Works by Iriepa, Isabel

Results: 28

Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer's disease therapy.
Published in:
Journal of Enzyme Inhibition & Medicinal Chemistry, 2019, v. 34, n. 1, p. 479, doi. 10.1080/14756366.2018.1545766
By:
- Pachón-Angona, Irene;
- Refouvelet, Bernard;
- Andrýs, Rudolf;
- Martin, Helène;
- Luzet, Vincent;
- Iriepa, Isabel;
- Moraleda, Ignacio;
- Diez-Iriepa, Daniel;
- Oset-Gasque, María-Jesús;
- Marco-Contelles, José;
- Musilek, Kamil;
- Ismaili, Lhassane
Publication type:
Article
Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy.
Published in:
Journal of Enzyme Inhibition & Medicinal Chemistry, 2019, v. 34, n. 1, p. 163, doi. 10.1080/14756366.2018.1538136
By:
- Dgachi, Youssef;
- Martin, Hélène;
- Malek, Rim;
- Jun, Daniel;
- Janockova, Jana;
- Sepsova, Vendula;
- Soukup, Ondrej;
- Iriepa, Isabel;
- Moraleda, Ignacio;
- Maalej, Emna;
- Carreiras, M. Carmo;
- Refouvelet, Bernard;
- Chabchoub, Fakher;
- Marco-Contelles, José;
- Ismaili, Lhassane
Publication type:
Article
Structural basis of drugs that increase cardiac inward rectifier Kir2.1 currents.
Published in:
Cardiovascular Research, 2014, v. 104, n. 2, p. 337, doi. 10.1093/cvr/cvu203
By:
- Gómez, Ricardo;
- Caballero, Ricardo;
- Barana, Adriana;
- Amorós, Irene;
- De Palm, Sue-Haida;
- Matamoros, Marcos;
- Núñez, Mercedes;
- Pérez-Hernández, Marta;
- Iriepa, Isabel;
- Tamargo, Juan;
- Delpón, Eva
Publication type:
Article
Synthesis of N -Substituted Pyrroles Catalyzed by Low-Cost and Commercially Available Aluminas.
Published in:
Catalysts (2073-4344), 2023, v. 13, n. 3, p. 603, doi. 10.3390/catal13030603
By:
- Portilla-Zúñiga, Omar;
- Bautista-Aguilera, Óscar M.;
- Martínez, José J.;
- Rojas, Hugo;
- Macías, Mario A.;
- Iriepa, Isabel;
- Pérez-Redondo, Adrián;
- Sathicq, Ángel;
- Castillo, Juan-Carlos;
- Romanelli, Gustavo P.
Publication type:
Article
Synthesis and Biological Assessment of PyrimidoTacrines as Promising Agents for Alzheimer's Disease Therapy.
Published in:
ChemistrySelect, 2021, v. 6, n. 37, p. 9975, doi. 10.1002/slct.202102363
By:
- Dakhlaoui, Imen;
- Maalej, Emna;
- Martin, Helene;
- Lucht, Aurélia;
- Iriepa, Isabel;
- Moraleda, Ignacio;
- Marco‐Contelles, Jose;
- Chabchoub, Fakher;
- Ismaili, Lhassane
Publication type:
Article
Automated Synthesis of New Quinoxalinetacrines.
Published in:
ChemistrySelect, 2020, v. 5, n. 21, p. 6491, doi. 10.1002/slct.202001593
By:
- Bautista‐Aguilera, Óscar M.;
- Ismaili, Lhassane;
- Chioua, Mourad;
- Iriepa, Isabel;
- Ángeles Martinez‐Grau, Marìa;
- Beadle, Christopher D.;
- Vetman, Tatiana;
- López‐Muñoz, Francisco;
- Marco‐Contelles, José
Publication type:
Article
Synthesis of (±)‐cis‐1‐Aryl‐3‐oxo‐2,3‐dihydro‐1H‐benzo[f]chromene‐2‐carbonitriles and (±)‐trans‐4‐Aryl‐2‐oxo‐3,4‐dihydro‐2H‐benzo[h]chromene‐3‐carbonitriles
Published in:
ChemistrySelect, 2019, v. 4, n. 44, p. 12902, doi. 10.1002/slct.201903982
By:
- Mkaouar, Kamar;
- Iriepa, Isabel;
- Diez‐Iriepa, Daniel;
- Marco‐Contelles, José;
- Ismaili, Lhassane;
- Chabchoub, Fakher
Publication type:
Article
Cs2CO3‐Promoted Alkylation of 3‐Cyano‐2(1H)‐Pyridones: Anticancer Evaluation and Molecular Docking.
Published in:
ChemPlusChem, 2024, v. 89, n. 9, p. 1, doi. 10.1002/cplu.202400172
By:
- Salamanca‐Perdigón, Kevin;
- Hurtado‐Rodríguez, Diana;
- Portilla, Jaime;
- Iriepa, Isabel;
- Rojas, Hugo;
- Becerra, Diana;
- Castillo, Juan‐Carlos
Publication type:
Article
Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids.
Published in:
Drug Design, Development & Therapy, 2014, v. 8, p. 1893, doi. 10.2147/DDDT.S69258
By:
- Bautista-Aguilera, Oscar M.;
- Esteban, Gerard;
- Chioua, Mourad;
- Nikolic, Katarina;
- Agbaba, Danica;
- Moraleda, Ignacio;
- Iriepa, Isabel;
- Soriano, Elena;
- Samadi, Abdelouahid;
- Unzeta, Mercedes;
- Marco-Contelles, José
Publication type:
Article
Chemical and Pharmacological Studies on Enantiomerically Pure p-Methoxytacripyrines, Promising Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease.
Published in:
ChemMedChem, 2011, v. 6, n. 11, p. 1990, doi. 10.1002/cmdc.201100239
By:
- Bartolini, Manuela;
- Pistolozzi, Marco;
- Andrisano, Vincenza;
- Egea, Javier;
- López, Manuela G.;
- Iriepa, Isabel;
- Moraleda, Ignacio;
- Gálvez, Enrique;
- Marco-Contelles, José;
- Samadi, Abdelouahid
Publication type:
Article
Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer's Disease Treatment.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 11, p. 9742, doi. 10.3390/ijms24119742
By:
- Dakhlaoui, Imen;
- Bernard, Paul J.;
- Pietrzak, Diana;
- Simakov, Alexey;
- Maj, Maciej;
- Refouvelet, Bernard;
- Béduneau, Arnaud;
- Cornu, Raphaël;
- Jozwiak, Krzysztof;
- Chabchoub, Fakher;
- Iriepa, Isabel;
- Martin, Helene;
- Marco-Contelles, José;
- Ismaili, Lhassane
Publication type:
Article
Homo-Tris-Nitrones Derived from α-Phenyl- N-tert -butylnitrone: Synthesis, Neuroprotection and Antioxidant Properties.
Published in:
International Journal of Molecular Sciences, 2020, v. 21, n. 21, p. 7949, doi. 10.3390/ijms21217949
By:
- Diez-Iriepa, Daniel;
- Chamorro, Beatriz;
- Talaván, Marta;
- Chioua, Mourad;
- Iriepa, Isabel;
- Hadjipavlou-Litina, Dimitra;
- López-Muñoz, Francisco;
- Marco-Contelles, José;
- Oset-Gasque, María Jesús
Publication type:
Article
Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives.
Published in:
International Journal of Molecular Sciences, 2020, v. 21, n. 20, p. 7652, doi. 10.3390/ijms21207652
By:
- Pachón Angona, Irene;
- Martin, Helene;
- Daniel, Solene;
- Moraleda, Ignacio;
- Bonet, Alexandre;
- Wnorowski, Artur;
- Maj, Maciej;
- Jozwiak, Krzysztof;
- Iriepa, Isabel;
- Refouvelet, Bernard;
- Marco-Contelles, José;
- Ismaili, Lhassane
Publication type:
Article
Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer's Disease Therapy.
Published in:
International Journal of Molecular Sciences, 2020, v. 21, n. 11, p. 3913, doi. 10.3390/ijms21113913
By:
- Bautista-Aguilera, Óscar M.;
- Ismaili, Lhassane;
- Chioua, Mourad;
- Andrys, Rudolf;
- Schmidt, Monika;
- Bzonek, Petr;
- Martínez-Grau, María Ángeles;
- Beadle, Christopher D.;
- Vetman, Tatiana;
- López-Muñoz, Francisco;
- Iriepa, Isabel;
- Refouvelet, Bernard;
- Musilek, Kamil;
- Marco-Contelles, José
Publication type:
Article
N -Hydroxy- N -Propargylamide Derivatives of Ferulic Acid: Inhibitors of Cholinesterases and Monoamine Oxidases.
Published in:
Molecules, 2022, v. 27, n. 21, p. 7437, doi. 10.3390/molecules27217437
By:
- Bautista-Aguilera, Óscar M.;
- Alonso, José M.;
- Catto, Marco;
- Iriepa, Isabel;
- Knez, Damijan;
- Gobec, Stanislav;
- Marco-Contelles, José
Publication type:
Article
Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer's Disease Therapy.
Published in:
Molecules, 2020, v. 25, n. 14, p. 3190, doi. 10.3390/molecules25143190
By:
- Zribi, Lazhar;
- Pachòn-Angona, Irene;
- Bautista-Aguilera, Òscar M.;
- Diez-Iriepa, Daniel;
- Marco-Contelles, José;
- Ismaili, Lhassane;
- Iriepa, Isabel;
- Chabchoub, Fakher;
- Branco, Paula Sério
Publication type:
Article
QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer's Disease Therapy.
Published in:
Molecules, 2019, v. 24, n. 8, p. 1503, doi. 10.3390/molecules24081503
By:
- Ramos, Eva;
- Palomino-Antolín, Alejandra;
- Bartolini, Manuela;
- Iriepa, Isabel;
- Moraleda, Ignacio;
- Diez-Iriepa, Daniel;
- Samadi, Abdelouahid;
- Cortina, Carol V.;
- Chioua, Mourad;
- Egea, Javier;
- Romero, Alejandro;
- Marco-Contelles, José;
- Jean, Ludovic
Publication type:
Article
Exploiting the Chalcone Scaffold to Develop Multifunctional Agents for Alzheimer’s Disease.
Published in:
Molecules, 2018, v. 23, n. 8, p. 1902, doi. 10.3390/molecules23081902
By:
- Muñoz-Torrero, Diego;
- Rampa, Angela;
- Bartolini, Manuela;
- Naldi, Marina;
- Belluti, Federica;
- Gobbi, Silvia;
- Bisi, Alessandra;
- Pruccoli, Letizia;
- Tarozzi, Andrea;
- Iriepa, Isabel;
- Moraleda, Ignacio
Publication type:
Article
Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer1s Disease Therapy.
Published in:
Molecules, 2016, v. 21, n. 4, p. 400, doi. 10.3390/molecules21040400
By:
- Boulebd, Houssem;
- Ismaili, Lhassane;
- Bartolini, Manuela;
- Bouraiou, Abdelmalek;
- Andrisano, Vincenza;
- Martin, Helene;
- Bonet, Alexandre;
- Moraleda, Ignacio;
- Iriepa, Isabel;
- Chioua, Mourad;
- Belfaitah, Ali;
- Marco-Contelles, José
Publication type:
Article
Polyfunctionalized α-Phenyl-tert-butyl(benzyl)nitrones: Multifunctional Antioxidants for Stroke Treatment.
Published in:
Antioxidants, 2022, v. 11, n. 9, p. 1735, doi. 10.3390/antiox11091735
By:
- Diez-Iriepa, Daniel;
- Knez, Damijan;
- Gobec, Stanislav;
- Iriepa, Isabel;
- de los Ríos, Cristóbal;
- Bravo, Isaac;
- López-Muñoz, Francisco;
- Marco-Contelles, José;
- Hadjipavlou-Litina, Dimitra
Publication type:
Article
Synthesis and Antioxidant Properties of HeteroBisNitrones Derived from Benzene Dicarbaldehydes.
Published in:
Antioxidants, 2022, v. 11, n. 8, p. N.PAG, doi. 10.3390/antiox11081575
By:
- Diez-Iriepa, Daniel;
- Iriepa, Isabel;
- López-Muñoz, Francisco;
- Marco-Contelles, José;
- Hadjipavlou-Litina, Dimitra
Publication type:
Article
Privileged Quinolylnitrones for the Combined Therapy of Ischemic Stroke and Alzheimer's Disease.
Published in:
Pharmaceuticals (14248247), 2021, v. 14, n. 9, p. 861, doi. 10.3390/ph14090861
By:
- Alonso, José M.;
- Escobar-Peso, Alejandro;
- Palomino-Antolín, Alejandra;
- Diez-Iriepa, Daniel;
- Chioua, Mourad;
- Martínez-Alonso, Emma;
- Iriepa, Isabel;
- Egea, Javier;
- Alcázar, Alberto;
- Marco-Contelles, José
Publication type:
Article
