Works by Iliakis, George

Results: 86

The p97-Ufd1-NpI4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation.

Published in:

Cell Cycle, 2014, v. 13, n. 6, p. 919, doi. 10.4161/cc.27779

By:

Riemer, Anne;
Dobrynin, Grzegorz;
Dressler, Alina;
Bremer, Sebastian;
Soni, Aashish;
Iliakis, George;
Meyer, Hemmo

Publication type:

Article

Interferon alpha 2a downregulates VEGF expression through PI3 kinase and MAP kinase signaling pathways.

Published in:

Journal of Cancer Research & Clinical Oncology, 2005, v. 131, n. 3, p. 169, doi. 10.1007/s00432-004-0615-2

By:

Wu, Wei-Zhong;
Sun, Hui-Chuan;
Shen, Yue-Fang;
Chen, Jie;
Wang, Lu;
Tang, Zhao-You;
Iliakis, George;
Liu, Kang-Da

Publication type:

Article

Low CDK Activity and Enhanced Degradation by APC/C CDH1 Abolishes CtIP Activity and Alt-EJ in Quiescent Cells.

Published in:

Cells (2073-4409), 2023, v. 12, n. 11, p. 1530, doi. 10.3390/cells12111530

By:

Li, Fanghua;
Mladenov, Emil;
Sun, Yanjie;
Soni, Aashish;
Stuschke, Martin;
Timmermann, Beate;
Iliakis, George

Publication type:

Article

The p38/MK2 Pathway Functions as Chk1-Backup Downstream of ATM/ATR in G 2 -Checkpoint Activation in Cells Exposed to Ionizing Radiation.

Published in:

Cells (2073-4409), 2023, v. 12, n. 10, p. 1387, doi. 10.3390/cells12101387

By:

Luo, Daxian;
Mladenov, Emil;
Soni, Aashish;
Stuschke, Martin;
Iliakis, George

Publication type:

Article

Increased Resection at DSBs in G 2 -Phase Is a Unique Phenotype Associated with DNA-PKcs Defects That Is Not Shared by Other Factors of c-NHEJ.

Published in:

Cells (2073-4409), 2022, v. 11, n. 13, p. N.PAG, doi. 10.3390/cells11132099

By:

Xiao, Huaping;
Li, Fanghua;
Mladenov, Emil;
Soni, Aashish;
Mladenova, Veronika;
Pan, Bing;
Dueva, Rositsa;
Stuschke, Martin;
Timmermann, Beate;
Iliakis, George

Publication type:

Article

Depletion of HIF-1α by Inducible Cre/loxP Increases the Sensitivity of Cultured Murine Hepatocytes to Ionizing Radiation in Hypoxia.

Published in:

Cells (2073-4409), 2022, v. 11, n. 10, p. 1671, doi. 10.3390/cells11101671

By:

Hamidi, Akram;
Wolf, Alexandra;
Dueva, Rositsa;
Kaufmann, Melanie;
Göpelt, Kirsten;
Iliakis, George;
Metzen, Eric

Publication type:

Article

Shift in G 1 -Checkpoint from ATM-Alone to a Cooperative ATM Plus ATR Regulation with Increasing Dose of Radiation.

Published in:

Cells (2073-4409), 2022, v. 11, n. 1, p. 63, doi. 10.3390/cells11010063

By:

Li, Fanghua;
Mladenov, Emil;
Dueva, Rositsa;
Stuschke, Martin;
Timmermann, Beate;
Iliakis, George

Publication type:

Article

Functional redundancy between DNA ligases I and III in DNA replication in vertebrate cells.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 6, p. 2599, doi. 10.1093/nar/gkr1024

By:

Arakawa, Hiroshi;
Bednar, Theresa;
Wang, Minli;
Paul, Katja;
Mladenov, Emil;
Bencsik-Theilen, Alena A.;
Iliakis, George

Publication type:

Article

Post-irradiation chemical processing of DNA damage generates double-strand breaks in cells already engaged in repair.

Published in:

Nucleic Acids Research, 2011, v. 39, n. 19, p. 8416, doi. 10.1093/nar/gkr463

By:

Singh, Satyendra K.;
Wang, Minli;
Staudt, Christian;
Iliakis, George

Publication type:

Article

γ-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin.

