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Characterization of a new model of chemotherapy-induced heart failure with reduced ejection fraction and nephrotic syndrome in Ren-2 transgenic rats.
Published in:
Hypertension Research, 2024, v. 47, n. 11, p. 3126, doi. 10.1038/s41440-024-01865-7
By:
- Gawrys, Olga;
- Jíchová, Šárka;
- Miklovič, Matúš;
- Husková, Zuzana;
- Kikerlová, Soňa;
- Sadowski, Janusz;
- Kollárová, Petra;
- Lenčová-Popelova, Olga;
- Hošková, Lenka;
- Imig, John D.;
- Mazurova, Yvona;
- Kolář, František;
- Melenovský, Vojtěch;
- Štěrba, Martin;
- Červenka, Luděk
Publication type:
Article
Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases.
Published in:
2009
By:
- Imig, John D.;
- Hammock, Bruce D.
Publication type:
journal article
Early Renal Vasodilator and Hypotensive Action of Epoxyeicosatrienoic Acid Analog (EET-A) and 20-HETE Receptor Blocker (AAA) in Spontaneously Hypertensive Rats.
Published in:
Frontiers in Physiology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphys.2021.622882
By:
- Walkowska, Agnieszka;
- Červenka, Luděk;
- Imig, John D.;
- Falck, John R.;
- Sadowski, Janusz;
- Kompanowska-Jezierska, Elżbieta
Publication type:
Article
Editorial: Renal Function in Acute and Chronic Kidney Diseases.
Published in:
2020
By:
- Imig, John D.;
- Hye Khan, Md Abdul;
- Zhao, Xueying
Publication type:
Editorial
Kidney-Targeted Epoxyeicosatrienoic Acid Analog, EET-F01, Reduces Inflammation, Oxidative Stress, and Cisplatin-Induced Nephrotoxicity.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 6, p. 2793, doi. 10.3390/ijms22062793
By:
- Imig, John D.;
- Hye Khan, Md Abdul;
- Burkhan, Anna;
- Chen, Guan;
- Adebesin, Adeniyi Michael;
- Falck, John R.;
- Hamar, Peter
Publication type:
Article
Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis.
Published in:
International Journal of Molecular Sciences, 2016, v. 17, n. 5, p. 751, doi. 10.3390/ijms17050751
By:
- Sharma, Amit;
- Khan, Md. Abdul Hye;
- Levick, Scott P.;
- Kin Sing Stephen Lee;
- Hammock, Bruce D.;
- Imig, John D.
Publication type:
Article
Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting.
Published in:
2007
By:
- Guan, Youfei;
- Yahua Zhang;
- Jing Wu;
- Zhonghua Qi;
- Guangrui Yang;
- Dou Dou;
- Yuansheng Gao;
- Lihong Chen;
- Xiaoyan Zhang;
- Davis, Linda S.;
- Mingfeng Wei;
- Xuefeng Fan;
- Carmosino, Monica;
- Chuanming Hao;
- Imig, John D.;
- Breyer, Richard M.;
- Breyer, Matthew D.;
- Zhang, Yahua;
- Wu, Jing;
- Qi, Zhonghua
Publication type:
journal article
Contribution of cytochrome P450 epoxygenase and hydroxylase pathways to afferent arteriolar autoregulatory responsiveness.
Published in:
1999
By:
- Imig, John D;
- Falck, John R;
- Inscho, Edward W;
- Imig, J D;
- Falck, J R;
- Inscho, E W
Publication type:
journal article
A novel dual PPAR-γ agonist/sEH inhibitor treats diabetic complications in a rat model of type 2 diabetes.
Published in:
Diabetologia, 2018, v. 61, n. 10, p. 2235, doi. 10.1007/s00125-018-4685-0
By:
- Hye Khan, Md Abdul;
- Kolb, Lauren;
- Skibba, Melissa;
- Hartmann, Markus;
- Blöcher, René;
- Proschak, Ewgenij;
- Imig, John D.
