Works by Infante, Paola

Results: 30
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    A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth.

    Published in:
    Cancers, 2019, v. 11, n. 10, p. 1518, doi. 10.3390/cancers11101518
    By:
    • Lospinoso Severini, Ludovica;
    • Quaglio, Deborah;
    • Basili, Irene;
    • Ghirga, Francesca;
    • Bufalieri, Francesca;
    • Caimano, Miriam;
    • Balducci, Silvia;
    • Moretti, Marta;
    • Romeo, Isabella;
    • Loricchio, Elena;
    • Maroder, Marella;
    • Botta, Bruno;
    • Mori, Mattia;
    • Infante, Paola;
    • Di Marcotullio, Lucia
    Publication type:
    Article
    5

    Gli1/ DNA interaction is a druggable target for Hedgehog-dependent tumors.

    Published in:
    EMBO Journal, 2015, v. 34, n. 2, p. 200, doi. 10.15252/embj.201489213
    By:
    • Infante, Paola;
    • Mori, Mattia;
    • Alfonsi, Romina;
    • Ghirga, Francesca;
    • Aiello, Federica;
    • Toscano, Sara;
    • Ingallina, Cinzia;
    • Siler, Mariangela;
    • Cucchi, Danilo;
    • Po, Agnese;
    • Miele, Evelina;
    • D'Amico, Davide;
    • Canettieri, Gianluca;
    • De Smaele, Enrico;
    • Ferretti, Elisabetta;
    • Screpanti, Isabella;
    • Uccello Barretta, Gloria;
    • Botta, Maurizio;
    • Botta, Bruno;
    • Gulino, Alberto
    Publication type:
    Article
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    Histone deacetylase and Cullin3–REN<sup>KCTD11</sup> ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation.

    Published in:
    Nature Cell Biology, 2010, v. 12, n. 2, p. 132, doi. 10.1038/ncb2013
    By:
    • Canettieri, Gianluca;
    • Di Marcotullio, Lucia;
    • Greco, Azzura;
    • Coni, Sonia;
    • Antonucci, Laura;
    • Infante, Paola;
    • Pietrosanti, Laura;
    • De Smaele, Enrico;
    • Ferretti, Elisabetta;
    • Miele, Evelina;
    • Pelloni, Marianna;
    • De Simone, Giuseppina;
    • Pedone, Emilia Maria;
    • Gallinari, Paola;
    • Giorgi, Alessandra;
    • Steink&;#x00FC;hler, Christian;
    • Vitagliano, Luigi;
    • Pedone, Carlo;
    • Schinin, M. Eugenià;
    • Screpanti, Isabella
    Publication type:
    Article
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    Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.

    Published in:
    Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03339-0
    By:
    • Infante, Paola;
    • Faedda, Roberta;
    • Bernardi, Flavia;
    • Bufalier, Francesca;
    • Severini, Ludovica Lospinoso;
    • Alfonsi, Romina;
    • Mazzà, Daniela;
    • Siler, Mariangela;
    • Coni, Sonia;
    • Po, Agnese;
    • Petroni, Marialaura;
    • Ferretti, Elisabetta;
    • Mori, Mattia;
    • De Smaele, Enrico;
    • Canettieri, Gianluca;
    • Capalbo, Carlo;
    • Maroder, Marella;
    • Screpanti, Isabella;
    • Kool, Marcel;
    • Pfister, Stefan M.
    Publication type:
    Article
    9

    Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation.

    Published in:
    Cell Death & Disease, 2020, v. 11, n. 12, p. 1, doi. 10.1038/s41419-020-03174-6
    By:
    • Coni, Sonia;
    • Serrao, Silvia Maria;
    • Yurtsever, Zuleyha Nihan;
    • Di Magno, Laura;
    • Bordone, Rosa;
    • Bertani, Camilla;
    • Licursi, Valerio;
    • Ianniello, Zaira;
    • Infante, Paola;
    • Moretti, Marta;
    • Petroni, Marialaura;
    • Guerrieri, Francesca;
    • Fatica, Alessandro;
    • Macone, Alberto;
    • De Smaele, Enrico;
    • Di Marcotullio, Lucia;
    • Giannini, Giuseppe;
    • Maroder, Marella;
    • Agostinelli, Enzo;
    • Canettieri, Gianluca
    Publication type:
    Article
    10

    MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors.

