Works by Hung, Kuo-Sheng

Results: 36

Population-based 5-year follow-up study in taiwan of osteoporosis and risk of periodontitis.

Published in:

2014

By:

Chang, Wei-Pin;
Chang, Wei-Chiao;
Wu, Mei-Shin;
Pai, Jei-Tsung;
Guo, Yuh-Cherng;
Chen, Ku-Chung;
Liu, Mu-En;
Chiu, Wen-Ta;
Hung, Kuo-Sheng

Publication type:

Journal Article

Influences of Genetic and Environmental Factors on Chronic Migraine: A Narrative Review.

Published in:

Current Pain & Headache Reports, 2024, v. 28, n. 4, p. 169, doi. 10.1007/s11916-024-01228-4

By:

Yeh, Po-Kuan;
An, Yu-Chin;
Hung, Kuo-Sheng;
Yang, Fu-Chi

Publication type:

Article

Clinical Comparative Evaluation of the LabTurboTM AIO® Reverse Transcription-Polymerase Chain Reaction and World Health Organization-Recommended Assays for the Detection of Emerging SARS-CoV-2 Variants of Concern.

Published in:

Infection & Drug Resistance, 2022, v. 15, p. 595, doi. 10.2147/IDR.S349669

By:

Chang, Chih-Kai;
Jian, Ming-Jr;
Chung, Hsing-Yi;
Lin, Jung-Chung;
Hsieh, Shan-Shan;
Tang, Sheng‐Hui;
Perng, Cherng-Lih;
Chen, Chien-Wen;
Hung, Kuo-Sheng;
Chang, Feng-Yee;
Shang, Hung-Sheng

Publication type:

Article

Investigation of One Familial Cluster of COVID-19 in Taiwan: Differentiation of Genetic Variation Among Isolates and Implications for Epidemiological Investigation and Surveillance by Genomic Assay.

Published in:

Infection & Drug Resistance, 2021, v. 14, p. 971, doi. 10.2147/IDR.S298451

By:

Jian, Ming-Jr;
Chung, Hsing-Yi;
Chang, Chih-Kai;
Hsieh, Shan-Shan;
Lin, Jung-Chung;
Yeh, Kuo-Ming;
Chen, Chien-Wen;
Chang, Feng-Yee;
Chiu, Sheng-Kang;
Hung, Kuo-Sheng;
Liu, Ming-Tsan;
Yang, Ji-Rong;
Perng, Cherng-Lih;
Shang, Hung-Sheng

Publication type:

Article

Comparative Transcriptome Analysis of Organ-Specific Adaptive Responses to Hypoxia Provides Insights to Human Diseases.

Published in:

Genes, 2022, v. 13, n. 6, p. 1096, doi. 10.3390/genes13061096

By:

Hung, Kuo-Sheng;
Chen, Shiow-Yi;
Hsu, Pang-Hung;
Lin, Bo-An;
Hu, Chin-Hua;
Yang, Cing-Han;
Pai, Tun-Wen;
Tzou, Wen-Shyong;
Chung, Hsin-Yu

Publication type:

Article

From simple and specific zymographic detections to the annotation of a fungus Daldinia caldariorum D263 that encodes a wide range of highly bioactive cellulolytic enzymes.

Published in:

Biotechnology for Biofuels, 2021, v. 14, n. 1, p. 1, doi. 10.1186/s13068-021-01959-1

By:

Lin, Meng-Chun;
Kuo, Hsion-Wen;
Kao, Mu-Rong;
Lin, Wen-Dar;
Li, Chen-Wei;
Hung, Kuo-Sheng;
Yang, Sheng-Chih;
Yu, Su-May;
Ho, Tuan-Hua David

Publication type:

Article

An Innovative Customized Biomimetic Hydrogel for Drug Screening Application Potential: Biocompatibility and Cell Invasion Ability.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 3, p. 1488, doi. 10.3390/ijms23031488

By:

Ou, Keng-Liang;
Huang, Chiung-Fang;
Lan, Wen-Chien;
Huang, Bai-Hung;
Pan, Hsu-An;
Shen, Yung-Kang;
Saito, Takashi;
Tsai, Hsin-Yu;
Cho, Yung-Chieh;
Hung, Kuo-Sheng;
Chou, Hsin-Hua

Publication type:

Article

Fabrication of a Potential Electrodeposited Nanocomposite for Dental Applications.