Publication type:
Article
Epoxyeicosatrienoic Acid Analog and 20-HETE Antagonist Combination Prevent Hypertension Development in Spontaneously Hypertensive Rats.
Published in:
Frontiers in Pharmacology, 2022, v. 12, p. 1, doi. 10.3389/fphar.2021.798642
By:
- Baranowska, Iwona;
- Gawrys, Olga;
- Walkowska, Agnieszka;
- Olszynski, Krzysztof H.;
- Červenka, Luděk;
- Falck, John R.;
- Adebesin, Adeniyi M.;
- Imig, John D.;
- Kompanowska-Jezierska, Elżbieta
Publication type:
Article
Dual sEH/COX-2 Inhibition Using PTUPB—A Promising Approach to Antiangiogenesis-Induced Nephrotoxicity.
Published in:
Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.744776
By:
- Jankiewicz, Wojciech K.;
- Barnett, Scott D.;
- Stavniichuk, Anna;
- Hwang, Sung Hee;
- Hammock, Bruce D.;
- Belayet, Jawad B.;
- Khan, A. H.;
- Imig, John D.
Publication type:
Article
Multi-Target Approaches in Metabolic Syndrome.
Published in:
Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.554961
By:
- Lillich, Felix F.;
- Imig, John D.;
- Proschak, Ewgenij
Publication type:
Article
Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: Studies in Cyp1a1-Ren-2 transgenic rats.
Published in:
Clinical & Experimental Pharmacology & Physiology, 2014, v. 41, n. 12, p. 1003, doi. 10.1111/1440-1681.12310
By:
- Sporková, Alexandra;
- Jíchová, Šárka;
- Husková, Zuzana;
- Kopkan, Libor;
- Nishiyama, Akira;
- Hwang, Sung H;
- Hammock, Bruce D;
- Imig, John D;
- Kompanowska‐Jezierska, Elzbieta;
- Sadowski, Janusz;
- Kramer, Herbert J;
- Červenka, Luděk
Publication type:
Article
Inhibition of soluble epoxide hydrolase is renoprotective in 5/6 nephrectomized Ren-2 transgenic hypertensive rats.
Published in:
Clinical & Experimental Pharmacology & Physiology, 2014, v. 41, n. 3, p. 227, doi. 10.1111/1440-1681.12204
By:
- Kujal, Petr;
- Čertíková Chábová, Vera;
- Škaroupková, Petra;
- Husková, Zuzana;
- Vernerová, Zdena;
- Kramer, Herbert J;
- Walkowska, Agnieszka;
- Kompanowska‐Jezierska, Elzbieta;
- Sadowski, Janusz;
- Kitada, Kento;
- Nishiyama, Akira;
- Hwang, Sung H;
- Hammock, Bruce D;
- Imig, John D;
- Červenka, Ludek
Publication type:
Article
Antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats is mediated by suppression of the intrarenal renin-angiotensin system.
Published in:
Clinical & Experimental Pharmacology & Physiology, 2013, v. 40, n. 4, p. 273, doi. 10.1111/1440-1681.12018
By:
- Varcabova, Sarka;
- Huskova, Zuzana;
- Kramer, Herbert J;
- Hwang, Sung Hee;
- Hammock, Bruce D;
- Imig, John D;
- Kitada, Kento;
- Cervenka, Ludek
Publication type:
Article
Captopril attenuates hypertension and renal injury induced by the vascular endothelial growth factor inhibitor sorafenib.
Published in:
Clinical & Experimental Pharmacology & Physiology, 2012, v. 39, n. 5, p. 454, doi. 10.1111/j.1440-1681.2012.05699.x
By:
- Nagasawa, Tasuku;
- Hye Khan, Md Abdul;
- Imig, John D
Publication type:
Article
OBESITY INDUCED RENAL OXIDATIVE STRESS CONTRIBUTES TO RENAL INJURY IN SALT-SENSITIVE HYPERTENSION.