Published in:

Nucleic Acids Research, 2008, v. 36, n. 17, p. 5678, doi. 10.1093/nar/gkn550

By:

Kinner, Andrea;
Wu, Wenqi;
Staudt, Christian;
Iliakis, George

Publication type:

Article

Histone H1 functions as a stimulatory factor in backup pathways of NHEJ.

Published in:

Nucleic Acids Research, 2008, v. 36, n. 5, p. 1610, doi. 10.1093/nar/gkn013

By:

Rosidi, Bustanur;
Wang, Minli;
Wu, Wenqi;
Sharma, Aparna;
Wang, Huichen;
Iliakis, George

Publication type:

Article

PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways.

Published in:

Nucleic Acids Research, 2006, v. 34, n. 21, p. 6170, doi. 10.1093/nar/gkl840

By:

Wang, Minli;
Wu, Weizhong;
Wu, Wenqi;
Rosidi, Bustanur;
Zhang, Lihua;
Wang, Huichen;
Iliakis, George

Publication type:

Article

Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation.

Published in:

Nucleic Acids Research, 2004, v. 32, n. 2, p. 767, doi. 10.1093/nar/gkh243

By:

Wang, Xiang;
Guan, Jun;
Hu, Baocheng;
Weiss, Robert S.;
Iliakis, George;
Wang, Ya

Publication type:

Article

Biochemical evidence for Ku‐independent backup pathways of NHEJ.

Published in:

Nucleic Acids Research, 2003, v. 31, n. 18, p. 5377, doi. 10.1093/nar/gkg728

By:

Wang, Huichen;
Perrault, Ange Ronel;
Takeda, Yoshihiko;
Qin, Wei;
Wang, Hongyan;
Iliakis, George

Publication type:

Article

Strong Shift to ATR-Dependent Regulation of the G 2 -Checkpoint after Exposure to High-LET Radiation.

Published in:

Life (2075-1729), 2021, v. 11, n. 6, p. 560, doi. 10.3390/life11060560

By:

Mladenova, Veronika;
Mladenov, Emil;
Scholz, Michael;
Stuschke, Martin;
Iliakis, George

Publication type:

Article

Dependence of adaptive response and its bystander transmission on the genetic background of tested cells.

Published in:

International Journal of Radiation Biology, 2012, v. 88, n. 10, p. 720, doi. 10.3109/09553002.2012.691613

By:

Klammer, Holger;
Zhang, Li-Hua;
Kadhim, Munira;
Iliakis, George

Publication type:

Article

The impact of serotonin on the development of bystander damage assessed by γ-H2AX foci analysis.

Published in:

International Journal of Radiation Biology, 2012, v. 88, n. 10, p. 777, doi. 10.3109/09553002.2012.703364

By:

Klammer, Holger;
Iliakis, George

Publication type:

Article

A laboratory inter-comparison of the importance of serum serotonin levels in the measurement of a range of radiation-induced bystander effects: Overview of study and results presentation.

Published in:

International Journal of Radiation Biology, 2012, v. 88, n. 10, p. 763, doi. 10.3109/09553002.2012.715795

By:

Mothersill, Carmel;
Antonelli, Francesca;
Dahle, Jostein;
Dini, Valentina;
Hegyesi, Hargita;
Iliakis, George;
Kämäräinen, Kamy;
Launonen, Virpi;
Lumniczky, Katalin;
Lyng, Fiona;
Safrany, Géza;
Salomaa, Sisko;
Schilling-Tóth, Boglárka;
Tabocchini, Antonella;
Kadhim, Munira A.

Publication type:

Article

Linear DNA Elution Dose Response Curves Obtained in CHO Cells with Non-unwinding Filter Elution after Appropriate Selection of the Lysis Conditions.

Published in:

International Journal of Radiation Biology, 1989, v. 55, n. 4, p. 569, doi. 10.1080/713863336

By:

Okayasu, Ryuichi;
Iliakis, George

Publication type:

Article

Radiosensitive Xrs-5 and Parental CHO Cells Show Identical DNA Neutral Filter Elution Dose - response: Implications for a Relationship between Cell Radiosensitivity and Induction of DNA Double-strand Breaks.

