Works matching AU Irwin, Nigel

Results: 76

Cafeteria diet compromises natural adaptations of islet cell transdifferentiation and turnover in pregnancy.

Published in:

Diabetic Medicine, 2025, v. 42, n. 1, p. 1, doi. 10.1111/dme.15434

By:

Dubey, Vaibhav;
Tanday, Neil;
Irwin, Nigel;
Tarasov, Andrei I.;
Flatt, Peter R.;
Moffett, R. Charlotte

Publication type:

Article

Amplifying the antidiabetic actions of glucagon‐like peptide‐1: Potential benefits of new adjunct therapies.

Published in:

Diabetic Medicine, 2021, v. 38, n. 12, p. 1, doi. 10.1111/dme.14699

By:

Tanday, Neil;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Proglucagon-Derived Peptides as Therapeutics.

Published in:

Frontiers in Endocrinology, 2021, v. 11, p. N.PAG, doi. 10.3389/fendo.2021.689678

By:

Lafferty, Ryan A.;
O'Harte, Finbarr P. M.;
Irwin, Nigel;
Gault, Victor A.;
Flatt, Peter R.

Publication type:

Article

Benefits of Sustained Upregulated Unimolecular GLP-1 and CCK Receptor Signalling in Obesity-Diabetes.

Published in:

Frontiers in Endocrinology, 2021, v. 11, p. N.PAG, doi. 10.3389/fendo.2021.674704

By:

Tanday, Neil;
English, Andrew;
Lafferty, Ryan A.;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Positive Effects of NPY1 Receptor Activation on Islet Structure Are Driven by Pancreatic Alpha- and Beta-Cell Transdifferentiation in Diabetic Mice.

Published in:

Frontiers in Endocrinology, 2021, v. 11, p. N.PAG, doi. 10.3389/fendo.2021.633625

By:

Lafferty, Ryan A.;
Tanday, Neil;
Moffett, R. Charlotte;
Reimann, Frank;
Gribble, Fiona M.;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

The Beneficial Impact of a Novel Pancreatic Polypeptide Analogue on Islet Cell Lineage.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 9, p. 4215, doi. 10.3390/ijms26094215

By:

Zhu, Wuyun;
Tanday, Neil;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

An enzymatically stable GIP/xenin hybrid peptide restores GIP sensitivity, enhances beta cell function and improves glucose homeostasis in high-fat-fed mice.

Published in:

Diabetologia, 2017, v. 60, n. 3, p. 541, doi. 10.1007/s00125-016-4186-y

By:

Hasib, Annie;
Ng, Ming;
Gault, Victor;
Khan, Dawood;
Parthsarathy, Vadivel;
Flatt, Peter;
Irwin, Nigel

Publication type:

Article

Sequential induction of beta cell rest and stimulation using stable GIP inhibitor and GLP-1 mimetic peptides improves metabolic control in C57BL/KsJ db/db mice.

Published in:

Diabetologia, 2015, v. 58, n. 9, p. 2144, doi. 10.1007/s00125-015-3653-1

By:

Pathak, Varun;
Vasu, Srividya;
Gault, Victor;
Flatt, Peter;
Irwin, Nigel

Publication type:

Article

A novel DPP IV-resistant C-terminally extended glucagon analogue exhibits weight-lowering and diabetes-protective effects in high-fat-fed mice mediated through glucagon and GLP-1 receptor activation.

Published in:

Diabetologia, 2014, v. 57, n. 9, p. 1927, doi. 10.1007/s00125-014-3296-7

By:

Lynch, Aisling;
Pathak, Nupur;
Pathak, Varun;
O'Harte, Finbarr;
Flatt, Peter;
Irwin, Nigel;
Gault, Victor

Publication type:

Article

[P3]PP, a stable, long‐acting pancreatic polypeptide analogue, evokes weight lowering and pancreatic beta‐cell‐protective effects in obesity‐associated diabetes.

Published in:

Diabetes, Obesity & Metabolism, 2024, v. 26, n. 11, p. 4945, doi. 10.1111/dom.15897

By:

Tanday, Neil;
Zhu, Wuyun;
Tarasov, Andrei I.;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Sustained metabolic benefits of ΔTRTX‐Ac1, a tarantula venom‐derived peptide, when administered together with exenatide in high‐fat fed mice.

