Works matching AU Iriepa, Isabel

Results: 29

Tacrines as Therapeutic Agents for Alzheimer's Disease. V. Recent Developments.

Published in:

Chemical Record, 2021, v. 21, n. 1, p. 162, doi. 10.1002/tcr.202000107

By:

Bautista‐Aguilera, Óscar M.;
Ismaili, Lhassane;
Iriepa, Isabel;
Diez‐Iriepa, Daniel;
Chabchoub, Fakher;
Marco‐Contelles, José;
Pérez, Marta

Publication type:

Article

Synthesis of N -Substituted Pyrroles Catalyzed by Low-Cost and Commercially Available Aluminas.

Published in:

Catalysts (2073-4344), 2023, v. 13, n. 3, p. 603, doi. 10.3390/catal13030603

By:

Portilla-Zúñiga, Omar;
Bautista-Aguilera, Óscar M.;
Martínez, José J.;
Rojas, Hugo;
Macías, Mario A.;
Iriepa, Isabel;
Pérez-Redondo, Adrián;
Sathicq, Ángel;
Castillo, Juan-Carlos;
Romanelli, Gustavo P.

Publication type:

Article

Privileged Quinolylnitrones for the Combined Therapy of Ischemic Stroke and Alzheimer's Disease.

Published in:

Pharmaceuticals (14248247), 2021, v. 14, n. 9, p. 861, doi. 10.3390/ph14090861

By:

Alonso, José M.;
Escobar-Peso, Alejandro;
Palomino-Antolín, Alejandra;
Diez-Iriepa, Daniel;
Chioua, Mourad;
Martínez-Alonso, Emma;
Iriepa, Isabel;
Egea, Javier;
Alcázar, Alberto;
Marco-Contelles, José

Publication type:

Article

Synthesis and Biological Assessment of PyrimidoTacrines as Promising Agents for Alzheimer's Disease Therapy.

Published in:

ChemistrySelect, 2021, v. 6, n. 37, p. 9975, doi. 10.1002/slct.202102363

By:

Dakhlaoui, Imen;
Maalej, Emna;
Martin, Helene;
Lucht, Aurélia;
Iriepa, Isabel;
Moraleda, Ignacio;
Marco‐Contelles, Jose;
Chabchoub, Fakher;
Ismaili, Lhassane

Publication type:

Article

Automated Synthesis of New Quinoxalinetacrines.

Published in:

ChemistrySelect, 2020, v. 5, n. 21, p. 6491, doi. 10.1002/slct.202001593

By:

Bautista‐Aguilera, Óscar M.;
Ismaili, Lhassane;
Chioua, Mourad;
Iriepa, Isabel;
Ángeles Martinez‐Grau, Marìa;
Beadle, Christopher D.;
Vetman, Tatiana;
López‐Muñoz, Francisco;
Marco‐Contelles, José

Publication type:

Article

Synthesis of (±)‐cis‐1‐Aryl‐3‐oxo‐2,3‐dihydro‐1H‐benzo[f]chromene‐2‐carbonitriles and (±)‐trans‐4‐Aryl‐2‐oxo‐3,4‐dihydro‐2H‐benzo[h]chromene‐3‐carbonitriles

Published in:

ChemistrySelect, 2019, v. 4, n. 44, p. 12902, doi. 10.1002/slct.201903982

By:

Mkaouar, Kamar;
Iriepa, Isabel;
Diez‐Iriepa, Daniel;
Marco‐Contelles, José;
Ismaili, Lhassane;
Chabchoub, Fakher

Publication type:

Article

Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer's disease therapy.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2019, v. 34, n. 1, p. 479, doi. 10.1080/14756366.2018.1545766

By:

Pachón-Angona, Irene;
Refouvelet, Bernard;
Andrýs, Rudolf;
Martin, Helène;
Luzet, Vincent;
Iriepa, Isabel;
Moraleda, Ignacio;
Diez-Iriepa, Daniel;
Oset-Gasque, María-Jesús;
Marco-Contelles, José;
Musilek, Kamil;
Ismaili, Lhassane

Publication type:

Article

Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2019, v. 34, n. 1, p. 163, doi. 10.1080/14756366.2018.1538136

By:

Dgachi, Youssef;
Martin, Hélène;
Malek, Rim;
Jun, Daniel;
Janockova, Jana;
Sepsova, Vendula;
Soukup, Ondrej;
Iriepa, Isabel;
Moraleda, Ignacio;
Maalej, Emna;
Carreiras, M. Carmo;
Refouvelet, Bernard;
Chabchoub, Fakher;
Marco-Contelles, José;
Ismaili, Lhassane

Publication type:

Article

Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 1893, doi. 10.2147/DDDT.S69258

By:

Bautista-Aguilera, Oscar M.;
Esteban, Gerard;
Chioua, Mourad;
Nikolic, Katarina;
Agbaba, Danica;
Moraleda, Ignacio;
Iriepa, Isabel;
Soriano, Elena;
Samadi, Abdelouahid;
Unzeta, Mercedes;
Marco-Contelles, José

Publication type:

Article

Structural basis of drugs that increase cardiac inward rectifier Kir2.1 currents.

Published in:

Cardiovascular Research, 2014, v. 104, n. 2, p. 337, doi. 10.1093/cvr/cvu203

By:

Gómez, Ricardo;
Caballero, Ricardo;
Barana, Adriana;
Amorós, Irene;
De Palm, Sue-Haida;
Matamoros, Marcos;
Núñez, Mercedes;
Pérez-Hernández, Marta;
Iriepa, Isabel;
Tamargo, Juan;
Delpón, Eva

Publication type:

Article

Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer's Disease Treatment.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 11, p. 9742, doi. 10.3390/ijms24119742

By:

Dakhlaoui, Imen;
Bernard, Paul J.;
Pietrzak, Diana;
Simakov, Alexey;
Maj, Maciej;
Refouvelet, Bernard;
Béduneau, Arnaud;
Cornu, Raphaël;
Jozwiak, Krzysztof;
Chabchoub, Fakher;
Iriepa, Isabel;
Martin, Helene;
Marco-Contelles, José;
Ismaili, Lhassane

Publication type:

Article

Homo-Tris-Nitrones Derived from α-Phenyl- N-tert -butylnitrone: Synthesis, Neuroprotection and Antioxidant Properties.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 21, p. 7949, doi. 10.3390/ijms21217949

By:

Diez-Iriepa, Daniel;
Chamorro, Beatriz;
Talaván, Marta;
Chioua, Mourad;
Iriepa, Isabel;
Hadjipavlou-Litina, Dimitra;
López-Muñoz, Francisco;
Marco-Contelles, José;
Oset-Gasque, María Jesús

Publication type:

Article

Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 20, p. 7652, doi. 10.3390/ijms21207652

By:

Pachón Angona, Irene;
Martin, Helene;
Daniel, Solene;
Moraleda, Ignacio;
Bonet, Alexandre;
Wnorowski, Artur;
Maj, Maciej;
Jozwiak, Krzysztof;
Iriepa, Isabel;
Refouvelet, Bernard;
Marco-Contelles, José;
Ismaili, Lhassane

Publication type:

Article

Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer's Disease Therapy.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 11, p. 3913, doi. 10.3390/ijms21113913

By:

Bautista-Aguilera, Óscar M.;
Ismaili, Lhassane;
Chioua, Mourad;
Andrys, Rudolf;
Schmidt, Monika;
Bzonek, Petr;
Martínez-Grau, María Ángeles;
Beadle, Christopher D.;
Vetman, Tatiana;
López-Muñoz, Francisco;
Iriepa, Isabel;
Refouvelet, Bernard;
Musilek, Kamil;
Marco-Contelles, José

Publication type:

Article

Nitric oxide blocks hKv1.5 channels by S-nitrosylation and by a cyclic GMP-dependent mechanism

Published in:

Cardiovascular Research, 2006, v. 72, n. 1, p. 80, doi. 10.1016/j.cardiores.2006.06.021

By:

Núñez, Lucía;
Vaquero, Miguel;
Gómez, Ricardo;
Caballero, Ricardo;
Mateos-Cáceres, Petra;
Macaya, Carlos;
Iriepa, Isabel;
Gálvez, Enrique;
López-Farré, Antonio;
Tamargo, Juan;
Delpón, Eva

Publication type:

Article

Chemical and Pharmacological Studies on Enantiomerically Pure p-Methoxytacripyrines, Promising Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease.