Published in:

International Journal of Radiation Biology, 1988, v. 54, n. 1, p. 55, doi. 10.1080/09553008814551501

By:

Iliakis, George;
Okayasu, Ryuichi;
Seaner, Robert

Publication type:

Article

Alternative Okazaki Fragment Ligation Pathway by DNA Ligase III.

Published in:

Genes, 2015, v. 6, n. 2, p. 385, doi. 10.3390/genes6020385

By:

Hiroshi Arakawa;
Iliakis, George

Publication type:

Article

Fisetin induces DNA double-strand break and interferes with the repair of radiation-induced damage to radiosensitize triple negative breast cancer cells.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2022, v. 41, n. 1, p. 1, doi. 10.1186/s13046-022-02442-x

By:

Khozooei, Shayan;
Lettau, Konstanze;
Barletta, Francesca;
Jost, Tina;
Rebholz, Simone;
Veerappan, Soundaram;
Franz-Wachtel, Mirita;
Macek, Boris;
Iliakis, George;
Distel, Luitpold V.;
Zips, Daniel;
Toulany, Mahmoud

Publication type:

Article

New Facets of DNA Double Strand Break Repair: Radiation Dose as Key Determinant of HR versus c-NHEJ Engagement.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 19, p. 14956, doi. 10.3390/ijms241914956

By:

Mladenov, Emil;
Mladenova, Veronika;
Stuschke, Martin;
Iliakis, George

Publication type:

Article

Chemical Inhibition of RPA by HAMNO Alters Cell Cycle Dynamics by Impeding DNA Replication and G2-to-M Transition but Has Little Effect on the Radiation-Induced DNA Damage Response.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 19, p. 14941, doi. 10.3390/ijms241914941

By:

Dueva, Rositsa;
Krieger, Lisa Marie;
Li, Fanghua;
Luo, Daxian;
Xiao, Huaping;
Stuschke, Martin;
Metzen, Eric;
Iliakis, George

Publication type:

Article

Impact of Manganese and Chromate on Specific DNA Double-Strand Break Repair Pathways.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 12, p. 10392, doi. 10.3390/ijms241210392

By:

Haberland, Vivien M. M.;
Magin, Simon;
Iliakis, George;
Hartwig, Andrea

Publication type:

Article

PTEN Loss Enhances Error-Prone DSB Processing and Tumor Cell Radiosensitivity by Suppressing RAD51 Expression and Homologous Recombination.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 21, p. 12876, doi. 10.3390/ijms232112876

By:

Pei, Xile;
Mladenov, Emil;
Soni, Aashish;
Li, Fanghua;
Stuschke, Martin;
Iliakis, George

Publication type:

Article

Increased Gene Targeting in Hyper-Recombinogenic LymphoBlastoid Cell Lines Leaves Unchanged DSB Processing by Homologous Recombination.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 16, p. 9180, doi. 10.3390/ijms23169180

By:

Mladenov, Emil;
Paul-Konietzko, Katja;
Mladenova, Veronika;
Stuschke, Martin;
Iliakis, George

Publication type:

Article

ATR Contributes More Than ATM in Intra-S-Phase Checkpoint Activation after IR, and DNA-PKcs Facilitates Recovery: Evidence for Modular Integration of ATM/ATR/DNA-PKcs Functions.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 14, p. 7506, doi. 10.3390/ijms23147506

By:

Soni, Aashish;
Duan, Xiaolu;
Stuschke, Martin;
Iliakis, George

Publication type:

Article

Disruption of Chromatin Dynamics by Hypotonic Stress Suppresses HR and Shifts DSB Processing to Error-Prone SSA.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 20, p. 10957, doi. 10.3390/ijms222010957

By:

Krieger, Lisa Marie;
Mladenov, Emil;
Soni, Aashish;
Demond, Marilen;
Stuschke, Martin;
Iliakis, George

Publication type:

Article

Relating Linear Energy Transfer to the Formation and Resolution of DNA Repair Foci After Irradiation with Equal Doses of X-ray Photons, Plateau, or Bragg-Peak Protons.

Published in:

International Journal of Molecular Sciences, 2018, v. 19, n. 12, p. 3779, doi. 10.3390/ijms19123779

By:

Oeck, Sebastian;
Szymonowicz, Klaudia;
Wiel, Gesa;
Krysztofiak, Adam;
Lambert, Jamil;
Koska, Benjamin;
Iliakis, George;
Timmermann, Beate;
Jendrossek, Verena

Publication type:

Article

Restraining Akt1 Phosphorylation Attenuates the Repair of Radiation-Induced DNA Double-Strand Breaks and Reduces the Survival of Irradiated Cancer Cells.