Published in:
Clinical & Experimental Pharmacology & Physiology, 2009, v. 36, n. 7, p. 724, doi. 10.1111/j.1440-1681.2009.05139.x
By:
- Quigley, Jeffrey E;
- Elmarakby, Ahmed A;
- Knight, Sarah F;
- Manhiani, Marlina M;
- Stepp, David W;
- Olearzcyk, Jeffrey J;
- Imig, John D
Publication type:
Article
Elevated Aminopeptidase P Attenuates Cerebral Arterial Responses to Bradykinin in Fawn-Hooded Hypertensive Rats.
Published in:
PLoS ONE, 2015, v. 10, n. 12, p. 1, doi. 10.1371/journal.pone.0145335
By:
- Khan, Md Abdul Hye;
- Sharma, Amit;
- Rarick, Kevin R.;
- Roman, Richard J.;
- Harder, David R.;
- Imig, John D.
Publication type:
Article
557 Dual TGFβR1/MAP4K4 inhibitor reduces kidney injury in a mouse model of renal fibrosis.
Published in:
2024
By:
- Palfrey, Henry Anthony;
- Goorani, Samaneh;
- Sharma, Amod;
- Acharya, Baku;
- Frett, Brendan;
- Imig, John D.
Publication type:
Abstract
Editorial: Clinical Paths for Soluble Epoxide Hydrolase Inhibitors.
Published in:
2020
By:
- Imig, John D.;
- Morisseau, Christophe
Publication type:
Editorial
Editorial: Nuclear receptors in hemodynamics and blood pressure control.
Published in:
Frontiers in Physiology, 2023, p. 01, doi. 10.3389/fphys.2023.1290411
By:
- Imig, John D.;
- Jing Wu;
- Gohar, Eman Y.
Publication type:
Article
Peroxisome proliferator-activated receptors, farnesoid X receptor, and dual modulating drugs in hypertension.
Published in:
Frontiers in Physiology, 2023, p. 1, doi. 10.3389/fphys.2023.1186477
By:
- Imig, John D.
Publication type:
Article
Editorial: The future of physiology: 2020 and beyond, Volume III.
Published in:
Frontiers in Physiology, 2023, v. 14, p. 1, doi. 10.3389/fphys.2023.1159406
By:
- Imig, John D.
Publication type:
Article
Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo.
Published in:
Cancers, 2020, v. 12, n. 11, p. 3412, doi. 10.3390/cancers12113412
By:
- Maranto, Cristina;
- Udhane, Vindhya;
- Jia, Jing;
- Verma, Ranjit;
- Müller-Newen, Gerhard;
- LaViolette, Peter S.;
- Pereckas, Michael;
- Sabharwal, Lavannya;
- Terhune, Scott;
- Pattabiraman, Nagarajan;
- Njar, Vincent C.O.;
- Imig, John D.;
- Wang, Liang;
- Nevalainen, Marja T.
Publication type:
Article
Epoxyeicosatrienoic acid analogue lowers blood pressure through vasodilation and sodium channel inhibition.
Published in:
Clinical Science, 2014, v. 127, n. 7, p. 463, doi. 10.1042/CS20130479
By:
- KHAN, Md. Abdul Hye;
- PAVLOV, Tengis S.;
- CHRISTAIN, Sarah V.;
- NECKÁŘ, Jan;
- STARUSCHENKO, Alexander;
- GAUTHIER, Kathryn M.;
- CAPDEVILA, Jorge H.;
- FALCK, John R.;
- CAMPBELL, William B.;
- IMIG, John D.
Publication type:
Article
Azilsartan Improves Glycemic Status and Reduces Kidney Damage in Zucker Diabetic Fatty Rats.
Published in:
American Journal of Hypertension, 2014, v. 27, n. 8, p. 1087, doi. 10.1093/ajh/hpu016
By:
- Khan, Md. Abdul Hye;
- Neckář, Jan;
- Haines, Jasmine;
- Imig, John D.
