Works matching AU Hurdle, Julian G.

Results: 23

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections.

Published in:

Nature Reviews Microbiology, 2011, v. 9, n. 1, p. 62, doi. 10.1038/nrmicro2474

By:

Hurdle, Julian G.;
O'Neill, Alex J.;
Chopra, Ian;
Lee, Richard E.

Publication type:

Article

The Clostridium difficile proline racemase is not essential for early logarithmic growth and infection.

Published in:

Canadian Journal of Microbiology, 2014, v. 60, n. 4, p. 251, doi. 10.1139/cjm-2013-0903

By:

Wu, Xiaoqian;
Hurdle, Julian G.

Publication type:

Article

Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux.

Published in:

Nature Medicine, 2014, v. 20, n. 2, p. 152, doi. 10.1038/nm.3458

By:

Lee, Richard E;
Hurdle, Julian G;
Liu, Jiuyu;
Bruhn, David F;
Matt, Tanja;
Scherman, Michael S;
Vaddady, Pavan K;
Zheng, Zhong;
Qi, Jianjun;
Akbergenov, Rashid;
Das, Sourav;
Madhura, Dora B;
Rathi, Chetan;
Trivedi, Ashit;
Villellas, Cristina;
Lee, Robin B;
Rakesh;
Waidyarachchi, Samanthi L;
Sun, Dianqing;
McNeil, Michael R

Publication type:

Article

Gastrointestinal localization of metronidazole by a lactobacilli-inspired tetramic acid motif improves treatment outcomes in the hamster model of Clostridium difficile infection.

Published in:

2015

By:

Cherian, Philip T.;
Xiaoqian Wu;
Lei Yang;
Scarborough, Jerrod S.;
Singh, Aman P.;
Alam, Zahidul A.;
Lee, Richard E.;
Hurdle, Julian G.;
Wu, Xiaoqian;
Yang, Lei

Publication type:

journal article

The membrane as a target for controlling hypervirulent Clostridium difficile infections.

Published in:

2013

By:

Wu, Xiaoqian;
Cherian, Philip T;
Lee, Richard E;
Hurdle, Julian G

Publication type:

journal article

The membrane as a target for controlling hypervirulent Clostridium difficile infections.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2013, v. 68, n. 4, p. 806

By:

Wu, Xiaoqian;
Cherian, Philip T.;
Lee, Richard E.;
Hurdle, Julian G.

Publication type:

Article

Reutericyclin and related analogues kill stationary phase Clostridium difficile at achievable colonic concentrations.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2011, v. 66, n. 8, p. 1773, doi. 10.1093/jac/dkr201

By:

Hurdle, Julian G.;
Heathcott, Amy E.;
Yang, Lei;
Yan, Bing;
Lee, Richard E.

Publication type:

Article

In vivo transfer of high-level mupirocin resistance from Staphylococcus epidermidis to methicillin-resistant Staphylococcus aureus associated with failure of mupirocin prophylaxis.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2005, v. 56, n. 6, p. 1166, doi. 10.1093/jac/dki387

By:

Julian G. Hurdle;
Alex J. O'Neill;
Lona Mody;
Ian Chopra;
Suzanne F. Bradley

Publication type:

Article

The isoleucyl-tRNA synthetase mutation V588F conferring mupirocin resistance in glycopeptide-intermediate Staphylococcus aureus is not associated with a significant fitness burden.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2004, v. 53, n. 1, p. 102

By:

Julian G. Hurdle;
Alex J. O'Neill;
Ian Chopra

Publication type:

Article

Genetic Mechanisms of Vancomycin Resistance in Clostridioides difficile : A Systematic Review.

Published in:

Antibiotics (2079-6382), 2022, v. 11, n. 2, p. 258, doi. 10.3390/antibiotics11020258

By:

Eubank, Taryn A.;
Gonzales-Luna, Anne J.;
Hurdle, Julian G.;
Garey, Kevin W.

Publication type:

Article

Reduced Vancomycin Susceptibility in Clostridioides difficile Is Associated With Specific Ribotypes.

Published in:

Open Forum Infectious Diseases, 2024, v. 11, n. 11, p. 1, doi. 10.1093/ofid/ofae588

By:

Eubank, Taryn A;
Dureja, Chetna;
Gonzales-Luna, Anne J;
Hurdle, Julian G;
Garey, Kevin W

Publication type:

Article

Reduced Susceptibility to Metronidazole Is Associated With Initial Clinical Failure in Clostridioides difficile Infection.

Published in:

Open Forum Infectious Diseases, 2021, v. 8, n. 8, p. 1, doi. 10.1093/ofid/ofab365

By:

Gonzales-Luna, Anne J;
Olaitan, Abiola O;
Shen, Wan-Jou;
Deshpande, Aditi;
Carlson, Travis J;
Dotson, Kierra M;
Lancaster, Chris;
Begum, Khurshida;
Alam, M Jahangir;
Hurdle, Julian G;
Garey, Kevin W

Publication type:

Article

Epidemic Clostridioides difficile Ribotype 027 Lineages: Comparisons of Texas Versus Worldwide Strains.