Published in:

Diabetes, Obesity & Metabolism, 2024, v. 26, n. 1, p. 329, doi. 10.1111/dom.15319

By:

Coulter‐Parkhill, Aimee;
Tanday, Neil;
Cobice, Diego;
McLaughlin, Christopher M.;
McClean, Stephen;
Gault, Victor A.;
Irwin, Nigel

Publication type:

Article

Pancreatic islet cell plasticity: Pathogenic or therapeutically exploitable?

Published in:

Diabetes, Obesity & Metabolism, 2024, v. 26, n. 1, p. 16, doi. 10.1111/dom.15300

By:

Tanday, Neil;
Tarasov, Andrei I.;
Moffett, R. Charlotte;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Beneficial metabolic effects of recurrent periods of beta‐cell rest and stimulation using stable neuropeptide Y1 and glucagon‐like peptide‐1 receptor agonists.

Published in:

Diabetes, Obesity & Metabolism, 2022, v. 24, n. 12, p. 2353, doi. 10.1111/dom.14821

By:

Tanday, Neil;
Lafferty, Ryan A.;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Weight‐reducing, lipid‐lowering and antidiabetic activities of a novel arginine vasopressin analogue acting at the V1a and V1b receptors in high‐fat‐fed mice.

Published in:

Diabetes, Obesity & Metabolism, 2021, v. 23, n. 10, p. 2215, doi. 10.1111/dom.14462

By:

Mohan, Shruti;
Flatt, Peter R.;
Irwin, Nigel;
Moffett, R. Charlotte

Publication type:

Article

Beneficial actions of a long‐acting apelin analogue in diabetes are related to positive effects on islet cell turnover and transdifferentiation.

Published in:

Diabetes, Obesity & Metabolism, 2020, v. 22, n. 12, p. 2468, doi. 10.1111/dom.14177

By:

Tanday, Neil;
Irwin, Nigel;
Moffett, R. Charlotte;
Flatt, Peter R.;
O'Harte, Finbarr P. M.

Publication type:

Article

Peptide YY (1–36) peptides from phylogenetically ancient fish targeting mammalian neuropeptide Y1 receptors demonstrate potent effects on pancreatic β‐cell function, growth and survival.

Published in:

Diabetes, Obesity & Metabolism, 2020, v. 22, n. 3, p. 404, doi. 10.1111/dom.13908

By:

Lafferty, Ryan A.;
Tanday, Neil;
McCloskey, Andrew;
Bompada, Pradeep;
De Marinis, Yang;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Comparison of the subchronic antidiabetic effects of DPP IV-resistant GIP and GLP-1 analogues in obese diabetic ( ob/ob) mice.

Published in:

Journal of Peptide Science, 2007, v. 13, n. 6, p. 400, doi. 10.1002/psc.861

By:

Irwin, Nigel;
McClean, Paula L.;
Flatt, Peter R.

Publication type:

Article

Potential Therapeutic Role for Apelin and Related Peptides in Diabetes: An Update.

Published in:

Clinical Medicine Insights: Endocrinology & Diabetes, 2022, p. 1, doi. 10.1177/11795514221074679

By:

Palmer, Ethan S;
Irwin, Nigel;
O'Harte, Finbarr PM

Publication type:

Article

Potential Therapeutic Role for Apelin and Related Peptides in Diabetes: An Update.

Published in:

Clinical Medicine Insights: Endocrinology & Diabetes, 2022, v. 15, p. 1, doi. 10.1177/11795514221074679

By:

Palmer, Ethan S.;
Irwin, Nigel;
O'Harte, Finbarr P. M.

Publication type:

Article

Xenin and Related Peptides: Potential Therapeutic Role in Diabetes and Related Metabolic Disorders.

Published in:

Clinical Medicine Insights: Endocrinology & Diabetes, 2021, p. 1, doi. 10.1177/11795514211043868

By:

Craig, Sarah L;
Irwin, Nigel;
Gault, Victor A

Publication type:

Article

Therapeutic Potential of Peptides Derived from Animal Venoms: Current Views and Emerging Drugs for Diabetes.

Published in:

Clinical Medicine Insights: Endocrinology & Diabetes, 2021, p. 1, doi. 10.1177/11795514211006071

By:

Coulter-Parkhill, Aimee;
McClean, Stephen;
Gault, Victor A;
Irwin, Nigel

Publication type:

Article

Nonclassical Islet Peptides: Pancreatic and Extrapancreatic Actions.

