Works by Huot, Philippe

Results: 53

5-HT2A blockade for dyskinesia and psychosis in Parkinson's disease: is there a limit to the efficacy of this approach? A study in the MPTP-lesioned marmoset and a literature mini-review.

Published in:

Experimental Brain Research, 2019, v. 237, n. 2, p. 435, doi. 10.1007/s00221-018-5434-9

By:

Kwan, Cynthia;
Frouni, Imane;
Bédard, Dominique;
Nuara, Stephen G.;
Gourdon, Jim C.;
Hamadjida, Adjia;
Huot, Philippe

Publication type:

Article

Effect of the selective 5-HT2A receptor antagonist EMD-281,014 on L-DOPA-induced abnormal involuntary movements in the 6-OHDA-lesioned rat.

Published in:

Experimental Brain Research, 2019, v. 237, n. 1, p. 29, doi. 10.1007/s00221-018-5390-4

By:

Frouni, Imane;
Kwan, Cynthia;
Bédard, Dominique;
Belliveau, Sébastien;
Bourgeois-Cayer, Élodie;
Gaudette, Fleur;
Beaudry, Francis;
Hamadjida, Adjia;
Huot, Philippe

Publication type:

Article

The serotonergic system in motor and non-motor manifestations of Parkinson's disease.

Published in:

Experimental Brain Research, 2013, v. 230, n. 4, p. 463, doi. 10.1007/s00221-013-3621-2

By:

Huot, Philippe;
Fox, Susan

Publication type:

Article

Effect of the mGlu2 positive allosteric modulator CBiPES on dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset.

Published in:

Journal of Neural Transmission, 2021, v. 128, n. 1, p. 73, doi. 10.1007/s00702-020-02287-8

By:

Frouni, Imane;
Kwan, Cynthia;
Nuara, Stephen G.;
Belliveau, Sébastien;
Kang, Woojin;
Hamadjida, Adjia;
Bédard, Dominique;
Gourdon, Jim C.;
Huot, Philippe

Publication type:

Article

The MPTP-lesioned marmoset model of Parkinson's disease: proposed efficacy thresholds that may potentially predict successful clinical trial results.

Published in:

Journal of Neural Transmission, 2020, v. 127, n. 10, p. 1343, doi. 10.1007/s00702-020-02247-2

By:

Beaudry, Francis;
Huot, Philippe

Publication type:

Article

Combined mGlu2 orthosteric stimulation and positive allosteric modulation alleviates l-DOPA-induced psychosis-like behaviours and dyskinesia in the parkinsonian marmoset.

Published in:

Journal of Neural Transmission, 2020, v. 127, n. 7, p. 1023, doi. 10.1007/s00702-020-02185-z

By:

Nuara, Stephen G.;
Hamadjida, Adjia;
Kwan, Cynthia;
Bédard, Dominique;
Frouni, Imane;
Gourdon, Jim C.;
Huot, Philippe

Publication type:

Article

The mGlu2/3 antagonist LY-341,495 reverses the anti-dyskinetic and anti-psychotic effects of the mGlu2 activators LY-487,379 and LY-354,740 in the MPTP-lesioned marmoset.

Published in:

Journal of Neural Transmission, 2020, v. 127, n. 7, p. 1013, doi. 10.1007/s00702-020-02196-w

By:

Nuara, Stephen G.;
Hamadjida, Adjia;
Gourdon, Jim C.;
Huot, Philippe

Publication type:

Article

Trazodone alleviates both dyskinesia and psychosis in the parkinsonian marmoset model of Parkinson’s disease.

Published in:

Journal of Neural Transmission, 2018, v. 125, n. 9, p. 1355, doi. 10.1007/s00702-017-1830-8

By:

Hamadjida, Adjia;
Nuara, Stephen G.;
Gourdon, Jim C.;
Huot, Philippe

Publication type:

Article

Increased levels of 5-HT1A receptor binding in ventral visual pathways in Parkinson's disease.

