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An enzymatically stable GIP/xenin hybrid peptide restores GIP sensitivity, enhances beta cell function and improves glucose homeostasis in high-fat-fed mice.
- Published in:
- Diabetologia, 2017, v. 60, n. 3, p. 541, doi. 10.1007/s00125-016-4186-y
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- Publication type:
- Article
Amplifying the antidiabetic actions of glucagon‐like peptide‐1: Potential benefits of new adjunct therapies.
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- Diabetic Medicine, 2021, v. 38, n. 12, p. 1, doi. 10.1111/dme.14699
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- Article
Sustained metabolic benefits of ΔTRTX‐Ac1, a tarantula venom‐derived peptide, when administered together with exenatide in high‐fat fed mice.
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- Diabetes, Obesity & Metabolism, 2024, v. 26, n. 1, p. 329, doi. 10.1111/dom.15319
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- Article
Pancreatic islet cell plasticity: Pathogenic or therapeutically exploitable?
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- Diabetes, Obesity & Metabolism, 2024, v. 26, n. 1, p. 16, doi. 10.1111/dom.15300
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- Article
Beneficial metabolic effects of recurrent periods of beta‐cell rest and stimulation using stable neuropeptide Y1 and glucagon‐like peptide‐1 receptor agonists.
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- Diabetes, Obesity & Metabolism, 2022, v. 24, n. 12, p. 2353, doi. 10.1111/dom.14821
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- Article
Weight‐reducing, lipid‐lowering and antidiabetic activities of a novel arginine vasopressin analogue acting at the V1a and V1b receptors in high‐fat‐fed mice.
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- Diabetes, Obesity & Metabolism, 2021, v. 23, n. 10, p. 2215, doi. 10.1111/dom.14462
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- Article
Beneficial actions of a long‐acting apelin analogue in diabetes are related to positive effects on islet cell turnover and transdifferentiation.
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- Diabetes, Obesity & Metabolism, 2020, v. 22, n. 12, p. 2468, doi. 10.1111/dom.14177
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- Article
Peptide YY (1–36) peptides from phylogenetically ancient fish targeting mammalian neuropeptide Y1 receptors demonstrate potent effects on pancreatic β‐cell function, growth and survival.
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- Diabetes, Obesity & Metabolism, 2020, v. 22, n. 3, p. 404, doi. 10.1111/dom.13908
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- Article
Development of a First‐in‐Class Unimolecular Dual GIP/GLP‐2 Analogue, GL‐0001, for the Treatment of Bone Fragility.
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- Journal of Bone & Mineral Research, 2023, v. 38, n. 5, p. 733, doi. 10.1002/jbmr.4792
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- Article
Enteroendocrine K Cells Exert Complementary Effects to Control Bone Quality and Mass in Mice.
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- Journal of Bone & Mineral Research, 2020, v. 35, n. 7, p. 1363, doi. 10.1002/jbmr.4004
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- Article
Beneficial impact of Ac3IV, an AVP analogue acting specifically at V1a and V1b receptors, on diabetes islet morphology and transdifferentiation of alpha- and beta-cells.
- Published in:
- PLoS ONE, 2021, v. 16, n. 12, p. 1, doi. 10.1371/journal.pone.0261608
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- Article
Erratum. A Novel CCK-8/GLP-1 Hybrid Peptide Exhibiting Prominent Insulinotropic, Glucose-Lowering, and Satiety Actions With Significant Therapeutic Potential in High-Fat-Fed Mice. Diabetes 2015;64:2996-3009.
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- 2016
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- Publication type:
- journal article
A Novel CCK-8/GLP-1 Hybrid Peptide Exhibiting Prominent Insulinotropic, Glucose-Lowering, and Satiety Actions With Significant Therapeutic Potential in High-Fat-Fed Mice.
- Published in:
- 2015
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- Publication type:
- journal article
A Novel CCK-8/GLP-1 Hybrid Peptide Exhibiting Prominent Insulinotropic, Glucose-Lowering, and Satiety Actions With Significant Therapeutic Potential ? in High-Fat-Fed Mice.
- Published in:
- Diabetes, 2015, v. 64, n. 8, p. 2996, doi. 10.2337/db15-0220
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- Article
Unraveling the Mechanisms Underlying Olanzapine-Induced Insulin Resistance.
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- 2013
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- Publication type:
- Opinion
Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro3)GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-related diabetes.
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- 2005
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- Publication type:
- journal article
Chemical Ablation of Gastric Inhibitory Polypeptide Receptor Action by Daily (Pro<sup>3</sup>)GIP Administration Improves Glucose Tolerance and Ameliorates Insulin Resistance and Abnormalities of Islet Structure in Obesity-Related Diabetes.
