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Engineered mini-G proteins block the internalization of cognate GPCRs and disrupt downstream intracellular signaling.
- Published in:
- Science Signaling, 2024, v. 17, n. 843, p. 1, doi. 10.1126/scisignal.abq7038
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- Article
G protein–coupled receptor endocytosis generates spatiotemporal bias in β-arrestin signaling.
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- Science Signaling, 2024, v. 17, n. 842, p. 1, doi. 10.1126/scisignal.adi0934
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- Article
Structure and dynamics of the pyroglutamylated RF-amide peptide QRFP receptor GPR103.
- Published in:
- Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-49030-5
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- Publication type:
- Article
Therapeutic potentials of nonpeptidic V2R agonists for partial cNDI-causing V2R mutants.
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- PLoS ONE, 2024, v. 19, n. 5, p. 1, doi. 10.1371/journal.pone.0303507
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- Publication type:
- Article
A cAMP-biosensor-based assay for measuring plasma arginine–vasopressin levels.
- Published in:
- Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-60035-4
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- Article
GPCR signaling bias: an emerging framework for opioid drug development.
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- Journal of Biochemistry, 2024, v. 175, n. 4, p. 367, doi. 10.1093/jb/mvae013
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- Article
Molecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq.
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- Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-06056-1
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- Article
Designer high-density lipoprotein particles enhance endothelial barrier function and suppress inflammation.
- Published in:
- Science Signaling, 2024, v. 17, n. 824, p. 1, doi. 10.1126/scisignal.adg9256
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- Publication type:
- Article
Mechanisms of biased agonism by Gα<sub>i/o</sub>-biased stapled peptide agonists of the relaxin-3 receptor.
- Published in:
- Science Signaling, 2024, v. 17, n. 823, p. 1, doi. 10.1126/scisignal.abl5880
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- Article
A single‐domain intrabody targeting the follicle‐stimulating hormone receptor impacts FSH‐induced G protein‐dependent signalling.
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- FEBS Letters, 2024, v. 598, n. 2, p. 220, doi. 10.1002/1873-3468.14765
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- Article
Eriodictyol and thymonin act as GPR35 agonists.
- Published in:
- Bioscience, Biotechnology & Biochemistry, 2023, v. 87, n. 12, p. 1514, doi. 10.1093/bbb/zbad125
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- Article
Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-42764-8
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- Article
Stepwise phosphorylation of BLT1 defines complex assemblies with β‐arrestin serving distinct functions.
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- FASEB Journal, 2023, v. 37, n. 11, p. 1, doi. 10.1096/fj.202301440R
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- Article
Chemogenetic activation of G<sub>12</sub> signaling enhances adipose tissue browning.
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- 2023
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- Publication type:
- Letter
Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40482-9
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- Article
GPCRome-wide analysis of G-protein-coupling diversity using a computational biology approach.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40045-y
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- Article
Structural basis of CXC chemokine receptor 1 ligand binding and activation.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-39799-2
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- Article
Endocytic proteins mediating GPR15 receptor internalization provide insight into the underlying mechanisms.
- Published in:
- FEBS Letters, 2023, v. 597, n. 11, p. 1528, doi. 10.1002/1873-3468.14622
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- Article
Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction.
- Published in:
- Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-04888-x
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- Article
Structural basis for activation of CB1 by an endocannabinoid analog.
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- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-37864-4
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- Article
Reply to: How carvedilol does not activate β<sub>2</sub>-adrenoceptors.
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- 2023
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- Publication type:
- Letter
Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-37233-1
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- Article
Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization.
- Published in:
- Science Signaling, 2023, v. 16, n. 779, p. 1, doi. 10.1126/scisignal.abl4283
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- Article
Correction to: Novel interaction between neurotrophic factor-α1/carboxypeptidase E and serotonin receptor, 5-HTR1E, protects human neurons against oxidative/neuroexcitotoxic stress via β-arrestin/ERK signaling.
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- 2023
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- Publication type:
- Correction Notice
Potential of HMGB‐inhibitory oligodeoxynucleotide ISM ODN to neutrophil recruitment in mouse model of hepatitis.