Published in:

Clinical Medicine Insights: Endocrinology & Diabetes, 2019, v. 12, p. N.PAG, doi. 10.1177/1179551419888871

By:

English, Andrew;
Irwin, Nigel

Publication type:

Article

Effects of 2 Novel PYY(1-36) Analogues, (P 3 L 31 P 34)PYY(1-36) and PYY(1-36)(Lys 12 PAL), on Pancreatic Beta-Cell Function, Growth, and Survival.

Published in:

Clinical Medicine Insights: Endocrinology & Diabetes, 2019, v. 12, p. N.PAG, doi. 10.1177/1179551419855626

By:

Lafferty, Ryan A;
Gault, Victor A;
Flatt, Peter R;
Irwin, Nigel

Publication type:

Article

Effects of 2 Novel PYY(1-36) Analogues, (P 3 L 31 P 34)PYY(1-36) and PYY(1-36)(Lys 12 PAL), on Pancreatic Beta-Cell Function, Growth, and Survival.

Published in:

Clinical Medicine Insights: Endocrinology & Diabetes, 2019, v. 12, p. N.PAG, doi. 10.1177/1179551419855626

By:

Lafferty, Ryan A;
Gault, Victor A;
Flatt, Peter R;
Irwin, Nigel

Publication type:

Article

Gastric Inhibitory Polypeptide (GIP) Is Selectively Decreased in the Roux-Limb of Dietary Obese Mice after RYGB Surgery.

Published in:

PLoS ONE, 2015, v. 10, n. 8, p. 1, doi. 10.1371/journal.pone.0134728

By:

Zhou, Jiaqiang;
Hao, Zheng;
Irwin, Nigel;
Berthoud, Hans-Rudolf;
Ye, Jianping

Publication type:

Article

Alterations of Glucose-Dependent Insulinotropic Polypeptide and Expression of Genes Involved in Mammary Gland and Adipose Tissue Lipid Metabolism during Pregnancy and Lactation.

Published in:

PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0078560

By:

Moffett, R. Charlotte;
Irwin, Nigel;
Francis, Jacqueline M. E.;
Flatt, Peter R.

Publication type:

Article

Fertility and Pregnancy-Associated Β-Cell Proliferation in Mice Deficient in Proglucagon-Derived Peptides.

Published in:

PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0043745

By:

Sugiyama, Chisato;
Yamamoto, Michiyo;
Kotani, Tomomi;
Kikkawa, Fumitaka;
Murata, Yoshiharu;
Hayashi, Yoshitaka;
Irwin, Nigel

Publication type:

Article

Duodenal Enteroendocrine I-Cells Contain mRNA Transcripts Encoding Key Endocannabinoid and Fatty Acid Receptors.

Published in:

PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0042373

By:

Sykaras, Alexandros G.;
Demenis, Claire;
Case, R. Maynard;
McLaughlin, John T.;
Smith, Craig P.;
Irwin, Nigel

Publication type:

Article

Antidiabetic potential of two novel fatty acid derivatised, N-terminally modified analogues of glucose-dependent insulinotropic polypeptide (GIP): N-AcGIP(LysPAL16) and N-AcGIP(LysPAL37).

Published in:

Biological Chemistry, 2005, v. 386, n. 7, p. 679, doi. 10.1515/BC.2005.079

By:

Irwin, Nigel;
Gault, Victor A.;
Green, Brian D.;
Greer, Brett;
Harriott, Patrick;
Bailey, Clifford J.;
Flatt, Peter R.;
O'Harte, Finbarr P.M.

Publication type:

Article

Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice.

Published in:

Biological Chemistry, 2004, v. 385, n. 9, p. 845, doi. 10.1515/BC.2004.110

By:

Irwin, Nigel;
Gault, Victor A.;
Green, Brian D.;
Greer, Brett;
McCluskey, Jane T.;
Harriott, Patrick;
O'Harte, Finbarr P. M.;
Flatt, Peter R.

Publication type:

Article

Degradation, receptor binding, insulin secreting and antihyperglycaemic actions of palmitate-derivatised native and Ala8 -substituted GLP-1 analogues.

Published in:

Biological Chemistry, 2004, v. 385, n. 2, p. 169, doi. 10.1515/BC.2004.035

By:

Green, Brian D.;
Gault, Victor A.;
Mooney, Mark H.;
Irwin, Nigel;
Harriott, Patrick;
Greer, Brett;
Bailey, Cliff J.;
O'Harte, Finbarr P. M.;
Flatt, Peter R.