    Published in:
    Cell Death & Disease, 2018, v. 9, n. 9, p. 1, doi. 10.1038/s41419-018-0924-z
    By:
    • Petroni, Marialaura;
    • Sardina, Francesca;
    • Infante, Paola;
    • Bartolazzi, Armando;
    • Locatelli, Erica;
    • Fabretti, Francesca;
    • Di Giulio, Stefano;
    • Capalbo, Carlo;
    • Cardinali, Beatrice;
    • Coppa, Anna;
    • Tessitore, Alessandra;
    • Colicchia, Valeria;
    • Sahùn Roncero, Maria;
    • Belardinilli, Francesca;
    • Di Marcotullio, Lucia;
    • Soddu, Silvia;
    • Comes Franchini, Mauro;
    • Petricci, Elena;
    • Gulino, Alberto;
    • Giannini, Giuseppe
    Publication type:
    Article
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    SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.

    Published in:
    EMBO Journal, 2016, v. 35, n. 13, p. 1400, doi. 10.15252/embj.201593374
    By:
    • Raducu, Madalina;
    • Fung, Ella;
    • Serres, Sébastien;
    • Infante, Paola;
    • Barberis, Alessandro;
    • Fischer, Roman;
    • Bristow, Claire;
    • Thézénas, Marie‐Laëtitia;
    • Finta, Csaba;
    • Christianson, John C;
    • Buffa, Francesca M;
    • Kessler, Benedikt M;
    • Sibson, Nicola R;
    • Di Marcotullio, Lucia;
    • Toftgård, Rune;
    • D'Angiolella, Vincenzo
    Publication type:
    Article
    13

    β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells.

    Published in:
    2017
    By:
    • Miele, Evelina;
    • Po, Agnese;
    • Begalli, Federica;
    • Antonucci, Laura;
    • Mastronuzzi, Angela;
    • Marras, Carlo Efisio;
    • Carai, Andrea;
    • Cucchi, Danilo;
    • Abballe, Luana;
    • Besharat, Zein Mersini;
    • Catanzaro, Giuseppina;
    • Infante, Paola;
    • Di Marcotullio, Lucia;
    • Canettieri, Gianluca;
    • De Smaele, Enrico;
    • Screpanti, Isabella;
    • Locatelli, Franco;
    • Ferretti, Elisabetta
    Publication type:
    journal article
    14

    Combined mitoxantrone and anti-TGFβ treatment with PD-1 blockade enhances antitumor immunity by remodelling the tumor immune landscape in neuroblastoma.

    Published in:
    Journal of Experimental & Clinical Cancer Research (17569966), 2022, v. 41, n. 1, p. 1, doi. 10.1186/s13046-022-02525-9
    By:
    • Lucarini, Valeria;
    • Melaiu, Ombretta;
    • D'Amico, Silvia;
    • Pastorino, Fabio;
    • Tempora, Patrizia;
    • Scarsella, Marco;
    • Pezzullo, Marco;
    • De Ninno, Adele;
    • D'Oria, Valentina;
    • Cilli, Michele;
    • Emionite, Laura;
    • Infante, Paola;
    • Di Marcotullio, Lucia;
    • De Ioris, Maria Antonietta;
    • Barillari, Giovanni;
    • Alaggio, Rita;
    • Businaro, Luca;
    • Ponzoni, Mirco;
    • Locatelli, Franco;
    • Fruci, Doriana
    Publication type:
    Article
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    ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP.

    Published in:
    Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-11093-0
    By:
    • Bufalieri, Francesca;
    • Infante, Paola;
    • Bernardi, Flavia;
    • Caimano, Miriam;
    • Romania, Paolo;
    • Moretti, Marta;
    • Lospinoso Severini, Ludovica;
    • Talbot, Julie;
    • Melaiu, Ombretta;
    • Tanori, Mirella;
    • Di Magno, Laura;
    • Bellavia, Diana;
    • Capalbo, Carlo;
    • Puget, Stéphanie;
    • De Smaele, Enrico;
    • Canettieri, Gianluca;
    • Guardavaccaro, Daniele;
    • Busino, Luca;
    • Peschiaroli, Angelo;
    • Pazzaglia, Simonetta
    Publication type:
    Article
    17

    A Simplified Genomic Profiling Approach Predicts Outcome in Metastatic Colorectal Cancer.