Published in:

Inorganics, 2022, v. 10, n. 10, p. 165, doi. 10.3390/inorganics10100165

By:

Chang, Chun-Wei;
Tsou, Chen-Han;
Huang, Bai-Hung;
Hung, Kuo-Sheng;
Cho, Yung-Chieh;
Saito, Takashi;
Tsai, Chi-Hsun;
Hsieh, Chia-Chien;
Liu, Chung-Ming;
Lan, Wen-Chien

Publication type:

Article

Risk factors for 14-day rehospitalization following trauma with new traumatic spinal cord injury diagnosis: A 10-year nationwide study in Taiwan.

Published in:

PLoS ONE, 2017, v. 12, n. 9, p. 1, doi. 10.1371/journal.pone.0184253

By:

Lam, Carlos;
Chen, Ping-Ling;
Kang, Jiunn-Horng;
Cheng, Kuang-Fu;
Chen, Ray-Jade;
Hung, Kuo-Sheng

Publication type:

Article

Genetic variants associated with response to anti-CGRP monoclonal antibody therapy in a chronic migraine Han Chinese population.

Published in:

Journal of Headache & Pain, 2024, v. 25, n. 1, p. 1, doi. 10.1186/s10194-024-01850-y

By:

An, Yu-Chin;
Hung, Kuo-Sheng;
Liang, Chih-Sung;
Tsai, Chia-Kuang;
Tsai, Chia-Lin;
Chen, Sy-Jou;
Lin, Yu-Kai;
Lin, Guan-Yu;
Yeh, Po-Kuan;
Yang, Fu-Chi

Publication type:

Article

Functional enrichment analysis based on long noncoding RNA associations.

Published in:

BMC Systems Biology, 2018, v. 12, p. N.PAG

By:

Hung, Kuo-Sheng;
Hsiao, Chung-Chi;
Pai, Tun-Wen;
Hu, Chin-Hwa;
Tzou, Wen-Shyong;
Wang, Wen-Der;
Chen, Yet-Ran

Publication type:

Article

Novel ABCD1 and MTHFSD Variants in Taiwanese Bipolar Disorder: A Genetic Association Study.

Published in:

Medicina (1010660X), 2025, v. 61, n. 3, p. 486, doi. 10.3390/medicina61030486

By:

Wang, Yi-Guang;
Huang, Chih-Chung;
Yeh, Ta-Chuan;
Chen, Wan-Ting;
Chang, Wei-Chou;
Singh, Ajeet B.;
Yeh, Chin-Bin;
Hung, Yi-Jen;
Hung, Kuo-Sheng;
Chang, Hsin-An

Publication type:

Article

Identification of Schizophrenia Susceptibility Loci in the Urban Taiwanese Population.

Published in:

Medicina (1010660X), 2024, v. 60, n. 8, p. 1271, doi. 10.3390/medicina60081271

By:

Huang, Chih-Chung;
Wang, Yi-Guang;
Hsu, Chun-Lun;
Yeh, Ta-Chuan;
Chang, Wei-Chou;
Singh, Ajeet B.;
Yeh, Chin-Bin;
Hung, Yi-Jen;
Hung, Kuo-Sheng;
Chang, Hsin-An

Publication type:

Article

Osteoporosis and the Risk of Symptomatic Nephrolithiasis: A Population-Based 5-Year Follow-Up Study in Taiwan.

Published in:

Calcified Tissue International, 2014, v. 95, n. 4, p. 317, doi. 10.1007/s00223-014-9895-y

By:

Chou, Ping-Song;
Kuo, Chun-Nan;
Hung, Kuo-Sheng;
Chang, Wei-Chiao;
Liao, Yu-Chien;
Chi, Ying-Chen;
Chou, Wei-Po;
Tsai, Shih-Jen;
Liu, Mu-En;
Lai, Chiou-Lian;
Chou, Yii-Her;
Chang, Wei-Pin

Publication type:

Article

The Role of Folate Deficiency as a Potential Risk Factor for Nontraumatic Anterior Spinal Artery Syndrome in an Adolescent Girl.