Publication type:

Article

Metabolic Stability, Receptor Binding, cAMP Generation, Insulin Secretion and Antihyperglycaemic Activity of Novel N-Terminal Glu[sup9] -Substituted Analogues of Glucagon-Like Peptide-1.

Published in:

Biological Chemistry, 2003, v. 384, n. 12, p. 1543, doi. 10.1515/BC.2003.171

By:

Green, Brian D.;
Gault, Victor A.;
Irwin, Nigel;
Mooney, Mark H.;
Bailey, Clifford J.;
Harriott, Patrick;
Greer, Brett;
Flatt, Peter R.;
O'Harte, Finbarr P. M.

Publication type:

Article

Comparison of the anti-diabetic effects of GIP- and GLP-1-receptor activation in obese diabetic ( ob/ob) mice: studies with DPP IV resistant N-AcGIP and exendin(1-39)amide.

Published in:

Diabetes/Metabolism Research & Reviews, 2007, v. 23, n. 7, p. 572, doi. 10.1002/dmrr.729

By:

Irwin, Nigel;
McClean, Paula L.;
Cassidy, Roslyn S.;
O'Harte, Finbarr P. M.;
Green, Brian D.;
Gault, Victor A.;
Harriott, Patrick;
Flatt, Peter R.

Publication type:

Article

GLP-1/GIP analogs: potential impact in the landscape of obesity pharmacotherapy.

Published in:

Expert Opinion on Pharmacotherapy, 2023, v. 24, n. 5, p. 587, doi. 10.1080/14656566.2023.2192865

By:

Lafferty, Ryan A.;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Have we got the guts to maintain target weight?

Published in:

Acta Physiologica, 2023, v. 238, n. 1, p. 1, doi. 10.1111/apha.13961

By:

Irwin, Nigel

Publication type:

Article

Benefits of Sustained Upregulated Unimolecular GLP-1 and CCK Receptor Signalling in Obesity-Diabetes.

Published in:

Frontiers in Endocrinology, 2022, v. 13, p. 1, doi. 10.3389/fendo.2021.674704

By:

Tanday, Neil;
English, Andrew;
Lafferty, Ryan A.;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Effect of poly(ethylene glycol) content and formulation parameters on particulate properties and intraperitoneal delivery of insulin from PLGA nanoparticles prepared using the double-emulsion evaporation procedure.

Published in:

Pharmaceutical Development & Technology, 2018, v. 23, n. 4, p. 370, doi. 10.1080/10837450.2017.1295066

By:

Haggag, Yusuf A.;
Faheem, Ahmed M.;
Tambuwala, Murtaza M.;
Osman, Mohamed A.;
El-Gizawy, Sanaa A.;
O’Hagan, Barry;
Irwin, Nigel;
McCarron, Paul A.

Publication type:

Article

Comparative Effects of GLP-1 and GLP-2 on Beta-Cell Function, Glucose Homeostasis and Appetite Regulation.

Published in:

Biomolecules (2218-273X), 2024, v. 14, n. 12, p. 1520, doi. 10.3390/biom14121520

By:

Ali, Asif;
Khan, Dawood;
Dubey, Vaibhav;
Tarasov, Andrei I.;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

(D-Ser2)Oxm[Lys38-γ-glu-PAL] improves hippocampal gene expression and cognition in a mouse model of type 1 diabetes.

Published in:

Journal of Experimental & Integrative Medicine, 2016, v. 6, n. 1, p. 1, doi. 10.5455/jeim.050216.br.027

By:

Pathak, Nupur Madhur;
Irwin, Nigel;
Pathak, Varun;
Gault, Victor Alan;
Flatt, Peter Raymond

Publication type:

Article

The GLP-1 Receptor Agonist Exenatide Ameliorates Bone Composition and Tissue Material Properties in High Fat Fed Diabetic Mice.

Published in:

Frontiers in Endocrinology, 2019, p. N.PAG, doi. 10.3389/fendo.2019.00051

By:

Mansur, Sity Aishah;
Mieczkowska, Aleksandra;
Flatt, Peter R.;
Chappard, Daniel;
Irwin, Nigel;
Mabilleau, Guillaume

Publication type:

Article

Novel enzyme‐resistant pancreatic polypeptide analogs evoke pancreatic beta‐cell rest, enhance islet cell turnover, and inhibit food intake in mice.