Published in:

International Journal of Molecular Sciences, 2018, v. 19, n. 8, p. 2233, doi. 10.3390/ijms19082233

By:

Szymonowicz, Klaudia;
Oeck, Sebastian;
Krysztofiak, Adam;
van der Linden, Jansje;
Iliakis, George;
Jendrossek, Verena

Publication type:

Article

Reduction in p48-ISGFγ Levels Confers Resistance to Interferon-α2a in MHCC97 Cells.

Published in:

Oncology, 2004, v. 67, n. 5/6, p. 428, doi. 10.1159/000082928

By:

Wei-Zhong Wu;
Hui-Chuan Sun;
Yan-Qin Gao;
Yan Li;
Lu Wang;
Kang Zhou;
Kang-Da Liu;
George Iliakis;
Zhao-You Tang

Publication type:

Article

Conformational transitions of proteins engaged in DNA double-strand break repair, analysed by tryptophan fluorescence emission and FRET.

Published in:

Biochemical Journal, 2012, v. 443, n. 3, p. 701, doi. 10.1042/BJ20112151

By:

STANKOVA, Katia;
IVANOVA, Katia;
MLADENOV, Emil;
ROSIDI, Bustanur;
SHARMA, Aparna;
BOTEVA, Rayna;
ILIAKIS, George

Publication type:

Article

Rewiring E2F1 with classical NHEJ via APLF suppression promotes bladder cancer invasiveness.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2019, v. 38, n. 1, p. N.PAG, doi. 10.1186/s13046-019-1286-9

By:

Richter, Christin;
Marquardt, Stephan;
Li, Fanghua;
Spitschak, Alf;
Murr, Nico;
Edelhäuser, Berdien A. H.;
Iliakis, George;
Pützer, Brigitte M.;
Logotheti, Stella

Publication type:

Article

DNA Ligases I and III Support Nucleotide Excision Repair in DT40 Cells with Similar Efficiency.

Published in:

Photochemistry & Photobiology, 2015, v. 91, n. 5, p. 1173, doi. 10.1111/php.12487

By:

Paul‐Konietzko, Katja;
Thomale, Juergen;
Arakawa, Hiroshi;
Iliakis, George

Publication type:

Article

Backup pathways of NHEJ are suppressed by DNA‐PK.

Published in:

Journal of Cellular Biochemistry, 2004, v. 92, n. 4, p. 781, doi. 10.1002/jcb.20104

By:

Ronel Perrault;
Huichen Wang;
Minli Wang;
Bustanur Rosidi;
George Iliakis

Publication type:

Article

Deregulated BCL-2 family proteins impact on repair of DNA double-strand breaks and are targets to overcome radioresistance in lung cancer.

Published in:

Journal of Cancer Research & Clinical Oncology, 2017, v. 143, n. 9, p. 1733, doi. 10.1007/s00432-017-2427-1

By:

Wieczorek, Sarah;
Breitenbuecher, Frank;
Soni, Aashish;
Paul-Konietzko, Katja;
Ziegler, Sophie;
Sak, Ali;
Iliakis, George;
Schuler, Martin

Publication type:

Article

DNA-PKcs and ATM epistatically suppress DNA end resection and hyperactivation of ATR-dependent G2-checkpoint in S-phase irradiated cells.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-51071-6

By:

Mladenov, Emil;
Fan, Xiaoxiang;
Paul-Konietzko, Katja;
Soni, Aashish;
Iliakis, George

Publication type:

Article

Radiation-dose-dependent functional synergisms between ATM, ATR and DNA-PKcs in checkpoint control and resection in G2-phase.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-44771-6

By:

Mladenov, Emil;
Fan, Xiaoxiang;
Dueva, Rositsa;
Soni, Aashish;
Iliakis, George

Publication type:

Article

The catalytic subunit DNA-dependent protein kinase (DNA-PKcs) facilitates recovery from radiation-induced inhibition of DNA replication.

