Works by Imig, John D.

Results: 94

Epoxyeicosatrienoic Acid Analog Decreases Renal Fibrosis by Reducing Epithelial-to-Mesenchymal Transition.

Published in:

Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00406

By:

Skibba, Melissa;
Hye Khan, Md. Abdul;
Kolb, Lauren L.;
Yeboah, Michael M.;
Falck, John R.;
Amaradhi, Radhika;
Imig, John D.

Publication type:

Article

Dual soluble epoxide hydrolase inhibitor – farnesoid X receptor agonist interventional treatment attenuates renal inflammation and fibrosis.

Published in:

Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2023.1269261

By:

Abdul Hye Khan, Md.;
Nolan, Benjamin;
Stavniichuk, Anna;
Merk, Daniel;
Imig, John D.

Publication type:

Article

Afferent Arteriolar Dilation to 11, 12-EET Analogs Involves PP2A Activity and Ca2 +-Activated K+ Channels.

Published in:

Microcirculation, 2008, v. 15, n. 2, p. 137, doi. 10.1080/10739680701456960

By:

Imig, John D.;
Dimitropoulou, Christiana;
Reddy, D. Sudarshan;
White, Richard E.;
Falck, John R.

Publication type:

Article

Obesity, Insulin Resistance, and Renal Function.

Published in:

Microcirculation, 2007, v. 14, n. 4/5, p. 349, doi. 10.1080/10739680701283018

By:

Knight, Sarah F.;
Imig, John D.

Publication type:

Article

Adaptations of the Renal Microcirculation to Hypertension.

Published in:

Microcirculation, 2002, v. 9, n. 4, p. 315, doi. 10.1080/mic.9.4.315.328

By:

Imig, John D;
Inscho, Edward W

Publication type:

Article

ETA and ETB receptors differentially modulate afferent and efferent arteriolar responses to endothelin.

Published in:

2005

By:

Inscho, Edward W;
Imig, John D;
Cook, Anthony K;
Pollock, David M

Publication type:

journal article

Contribution of cytochrome P450 epoxygenase and hydroxylase pathways to afferent arteriolar autoregulatory responsiveness.

Published in:

1999

By:

Imig, John D;
Falck, John R;
Inscho, Edward W;
Imig, J D;
Falck, J R;
Inscho, E W

Publication type:

journal article

Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats.

Published in:

Clinical Science, 2019, v. 133, n. 8, p. 939, doi. 10.1042/CS20180728

By:

Neckář, Jan;
Khan, Md. Abdul Hye;
Gross, Garrett J.;
Cyprová, Michaela;
Hrdlička, Jaroslav;
Kvasilová, Alena;
Falck, John R.;
Campbell, William B.;
á, Lenka Sedlákov;
Škutová, Šárka;
Olejníčková, Veronika;
á, Martina Gregorovičov;
Sedmera, David;
Kolář, Franti šek;
Imig, John D.

Publication type:

Article

Epoxyeicosatrienoic acid analogue mitigates kidney injury in a rat model of radiation nephropathy.

Published in:

Clinical Science, 2016, v. 130, n. 8, p. 587, doi. 10.1042/CS20150778

By:

Khan, Md. Abdul Hye;
Fish, Brian;
Wah, Geneva;
Sharma, Amit;
Falck, John R.;
Paudyal, Mahesh P.;
Moulder, John E.;
Imig, John D.;
Cohen, Eric P.

Publication type:

Article

Epoxyeicosatrienoic acid analogue lowers blood pressure through vasodilation and sodium channel inhibition.

Published in:

Clinical Science, 2014, v. 127, n. 7, p. 463, doi. 10.1042/CS20130479

By:

KHAN, Md. Abdul Hye;
PAVLOV, Tengis S.;
CHRISTAIN, Sarah V.;
NECKÁŘ, Jan;
STARUSCHENKO, Alexander;
GAUTHIER, Kathryn M.;
CAPDEVILA, Jorge H.;
FALCK, John R.;
CAMPBELL, William B.;
IMIG, John D.

Publication type:

Article

Characterization of a new model of chemotherapy-induced heart failure with reduced ejection fraction and nephrotic syndrome in Ren-2 transgenic rats.

Published in:

Hypertension Research, 2024, v. 47, n. 11, p. 3126, doi. 10.1038/s41440-024-01865-7

By:

Gawrys, Olga;
Jíchová, Šárka;
Miklovič, Matúš;
Husková, Zuzana;
Kikerlová, Soňa;
Sadowski, Janusz;
Kollárová, Petra;
Lenčová-Popelova, Olga;
Hošková, Lenka;
Imig, John D.;
Mazurova, Yvona;
Kolář, František;
Melenovský, Vojtěch;
Štěrba, Martin;
Červenka, Luděk

Publication type:

Article

Role of the cytochrome P-450/ epoxyeicosatrienoic acids pathway in the pathogenesis of renal dysfunction in cirrhosis.