Published in:

Brain Sciences (2076-3425), 2022, v. 12, n. 11, p. 1470, doi. 10.3390/brainsci12111470

By:

Hu, Chun-Chieh;
Yang, Yung-Yu;
Luxton, G. W. Gant;
Lin, Yu-Pang;
Hung, Kuo-Sheng;
Hu, Chih-Fen

Publication type:

Article

Rider factors associated with severe injury after a light motorcycle crash: A multicentre study in an emerging economy setting.

Published in:

PLoS ONE, 2019, v. 14, n. 6, p. 1, doi. 10.1371/journal.pone.0219132

By:

Lam, Carlos;
Pai, Chih-Wei;
Chuang, Chia-Chang;
Yen, Yu-Chun;
Wu, Chia-Chieh;
Yu, Shih-Hsiang;
Hung, Kuo-Sheng;
Chiu, Wen-Ta

Publication type:

Article

Accelerating pandemic response with the emergency Omicron RT‐PCR test: A comprehensive solution for COVID‐19 diagnosis and tracking.

Published in:

Journal of Medical Virology, 2023, v. 95, n. 7, p. 1, doi. 10.1002/jmv.28914

By:

Chung, Hsing‐Yi;
Jian, Ming‐Jr;
Chang, Chih‐Kai;
Lin, Jung‐Chung;
Yeh, Kuo‐Ming;
Chen, Chien‐Wen;
Hsieh, Shan‐Shan;
Hung, Kuo‐Sheng;
Chen, Chi‐Sheng;
Tang, Sheng‐Hui;
Perng, Cherng‐Lih;
Chang, Feng‐Yee;
Wang, Chih‐Hung;
Hung, Yi‐Jen;
Shang, Hung‐Sheng

Publication type:

Article

Identifying genetic variants for age of migraine onset in a Han Chinese population in Taiwan.

Published in:

Journal of Headache & Pain, 2021, v. 22, n. 1, p. 1, doi. 10.1186/s10194-021-01301-y

By:

Tsai, Chia-Kuang;
Liang, Chih-Sung;
Lin, Guan-Yu;
Tsai, Chia-Lin;
Lee, Jiunn-Tay;
Sung, Yueh-Feng;
Lin, Yu-Kai;
Hung, Kuo-Sheng;
Chen, Wei-Liang;
Yang, Fu-Chi

Publication type:

Article

Meta‐Analysis of Genome‐Wide Association Studies Identifies Three Loci Associated With Stiffness Index of the Calcaneus.

Published in:

Journal of Bone & Mineral Research, 2019, v. 34, n. 7, p. 1275, doi. 10.1002/jbmr.3703

By:

Lu, Hsing‐Fang;
Hung, Kuo‐Sheng;
Chu, Hou‐Wei;
Wong, Henry Sung‐Ching;
Kim, Jihye;
Kim, Mi Kyung;
Choi, Bo Youl;
Tai, Yu‐Ting;
Ikegawa, Shiro;
Cho, Er‐Chieh;
Chang, Wei‐Chiao

Publication type:

Article

Association of genetic variants in migraineurs with and without restless legs syndrome.

Published in:

Annals of Clinical & Translational Neurology, 2020, v. 7, n. 10, p. 1942, doi. 10.1002/acn3.51186

By:

Lin, Guan‐Yu;
Lin, Yu‐Kai;
Liang, Chih‐Sung;
Lee, Jiunn‐Tay;
Tsai, Chia‐Lin;
Hung, Kuo‐Sheng;
Luo, Wen‐Jie;
Tsai, Chia‐Kuang;
Hsu, Yu‐Wei;
Ho, Tsung‐Han;
Yang, Fu‐Chi

Publication type:

Article

Low dose of valproate improves motor function after traumatic brain injury.

Published in:

2014

By:

Tai, Yu-Ting;
Lee, Wen-Yuan;
Lee, Fei-Peng;
Lin, Tien-Jen;
Shih, Chia-Lin;
Wang, Jia-Yi;
Chiu, Wen-Ta;
Hung, Kuo-Sheng

Publication type:

Journal Article

BioInnovate AI: A Machine Learning Platform for Rapid PCR Assay Design in Emerging Infectious Disease Diagnostics.