Publication type:
Article
Telmisartan Provides Better Renal Protection Than Valsartan in a Rat Model of Metabolic Syndrome.
Published in:
American Journal of Hypertension, 2011, v. 24, n. 7, p. 816, doi. 10.1038/ajh.2011.34
By:
- Khan, Md. Abdul Hye;
- Imig, John D.
Publication type:
Article
Afferent arteriolar reactivity to angiotensin II is enhanced during the early phase of angiotensin II hypertension<sup>*</sup>.
Published in:
American Journal of Hypertension, 2000, v. 13, n. 7, p. 810, doi. 10.1016/S0895-7061(00)00264-8
By:
- Imig, John D.
Publication type:
Article
Renal responses to AT<sub>1</sub> receptor blockade.
Published in:
American Journal of Hypertension, 2000, v. 13, p. 45S, doi. 10.1016/S0895-7061(99)00248-4
By:
- Navar, L.Gabriel;
- Harrison-Bernard, Lisa M.;
- Imig, John D.;
- Cervenka, Ludek;
- Mitchell, Kenneth D.
Publication type:
Article
Regulation of Cardiac Mast Cell Maturation and Function by the Neurokinin-1 Receptor in the Fibrotic Heart.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-47369-0
By:
- Widiapradja, Alexander;
- Manteufel, Edward J.;
- Dehlin, Heather M.;
- Pena, James;
- Goldspink, Paul H.;
- Sharma, Amit;
- Kolb, Lauren L.;
- Imig, John D.;
- Janicki, Joseph S.;
- Lu, Bao;
- Levick, Scott P.
Publication type:
Article
Dual soluble epoxide hydrolase inhibitor – farnesoid X receptor agonist interventional treatment attenuates renal inflammation and fibrosis.
Published in:
Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2023.1269261
By:
- Abdul Hye Khan, Md.;
- Nolan, Benjamin;
- Stavniichuk, Anna;
- Merk, Daniel;
- Imig, John D.
Publication type:
Article
Carbonylation Modification Regulates Na/K-ATPase Signaling and Salt Sensitivity: A Review and a Hypothesis.
Published in:
Frontiers in Physiology, 2016, p. 1, doi. 10.3389/fphys.2016.00256
By:
- Shah, Preeya T.;
- Martin, Rebecca;
- Yanling Yan;
- Shapiro, Joseph I.;
- Jiang Liu;
- Imig, John D.;
- Bogdanova, Anna
Publication type:
Article
Novel orally active epoxyeicosatrienoic acid (EET) analogs attenuate cisplatin nephrotoxicity.
Published in:
FASEB Journal, 2013, v. 27, n. 8, p. 2946, doi. 10.1096/fj.12-218040
By:
- Khan, Md. Abdul Hye;
- Jing Liu;
- Kumar, Ganesh;
- Skapek, Stephen X.;
- Falck, John R.;
- Imig, John D.
Publication type:
Article
Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice.
Published in:
FASEB Journal, 2010, v. 24, n. 10, p. 3770, doi. 10.1096/fj.10-160119
By:
- Lee, Craig R.;
- Imig, John D.;
- Edin, Matthew L.;
- Foley, Julie;
- DeGraff, Laura M.;
- Bradbury, J. Alyce;
- Graves, Joan P.;
- Lih, Fred B.;
- Clark, James;
- Myers, Page;
- Perrow, A. Ligon;
- Lepp, Adrienne N.;
- Kannon, M. Alison;
- Ronnekleiv, Oline K.;
- Alkayed, Nabil J.;
- Falck, John R.;
- Tomer, Kenneth B.;
- Zeldin, Darryl C.
Publication type:
Article
Increased blood pressure in mice lacking cytochrome P450 2J5.