    Published in:
    Cancers, 2019, v. 11, n. 2, p. 147, doi. 10.3390/cancers11020147
    By:
    • Capalbo, Carlo;
    • Belardinilli, Francesca;
    • Raimondo, Domenico;
    • Milanetti, Edoardo;
    • Malapelle, Umberto;
    • Pisapia, Pasquale;
    • Magri, Valentina;
    • Prete, Alessandra;
    • Pecorari, Silvia;
    • Colella, Mariarosaria;
    • Coppa, Anna;
    • Bonfiglio, Caterina;
    • Nicolussi, Arianna;
    • Valentini, Virginia;
    • Tessitore, Alessandra;
    • Cardinali, Beatrice;
    • Petroni, Marialaura;
    • Infante, Paola;
    • Santoni, Matteo;
    • Filetti, Marco
    Publication type:
    Article
    18

    <sup>1</sup>H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma.

    Published in:
    Cell Communication & Signaling, 2019, v. 17, n. 1, p. N.PAG, doi. 10.1186/s12964-019-0421-8
    By:
    • D'Alessandro, Giuseppina;
    • Quaglio, Deborah;
    • Monaco, Lucia;
    • Lauro, Clotilde;
    • Ghirga, Francesca;
    • Ingallina, Cinzia;
    • De Martino, Michela;
    • Fucile, Sergio;
    • Porzia, Alessandra;
    • Di Castro, Maria Amalia;
    • Bellato, Federica;
    • Mastrotto, Francesca;
    • Mori, Mattia;
    • Infante, Paola;
    • Turano, Paola;
    • Salmaso, Stefano;
    • Caliceti, Paolo;
    • Di Marcotullio, Lucia;
    • Botta, Bruno;
    • Ghini, Veronica
    Publication type:
    Article
    19

    SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors.

    Published in:
    Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-56057-y
    By:
    • Petroni, Marialaura;
    • Sahùn Roncero, Maria;
    • Ramponi, Valentina;
    • Fabretti, Francesca;
    • Nicolis Di Robilant, Vittoria;
    • Moretti, Marta;
    • Alfano, Vincenzo;
    • Corsi, Alessandro;
    • De Panfilis, Simone;
    • Giubettini, Maria;
    • Di Giulio, Stefano;
    • Capalbo, Carlo;
    • Belardinilli, Francesca;
    • Coppa, Anna;
    • Sardina, Francesca;
    • Colicchia, Valeria;
    • Pedretti, Flaminia;
    • Infante, Paola;
    • Cardinali, Beatrice;
    • Tessitore, Alessandra
    Publication type:
    Article
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    KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2.

    Published in:
    Oncogenesis, 2019, v. 8, n. 11, p. 1, doi. 10.1038/s41389-019-0175-6
    By:
    • Spiombi, Eleonora;
    • Angrisani, Annapaola;
    • Fonte, Simone;
    • De Feudis, Giuseppina;
    • Fabretti, Francesca;
    • Cucchi, Danilo;
    • Izzo, Mariapaola;
    • Infante, Paola;
    • Miele, Evelina;
    • Po, Agnese;
    • Di Magno, Laura;
    • Magliozzi, Roberto;
    • Guardavaccaro, Daniele;
    • Maroder, Marella;
    • Canettieri, Gianluca;
    • Giannini, Giuseppe;
    • Ferretti, Elisabetta;
    • Gulino, Alberto;
    • Di Marcotullio, Lucia;
    • Moretti, Marta
    Publication type:
    Article
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    Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61.

    Published in:
    Journal of Enzyme Inhibition & Medicinal Chemistry, 2018, v. 33, n. 1, p. 349, doi. 10.1080/14756366.2017.1419221
    By:
    • Calcaterra, Andrea;
    • Iovine, Valentina;
    • Botta, Bruno;
    • Quaglio, Deborah;
    • D’Acquarica, Ilaria;
    • Ciogli, Alessia;
    • Iazzetti, Antonia;
    • Alfonsi, Romina;
    • Lospinoso Severini, Ludovica;
    • Infante, Paola;
    • Di Marcotullio, Lucia;
    • Mori, Mattia;
    • Ghirga, Francesca
    Publication type:
    Article
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    Click Reaction as a Tool to Combine Pharmacophores: The Case of Vismodegib.

    Published in:
    ChemPlusChem, 2015, v. 80, n. 6, p. 938, doi. 10.1002/cplu.201402435
    By:
    • Christodoulou, Michael S.;
    • Mori, Mattia;
    • Pantano, Rebecca;
    • Alfonsi, Romina;
    • Infante, Paola;
    • Botta, Maurizio;
    • Damia, Giovanna;
    • Ricci, Francesca;
    • Sotiropoulou, Panagiota A.;
    • Liekens, Sandra;
    • Botta, Bruno;
    • Passarella, Daniele
    Publication type:
    Article
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