Published in:

Nucleic Acids Research, 2000, v. 28, n. 5, p. 1183, doi. 10.1093/nar/28.5.1183

By:

Guan, Jun;
DiBiase, Steven;
Iliakis, George

Publication type:

Article

Necessities in the Processing of DNA Double Strand Breaks and Their Effects on Genomic Instability and Cancer.

Published in:

Cancers, 2019, v. 11, n. 11, p. 1671, doi. 10.3390/cancers11111671

By:

Iliakis, George;
Mladenov, Emil;
Mladenova, Veronika

Publication type:

Article

The anatomy and cell cycle evolution of DNA damage signaling and repair foci.

Published in:

Cell Cycle, 2010, v. 9, n. 3, p. 444, doi. 10.4161/cc.9.3.10731

By:

Iliakis, George

Publication type:

Article

CHK1-Tegulated S-phase Checkpoint Response Reduces Camptothecin Cytotoxity.

Published in:

Cell Cycle, 2002, v. 1, n. 4, p. 267, doi. 10.4161/cc.1.4.137

By:

Jia-Lun Wang;
Xiang Wang;
Hongyan Wang;
Iliakis, George;
Ya Wang

Publication type:

Article

NGS Detects Extensive Genomic Alterations in Survivors of Irradiated Normal Human Fibroblast Cells.

Published in:

Radiation Research, 2025, v. 203, n. 1, p. 37, doi. 10.1667/RADE-24-00094.1

By:

Soni, Aashish;
Beisser, Daniela;
Mladenov, Emil;
Höller, Matthias;
Wohlers, Inken;
Nikolov, Vladimir;
Magin, Simon;
Mussfeldt, Tamara;
Klein-Hitpass, Ludger;
Cornforth, Michael N.;
Loucas, Bradford D.;
Rahmann, Sven;
Iliakis, George

Publication type:

Article

The presumed MTH1-inhibitor TH588 sensitizes colorectal carcinoma cells to ionizing radiation in hypoxia.

Published in:

2018

By:

Pompsch, Mosche;
Vogel, Julia;
Classen, Fabian;
Kranz, Philip;
Iliakis, George;
Riffkin, Helena;
Brockmeier, Ulf;
Metzen, Eric

Publication type:

journal article

Usp18 Driven Enforced Viral Replication in Dendritic Cells Contributes to Break of Immunological Tolerance in Autoimmune Diabetes.

Published in:

PLoS Pathogens, 2013, v. 9, n. 10, p. 1, doi. 10.1371/journal.ppat.1003650

By:

Honke, Nadine;
Shaabani, Namir;
Zhang, Dong-Er;
Iliakis, George;
Xu, Haifeng C.;
Häussinger, Dieter;
Recher, Mike;
Löhning, Max;
Lang, Philipp A.;
Lang, Karl S.

Publication type:

Article

Selective vulnerability of ARID1A deficient colon cancer cells to combined radiation and ATR-inhibitor therapy.

Published in:

Frontiers in Oncology, 2022, v. 12, p. 1, doi. 10.3389/fonc.2022.999626

By:

Shan Xu;
Sak, Ali;
Niedermaier, Ben;
Erol, Yasin Bahadir;
Groneberg, Michael;
Mladenov, Emil;
Ming Wei Kang;
Iliakis, George;
Stuschke, Martin

Publication type:

Article

DNA double-strand break repair as determinant of cellular radiosensitivity to killing and target in radiation therapy.

Published in:

Frontiers in Oncology, 2013, v. 3, p. 1, doi. 10.3389/fonc.2013.00113

By:

Mladenov, Emil;
Magin, Simon;
Soni, Aashish;
Iliakis, George

Publication type:

Article

DNA Double-Strand Break Repair as determinant of cellular radiosensitivity to killing and target in radiation therapy.

Published in:

Frontiers in Oncology, 2013, p. 1, doi. 10.3389/fonc.2013.00113

By:

Mladenov, Emil;
Magin, Simon;
Soni, Aashish;
Iliakis, George

Publication type:

Article

DNA damage checkpoint control in cells exposed to ionizing radiation.

Published in:

Oncogene, 2003, v. 22, n. 37, p. 5834, doi. 10.1038/sj.onc.1206682

By:

Iliakis, George;
Wang, Ya;
Guan, Jun;
Wang, Huichen

Publication type:

Article