Tacrines as Therapeutic Agents for Alzheimer's Disease. V. Recent Developments.
Published in:
Chemical Record, 2021, v. 21, n. 1, p. 162, doi. 10.1002/tcr.202000107
By:
- Bautista‐Aguilera, Óscar M.;
- Ismaili, Lhassane;
- Iriepa, Isabel;
- Diez‐Iriepa, Daniel;
- Chabchoub, Fakher;
- Marco‐Contelles, José;
- Pérez, Marta
Publication type:
Article
2-{ N -[ω-(1-Benzylpiperidin-4-yl)alkyl]amino}-6-[(prop-2-yn-1-yl)amino]pyridine-3,5-dicarbonitriles Showing High Affinity for σ 1/2 Receptors.
Published in:
International Journal of Molecular Sciences, 2025, v. 26, n. 3, p. 1266, doi. 10.3390/ijms26031266
By:
- Deuther-Conrad, Winnie;
- Schepmann, Dirk;
- Iriepa, Isabel;
- López-Muñoz, Francisco;
- Chioua, Mourad;
- Wünsch, Bernhard;
- Samadi, Abdelouahid;
- Marco-Contelles, José
Publication type:
Article
Multipotente Liganden mit kombinierter Cholinesterase- und Monoaminooxidase-Inhibition sowie Histamin-H3R-Antagonismus bei neurodegenerativen Erkrankungen.
Published in:
Angewandte Chemie, 2017, v. 129, n. 41, p. 12939, doi. 10.1002/ange.201706072
By:
- Bautista ‐ Aguilera, Óscar M.;
- Hagenow, Stefanie;
- Palomino ‐ Antolin, Alejandra;
- Farré ‐ Alins, Víctor;
- Ismaili, Lhassane;
- Joffrin, Pierre ‐ Louis;
- Jimeno, María L.;
- Soukup, Ondřej;
- Janočková, Jana;
- Kalinowsky, Lena;
- Proschak, Ewgenij;
- Iriepa, Isabel;
- Moraleda, Ignacio;
- Schwed, Johannes S.;
- Romero Martínez, Alejandro;
- López ‐ Muñoz, Francisco;
- Chioua, Mourad;
- Egea, Javier;
- Ramsay, Rona R.;
- Marco ‐ Contelles, José
Publication type:
Article
Synthesis, antioxidant properties and neuroprotection of α-phenyl-tert-butylnitrone derived HomoBisNitrones in in vitro and in vivo ischemia models.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-70690-y
By:
- Chamorro, Beatriz;
- Diez-Iriepa, Daniel;
- Merás-Sáiz, Belén;
- Chioua, Mourad;
- García-Vieira, David;
- Iriepa, Isabel;
- Hadjipavlou-Litina, Dimitra;
- López-Muñoz, Francisco;
- Martínez-Murillo, Ricardo;
- Gonzàlez-Nieto, Daniel;
- Fernández, Israel;
- Marco-Contelles, José;
- Oset-Gasque, María Jesús
Publication type:
Article
Nitric oxide blocks hKv1.5 channels by S-nitrosylation and by a cyclic GMP-dependent mechanism
Published in:
Cardiovascular Research, 2006, v. 72, n. 1, p. 80, doi. 10.1016/j.cardiores.2006.06.021
By:
- Núñez, Lucía;
- Vaquero, Miguel;
- Gómez, Ricardo;
- Caballero, Ricardo;
- Mateos-Cáceres, Petra;
- Macaya, Carlos;
- Iriepa, Isabel;
- Gálvez, Enrique;
- López-Farré, Antonio;
- Tamargo, Juan;
- Delpón, Eva
Publication type:
Article
Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3R Antagonism for Neurodegenerative Diseases.
Published in:
Angewandte Chemie International Edition, 2017, v. 56, n. 41, p. 12765, doi. 10.1002/anie.201706072
By:
- Bautista‐Aguilera, Óscar M.;
- Hagenow, Stefanie;
- Palomino‐Antolin, Alejandra;
- Farré‐Alins, Víctor;
- Ismaili, Lhassane;
- Joffrin, Pierre‐Louis;
- Jimeno, María L.;
- Soukup, Ondřej;
- Janočková, Jana;
- Kalinowsky, Lena;
- Proschak, Ewgenij;
- Iriepa, Isabel;
- Moraleda, Ignacio;
- Schwed, Johannes S.;
- Romero Martínez, Alejandro;
- López‐Muñoz, Francisco;
- Chioua, Mourad;
- Egea, Javier;
- Ramsay, Rona R.;
- Marco‐Contelles, José
Publication type:
Article