- Published in:
- Diabetes, 2005, v. 54, n. 8, p. 2436, doi. 10.2337/diabetes.54.8.2436
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- Article
Sitagliptin Alters Bone Composition in High-Fat-Fed Mice.
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- 2019
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- Publication type:
- journal article
(D-Ser2)Oxm[Lys38-γ-glu-PAL] improves hippocampal gene expression and cognition in a mouse model of type 1 diabetes.
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- Journal of Experimental & Integrative Medicine, 2016, v. 6, n. 1, p. 1, doi. 10.5455/jeim.050216.br.027
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- Publication type:
- Article
The GLP-1 Receptor Agonist Exenatide Ameliorates Bone Composition and Tissue Material Properties in High Fat Fed Diabetic Mice.
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- Frontiers in Endocrinology, 2019, p. N.PAG, doi. 10.3389/fendo.2019.00051
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- Publication type:
- Article
Benefits of Sustained Upregulated Unimolecular GLP-1 and CCK Receptor Signalling in Obesity-Diabetes.
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- Frontiers in Endocrinology, 2022, v. 13, p. 1, doi. 10.3389/fendo.2021.674704
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- Article
RYGB surgery has modest effects on intestinal morphology and gut hormone populations in the bypassed biliopancreatic limb but causes reciprocal changes in GLP-2 and PYY in the alimentary limb.
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- PLoS ONE, 2023, v. 17, n. 5, p. 1, doi. 10.1371/journal.pone.0286062
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- Publication type:
- Article
A novel neurotensin/xenin fusion peptide enhances ß-cell function and exhibits antidiabetic efficacy in high-fat fed mice.
- Published in:
- Bioscience Reports, 2021, v. 41, n. 8, p. 1, doi. 10.1042/BSR20211275
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- Article
Dopamine signalling in pancreatic islet cells and role in adaptations to metabolic stress.
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- Journal of Pharmacy & Pharmacology, 2024, v. 76, n. 7, p. 861, doi. 10.1093/jpp/rgae049
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- Publication type:
- Article
Effects of artemether on pancreatic islet morphology, islet cell turnover and α-cell transdifferentiation in insulin-deficient Glu<sup>CreERT2</sup>;ROSA26-eYFP diabetic mice.
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- Journal of Pharmacy & Pharmacology, 2022, v. 74, n. 12, p. 1758, doi. 10.1093/jpp/rgac075
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- Publication type:
- Article
Short-term CFTR inhibition reduces islet area in C57BL/6 mice.
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- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-47745-w
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- Publication type:
- Article
Alterations of Glucose-Dependent Insulinotropic Polypeptide and Expression of Genes Involved in Mammary Gland and Adipose Tissue Lipid Metabolism during Pregnancy and Lactation.
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- PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0078560
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- Article
Fertility and Pregnancy-Associated Β-Cell Proliferation in Mice Deficient in Proglucagon-Derived Peptides.
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- PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0043745
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- Article
Duodenal Enteroendocrine I-Cells Contain mRNA Transcripts Encoding Key Endocannabinoid and Fatty Acid Receptors.
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- PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0042373
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- Publication type:
- Article
Gut-Derived Peptide Hormone Analogues and Potential Treatment of Bone Disorders in Obesity and Diabetes Mellitus.
- Published in:
- Clinical Medicine Insights: Endocrinology & Diabetes, 2024, p. 1, doi. 10.1177/11795514241238059
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- Publication type:
- Article
Synthesis and Evaluation of a Series of Long-Acting Glucagon-Like Peptide-1 (GLP-1) Pentasaccharide Conjugates for the Treatment of Type 2 Diabetes.
- Published in:
- ChemMedChem, 2015, v. 10, n. 8, p. 1424, doi. 10.1002/cmdc.201500140
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- Publication type:
- Article
Exendin-4(Lys<sup>27</sup> PAL)/gastrin/xenin-8-Gln: A novel acylated GLP-1/gastrin/xenin hybrid peptide that improves metabolic status in obese-diabetic (ob/ob) mice.
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- 2019
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- Publication type:
- journal article
Emerging therapeutic potential for xenin and related peptides in obesity and diabetes.
- Published in:
- 2018
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- Publication type:
- journal article
Positive effects of GLP-1 receptor activation with liraglutide on pancreatic islet morphology and metabolic control in C57BL/KsJ db/ db mice with degenerative diabetes.
- Published in:
- Diabetes/Metabolism Research & Reviews, 2015, v. 31, n. 3, p. 248, doi. 10.1002/dmrr.2608
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- Publication type:
- Article
Comparison of the anti-diabetic effects of GIP- and GLP-1-receptor activation in obese diabetic ( ob/ob) mice: studies with DPP IV resistant N-AcGIP and exendin(1-39)amide.