Published in:

Nephrology Dialysis Transplantation, 2018, v. 33, n. 8, p. 1333, doi. 10.1093/ndt/gfx354

By:

Yeboah, Michael M;
Khan, Md Abdul Hye;
Chesnik, Marla A;
Skibba, Melissa;
Kolb, Lauren L;
Imig, John D

Publication type:

Article

Effects of Epoxyeicosatrienoic Acid-Enhancing Therapy on the Course of Congestive Heart Failure in Angiotensin II-Dependent Rat Hypertension: From mRNA Analysis towards Functional In Vivo Evaluation.

Published in:

Biomedicines, 2021, v. 9, n. 8, p. 1053, doi. 10.3390/biomedicines9081053

By:

Kala, Petr;
Miklovič, Matúš;
Jíchová, Šárka;
Škaroupková, Petra;
Vaňourková, Zdeňka;
Maxová, Hana;
Gawrys, Olga;
Kompanowska-Jezierska, Elzbieta;
Sadowski, Janusz;
Imig, John D.;
Falck, John R.;
Veselka, Josef;
Červenka, Luděk;
Aiglová, Renáta;
Vícha, Marek;
Gloger, Vít;
Táborský, Miloš

Publication type:

Article

А SORAFENIB INDUCED MODEL OF GLOMERULAR KIDNEY DISEASE.

Published in:

Bulletin of Taras Shevchenko National University of Kyiv / Vestnik Kievskogo Nacional'Nogo Universiteta Imeni Tarasa Ševčenko, 2020, v. 81, n. 2, p. 25, doi. 10.17721/1728_2748.2020.81.25-31

By:

Stavniichuk, A.;
Savchuk, O.;
Khan, Abdul Hye;
Jankiewicz, Wojciech K.;
Imig, John D.

Publication type:

Article

А SORAFENIB INDUCED MODEL OF GLOMERULAR KIDNEY DISEASE.

Published in:

Bulletin of Taras Shevchenko National University of Kyiv / Vestnik Kievskogo Nacional'Nogo Universiteta Imeni Tarasa Ševčenko, 2020, v. 81, n. 2, p. 25, doi. 10.17721/1728_2748.2020.81.25-31

By:

Stavniichuk, A.;
Savchuk, O.;
Khan, Abdul Hye;
Jankiewicz, Wojciech K.;
Imig, John D.

Publication type:

Article

THE EFFECT OF COMPOUND DM509 ON KIDNEY FIBROSIS IN THE CONDITIONS OF THE EXPERIMENTAL MODEL.

Published in:

Bulletin of Taras Shevchenko National University of Kyiv / Vestnik Kievskogo Nacional'Nogo Universiteta Imeni Tarasa Ševčenko, 2020, v. 80, n. 1, p. 10, doi. 10.17721/1728_2748.2020.80.10-15

By:

Stavniichuk, A.;
Savchuk, O.;
Khan, Abdul Hye;
Jankiewicz, Wojciech K.;
Imig, John D.;
Merk, Daniel

Publication type:

Article

Replacement of Lost Substance P Reduces Fibrosis in the Diabetic Heart by Preventing Adverse Fibroblast and Macrophage Phenotype Changes.

Published in:

Cells (2073-4409), 2021, v. 10, n. 10, p. 2659, doi. 10.3390/cells10102659

By:

Widiapradja, Alexander;
Kasparian, Ainsley O.;
McCaffrey, Samuel L.;
Kolb, Lauren L.;
Imig, John D.;
Lacey, Jessica L.;
Melendez, Giselle C.;
Levick, Scott P.

Publication type:

Article

Frontiers in metabolic physiology grand challenges.

Published in:

Frontiers in Physiology, 2022, v. 13, p. 01, doi. 10.3389/fphys.2022.879617

By:

Imig, John D.

Publication type:

Article

Editorial: Interactions Between Podocytes, Mesangial Cells, and Glomerular Endothelial Cells in Glomerular Diseases.

Published in:

2022

By:

Imig, John D.;
Zhao, Xueying;
Elmarakby, Ahmed A.;
Pavlov, Tengis

Publication type:

Editorial

p66Shc regulates renal vascular tone in hypertension-induced nephropathy.

