Works by Ira, Grzegorz

Results: 27

Deficits in mitochondrial dynamics and iron balance result in templated insertions.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60546-2

By:

Fox, Jordan;
Yu, Yang;
Thakre, Pilendra;
Fox, Chloe;
Li, Qian;
Wang, Yunxia;
Hughes, Adam;
Wang, Xin;
Chen, Kaifu;
Ira, Grzegorz

Publication type:

Article

Yeast EndoG prevents genome instability by degrading extranuclear DNA species.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-52147-2

By:

Yu, Yang;
Wang, Xin;
Fox, Jordan;
Yu, Ruofan;
Thakre, Pilendra;
McCauley, Brenna;
Nikoloutsos, Nicolas;
Li, Qian;
Hastings, P. J.;
Dang, Weiwei;
Chen, Kaifu;
Ira, Grzegorz

Publication type:

Article

DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1.

Published in:

Nature, 2004, v. 431, n. 7011, p. 1011, doi. 10.1038/nature02964

By:

Ira, Grzegorz;
Pellicioli, Achille;
Balijja, Alitukiriza;
Wang, Xuan;
Fiorani, Simona;
Carotenuto, Walter;
Liberi, Giordano;
Bressan, Debra;
Wan, Lihong;
Hollingsworth, Nancy M.;
Haber, James E.;
Foiani, Marco

Publication type:

Article

Deciphering the mechanism of processive ssDNA digestion by the Dna2-RPA ensemble.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-021-27940-y

By:

Shen, Jiangchuan;
Zhao, Yiling;
Pham, Nhung Tuyet;
Li, Yuxi;
Zhang, Yixiang;
Trinidad, Jonathan;
Ira, Grzegorz;
Qi, Zhi;
Niu, Hengyao

Publication type:

Article

Defective Resection at DNA Double-Strand Breaks Leads to De Novo Telomere Formation and Enhances Gene Targeting.

Published in:

PLoS Genetics, 2010, v. 6, n. 5, p. 1, doi. 10.1371/journal.pgen.1000948

By:

Woo-Hyun Chung;
Zhu, Zhu;
Papusha, Alma;
Malkova, Anna;
Ira, Grzegorz

Publication type:

Article

A Microhomology-Mediated Break-Induced Replication Model for the Origin of Human Copy Number Variation.

Published in:

PLoS Genetics, 2009, v. 5, n. 1, p. 1, doi. 10.1371/journal.pgen.1000327

By:

Hastings, P. J.;
Ira, Grzegorz;
Lupski, James R.

Publication type:

Article

Mechanisms restraining break‐induced replication at two‐ended DNA double‐strand breaks.

Published in:

EMBO Journal, 2021, v. 40, n. 10, p. 1, doi. 10.15252/embj.2020104847

By:

Pham, Nhung;
Yan, Zhenxin;
Yu, Yang;
Faria Afreen, Mosammat;
Malkova, Anna;
Haber, James E;
Ira, Grzegorz

Publication type:

Article

Mechanisms of change in gene copy number.

Published in:

2009

By:

Hastings, P. J.;
Lupski, James R.;
Rosenberg, Susan M.;
Ira, Grzegorz

Publication type:

journal article

Meiotic double‐strand breaks in yeast artificial chromosomes containing human DNA.

Published in:

Nucleic Acids Research, 1998, v. 26, n. 10, p. 2415, doi. 10.1093/nar/26.10.2415

By:

Ira, Grzegorz;
Svetlova, Ekaterina;
Filipski, Jan

Publication type:

Article

RSC Facilitates Rad59-Dependent Homologous Recombination between Sister Chromatids by Promoting Cohesin Loading at DNA Double-Strand Breaks.

Published in:

Molecular & Cellular Biology, 2011, v. 31, n. 19, p. 3924, doi. 10.1128/MCB.01269-10

By:

Ji-Hyun Oum;
Changhyun Seong;
Youngho Kwon;
Jae-Hoon Ji;
Sid, Amy;
Ramakrishnan, Sreejith;
Ira, Grzegorz;
Malkova, Anna;
Sung, Patrick;
Sang Eun Lee;
Eun Yong Shim

Publication type:

Article

Conservative Inheritance of Newly Synthesized DNA in Double-Strand Break-Induced Gene Conversion.

Published in:

Molecular & Cellular Biology, 2006, v. 26, n. 24, p. 24, doi. 10.1128/MCB.01654-06

By:

Ira, Grzegorz;
Satory, Dominik;
Haber, James E.

Publication type:

Article

RPA and Rad27 limit templated and inverted insertions at DNA breaks.

Published in:

Nucleic Acids Research, 2025, v. 53, n. 1, p. 1, doi. 10.1093/nar/gkae1159

By:

Yu, Yang;
Wang, Xin;
Fox, Jordan;
Li, Qian;
Hastings, P J;
Chen, Kaifu;
Ira, Grzegorz

Publication type:

Article

Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNA.

Published in:

Nucleic Acids Research, 2017, v. 45, n. 10, p. 5850, doi. 10.1093/nar/gkx201

By:

Lopez, Christopher R.;
Singh, Shivani;
Hambarde, Shashank;
Griffin, Wezley C.;
Jun Gao;
Chib, Shubeena;
Yang Yu;
Ira, Grzegorz;
Raney, Kevin D.;
Nayun Kim

Publication type:

Article

Enrichment of Cdk1-cyclins at DNA double-strand breaks stimulates Fun30 phosphorylation and DNA end resection.