- Published in:
- Diabetes/Metabolism Research & Reviews, 2007, v. 23, n. 7, p. 572, doi. 10.1002/dmrr.729
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- Publication type:
- Article
Sequential induction of beta cell rest and stimulation using stable GIP inhibitor and GLP-1 mimetic peptides improves metabolic control in C57BL/KsJ db/db mice.
- Published in:
- Diabetologia, 2015, v. 58, n. 9, p. 2144, doi. 10.1007/s00125-015-3653-1
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- Publication type:
- Article
A novel DPP IV-resistant C-terminally extended glucagon analogue exhibits weight-lowering and diabetes-protective effects in high-fat-fed mice mediated through glucagon and GLP-1 receptor activation.
- Published in:
- Diabetologia, 2014, v. 57, n. 9, p. 1927, doi. 10.1007/s00125-014-3296-7
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- Publication type:
- Article
Have we got the guts to maintain target weight?
- Published in:
- Acta Physiologica, 2023, v. 238, n. 1, p. 1, doi. 10.1111/apha.13961
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- Article
Individual and combined effects of GIP and xenin on differentiation, glucose uptake and lipolysis in 3T3-L1 adipocytes.
- Published in:
- Biological Chemistry, 2020, v. 401, n. 11, p. 1293, doi. 10.1515/hsz-2020-0195
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- Publication type:
- Article
Locally produced xenin and the neurotensinergic system in pancreatic islet function and β-cell survival.
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- Biological Chemistry, 2018, v. 399, n. 1, p. 79, doi. 10.1515/hsz-2017-0136
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- Publication type:
- Article
Effects of short-term chemical ablation of glucagon signalling by peptide-based glucagon receptor antagonists on insulin secretion and glucose homeostasis in mice.
- Published in:
- Biological Chemistry, 2014, v. 395, n. 4, p. 433, doi. 10.1515/hsz-2013-0224
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- Publication type:
- Article
Insulin modulates glucose-dependent insulinotropic polypeptide (GIP) secretion from enteroendocrine K cells in rats.
- Published in:
- Biological Chemistry, 2011, v. 392, n. 10, p. 909, doi. 10.1515/BC.2011.176
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- Publication type:
- Article
Active immunisation against gastric inhibitory polypeptide (GIP) improves blood glucose control in an animal model of obesity-diabetes.
- Published in:
- Biological Chemistry, 2009, v. 390, n. 1, p. 75, doi. 10.1515/BC.2009.002
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- Publication type:
- Article
Sub-chronic administration of the 11β-HSD1 inhibitor, carbenoxolone, improves glucose tolerance and insulin sensitivity in mice with diet-induced obesity.
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- Biological Chemistry, 2008, v. 389, n. 4, p. 441, doi. 10.1515/BC.2008.049
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- Publication type:
- Article
Effects of gastric inhibitory polypeptide (GIP) and related analogues on glucagon release at normo- and hyperglycaemia in Wistar rats and isolated islets.
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- Biological Chemistry, 2008, v. 389, n. 2, p. 189, doi. 10.1515/BC.2008.019
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- Publication type:
- Article
Characterisation and glucoregulatory actions of a novel acylated form of the (Pro<sup>3</sup>)GIP receptor antagonist in type 2 diabetes.
- Published in:
- Biological Chemistry, 2007, v. 388, n. 2, p. 173, doi. 10.1515/BC.2007.019
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- Publication type:
- Article
Metabolic effects of sub-chronic ablation of the incretin receptors by daily administration of (Pro<sup>3</sup>)GIP and exendin(9–39)amide in obese diabetic ( ob/ob) mice.
- Published in:
- Biological Chemistry, 2007, v. 388, n. 2, p. 221, doi. 10.1515/BC.2007.024
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- Publication type:
- Article
Antidiabetic potential of two novel fatty acid derivatised, N-terminally modified analogues of glucose-dependent insulinotropic polypeptide (GIP): N-AcGIP(LysPAL<sup>16</sup>) and N-AcGIP(LysPAL<sup>37</sup>).
- Published in:
- Biological Chemistry, 2005, v. 386, n. 7, p. 679, doi. 10.1515/BC.2005.079
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- Publication type:
- Article
Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice.
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- Biological Chemistry, 2004, v. 385, n. 9, p. 845, doi. 10.1515/BC.2004.110
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- Publication type:
- Article
Degradation, receptor binding, insulin secreting and antihyperglycaemic actions of palmitate-derivatised native and Ala<sup>8</sup> -substituted GLP-1 analogues.
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- Biological Chemistry, 2004, v. 385, n. 2, p. 169, doi. 10.1515/BC.2004.035
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- Article