Published in:

Diagnostics (2075-4418), 2025, v. 15, n. 12, p. 1445, doi. 10.3390/diagnostics15121445

By:

Lin, Hung-Hsin;
Chung, Hsing-Yi;
Lin, Tai-Han;
Chang, Chih-Kai;
Perng, Cherng-Lih;
Hung, Kuo-Sheng;
Yanagihara, Katsunori;
Shang, Hung-Sheng;
Jian, Ming-Jr

Publication type:

Article

Host-Pathogen Interactions in K. pneumoniae Urinary Tract Infections: Investigating Genetic Risk Factors in the Taiwanese Population.

Published in:

Diagnostics (2075-4418), 2024, v. 14, n. 4, p. 415, doi. 10.3390/diagnostics14040415

By:

Chen, Chi-Sheng;
Hung, Kuo-Sheng;
Jian, Ming-Jr;
Chung, Hsing-Yi;
Chang, Chih-Kai;
Perng, Cherng-Lih;
Chen, Hsiang-Cheng;
Chang, Feng-Yee;
Wang, Chih-Hung;
Hung, Yi-Jen;
Shang, Hung-Sheng

Publication type:

Article

Identification of Novel Genetic Variants Associated with Insomnia and Migraine Comorbidity.

Published in:

Nature & Science of Sleep, 2022, v. 14, p. 1075, doi. 10.2147/NSS.S365988

By:

An, Yu-Chin;
Tsai, Chia-Lin;
Liang, Chih-Sung;
Lin, Yu-Kai;
Lin, Guan-Yu;
Tsai, Chia-Kuang;
Liu, Yi;
Chen, Sy-Jou;
Tsai, Shih-Hung;
Hung, Kuo-Sheng;
Yang, Fu-Chi

Publication type:

Article

A Three-Dimensional Bioprinted Copolymer Scaffold with Biocompatibility and Structural Integrity for Potential Tissue Regeneration Applications.

Published in:

Polymers (20734360), 2022, v. 14, n. 16, p. 3415, doi. 10.3390/polym14163415

By:

Peng, Bou-Yue;
Ou, Keng-Liang;
Liu, Chung-Ming;
Chu, Shu-Fen;
Huang, Bai-Hung;
Cho, Yung-Chieh;
Saito, Takashi;
Tsai, Chi-Hsun;
Hung, Kuo-Sheng;
Lan, Wen-Chien

Publication type:

Article

Association Study between the FTCDNL1 (FONG) and Susceptibility to Osteoporosis.

Published in:

PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0140549

By:

Lu, Hsing-Fang;
Hung, Kuo-Sheng;
Hsu, Yu-Wen;
Tai, Yu-Ting;
Huang, Lin-Shan;
Wang, Yu-Jia;
Wong, Henry Sung-Ching;
Hsu, Yi-Hsiang;
Chang, Wei-Chiao

Publication type:

Article

A Replication Study for Association of ITPKC and CASP3 Two-Locus Analysis in IVIG Unresponsiveness and Coronary Artery Lesion in Kawasaki Disease.

Published in:

PLoS ONE, 2013, v. 8, n. 7, p. 1, doi. 10.1371/journal.pone.0069685

By:

Kuo, Ho-Chang;
Hsu, Yu-Wen;
Wu, Chung-Min;
Chen, Shawn Hsiang-Yin;
Hung, Kuo-Sheng;
Chang, Wei-Pin;
Yang, Kuender D.;
Hsieh, Kai-Sheng;
Chen, Wei-Chiao;
Onouchi, Yoshihiro;
Chang, Wei-Chiao

Publication type:

Article

Cell Type-Specific Dependency on the PI3K/Akt Signaling Pathway for the Endogenous Epo and VEGF Induction by Baicalein in Neurons versus Astrocytes.

Published in:

PLoS ONE, 2013, v. 8, n. 7, p. 1, doi. 10.1371/journal.pone.0069019

By:

Sun, Yu-Yo;
Lin, Shang-Hsuan;
Lin, Hung-Cheng;
Hung, Chia-Chi;
Wang, Chen-Yu;
Lin, Yen-Chu;
Hung, Kuo-Sheng;
Lien, Cheng-Chang;
Kuan, Chia-Yi;
Lee, Yi-Hsuan

Publication type:

Article

Population-Based 5-Year Follow-Up Study in Taiwan of Dementia and Risk of Stroke.