Published in:

2016

By:

Miller, Bradley;
Palygin, Oleg;
Rufanova, Victoriya A.;
Chong, Andrew;
Lazar, Jozef;
Jacob, Howard J.;
Mattson, David;
Roman, Richard J.;
Williams, Jan M.;
Cowley Jr., Allen W.;
Geurts, Aron M.;
Staruschenko, Alexander;
Imig, John D.;
Sorokin, Andrey;
Cowley, Allen W Jr

Publication type:

journal article

Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting.

Published in:

2007

By:

Guan, Youfei;
Yahua Zhang;
Jing Wu;
Zhonghua Qi;
Guangrui Yang;
Dou Dou;
Yuansheng Gao;
Lihong Chen;
Xiaoyan Zhang;
Davis, Linda S.;
Mingfeng Wei;
Xuefeng Fan;
Carmosino, Monica;
Chuanming Hao;
Imig, John D.;
Breyer, Richard M.;
Breyer, Matthew D.;
Zhang, Yahua;
Wu, Jing;
Qi, Zhonghua

Publication type:

journal article

Carbonylation Modification Regulates Na/K-ATPase Signaling and Salt Sensitivity: A Review and a Hypothesis.

Published in:

Frontiers in Physiology, 2016, p. 1, doi. 10.3389/fphys.2016.00256

By:

Shah, Preeya T.;
Martin, Rebecca;
Yanling Yan;
Shapiro, Joseph I.;
Jiang Liu;
Imig, John D.;
Bogdanova, Anna

Publication type:

Article

Regulation of ENaC-Mediated Sodium Reabsorption by Peroxisome Proliferator-Activated Receptors.

Published in:

PPAR Research, 2010, p. 1, doi. 10.1155/2010/703735

By:

Pavlov, Tengis S.;
Imig, John D.;
Staruschenko, Alexander

Publication type:

Article

Kidney-Targeted Epoxyeicosatrienoic Acid Analog, EET-F01, Reduces Inflammation, Oxidative Stress, and Cisplatin-Induced Nephrotoxicity.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 6, p. 2793, doi. 10.3390/ijms22062793

By:

Imig, John D.;
Hye Khan, Md Abdul;
Burkhan, Anna;
Chen, Guan;
Adebesin, Adeniyi Michael;
Falck, John R.;
Hamar, Peter

Publication type:

Article

Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis.

Published in:

International Journal of Molecular Sciences, 2016, v. 17, n. 5, p. 751, doi. 10.3390/ijms17050751

By:

Sharma, Amit;
Khan, Md. Abdul Hye;
Levick, Scott P.;
Kin Sing Stephen Lee;
Hammock, Bruce D.;
Imig, John D.

Publication type:

Article

Multi-Target Approaches in Metabolic Syndrome.

Published in:

Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.554961

By:

Lillich, Felix F.;
Imig, John D.;
Proschak, Ewgenij

Publication type:

Article

Editorial: Clinical Paths for Soluble Epoxide Hydrolase Inhibitors.

Published in:

2020

By:

Imig, John D.;
Morisseau, Christophe

Publication type:

Editorial

Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: Studies in Cyp1a1-Ren-2 transgenic rats.

Published in:

Clinical & Experimental Pharmacology & Physiology, 2014, v. 41, n. 12, p. 1003, doi. 10.1111/1440-1681.12310

By:

Sporková, Alexandra;
Jíchová, Šárka;
Husková, Zuzana;
Kopkan, Libor;
Nishiyama, Akira;
Hwang, Sung H;
Hammock, Bruce D;
Imig, John D;
Kompanowska‐Jezierska, Elzbieta;
Sadowski, Janusz;
Kramer, Herbert J;
Červenka, Luděk

Publication type:

Article

Inhibition of soluble epoxide hydrolase is renoprotective in 5/6 nephrectomized Ren-2 transgenic hypertensive rats.

Published in:

Clinical & Experimental Pharmacology & Physiology, 2014, v. 41, n. 3, p. 227, doi. 10.1111/1440-1681.12204

By:

Kujal, Petr;
Čertíková Chábová, Vera;
Škaroupková, Petra;
Husková, Zuzana;
Vernerová, Zdena;
Kramer, Herbert J;
Walkowska, Agnieszka;
Kompanowska‐Jezierska, Elzbieta;
Sadowski, Janusz;
Kitada, Kento;
Nishiyama, Akira;
Hwang, Sung H;
Hammock, Bruce D;
Imig, John D;
Červenka, Ludek

Publication type:

Article

Antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats is mediated by suppression of the intrarenal renin-angiotensin system.