Published in:

2012

By:

Huot P;
Johnston TH;
Visanji NP;
Darr T;
Pires D;
Hazrati LN;
Brotchie JM;
Fox SH;
Huot, Philippe;
Johnston, Tom H;
Visanji, Naomi P;
Darr, Tayyeba;
Pires, Donna;
Hazrati, Lili-Naz;
Brotchie, Jonathan M;
Fox, Susan H

Publication type:

journal article

Increased levels of 5-HT1A receptor binding in ventral visual pathways in Parkinson's disease.

Published in:

Movement Disorders, 2012, v. 27, n. 6, p. 735, doi. 10.1002/mds.24964

By:

Huot, Philippe;
Johnston, Tom H.;
Visanji, Naomi P.;
Darr, Tayyeba;
Pires, Donna;
Hazrati, Lili-Naz;
Brotchie, Jonathan M.;
Fox, Susan H.

Publication type:

Article

Increased 5-HT2A receptors in the temporal cortex of parkinsonian patients with visual hallucinations.

Published in:

Movement Disorders, 2010, v. 25, n. 10, p. 1399, doi. 10.1002/mds.23083

By:

Huot, Philippe;
Johnston, Tom H.;
Darr, Tayyeba;
Hazrati, Lili-Naz;
Visanji, Naomi P.;
Pires, Donna;
Brotchie, Jonathan M.;
Fox, Susan H.

Publication type:

Article

[3H]-NFPS binding to the glycine transporter 1 in the hemi-parkinsonian rat brain.

Published in:

Experimental Brain Research, 2024, v. 242, n. 5, p. 1203, doi. 10.1007/s00221-024-06815-w

By:

Frouni, Imane;
Kim, Esther;
Shaqfah, Judy;
Bédard, Dominique;
Kwan, Cynthia;
Belliveau, Sébastien;
Huot, Philippe

Publication type:

Article

The Monoamine Re-Uptake Inhibitor UWA-101 Improves Motor Fluctuations in the MPTP-Lesioned Common Marmoset.

Published in:

PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0045587

By:

Huot, Philippe;
Johnston, Tom H.;
Gandy, Michael N.;
Reyes, M. Gabriela;
Fox, Susan H.;
Piggott, Matthew J.;
Brotchie, Jonathan M.;
Sgambato-Faure, Veronique

Publication type:

Article

Progressive Neurodegeneration or Endogenous Compensation in an Animal Model of Parkinson's Disease Produced by Decreasing Doses of Alpha-Synuclein.

Published in:

PLoS ONE, 2011, v. 6, n. 3, p. 1, doi. 10.1371/journal.pone.0017698

By:

Koprich, James B.;
Johnston, Tom H.;
Huot, Philippe;
Reyes, M. Gabriela;
Espinosa, Maria;
Brotchie, Jonathan M.

Publication type:

Article

A novel MDMA analogue, UWA-101, that lacks psychoactivity and cytotoxicity, enhances L-DOPA benefit in parkinsonian primates.

Published in:

FASEB Journal, 2012, v. 26, n. 5, p. 2154, doi. 10.1096/fj.11-195016

By:

Johnston, Tom H.;
Millar, Zak;
Huot, Philippe;
Wagg, Keith;
Thiele, Sherri;
Salomonczyk, Danielle;
Yong-Kee, Christopher J.;
Gandy, Michael N.;
McIldowie, Matthew;
Lewis, Katie D.;
Gomez-Ramirez, Jordi;
Joohyung Lee;
Fox, Susan H.;
Martin-Iverson, Mathew;
Nash, Joanne E.;
Piggott, Matthew J.;
Brotchie, Jonathan M.

Publication type:

Article

Effect of the mGlu4 positive allosteric modulator ADX-88178 on parkinsonism, psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset.