Published in:
FASEB Journal, 2008, v. 22, n. 12, p. 4096, doi. 10.1096/fj.08-114413
By:
- Athirakul, Krairerk;
- Bradbury, J. Alyce;
- Graves, Joan P.;
- DeGraff, Laura M.;
- Jixiang Ma;
- Yun Zhao;
- Couse, John F.;
- Quigley, Raymond;
- Harder, David R.;
- Xueying Zhao;
- Imig, John D.;
- Pedersen, Theresa L.;
- Newman, John W.;
- Hammock, Bruce D.;
- Conley, Alan J.;
- Korach, Kenneth S.;
- Coffman, Thomas M.;
- Zeldin, Darryl C.
Publication type:
Article
p66Shc regulates renal vascular tone in hypertension-induced nephropathy.
Published in:
2016
By:
- Miller, Bradley;
- Palygin, Oleg;
- Rufanova, Victoriya A.;
- Chong, Andrew;
- Lazar, Jozef;
- Jacob, Howard J.;
- Mattson, David;
- Roman, Richard J.;
- Williams, Jan M.;
- Cowley Jr., Allen W.;
- Geurts, Aron M.;
- Staruschenko, Alexander;
- Imig, John D.;
- Sorokin, Andrey;
- Cowley, Allen W Jr
Publication type:
journal article
Epoxyeicosatrienoic acid analog attenuates angiotensin II hypertension and kidney injury.
Published in:
Frontiers in Pharmacology, 2014, v. 5, p. 1, doi. 10.3389/fphar.2014.00216
By:
- Khan, Abdul Hye;
- Falck, John R.;
- Manthati, Vijaya L.;
- Campbell, William B.;
- Imig, John D.
Publication type:
Article
Pharmacological manipulation of arachidonic acid-epoxygenase results in divergent effects on renal damage.
Published in:
Frontiers in Pharmacology, 2014, v. 5, p. 1, doi. 10.3389/fphar.2014.00187
By:
- Jing Li;
- Stier, Charles T.;
- Chander, Praveen N.;
- Manthati, Vijay L.;
- Falck, John R.;
- Carroll, Mairéad A.;
- Imig, John D.;
- Jurasz, Paul
Publication type:
Article
Tim-1 Deficiency Aggravates High-Fat Diet-Induced Steatohepatitis in Mice.
Published in:
Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.747794
By:
- George, Jasmine;
- Zhang, Yuanyuan;
- Sloan, Jacob;
- Sims, Joya M.;
- Imig, John D.;
- Zhao, Xueying
Publication type:
Article
Kidney Injury by Unilateral Ureteral Obstruction in Mice Lacks Sex Differences.
Published in:
Kidney & Blood Pressure Research, 2024, v. 49, n. 1, p. 69, doi. 10.1159/000535809
By:
- Goorani, Samaneh;
- Khan, Abdul Hye;
- Mishra, Abhishek;
- El-Meanawy, Ashraf;
- Imig, John D.
Publication type:
Article
Altered Renal Vascular Responsiveness to Vasoactive Agents in Rats with Angiotensin II-Dependent Hypertension and Congestive Heart Failure.
Published in:
Kidney & Blood Pressure Research, 2019, v. 44, n. 4, p. 792, doi. 10.1159/000501688
By:
- Vacková, Šárka;
- Kikerlová, Soňa;
- Melenovsky, Vojtěch;
- Kolář, František;
- Imig, John D.;
- Kompanowska-Jezierska, Elzbieta;
- Sadowski, Janusz;
- Červenka, Luděk
Publication type:
Article
Combined Inhibition of Soluble Epoxide Hydrolase and Renin-Angiotensin System Exhibits Superior Renoprotection to Renin-Angiotensin System Blockade in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats with Established Chronic Kidney Disease.