Published in:

Clinical & Experimental Pharmacology & Physiology, 2013, v. 40, n. 4, p. 273, doi. 10.1111/1440-1681.12018

By:

Varcabova, Sarka;
Huskova, Zuzana;
Kramer, Herbert J;
Hwang, Sung Hee;
Hammock, Bruce D;
Imig, John D;
Kitada, Kento;
Cervenka, Ludek

Publication type:

Article

Captopril attenuates hypertension and renal injury induced by the vascular endothelial growth factor inhibitor sorafenib.

Published in:

Clinical & Experimental Pharmacology & Physiology, 2012, v. 39, n. 5, p. 454, doi. 10.1111/j.1440-1681.2012.05699.x

By:

Nagasawa, Tasuku;
Hye Khan, Md Abdul;
Imig, John D

Publication type:

Article

OBESITY INDUCED RENAL OXIDATIVE STRESS CONTRIBUTES TO RENAL INJURY IN SALT-SENSITIVE HYPERTENSION.

Published in:

Clinical & Experimental Pharmacology & Physiology, 2009, v. 36, n. 7, p. 724, doi. 10.1111/j.1440-1681.2009.05139.x

By:

Quigley, Jeffrey E;
Elmarakby, Ahmed A;
Knight, Sarah F;
Manhiani, Marlina M;
Stepp, David W;
Olearzcyk, Jeffrey J;
Imig, John D

Publication type:

Article

Multitarget molecule, PTUPB, to treat diabetic nephropathy in rats.

Published in:

2021

By:

Khan, Md. Abdul Hye;
Hwang, Sung Hee;
Barnett, Scott D.;
Stavniichuk, Anna;
Jankiewicz, Wojciech K.;
Hammock, Bruce D.;
Imig, John D.;
Hye Khan, Md Abdul

Publication type:

journal article

Soluble epoxide hydrolase inhibition and peroxisome proliferator activated receptor γ agonist improve vascular function and decrease renal injury in hypertensive obese rats.

Published in:

Experimental Biology & Medicine, 2012, v. 237, n. 12, p. 1402, doi. 10.1258/ebm.2012.012225

By:

Imig, John D.;
Walsh, Katie A.;
Khan, Md Abdul Hye;
Nagasawa, Tasuku;
Cherian-Shaw, Mary;
Shaw, Sean M.;
Hammock, Bruce D.

Publication type:

Article

SARS-CoV-2 spike protein causes cardiovascular disease independent of viral infection.

Published in:

Clinical Science, 2022, v. 136, n. 6, p. 431, doi. 10.1042/CS20220028

By:

Imig, John D.

Publication type:

Article

Eicosanoid blood vessel regulation in physiological and pathological states.

Published in:

Clinical Science, 2020, v. 134, n. 20, p. 2707, doi. 10.1042/CS20191209

By:

Imig, John D.

Publication type:

Article

591 Low kidney mass contributes to enhanced fractionated irradiation-induced renal hemodynamic dysfunction in mice.

Published in:

Journal of Clinical & Translational Science, 2025, v. 9, p. 174, doi. 10.1017/cts.2024.1158

By:

Palfrey, Henry;
Goorani, Samaneh;
Mishra, Abhishek;
Abdul, Md;
Khan, Hye;
Pathak, Rupak;
Imig, John D.

Publication type:

Article

557 Dual TGFβR1/MAP4K4 inhibitor reduces kidney injury in a mouse model of renal fibrosis.

Published in:

2024

By:

Palfrey, Henry Anthony;
Goorani, Samaneh;
Sharma, Amod;
Acharya, Baku;
Frett, Brendan;
Imig, John D.

Publication type:

Abstract

Regulation of Cardiac Mast Cell Maturation and Function by the Neurokinin-1 Receptor in the Fibrotic Heart.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-47369-0

By:

Widiapradja, Alexander;
Manteufel, Edward J.;
Dehlin, Heather M.;
Pena, James;
Goldspink, Paul H.;
Sharma, Amit;
Kolb, Lauren L.;
Imig, John D.;
Janicki, Joseph S.;
Lu, Bao;
Levick, Scott P.

Publication type:

Article

Epoxyeicosatrienoic Acid Analog and 20-HETE Antagonist Combination Prevent Hypertension Development in Spontaneously Hypertensive Rats.