Published in:

Psychopharmacology, 2023, v. 240, n. 10, p. 2093, doi. 10.1007/s00213-023-06428-1

By:

Frouni, Imane;
Kwan, Cynthia;
Bédard, Dominique;
Kang, Woojin;
Hamadjida, Adjia;
Nuara, Stephen G.;
Gourdon, Jim C.;
Huot, Philippe

Publication type:

Article

The effect of mirtazapine on dopaminergic psychosis and dyskinesia in the parkinsonian marmoset.

Published in:

Psychopharmacology, 2017, v. 234, n. 6, p. 905, doi. 10.1007/s00213-017-4530-z

By:

Hamadjida, Adjia;
Nuara, Stephen;
Veyres, Nicolas;
Frouni, Imane;
Kwan, Cynthia;
Sid-Otmane, Lamia;
Harraka, Mery-Jane;
Gourdon, Jim;
Huot, Philippe

Publication type:

Article

Levodopa-induced dyskinesia: do current clinical trials hold hope for future treatment?

Published in:

2024

By:

Alsalmi, Mohammed;
Al-Kassmy, Jawad;
Kang, Woojin;
Palayew, Michael;
Huot, Philippe

Publication type:

Editorial

New insights into the organization of the basal ganglia.

Published in:

Current Neurology & Neuroscience Reports, 2009, v. 9, n. 4, p. 298, doi. 10.1007/s11910-009-0045-2

By:

Koprich, James;
Johnston, Tom;
Huot, Philippe;
Fox, Susan;
Brotchie, Jonathan

Publication type:

Article

The fate of striatal dopaminergic neurons in Parkinson's disease and Huntington's chorea.

Published in:

Brain: A Journal of Neurology, 2007, v. 130, n. 1, p. 222

By:

Philippe Huot;
Martin LÃ©vesque;
AndrÃ© Parent

Publication type:

Article

Oral treatment for mucopolysaccharidosis VI: Outcomes of the first phase IIa study with odiparcil.

Published in:

Journal of Inherited Metabolic Disease, 2022, v. 45, n. 2, p. 340, doi. 10.1002/jimd.12467

By:

Guffon, Nathalie;
Chowdary, Pratima;
Teles, Elisa Leão;
Hughes, Derralynn;
Hennermann, Julia B.;
Huot‐Marchand, Philippe;
Faudot‐Vernier, Elodie;
Lacombe, Olivier;
Fiquet, Anne;
Richard, Marie‐Paule;
Abitbol, Jean‐Louis;
Tallandier, Mireille;
Hendriksz, Christian J.

Publication type:

Article

Editorial: Circuits plasticity in neurodegenerative disorders: targeting mood disorders.

Published in:

Frontiers in Neural Circuits, 2025, p. 1, doi. 10.3389/fncir.2025.1592657

By:

Vachez, Yvan M.;
Huot, Philippe;
Magnard, Robin

Publication type:

Article

Neuropsychiatric Behaviors in the MPTP Marmoset Model of Parkinson's Disease.

Published in:

Canadian Journal of Neurological Sciences, 2010, v. 37, n. 1, p. 86, doi. 10.1017/S0317167100009707

By:

Fox, Susan H.;
Visanji, Naomi;
Reyes, Gaby;
Huot, Philippe;
Gomez-Ramirez, Jordi;
Johnston, Tom;
Brotchie, Jonathan M.

Publication type:

Article

Asynchronous Burst-Suppression on EEG in Severe, Diffuse Axonal Injury.

Published in:

2008

By:

Savard, Martin;
Huot, Philippe

Publication type:

Letter

Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer's disease.

Published in:

Alzheimer's Research & Therapy, 2021, v. 13, n. 1, p. 1, doi. 10.1186/s13195-021-00802-x

By:

Tissot, Cécile;
L. Benedet, Andréa;
Therriault, Joseph;
Pascoal, Tharick A.;
Lussier, Firoza Z.;
Saha-Chaudhuri, Paramita;
Chamoun, Mira;
Savard, Melissa;
Mathotaarachchi, Sulantha S.;
Bezgin, Gleb;
Wang, Yi-Ting;
Fernandez Arias, Jaime;
Rodriguez, Juan Lantero;
Snellman, Anniina;
Ashton, Nicholas J.;
Karikari, Thomas K.;
Blennow, Kaj;
Zetterberg, Henrik;
De Villers-Sidani, Etienne;
Huot, Philippe

Publication type:

Article

Effectiveness of the Crizotinib Therapeutic Management Guide in Communicating Risks, and Recommended Actions to Minimize Risks, Among Physicians Prescribing Crizotinib in Europe.