Published in:

PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0061771

By:

Liu, Mu-En;
Tsai, Shih-Jen;
Chang, Wei-Chiao;
Hsu, Chun-Hung;
Lu, Ti;
Hung, Kuo-Sheng;
Chiu, Wen-Ta;
Chang, Wei-Pin

Publication type:

Article

Effect of Glutamine and Bile Acid on Hepatocyte Apoptosis after Bile Duct Ligation in the Rat World J. Surg. Vol. 28, No. 5, May 2004.

Published in:

World Journal of Surgery, 2004, v. 28, n. 5, p. 457, doi. 10.1007/s00268-004-7189-7

By:

Sheen-Chen, Shyr-Ming;
Hung, Kuo-Sheng;
Ho, Hsin-Tsung;
Chen, Wei-Jen;
Eng, Hock-Liew

Publication type:

Article

Breathing-based leg exercises during hemodialysis improve quality of life: A randomized controlled trial.

Published in:

Clinical Rehabilitation, 2021, v. 35, n. 8, p. 1175, doi. 10.1177/02692155211000738

By:

Huang, Hsin-Yi;
Hung, Kuo-Sheng;
Yeh, Mei-Ling;
Chou, Hsiu-Ling;
Yeh, Albert Lou;
Liao, Tzu-Yi

Publication type:

Article

Protein tyrosine phosphatase receptor type O (Ptpro) regulates cerebellar formation during zebrafish development through modulating Fgf signaling.

Published in:

Cellular & Molecular Life Sciences, 2013, v. 70, n. 13, p. 2367, doi. 10.1007/s00018-013-1259-7

By:

Liao, Wei-Hao;
Cheng, Chia-Hsiung;
Hung, Kuo-Sheng;
Chiu, Wen-Ta;
Chen, Gen-Der;
Hwang, Pung-Pung;
Hwang, Sheng-Ping;
Kuan, Yung-Shu;
Huang, Chang-Jen

Publication type:

Article

Mind–body interactive qigong improves physical and mental aspects of quality of life in inpatients with stroke: A randomized control study.

Published in:

European Journal of Cardiovascular Nursing, 2019, v. 18, n. 8, p. 658, doi. 10.1177/1474515119860232

By:

Chen, Ching-Hsiang;
Hung, Kuo-Sheng;
Chung, Yu-Chu;
Yeh, Mei-Ling

Publication type:

Article

Three-Dimensional Printing of a Hybrid Bioceramic and Biopolymer Porous Scaffold for Promoting Bone Regeneration Potential.

Published in:

Materials (1996-1944), 2022, v. 15, n. 5, p. 1971, doi. 10.3390/ma15051971

By:

Hung, Kuo-Sheng;
Chen, May-Show;
Lan, Wen-Chien;
Cho, Yung-Chieh;
Saito, Takashi;
Huang, Bai-Hung;
Tsai, Hsin-Yu;
Hsieh, Chia-Chien;
Ou, Keng-Liang;
Lin, Hung-Yang

Publication type:

Article

Fluorescence assay for protein post-translational tyrosine sulfation.

Published in:

Analytical & Bioanalytical Chemistry, 2013, v. 405, n. 4, p. 1425, doi. 10.1007/s00216-012-6540-3

By:

Chen, Bo-Han;
Wang, Chen-Chu;
Lu, Lu-Yi;
Hung, Kuo-Sheng;
Yang, Yuh-Shyong

Publication type:

Article

Use of Heart Rate Variability and Photoplethysmograph-Derived Parameters as Assessment Signals of Radiofrequency Therapy Efficacy for Chronic Pain.

Published in:

Pain Practice, 2017, v. 17, n. 7, p. 879, doi. 10.1111/papr.12536

By:

Ye, Jing‐Jhao;
Chuang, Chiung‐Cheng;
Tai, Yu‐Ting;
Lee, Kuan‐Ting;
Hung, Kuo‐Sheng

Publication type:

Article

Works by Hung, Kuo-Sheng

Population-based 5-year follow-up study in taiwan of osteoporosis and risk of periodontitis.

Influences of Genetic and Environmental Factors on Chronic Migraine: A Narrative Review.