Published in:

ChemMedChem, 2011, v. 6, n. 11, p. 1990, doi. 10.1002/cmdc.201100239

By:

Bartolini, Manuela;
Pistolozzi, Marco;
Andrisano, Vincenza;
Egea, Javier;
López, Manuela G.;
Iriepa, Isabel;
Moraleda, Ignacio;
Gálvez, Enrique;
Marco-Contelles, José;
Samadi, Abdelouahid

Publication type:

Article

Multipotente Liganden mit kombinierter Cholinesterase- und Monoaminooxidase-Inhibition sowie Histamin-H3R-Antagonismus bei neurodegenerativen Erkrankungen.

Published in:

Angewandte Chemie, 2017, v. 129, n. 41, p. 12939, doi. 10.1002/ange.201706072

By:

Bautista ‐ Aguilera, Óscar M.;
Hagenow, Stefanie;
Palomino ‐ Antolin, Alejandra;
Farré ‐ Alins, Víctor;
Ismaili, Lhassane;
Joffrin, Pierre ‐ Louis;
Jimeno, María L.;
Soukup, Ondřej;
Janočková, Jana;
Kalinowsky, Lena;
Proschak, Ewgenij;
Iriepa, Isabel;
Moraleda, Ignacio;
Schwed, Johannes S.;
Romero Martínez, Alejandro;
López ‐ Muñoz, Francisco;
Chioua, Mourad;
Egea, Javier;
Ramsay, Rona R.;
Marco ‐ Contelles, José

Publication type:

Article

Polyfunctionalized α-Phenyl-tert-butyl(benzyl)nitrones: Multifunctional Antioxidants for Stroke Treatment.

Published in:

Antioxidants, 2022, v. 11, n. 9, p. 1735, doi. 10.3390/antiox11091735

By:

Diez-Iriepa, Daniel;
Knez, Damijan;
Gobec, Stanislav;
Iriepa, Isabel;
de los Ríos, Cristóbal;
Bravo, Isaac;
López-Muñoz, Francisco;
Marco-Contelles, José;
Hadjipavlou-Litina, Dimitra

Publication type:

Article

Synthesis and Antioxidant Properties of HeteroBisNitrones Derived from Benzene Dicarbaldehydes.

Published in:

Antioxidants, 2022, v. 11, n. 8, p. N.PAG, doi. 10.3390/antiox11081575

By:

Diez-Iriepa, Daniel;
Iriepa, Isabel;
López-Muñoz, Francisco;
Marco-Contelles, José;
Hadjipavlou-Litina, Dimitra

Publication type:

Article

Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer1s Disease Therapy.

Published in:

Molecules, 2016, v. 21, n. 4, p. 400, doi. 10.3390/molecules21040400

By:

Boulebd, Houssem;
Ismaili, Lhassane;
Bartolini, Manuela;
Bouraiou, Abdelmalek;
Andrisano, Vincenza;
Martin, Helene;
Bonet, Alexandre;
Moraleda, Ignacio;
Iriepa, Isabel;
Chioua, Mourad;
Belfaitah, Ali;
Marco-Contelles, José

Publication type:

Article

Synthesis, antioxidant properties and neuroprotection of α-phenyl-tert-butylnitrone derived HomoBisNitrones in in vitro and in vivo ischemia models.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-70690-y

By:

Chamorro, Beatriz;
Diez-Iriepa, Daniel;
Merás-Sáiz, Belén;
Chioua, Mourad;
García-Vieira, David;
Iriepa, Isabel;
Hadjipavlou-Litina, Dimitra;
López-Muñoz, Francisco;
Martínez-Murillo, Ricardo;
Gonzàlez-Nieto, Daniel;
Fernández, Israel;
Marco-Contelles, José;
Oset-Gasque, María Jesús

Publication type:

Article

Cs2CO3‐Promoted Alkylation of 3‐Cyano‐2(1H)‐Pyridones: Anticancer Evaluation and Molecular Docking.