- Published in:
- Genes to Cells, 2023, v. 28, n. 3, p. 202, doi. 10.1111/gtc.13002
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- Article
Structural basis of lysophosphatidylserine receptor GPR174 ligand recognition and activation.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-36575-0
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- Publication type:
- Article
Generation of Gαi knock-out HEK293 cells illuminates Gαi-coupling diversity of GPCRs.
- Published in:
- Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-04465-2
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- Publication type:
- Article
Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-022-35726-z
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- Publication type:
- Article
Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels.
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- PLoS ONE, 2023, v. 17, n. 1, p. 1, doi. 10.1371/journal.pone.0280448
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- Article
Constitutively active GPR43 is crucial for proper leukocyte differentiation.
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- FASEB Journal, 2023, v. 37, n. 1, p. 1, doi. 10.1096/fj.202201591R
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- Article
How Carvedilol activates β<sub>2</sub>-adrenoceptors.
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- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-34765-w
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- Publication type:
- Article
β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the same GPCR in living cells.
- Published in:
- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-33307-8
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- Publication type:
- Article
Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody.
- Published in:
- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32386-x
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- Publication type:
- Article
Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface.
- Published in:
- PLoS Biology, 2022, v. 20, n. 8, p. 1, doi. 10.1371/journal.pbio.3001714
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- Article
PRECOGx: exploring GPCR signaling mechanisms with deep protein representations.
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- Nucleic Acids Research, 2022, v. 50, n. W1, p. W598, doi. 10.1093/nar/gkac426
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- Article
Abnormal male reproduction and embryonic development induced by downregulation of a phospholipid fatty acid-introducing enzyme Lpgat1 in zebrafish.
- Published in:
- Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-11002-4
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- Article
Understanding the Role of Gβγ in the Cellular Regulation of Mutationally Activated Gα<sub>q/11</sub>.
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- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R4039
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- Article
Membrane Targeting of Constitutively Active Gαq Regulates Inhibition by YM‐254980.
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- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R5039
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- Publication type:
- Article
Phosphorylation barcode ensembles encoded by biased CXCR3 agonists direct non‐redundant chemokine signaling.
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- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.0R486
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- Publication type:
- Article
Membrane Phosphoinositides Stabilize GPCR‐arrestin Complexes and Provide Temporal Control of Complex Assembly and Dynamics.
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- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R6320
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- Publication type:
- Article
YM‐254890 Promotes the Subcellular Redistribution of Gαq.
- Published in:
- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R5307
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- Publication type:
- Article
Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex.
- Published in:
- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-30081-5
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- Publication type:
- Article
Common coupling map advances GPCR-G protein selectivity.
- Published in:
- eLife, 2022, p. 1, doi. 10.7554/eLife.74107
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- Article
OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gα<sub>z</sub>.
- Published in:
- Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03191-5
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- Publication type:
- Article
Biased agonists of the chemokine receptor CXCR3 differentially signal through Gα<sub>i</sub>:β-arrestin complexes.
- Published in:
- Science Signaling, 2022, v. 15, n. 726, p. 1, doi. 10.1126/scisignal.abg5203
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- Article
Lateral access mechanism of LPA receptor probed by molecular dynamics simulation.
- Published in:
- PLoS ONE, 2022, v. 17, n. 2, p. 1, doi. 10.1371/journal.pone.0263296
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- Publication type:
- Article
Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias.
- Published in:
- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28056-7
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- Publication type:
- Article
Vibrational spectroscopy analysis of ligand efficacy in human M<sub>2</sub> muscarinic acetylcholine receptor (M<sub>2</sub>R).
- Published in:
- Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02836-1
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- Article
Label-Free Investigations on the G Protein Dependent Signaling Pathways of Histamine Receptors.
- Published in:
- International Journal of Molecular Sciences, 2021, v. 22, n. 18, p. 9739, doi. 10.3390/ijms22189739
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- Article
Pharmacological Characterization of Low Molecular Weight Biased Agonists at the Follicle Stimulating Hormone Receptor.
- Published in:
- International Journal of Molecular Sciences, 2021, v. 22, n. 18, p. 9850, doi. 10.3390/ijms22189850
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- Article