Clinical Comparative Evaluation of the LabTurbo<sup>TM</sup> AIO<sup>®</sup> Reverse Transcription-Polymerase Chain Reaction and World Health Organization-Recommended Assays for the Detection of Emerging SARS-CoV-2 Variants of Concern.

Investigation of One Familial Cluster of COVID-19 in Taiwan: Differentiation of Genetic Variation Among Isolates and Implications for Epidemiological Investigation and Surveillance by Genomic Assay.

Comparative Transcriptome Analysis of Organ-Specific Adaptive Responses to Hypoxia Provides Insights to Human Diseases.

From simple and specific zymographic detections to the annotation of a fungus Daldinia caldariorum D263 that encodes a wide range of highly bioactive cellulolytic enzymes.

An Innovative Customized Biomimetic Hydrogel for Drug Screening Application Potential: Biocompatibility and Cell Invasion Ability.

Fabrication of a Potential Electrodeposited Nanocomposite for Dental Applications.

Risk factors for 14-day rehospitalization following trauma with new traumatic spinal cord injury diagnosis: A 10-year nationwide study in Taiwan.

Genetic variants associated with response to anti-CGRP monoclonal antibody therapy in a chronic migraine Han Chinese population.

Functional enrichment analysis based on long noncoding RNA associations.

Novel ABCD1 and MTHFSD Variants in Taiwanese Bipolar Disorder: A Genetic Association Study.

Identification of Schizophrenia Susceptibility Loci in the Urban Taiwanese Population.

Osteoporosis and the Risk of Symptomatic Nephrolithiasis: A Population-Based 5-Year Follow-Up Study in Taiwan.

The Role of Folate Deficiency as a Potential Risk Factor for Nontraumatic Anterior Spinal Artery Syndrome in an Adolescent Girl.

Rider factors associated with severe injury after a light motorcycle crash: A multicentre study in an emerging economy setting.

Accelerating pandemic response with the emergency Omicron RT‐PCR test: A comprehensive solution for COVID‐19 diagnosis and tracking.

Identifying genetic variants for age of migraine onset in a Han Chinese population in Taiwan.

Meta‐Analysis of Genome‐Wide Association Studies Identifies Three Loci Associated With Stiffness Index of the Calcaneus.

Association of genetic variants in migraineurs with and without restless legs syndrome.

Low dose of valproate improves motor function after traumatic brain injury.

BioInnovate AI: A Machine Learning Platform for Rapid PCR Assay Design in Emerging Infectious Disease Diagnostics.

Host-Pathogen Interactions in K. pneumoniae Urinary Tract Infections: Investigating Genetic Risk Factors in the Taiwanese Population.

Identification of Novel Genetic Variants Associated with Insomnia and Migraine Comorbidity.

A Three-Dimensional Bioprinted Copolymer Scaffold with Biocompatibility and Structural Integrity for Potential Tissue Regeneration Applications.

Association Study between the FTCDNL1 (FONG) and Susceptibility to Osteoporosis.

A Replication Study for Association of <i>ITPKC</i> and <i>CASP3</i> Two-Locus Analysis in IVIG Unresponsiveness and Coronary Artery Lesion in Kawasaki Disease.

Cell Type-Specific Dependency on the PI3K/Akt Signaling Pathway for the Endogenous Epo and VEGF Induction by Baicalein in Neurons versus Astrocytes.

Population-Based 5-Year Follow-Up Study in Taiwan of Dementia and Risk of Stroke.

Effect of Glutamine and Bile Acid on Hepatocyte Apoptosis after Bile Duct Ligation in the Rat World J. Surg. Vol. 28, No. 5, May 2004.

Breathing-based leg exercises during hemodialysis improve quality of life: A randomized controlled trial.

Protein tyrosine phosphatase receptor type O (Ptpro) regulates cerebellar formation during zebrafish development through modulating Fgf signaling.

Mind–body interactive qigong improves physical and mental aspects of quality of life in inpatients with stroke: A randomized control study.

Three-Dimensional Printing of a Hybrid Bioceramic and Biopolymer Porous Scaffold for Promoting Bone Regeneration Potential.

Fluorescence assay for protein post-translational tyrosine sulfation.

Use of Heart Rate Variability and Photoplethysmograph-Derived Parameters as Assessment Signals of Radiofrequency Therapy Efficacy for Chronic Pain.