Published in:

Nucleic Acids Research, 2016, v. 44, n. 6, p. 2742, doi. 10.1093/nar/gkv1544

By:

Xuefeng Chen;
Hengyao Niu;
Yang Yu;
Jingjing Wang;
Shuangyi Zhu;
Jianjie Zhou;
Alma Papusha;
Dandan Cui;
Xuewen Pan;
Youngho Kwon;
Patrick Sung;
Ira, Grzegorz

Publication type:

Article

Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01987-2

By:

Elango, Rajula;
Ziwei Sheng;
Jackson, Jessica;
DeCata, Jenna;
Ibrahim, Younis;
Pham, Nhung T.;
Liang, Diana H.;
Sakofsky, Cynthia J.;
Vindigni, Alessandro;
Lobachev, Kirill S.;
Ira, Grzegorz;
Malkova, Anna

Publication type:

Article

MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01180-5

By:

Lemaçon, Delphine;
Jackson, Jessica;
Quinet, Annabel;
Brickner, Joshua R.;
Shan Li;
Yazinski, Stephanie;
Zhongsheng You;
Ira, Grzegorz;
Lee Zou;
Mosammaparast, Nima;
Vindigni, Alessandro

Publication type:

Article

Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks.

Published in:

EMBO Journal, 2010, v. 29, n. 19, p. 3370, doi. 10.1038/emboj.2010.219

By:

Eun Yong Shim;
Woo-Hyun Chung;
Nicolette, Matthew L.;
Yu Zhang;
Davis, Melody;
Zhu Zhu;
Paull, Tanya T.;
Ira, Grzegorz;
Sang Eun Lee

Publication type:

Article

A Rad51-independent pathway promotes single-strand template repair in gene editing.

Published in:

PLoS Genetics, 2020, v. 16, n. 10, p. 1, doi. 10.1371/journal.pgen.1008689

By:

Gallagher, Danielle N.;
Pham, Nhung;
Tsai, Annie M.;
Janto, Abigail N.;
Choi, Jihyun;
Ira, Grzegorz;
Haber, James E.

Publication type:

Article

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 9, p. 1015, doi. 10.1038/nsmb.2105

By:

Xuefeng Chen;
Hengyao Niu;
Woo-Hyun Chung;
Zhu Zhu;
Papusha, Alma;
Eun Yong Shim;
Sang Eun Lee;
Sung, Patrick;
Ira, Grzegorz

Publication type:

Article

DNA breakage drives nuclear search.

Published in:

Nature Cell Biology, 2012, v. 14, n. 5, p. 448, doi. 10.1038/ncb2494

By:

Ira, Grzegorz;
Hastings, Philip J.

Publication type:

Article

Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration.

Published in:

Nature, 2013, v. 502, n. 7471, p. 393, doi. 10.1038/nature12585

By:

Wilson, Marenda A.;
Kwon, YoungHo;
Xu, Yuanyuan;
Chung, Woo-Hyun;
Chi, Peter;
Niu, Hengyao;
Mayle, Ryan;
Chen, Xuefeng;
Malkova, Anna;
Sung, Patrick;
Ira, Grzegorz

Publication type:

Article

Migrating bubble during break-induced replication drives conservative DNA synthesis.

Published in:

Nature, 2013, v. 502, n. 7471, p. 389, doi. 10.1038/nature12584

By:

Saini, Natalie;
Ramakrishnan, Sreejith;
Elango, Rajula;
Ayyar, Sandeep;
Zhang, Yu;
Deem, Angela;
Ira, Grzegorz;
Haber, James E.;
Lobachev, Kirill S.;
Malkova, Anna

Publication type:

Article

The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends.

Published in:

Nature, 2012, v. 489, n. 7417, p. 576, doi. 10.1038/nature11355

By:

Chen, Xuefeng;
Cui, Dandan;
Papusha, Alma;
Zhang, Xiaotian;
Chu, Chia-Dwo;
Tang, Jiangwu;
Chen, Kaifu;
Pan, Xuewen;
Ira, Grzegorz

Publication type:

Article

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae.

Published in:

Nature, 2010, v. 467, n. 7311, p. 108, doi. 10.1038/nature09318

By:

Hengyao Niu;
Woo-Hyun Chung;
Zhu Zhu;
Youngho Kwon;
Weixing Zhao;
Chi, Peter;
Prakash, Rohit;
Changhyun Seong;
Dongqing Liu;
Lu, Lucy;
Ira, Grzegorz;
Sung, Patrick

Publication type:

Article

RAD51-Dependent Break-Induced Replication Differs in Kinetics and Checkpoint Responses from RAD51-Mediated Gene Conversion.

Published in:

Molecular & Cellular Biology, 2005, v. 25, n. 3, p. 933, doi. 10.1128/MCB.25.3.933-944.2005

By:

Malkova, Anna;
Naylor, Maria L.;
Yamaguchi, Miyuki;
Ira, Grzegorz;
Haber, James E.

Publication type:

Article

Role of DNA Replication Proteins in Double-Strand Break-Induced Recombination in Saccharomyces cerevisiae.

Published in:

Molecular & Cellular Biology, 2004, v. 24, n. 16, p. 6891, doi. 10.1128/MCB.24.16.6891-6899.2004

By:

Xuan Wang;
Ira, Grzegorz;
Tercero, José Antonio;
Holmes, Allyson M.;
Diffley, John F. X.;
Haber, James E.

Publication type:

Article

A new Riff: Rif1 eats its cake and has it too.

Published in:

EMBO Reports, 2014, v. 15, n. 6, p. 622, doi. 10.1002/embr.201438825

By:

Ira, Grzegorz;
Nussenzweig, André

Publication type:

Article