet Structure Are Driven by Pancreatic Alpha- and Beta-Cell Transdifferentiation in Diabetic Mice.
Published in:
Frontiers in Endocrinology, 2021, v. 11, p. N.PAG, doi. 10.3389/fendo.2021.633625
By:
- Lafferty, Ryan A.;
- Tanday, Neil;
- Moffett, R. Charlotte;
- Reimann, Frank;
- Gribble, Fiona M.;
- Flatt, Peter R.;
- Irwin, Nigel
Publication type:
Article
RYGB surgery has modest effects on intestinal morphology and gut hormone populations in the bypassed biliopancreatic limb but causes reciprocal changes in GLP-2 and PYY in the alimentary limb.
Published in:
PLoS ONE, 2023, v. 18, n. 5, p. 1, doi. 10.1371/journal.pone.0286062
By:
- Sridhar, Ananyaa;
- Khan, Dawood;
- Elliott, Jessie A.;
- Naughton, Violetta;
- Flatt, Peter R.;
- Irwin, Nigel;
- Moffett, Charlotte R.
Publication type:
Article