Published in:

Biofactors, 2024, v. 50, n. 6, p. 1101, doi. 10.1002/biof.2059

By:

Zhu, Wuyun;
Tanday, Neil;
Lafferty, Ryan A.;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Development of a First‐in‐Class Unimolecular Dual GIP/GLP‐2 Analogue, GL‐0001, for the Treatment of Bone Fragility.

Published in:

Journal of Bone & Mineral Research, 2023, v. 38, n. 5, p. 733, doi. 10.1002/jbmr.4792

By:

Gobron, Benoit;
Couchot, Malory;
Irwin, Nigel;
Legrand, Erick;
Bouvard, Béatrice;
Mabilleau, Guillaume

Publication type:

Article

Enteroendocrine K Cells Exert Complementary Effects to Control Bone Quality and Mass in Mice.

Published in:

Journal of Bone & Mineral Research, 2020, v. 35, n. 7, p. 1363, doi. 10.1002/jbmr.4004

By:

Gobron, Benoît;
Bouvard, Béatrice;
Vyavahare, Sagar;
Blom, Liv VV;
Pedersen, Kristian K;
Windeløv, Johanne A;
Boer, Geke A;
Harada, Norio;
Zhang, Sheng;
Shimazu‐Kuwahara, Satoko;
Wice, Burton;
Inagaki, Nobuya;
Legrand, Erick;
Flatt, Peter R;
Chappard, Daniel;
Hartmann, Bolette;
Holst, Jens J;
Rosenkilde, Mette M;
Irwin, Nigel;
Mabilleau, Guillaume

Publication type:

Article

Stable Incretin Mimetics Counter Rapid Deterioration of Bone Quality in Type 1 Diabetes Mellitus.

Published in:

Journal of Cellular Physiology, 2015, v. 230, n. 12, p. 3009, doi. 10.1002/jcp.25033

By:

Mansur, Sity Aishah;
Mieczkowska, Aleksandra;
Bouvard, Béatrice;
Flatt, Peter R.;
Chappard, Daniel;
Irwin, Nigel;
Mabilleau, Guillaume

Publication type:

Article

Effects of glucose-dependent insulinotropic polypeptide receptor knockout and a high-fat diet on cognitive function and hippocampal gene expression in mice.

Published in:

Molecular Medicine Reports, 2015, v. 12, n. 1, p. 1544, doi. 10.3892/mmr.2015.3447

By:

LENNOX, RACHAEL R.;
MOFFETT, CHARLOTTE;
PORTER, DAVID W.;
IRWIN, NIGEL;
GAULT, VICTOR A.;
FLATT, PETER R.

Publication type:

Article

RYGB surgery has modest effects on intestinal morphology and gut hormone populations in the bypassed biliopancreatic limb but causes reciprocal changes in GLP-2 and PYY in the alimentary limb.

Published in:

PLoS ONE, 2023, v. 18, n. 5, p. 1, doi. 10.1371/journal.pone.0286062

By:

Sridhar, Ananyaa;
Khan, Dawood;
Elliott, Jessie A.;
Naughton, Violetta;
Flatt, Peter R.;
Irwin, Nigel;
Moffett, Charlotte R.

Publication type:

Article

A novel neurotensin/xenin fusion peptide enhances ß-cell function and exhibits antidiabetic efficacy in high-fat fed mice.

Published in:

Bioscience Reports, 2021, v. 41, n. 8, p. 1, doi. 10.1042/BSR20211275

By:

Perry, Rachele A.;
Craig, Sarah. L.;
Gault, Victor A.;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Enzymatically stable analogue of the gut‐derived peptide xenin on beta‐cell transdifferentiation in high fat fed and insulin‐deficient Ins1Cre/+;Rosa26‐eYFP mice.

Published in:

Diabetes/Metabolism Research & Reviews, 2021, v. 37, n. 3, p. 1, doi. 10.1002/dmrr.3384

By:

Tanday, Neil;
Moffett, R. Charlotte;
Gault, Victor A.;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Exendin-4(Lys27 PAL)/gastrin/xenin-8-Gln: A novel acylated GLP-1/gastrin/xenin hybrid peptide that improves metabolic status in obese-diabetic (ob/ob) mice.

Published in:

2019

By:

Hasib, Annie;
Ng, Ming T.;
Tanday, Neil;
Craig, Sarah L.;
Gault, Victor A.;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

journal article

Emerging therapeutic potential for xenin and related peptides in obesity and diabetes.

Published in:

2018

By:

Craig, Sarah L.;
Gault, Victor A.;
Irwin, Nigel

Publication type:

journal article