Published in:

ChemPlusChem, 2024, v. 89, n. 9, p. 1, doi. 10.1002/cplu.202400172

By:

Salamanca‐Perdigón, Kevin;
Hurtado‐Rodríguez, Diana;
Portilla, Jaime;
Iriepa, Isabel;
Rojas, Hugo;
Becerra, Diana;
Castillo, Juan‐Carlos

Publication type:

Article

2-{ N -[ω-(1-Benzylpiperidin-4-yl)alkyl]amino}-6-[(prop-2-yn-1-yl)amino]pyridine-3,5-dicarbonitriles Showing High Affinity for σ 1/2 Receptors.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 3, p. 1266, doi. 10.3390/ijms26031266

By:

Deuther-Conrad, Winnie;
Schepmann, Dirk;
Iriepa, Isabel;
López-Muñoz, Francisco;
Chioua, Mourad;
Wünsch, Bernhard;
Samadi, Abdelouahid;
Marco-Contelles, José

Publication type:

Article

Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3R Antagonism for Neurodegenerative Diseases.

Published in:

Angewandte Chemie International Edition, 2017, v. 56, n. 41, p. 12765, doi. 10.1002/anie.201706072

By:

Bautista‐Aguilera, Óscar M.;
Hagenow, Stefanie;
Palomino‐Antolin, Alejandra;
Farré‐Alins, Víctor;
Ismaili, Lhassane;
Joffrin, Pierre‐Louis;
Jimeno, María L.;
Soukup, Ondřej;
Janočková, Jana;
Kalinowsky, Lena;
Proschak, Ewgenij;
Iriepa, Isabel;
Moraleda, Ignacio;
Schwed, Johannes S.;
Romero Martínez, Alejandro;
López‐Muñoz, Francisco;
Chioua, Mourad;
Egea, Javier;
Ramsay, Rona R.;
Marco‐Contelles, José

Publication type:

Article

N -Hydroxy- N -Propargylamide Derivatives of Ferulic Acid: Inhibitors of Cholinesterases and Monoamine Oxidases.

Published in:

Molecules, 2022, v. 27, n. 21, p. 7437, doi. 10.3390/molecules27217437

By:

Bautista-Aguilera, Óscar M.;
Alonso, José M.;
Catto, Marco;
Iriepa, Isabel;
Knez, Damijan;
Gobec, Stanislav;
Marco-Contelles, José

Publication type:

Article

Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer's Disease Therapy.

Published in:

Molecules, 2020, v. 25, n. 14, p. 3190, doi. 10.3390/molecules25143190

By:

Zribi, Lazhar;
Pachòn-Angona, Irene;
Bautista-Aguilera, Òscar M.;
Diez-Iriepa, Daniel;
Marco-Contelles, José;
Ismaili, Lhassane;
Iriepa, Isabel;
Chabchoub, Fakher;
Branco, Paula Sério

Publication type:

Article

QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer's Disease Therapy.

Published in:

Molecules, 2019, v. 24, n. 8, p. 1503, doi. 10.3390/molecules24081503

By:

Ramos, Eva;
Palomino-Antolín, Alejandra;
Bartolini, Manuela;
Iriepa, Isabel;
Moraleda, Ignacio;
Diez-Iriepa, Daniel;
Samadi, Abdelouahid;
Cortina, Carol V.;
Chioua, Mourad;
Egea, Javier;
Romero, Alejandro;
Marco-Contelles, José;
Jean, Ludovic

Publication type:

Article

Exploiting the Chalcone Scaffold to Develop Multifunctional Agents for Alzheimer’s Disease.