Works by Iriepa, Isabel

Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer's disease therapy.

Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy.

Structural basis of drugs that increase cardiac inward rectifier Kir2.1 currents.

Synthesis of N -Substituted Pyrroles Catalyzed by Low-Cost and Commercially Available Aluminas.

Synthesis and Biological Assessment of PyrimidoTacrines as Promising Agents for Alzheimer's Disease Therapy.

Automated Synthesis of New Quinoxalinetacrines.

Synthesis of (±)‐cis‐1‐Aryl‐3‐oxo‐2,3‐dihydro‐1H‐benzo[f]chromene‐2‐carbonitriles and (±)‐trans‐4‐Aryl‐2‐oxo‐3,4‐dihydro‐2H‐benzo[h]chromene‐3‐carbonitriles

Cs<sub>2</sub>CO<sub>3</sub>‐Promoted Alkylation of 3‐Cyano‐2(1H)‐Pyridones: Anticancer Evaluation and Molecular Docking.

Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids.

Chemical and Pharmacological Studies on Enantiomerically Pure p-Methoxytacripyrines, Promising Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease.

Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer's Disease Treatment.

Homo-Tris-Nitrones Derived from α-Phenyl- N-tert -butylnitrone: Synthesis, Neuroprotection and Antioxidant Properties.

Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives.

Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer's Disease Therapy.

N -Hydroxy- N -Propargylamide Derivatives of Ferulic Acid: Inhibitors of Cholinesterases and Monoamine Oxidases.

Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer's Disease Therapy.

QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer's Disease Therapy.

Exploiting the Chalcone Scaffold to Develop Multifunctional Agents for Alzheimer’s Disease.

Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer1s Disease Therapy.

Polyfunctionalized α-Phenyl-tert-butyl(benzyl)nitrones: Multifunctional Antioxidants for Stroke Treatment.

Synthesis and Antioxidant Properties of HeteroBisNitrones Derived from Benzene Dicarbaldehydes.

Privileged Quinolylnitrones for the Combined Therapy of Ischemic Stroke and Alzheimer's Disease.

Tacrines as Therapeutic Agents for Alzheimer's Disease. V. Recent Developments.

2-{ N -[ω-(1-Benzylpiperidin-4-yl)alkyl]amino}-6-[(prop-2-yn-1-yl)amino]pyridine-3,5-dicarbonitriles Showing High Affinity for σ 1/2 Receptors.

Multipotente Liganden mit kombinierter Cholinesterase- und Monoaminooxidase-Inhibition sowie Histamin-H<sub>3</sub>R-Antagonismus bei neurodegenerativen Erkrankungen.

Synthesis, antioxidant properties and neuroprotection of α-phenyl-tert-butylnitrone derived HomoBisNitrones in in vitro and in vivo ischemia models.

Nitric oxide blocks hKv1.5 channels by S-nitrosylation and by a cyclic GMP-dependent mechanism

Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H<sub>3</sub>R Antagonism for Neurodegenerative Diseases.