Published in:

Frontiers in Pharmacology, 2022, v. 12, p. 1, doi. 10.3389/fphar.2021.798642

By:

Baranowska, Iwona;
Gawrys, Olga;
Walkowska, Agnieszka;
Olszynski, Krzysztof H.;
Červenka, Luděk;
Falck, John R.;
Adebesin, Adeniyi M.;
Imig, John D.;
Kompanowska-Jezierska, Elżbieta

Publication type:

Article

Dual sEH/COX-2 Inhibition Using PTUPB—A Promising Approach to Antiangiogenesis-Induced Nephrotoxicity.

Published in:

Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.744776

By:

Jankiewicz, Wojciech K.;
Barnett, Scott D.;
Stavniichuk, Anna;
Hwang, Sung Hee;
Hammock, Bruce D.;
Belayet, Jawad B.;
Khan, A. H.;
Imig, John D.

Publication type:

Article

Kidney Injury by Unilateral Ureteral Obstruction in Mice Lacks Sex Differences.

Published in:

Kidney & Blood Pressure Research, 2024, v. 49, n. 1, p. 69, doi. 10.1159/000535809

By:

Goorani, Samaneh;
Khan, Abdul Hye;
Mishra, Abhishek;
El-Meanawy, Ashraf;
Imig, John D.

Publication type:

Article

Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo.

Published in:

Cancers, 2020, v. 12, n. 11, p. 3412, doi. 10.3390/cancers12113412

By:

Maranto, Cristina;
Udhane, Vindhya;
Jia, Jing;
Verma, Ranjit;
Müller-Newen, Gerhard;
LaViolette, Peter S.;
Pereckas, Michael;
Sabharwal, Lavannya;
Terhune, Scott;
Pattabiraman, Nagarajan;
Njar, Vincent C.O.;
Imig, John D.;
Wang, Liang;
Nevalainen, Marja T.

Publication type:

Article

Epoxygenase Metabolites Contribute to Nitric Oxide-Independent Afferent Arteriolar Vasodilation in Response to Bradykinin.

Published in:

Journal of Vascular Research, 2001, v. 38, n. 3, p. 247, doi. 10.1159/000051053

By:

Imig, John D.;
Falck, John R.;
Shouzou Wei, John R.;
Capdevila, Jorge H.

Publication type:

Article

Role of Cytochrome P-450 in Elevating Renal Vascular Tone in Spontaneously Hypertensive Rats.

Published in:

Journal of Vascular Research, 1993, v. 30, n. 1, p. 53, doi. 10.1159/000158975

By:

Gebremedhin, Debebe;
Ma, Yunn-Hwa;
Imig, John D.;
Harder, David R.;
Roman, Richard J.

Publication type:

Article

A novel dual PPAR-γ agonist/sEH inhibitor treats diabetic complications in a rat model of type 2 diabetes.

Published in:

Diabetologia, 2018, v. 61, n. 10, p. 2235, doi. 10.1007/s00125-018-4685-0

By:

Hye Khan, Md Abdul;
Kolb, Lauren;
Skibba, Melissa;
Hartmann, Markus;
Blöcher, René;
Proschak, Ewgenij;
Imig, John D.

Publication type:

Article

Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension.

Published in:

Journal of Physiology, 2011, v. 589, n. 1, p. 207, doi. 10.1113/jphysiol.2010.199505

By:

Honetschlägerová, Zuzana;
Husková, Zuzana;
Vaňourková, Zdeňka;
Sporková, Alexandra;
Kramer, Herbert J.;
Hwang, Sung Hee;
Tsai, Hsing-Ju;
Hammock, Bruce D.;
Imig, John D.;
Červenka, Luděk;
Kopkan, Libor

Publication type:

Article

Glomerular expression of kidney injury molecule-1 and podocytopenia in diabetic glomerulopathy.

Published in:

2011

By:

Zhao, Xueying;
Zhang, Yuanyuan;
Li, Lingyun;
Mann, David;
Imig, John D.;
Emmett, Nerimiah;
Gibbons, Gary;
Jin, Li-Ming

Publication type:

journal article

Early diabetes mellitus stimulates proximal tubule renin mRNA expression in the rat.

Published in:

Kidney International, 2000, v. 58, n. 6, p. 2320, doi. 10.1046/j.1523-1755.2000.00416.x

By:

Zimpelmann, Joseph;
Kumar, Dinender;
Levine, David Z.;
Wehbi, George;
Imig, John D.;
Navar, Luis G.;
Burns, Kevin D.

Publication type:

Article

Heterogeneous activation mechanisms in the renal microvasculature.

Published in:

Kidney International, 1998, v. 54, p. S17, doi. 10.1046/j.1523-1755.1998.06704.x

By:

Navar, L. Gabriel;
Inscho, Edward W.;
Imig, John D.;
Mitchell, Kenneth D.

Publication type:

Article