Published in:

Pharmaceutical Medicine, 2018, v. 32, n. 5, p. 343, doi. 10.1007/s40290-018-0248-4

By:

Madison, Terri;
Huang, Kui;
Huot-Marchand, Philippe;
Wilner, Keith D.;
Mo, Jingping

Publication type:

Article

Use of catechol- O-methyltransferase inhibition to minimize L-3,4-dihydroxyphenylalanine-induced dyskinesia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque.

Published in:

European Journal of Neuroscience, 2013, v. 37, n. 5, p. 831, doi. 10.1111/ejn.12093

By:

Huot, Philippe;
Johnston, Tom H.;
Snoeren, Tessa;
Koprich, James B.;
Hill, Michael P.;
Fox, Susan H.;
Brotchie, Jonathan M.

Publication type:

Article

Dopaminergic neurons intrinsic to the striatum.

Published in:

Journal of Neurochemistry, 2007, v. 101, n. 6, p. 1441, doi. 10.1111/j.1471-4159.2006.04430.x

By:

Huot, Philippe;
Parent, Andr

Publication type:

Article

Effect of mGluR2 and mGluR2/3 activators on parkinsonism in the MPTP-lesioned non-human primate.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2024, v. 397, n. 11, p. 9135, doi. 10.1007/s00210-024-03216-2

By:

Frouni, Imane;
Kwan, Cynthia;
Bédard, Dominique;
Hamadjida, Adjia;
Kang, Woojin;
Belliveau, Sébastien;
Nuara, Stephen G.;
Gourdon, Jim C.;
Huot, Philippe

Publication type:

Article

Positive allosteric mGluR2 modulation with BINA alleviates dyskinesia and psychosis-like behaviours in the MPTP-lesioned marmoset.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2024, v. 397, n. 11, p. 8917, doi. 10.1007/s00210-024-03215-3

By:

Kang, Woojin;
Frouni, Imane;
Bédard, Dominique;
Kwan, Cynthia;
Hamadjida, Adjia;
Nuara, Stephen G.;
Gourdon, Jim C.;
Huot, Philippe

Publication type:

Article

The mGluR2/3 orthosteric agonist LY-404,039 reduces dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2023, v. 396, n. 10, p. 2347, doi. 10.1007/s00210-023-02587-2

By:

Kang, Woojin;
Nuara, Stephen G.;
Bédard, Dominique;
Frouni, Imane;
Kwan, Cynthia;
Hamadjida, Adjia;
Gourdon, Jim C.;
Gaudette, Fleur;
Beaudry, Francis;
Huot, Philippe

Publication type:

Article

Distribution of [11C]-JNJ-42491293 in the marmoset brain: a positron emission tomography study.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2023, v. 396, n. 9, p. 2095, doi. 10.1007/s00210-023-02458-w

By:

Kang, Min Su;
Hamadjida, Adjia;
Bédard, Dominique;
Nuara, Stephen G.;
Gourdon, Jim C.;
Frey, Stephen;
Aliaga, Arturo;
Ross, Karen;
Hopewell, Robert;
Bdair, Hussein;
Mathieu, Axel;
Tardif, Christine Lucas;
Soucy, Jean-Paul;
Massarweh, Gassan;
Rosa-Neto, Pedro;
Huot, Philippe

Publication type:

Article

Pharmacokinetic profile of bitopertin, a selective GlyT1 inhibitor, in the rat.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2023, v. 396, n. 5, p. 1053, doi. 10.1007/s00210-022-02378-1

By:

Frouni, Imane;
Bédard, Dominique;
Bourgeois-Cayer, Élodie;
Hamadjida, Adjia;
Gaudette, Fleur;
Beaudry, Francis;
Huot, Philippe

Publication type:

Article

Additive effects of mGluR2 positive allosteric modulation, mGluR2 orthosteric stimulation and 5-HT2AR antagonism on dyskinesia and psychosis-like behaviours in the MPTP-lesioned marmoset.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2021, v. 394, n. 12, p. 2381, doi. 10.1007/s00210-021-02162-7

By:

Nuara, Stephen G;
Gourdon, Jim C;
Maddaford, Shawn;
Huot, Philippe

Publication type:

Article

Further characterisation of psychosis-like behaviours induced by L-DOPA in the MPTP-lesioned marmoset.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2021, v. 394, n. 8, p. 1685, doi. 10.1007/s00210-021-02090-6

By:

Kwan, Cynthia;
Nuara, Stephen G.;
Gourdon, Jim C.;
Huot, Philippe

Publication type:

Article

Monoamine oxidase A inhibition as monotherapy reverses parkinsonism in the MPTP-lesioned marmoset.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2020, v. 393, n. 11, p. 2139, doi. 10.1007/s00210-020-01927-w

By:

Hamadjida, Adjia;
Nuara, Stephen G.;
Frouni, Imane;
Kwan, Cynthia;
Bédard, Dominique;
Gourdon, Jim C.;
Huot, Philippe

Publication type:

Article

Monoamine oxidase A inhibition with moclobemide enhances the anti-parkinsonian effect of L-DOPA in the MPTP-lesioned marmoset.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2020, v. 393, n. 11, p. 2157, doi. 10.1007/s00210-020-01933-y

By:

Hamadjida, Adjia;
Nuara, Stephen G.;
Kwan, Cynthia;
Frouni, Imane;
Bédard, Dominique;
Gourdon, Jim C.;
Huot, Philippe

Publication type:

Article

Nefazodone reduces dyskinesia, but not psychosis-like behaviours, in the parkinsonian marmoset.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2018, v. 391, n. 12, p. 1339, doi. 10.1007/s00210-018-1549-6

By:

Hamadjida, Adjia;
Nuara, Stephen G.;
Bédard, Dominique;
Frouni, Imane;
Kwan, Cynthia;
Gourdon, Jim C.;
Huot, Philippe

Publication type:

Article

Pemphigoid-like Skin Lesions Following Introduction of Safinamide.

Published in:

Canadian Journal of Neurological Sciences, 2023, v. 50, n. 4, p. 647, doi. 10.1017/cjn.2022.75

By:

Lachance, Lucie;
Huot, Philippe

Publication type:

Article

A Man With Persistent Dopamine Agonist Withdrawal Syndrome After 7 Years Being Off Dopamine Agonists.

Published in:

2016

By:

Huynh, Niem Tu;
Sid-Otmane, Lamia;
Panisset, Michel;
Huot, Philippe

Publication type:

Case Study

Propranolol-induced Somnambulism: A Case-report in a Patient with Essential Tremor.

Published in:

2014

By:

Huynh, Niem Tu;
Huot, Philippe

Publication type:

Case Study

Effect of the mGlu2 positive allosteric modulator biphenyl‐indanone A as a monotherapy and as adjunct to a low dose of L‐DOPA in the MPTP‐lesioned marmoset.

Published in:

European Journal of Neuroscience, 2024, v. 60, n. 9, p. 6175, doi. 10.1111/ejn.16454

By:

Kang, Woojin;
Frouni, Imane;
Kwan, Cynthia;
Bédard, Dominique;
Nuara, Stephen G.;
Hamadjida, Adjia;
Gourdon, Jim C.;
Huot, Philippe

Publication type:

Article

The 5‐HT2A/2C inverse agonist nelotanserin alleviates L‐DOPA‐induced dyskinesia in the MPTP‐lesioned marmoset.