Published in:

Molecules, 2018, v. 23, n. 8, p. 1902, doi. 10.3390/molecules23081902

By:

Muñoz-Torrero, Diego;
Rampa, Angela;
Bartolini, Manuela;
Naldi, Marina;
Belluti, Federica;
Gobbi, Silvia;
Bisi, Alessandra;
Pruccoli, Letizia;
Tarozzi, Andrea;
Iriepa, Isabel;
Moraleda, Ignacio

Publication type:

Article

Generation and validation of a novel multitarget small molecule in glioblastoma.

Published in:

Cell Death & Disease, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41419-025-07569-1

By:

Artetxe-Zurutuza, Aizpea;
Iturrioz-Rodriguez, Nerea;
Elizazu, Joseba;
Toledano-Pinedo, Mireia;
Porro-Pérez, Alicia;
De Goñi, Irati;
Elua-Pinin, Alejandro;
Schäker-Hübner, Linda;
Azkargorta, Mikel;
Elortza, Felix;
Iriepa, Isabel;
Lòpez-Muñoz, Francisco;
Moncho-Amor, Veronica;
Hansen, Finn K.;
Sampron, Nicolás;
Marco-Contelles, Jose Luis;
Matheu, Ander

Publication type:

Article

Works matching AU Iriepa, Isabel

Tacrines as Therapeutic Agents for Alzheimer's Disease. V. Recent Developments.

Synthesis of N -Substituted Pyrroles Catalyzed by Low-Cost and Commercially Available Aluminas.

Privileged Quinolylnitrones for the Combined Therapy of Ischemic Stroke and Alzheimer's Disease.

Synthesis and Biological Assessment of PyrimidoTacrines as Promising Agents for Alzheimer's Disease Therapy.

Automated Synthesis of New Quinoxalinetacrines.

Synthesis of (±)‐cis‐1‐Aryl‐3‐oxo‐2,3‐dihydro‐1H‐benzo[f]chromene‐2‐carbonitriles and (±)‐trans‐4‐Aryl‐2‐oxo‐3,4‐dihydro‐2H‐benzo[h]chromene‐3‐carbonitriles

Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer's disease therapy.

Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy.

Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids.

Structural basis of drugs that increase cardiac inward rectifier Kir2.1 currents.

Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer's Disease Treatment.

Homo-Tris-Nitrones Derived from α-Phenyl- N-tert -butylnitrone: Synthesis, Neuroprotection and Antioxidant Properties.

Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives.

Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer's Disease Therapy.

Nitric oxide blocks hKv1.5 channels by S-nitrosylation and by a cyclic GMP-dependent mechanism

Chemical and Pharmacological Studies on Enantiomerically Pure p-Methoxytacripyrines, Promising Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease.

Multipotente Liganden mit kombinierter Cholinesterase- und Monoaminooxidase-Inhibition sowie Histamin-H<sub>3</sub>R-Antagonismus bei neurodegenerativen Erkrankungen.

Polyfunctionalized α-Phenyl-tert-butyl(benzyl)nitrones: Multifunctional Antioxidants for Stroke Treatment.

Synthesis and Antioxidant Properties of HeteroBisNitrones Derived from Benzene Dicarbaldehydes.

Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer1s Disease Therapy.

Synthesis, antioxidant properties and neuroprotection of α-phenyl-tert-butylnitrone derived HomoBisNitrones in in vitro and in vivo ischemia models.

Cs<sub>2</sub>CO<sub>3</sub>‐Promoted Alkylation of 3‐Cyano‐2(1H)‐Pyridones: Anticancer Evaluation and Molecular Docking.

2-{ N -[ω-(1-Benzylpiperidin-4-yl)alkyl]amino}-6-[(prop-2-yn-1-yl)amino]pyridine-3,5-dicarbonitriles Showing High Affinity for σ 1/2 Receptors.

Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H<sub>3</sub>R Antagonism for Neurodegenerative Diseases.

N -Hydroxy- N -Propargylamide Derivatives of Ferulic Acid: Inhibitors of Cholinesterases and Monoamine Oxidases.

Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer's Disease Therapy.

QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer's Disease Therapy.

Exploiting the Chalcone Scaffold to Develop Multifunctional Agents for Alzheimer’s Disease.

Generation and validation of a novel multitarget small molecule in glioblastoma.