Published in:

Open Forum Infectious Diseases, 2019, v. 6, n. 2, p. N.PAG, doi. 10.1093/ofid/ofz013

By:

Endres, Bradley T;
Begum, Khurshida;
Sun, Hua;
Walk, Seth T;
Memariani, Ali;
Lancaster, Chris;
Gonzales-Luna, Anne J;
Dotson, Kierra M;
Bassères, Eugénie;
Offiong, Charlene;
Tupy, Shawn;
Kuper, Kristi;
Septimus, Edward;
Arafat, Raouf;
Alam, M Jahangir;
Zhao, Zhongming;
Hurdle, Julian G;
Savidge, Tor C;
Garey, Kevin W

Publication type:

Article

Pentacyclic Nitrofurans with <i>In Vivo</i> Efficacy and Activity against Nonreplicating <i>Mycobacterium tuberculosis</i>.

Published in:

PLoS ONE, 2014, v. 9, n. 2, p. 1, doi. 10.1371/journal.pone.0087909

By:

Rakesh;
Bruhn, David F.;
Scherman, Michael S.;
Woolhiser, Lisa K.;
Madhura, Dora B.;
Maddox, Marcus M.;
Singh, Aman P.;
Lee, Robin B.;
Hurdle, Julian G.;
McNeil, Michael R.;
Lenaerts, Anne J.;
Meibohm, Bernd;
Lee, Richard E.

Publication type:

Article

Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-39429-x

By:

Olaitan, Abiola O.;
Dureja, Chetna;
Youngblom, Madison A.;
Topf, Madeline A.;
Shen, Wan-Jou;
Gonzales-Luna, Anne J.;
Deshpande, Aditi;
Hevener, Kirk E.;
Freeman, Jane;
Wilcox, Mark H.;
Palmer, Kelli L.;
Garey, Kevin W.;
Pepperell, Caitlin S.;
Hurdle, Julian G.

Publication type:

Article

Constitutive expression of the cryptic vanGCd operon promotes vancomycin resistance in Clostridioides difficile clinical isolates.

Published in:

2020

By:

Shen, Wan-Jou;
Deshpande, Aditi;
Hevener, Kirk E;
Endres, Bradley T;
Garey, Kevin W;
Palmer, Kelli L;
Hurdle, Julian G

Publication type:

journal article

Design, synthesis and microbiological evaluation of ampicillin-tetramic acid hybrid antibiotics.

Published in:

Journal of Antibiotics, 2017, v. 70, n. 1, p. 65, doi. 10.1038/ja.2016.52

By:

Cherian, Philip T;
Deshpande, Aditi;
Cheramie, Martin N;
Bruhn, David F;
Hurdle, Julian G;
Lee, Richard E

Publication type:

Article

Syntheses and evaluation of macrocyclic engelhardione analogs as antitubercular and antibacterial agents.

Published in:

Journal of Antibiotics, 2013, v. 66, n. 6, p. 319, doi. 10.1038/ja.2013.21

By:

Shen, Li;
M Maddox, Marcus;
Adhikari, Sudip;
Bruhn, David F;
Kumar, Manish;
Lee, Robin E;
Hurdle, Julian G;
Lee, Richard E;
Sun, Dianqing

Publication type:

Article

Chemical Modulation of the Biological Activity of Reutericyclin: a Membrane-Active Antibiotic from Lactobacillus reuteri.

Published in:

Scientific Reports, 2014, p. 1, doi. 10.1038/srep04721

By:

Cherian, Philip T.;
Wu, Xiaoqian;
Maddox, Marcus M.;
Singh, Aman P.;
Lee, Richard E.;
Hurdle, Julian G.

Publication type:

Article

Reduced Vancomycin Susceptibility in Clostridioides difficile Is Associated With Lower Rates of Initial Cure and Sustained Clinical Response.

Published in:

Clinical Infectious Diseases, 2024, v. 79, n. 1, p. 15, doi. 10.1093/cid/ciae087

By:

Eubank, Taryn A;
Dureja, Chetna;
Garey, Kevin W;
Hurdle, Julian G;
Gonzales-Luna, Anne J

Publication type:

Article

Surveillance of Clostridioides difficile Antimicrobial Resistance in the United States.

Published in:

2023

By:

Gonzales-Luna, Anne J;
Dureja, Chetna;
Eubank, Taryn A;
Garey, Kevin W;
Hurdle, Julian G

Publication type:

Letter to the Editor

Evaluation of Flavonoid and Resveratrol Chemical Libraries Reveals Abyssinone II as a Promising Antibacterial Lead.

Published in:

ChemMedChem, 2012, v. 7, n. 9, p. 1541, doi. 10.1002/cmdc.201200253

By:

Sun, Dianqing;
Hurdle, Julian G.;
Lee, Robin;
Lee, Richard;
Cushman, Mark;
Pezzuto, John M.

Publication type:

Article

Novel Acyl Phosphate Mimics that Target PlsY, an Essential Acyltransferase in Gram-Positive Bacteria.

Published in:

ChemMedChem, 2008, v. 3, n. 12, p. 1936, doi. 10.1002/cmdc.200800218

By:

Grimes, Kimberly D.;
Lu, Ying-Jie;
Zhang, Yong-Mei;
Luna, Vicki A.;
Hurdle, Julian G.;
Carson, Elizabeth I.;
Qi, Jianjun;
Kudrimoti, Sucheta;
Rock, Charles O.;
Lee, Richard E.

Publication type:

Article