Published in:

European Journal of Neuroscience, 2024, v. 59, n. 6, p. 1169, doi. 10.1111/ejn.16104

By:

Kwan, Cynthia;
Frouni, Imane;
Bédard, Dominique;
Hamadjida, Adjia;
Nuara, Stephen G.;
Gourdon, Jim C.;
Huot, Philippe

Publication type:

Article

The highly selective mGlu2 receptor positive allosteric modulator LY‐487,379 alleviates l‐DOPA‐induced dyskinesia in the 6‐OHDA‐lesioned rat model of Parkinson's disease.

Published in:

European Journal of Neuroscience, 2020, v. 51, n. 12, p. 2412, doi. 10.1111/ejn.14679

By:

Hamadjida, Adjia;
Sid‐Otmane, Lamia;
Kwan, Cynthia;
Frouni, Imane;
Nafade, Vaidehi;
Bédard, Dominique;
Gagnon, Dave;
Wallman, Marie‐Josée;
Rouillard, Claude;
Parent, André;
Parent, Martin;
Huot, Philippe

Publication type:

Article

Quantitative determination of LY‐404,039, a metabotropic glutamate 2/3 receptor agonist, in rat plasma using chemical derivatization and HPLC–MRM/MS.

Published in:

Biomedical Chromatography, 2022, v. 36, n. 9, p. 1, doi. 10.1002/bmc.5423

By:

Kang, Woojin;
Gaudette, Fleur;
Bédard, Dominique;
Beaudry, Francis;
Huot, Philippe

Publication type:

Article

Clinical use of ferric carboxymaltose in patients with solid tumours or haematological malignancies in France.

Published in:

2016

By:

Toledano, Alain;
Luporsi, Elisabeth;
Morere, Jean;
Scotté, Florian;
Laribi, Kamel;
Barrière, Jérôme;
Huot-Marchand, Philippe;
Duvillié, Ladan;
Concas, Victor;
Bugat, Roland;
Morere, Jean François;
Scotté, Florian;
Barrière, Jérôme;
Duvillié, Ladan;
Concas, Victor Hugo

Publication type:

journal article

Sex Differences in Neuropsychiatric Symptoms in Alpha‐Synucleinopathies: A Systematic Review and Meta‐Analysis.

Published in:

Movement Disorders Clinical Practice, 2024, v. 11, n. 11, p. 1335, doi. 10.1002/mdc3.14227

By:

Couture, Vincent;
Carmel, Jean‐François;
Rousseau, Katerine;
Létourneau, Geneviève;
Clerc, Doris;
Huot, Philippe;
Forget, Marie‐France;
Nguyen, Quoc Dinh;
Camicioli, Richard;
Desmarais, Philippe

Publication type:

Article

Adenosine 2A Receptor Antagonists for the Treatment of Motor Symptoms in Parkinson's Disease.

Published in:

Movement Disorders Clinical Practice, 2015, v. 2, n. 4, p. 331, doi. 10.1002/mdc3.12187

By:

Pourcher, Emmanuelle;
Huot, Philippe

Publication type:

Article

The pan-PPAR agonist lanifibranor improves cardiometabolic health in patients with metabolic dysfunction-associated steatohepatitis.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-47919-9

By:

Cooreman, Michael P.;
Butler, Javed;
Giugliano, Robert P.;
Zannad, Faiez;
Dzen, Lucile;
Huot-Marchand, Philippe;
Baudin, Martine;
Beard, Daniel R.;
Junien, Jean-Louis;
Broqua, Pierre;
Abdelmalek, Manal F.;
Francque, Sven M.

Publication type:

Article

Towards an overdetermined design for informal high school girls' learning in geospatial technologies for climate change.

Published in:

International Research in Geographical & Environmental Education, 2019, v. 28, n. 2, p. 151, doi. 10.1080/10382046.2018.1513447

By:

Solís, Patricia;
Huynh, Niem Tu;
Huot, Philippe;
Zeballos, Marcela;
Ng, Astrid;
Menkiti, Nwasinachi

Publication type:

Article