Published in:
Kidney & Blood Pressure Research, 2018, v. 43, n. 2, p. 329, doi. 10.1159/000487902
By:
- Čertíková Chábová, Věra;
- Kujal, Petr;
- Škaroupková, Petra;
- Varňourková, Zdeňka;
- Vacková, Šárka;
- Husková, Zuzana;
- Kikerlová, Soňa;
- Sadowski, Janusz;
- Kompanowska-Jezierska, Elzbieta;
- Baranowska, Iwona;
- Hwang, Sung Hee;
- Hammock, Bruce D.;
- Imig, John D.;
- Tesař, Vladimír;
- Červenka, Ludek
Publication type:
Article
Soluble Epoxide Hydrolase Inhibition Exhibits Antihypertensive Actions Independently of Nitric Oxide in Mice with Renovascular Hypertension.
Published in:
Kidney & Blood Pressure Research, 2012, v. 35, n. 6, p. 595, doi. 10.1159/000339883
By:
- Kopkan, Libor;
- Husková, Zuzana;
- Sporková, Alexandra;
- Varcabová, Šárka;
- Honetschlägerová, Zuzana;
- Sung Hee Hwang;
- Hsing-Ju Tsai;
- Hammock, Bruce D.;
- Imig, John D.;
- Kramer, Herbert J.;
- Bürgelová, Marcela;
- Vojtíšková, Alžběta;
- Kujal, Petr;
- Vernerová, Zdenka;
- Červenka, Luděk
Publication type:
Article
The Roles of Intrarenal 20-Hydroxyeicosatetraenoic and Epoxyeicosatrienoic Acids in the Regulation of Renal Function in Hypertensive Ren-2 Transgenic Rats.
Published in:
Kidney & Blood Pressure Research, 2007, v. 30, n. 5, p. 335, doi. 10.1159/000107710
By:
- Chábová, Věra Čertíková;
- Kramer, Herbert J.;
- Vaně Čková, Ivana;
- Thumová, Monika;
- Škaroupková, Petra;
- Tesař, Vladimír;
- Falck, John R.;
- Imig, John D.;
- Červenka, Luděk
Publication type:
Article
Regulation of ENaC-Mediated Sodium Reabsorption by Peroxisome Proliferator-Activated Receptors.
Published in:
PPAR Research, 2010, p. 1, doi. 10.1155/2010/703735
By:
- Pavlov, Tengis S.;
- Imig, John D.;
- Staruschenko, Alexander
Publication type:
Article
Rosaglitazone (RGZ) decreases renal damage in spontaneously diabetic Goto- Kakizaki (GK) rats.
Published in:
FASEB Journal, 2007, v. 21, n. 6, p. A1194, doi. 10.1096/fasebj.21.6.a1194-b
By:
- Olearczyk, Jeffrey J.;
- Field, Mary B.;
- Imig, John D.
Publication type:
Article
Dietary fat increases renal injury in SHR in the absence of changes in insulin sensitivity or blood pressure.
Published in:
FASEB Journal, 2007, v. 21, n. 6, p. A1194, doi. 10.1096/fasebj.21.6.a1194-a
By:
- Knight, Sarah Frances;
- Roy, Siddhartha;
- Imig, John D.
Publication type:
Article
Long-term high fat diet treatment activates NF kappa B signaling and increases endothelial dysfunction in angiotensin II hypertensive rats.
Published in:
FASEB Journal, 2007, v. 21, n. 6, p. A1196, doi. 10.1096/fasebj.21.6.a1196-c
By:
- Elmarakby, Ahmed A.;
- Imig, John D.
Publication type:
Article
TNF-alpha inhibition reduces renal injury in DOCA-salt hypertensive rats.
Published in:
FASEB Journal, 2007, v. 21, n. 6, p. A900
By:
- Elmarakby, Ahmed A.;
- Quigley, Jeffrey E.;
- Imig, John D.;
- Pollock, Jennifer S.;
- Pollock, David M.
Publication type:
Article
Enhanced renal microvascular relaxation to acetylcholine in soluble epoxide hydrolase null mice.
Published in:
FASEB Journal, 2007, v. 21, n. 6, p. A869
By:
- Manhiani, Marlina M.;
- Field, Mary B.;
- Imig, John D.
Publication type:
Article

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