Works by Hughes, Zoë A

Results: 21

Intermediates Released from a Polyether-Producing Polyketide Synthase Provide Insight into the Mechanism of Oxidative Cyclization ( This research was supported by the Biotechnology and Biological Sciences Research Council (BBSRC). We gratefully acknowledge the support of a studentship from the BBSRC (to Z.A.H.-T.), the support of I.U.B. through a grant from Glaxo Group Research, Stevenage, UK (to P.F.L. and J.S.), and a grant from Roche Pharmaceuticals (Basel) and an EU Marie Curie Postdoctoral Training Fellowship (to C.B.W.S.). )

Published in:

Angewandte Chemie, 2003, v. 115, n. 37, p. 4613, doi. 10.1002/ange.200351375

By:

Zoë A. Hughes-Thomas;
Christian B. W. Stark;
Ines U. Böhm;
James Staunton;
Peter F. Leadlay

Publication type:

Article

Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor.

Published in:

Glia (0894-1491), 2016, v. 64, n. 10, p. 1788, doi. 10.1002/glia.23007

By:

Möller, Thomas;
Bard, Frédérique;
Bhattacharya, Anindya;
Biber, Knut;
Campbell, Brian;
Dale, Elena;
Eder, Claudia;
Gan, Li;
Garden, Gwenn A.;
Hughes, Zoë A.;
Pearse, Damien D.;
Staal, Roland G. W.;
Sayed, Faten A.;
Wes, Paul D.;
Boddeke, Hendrikus W. G. M.

Publication type:

Article

PDE4B as a microglia target to reduce neuroinflammation.

Published in:

Glia (0894-1491), 2016, v. 64, n. 10, p. 1698, doi. 10.1002/glia.22986

By:

Pearse, Damien D.;
Hughes, Zoë A.

Publication type:

Article

The novel persistent sodium current inhibitor PRAX‐562 has potent anticonvulsant activity with improved protective index relative to standard of care sodium channel blockers.

Published in:

Epilepsia (Series 4), 2022, v. 63, n. 3, p. 697, doi. 10.1111/epi.17149

By:

Kahlig, Kristopher M.;
Scott, Liam;
Hatch, Robert J.;
Griffin, Andrew;
Martinez Botella, Gabriel;
Hughes, Zoë A.;
Wittmann, Marion

Publication type:

Article

Evidence that a Novel Thioesterase is Responsible for Polyketide Chain Release during Biosynthesis of the Polyether Ionophore Monensin.

Published in:

ChemBioChem, 2006, v. 7, n. 9, p. 1435, doi. 10.1002/cbic.200500474

By:

Barbara M. Harvey;
Hui Hong;
Michelle A. Jones;
Zoë A. Hughes-Thomas;
Rebecca M. Goss;
Michelle L. Heathcote;
Victor M. Bolanos-Garcia;
Wolfgang Kroutil;
James Staunton;
Peter F. Leadlay;
Jonathan B. Spencer

Publication type:

Article

Translational Pharmacology of PRAX‐944, a Novel T‐Type Calcium Channel Blocker in Development for the Treatment of Essential Tremor.

Published in:

Movement Disorders, 2022, v. 37, n. 6, p. 1193, doi. 10.1002/mds.28969

By:

Scott, Liam;
Puryear, Corey B.;
Belfort, Gabriel M.;
Raines, Shane;
Hughes, Zoë A.;
Matthews, Lillian G.;
Ravina, Bernard;
Wittmann, Marion

Publication type:

Article

Prefrontal Cortical Kappa Opioid Receptors Attenuate Responses to Amygdala Inputs.

Published in:

Neuropsychopharmacology, 2015, v. 40, n. 13, p. 2856, doi. 10.1038/npp.2015.138

By:

Tejeda, Hugo A;
Hanks, Ashley N;
Scott, Liam;
Mejias-Aponte, Carlos;
Hughes, Zoë A;
O'Donnell, Patricio

Publication type:

Article

Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization.

Published in:

Molecular Microbiology, 2003, v. 49, n. 5, p. 1179, doi. 10.1046/j.1365-2958.2003.03571.x

By:

Oliynyk, Markiyan;
Stark, Christian B.W.;
Bhatt, Apoorva;
Jones, Michelle A.;
Hughes-Thomas, Zoë A.;
Wilkinso, Christopher;
Oliynyk, Zoryana;
Demydchuk, Yuliya;
Staunton, James;
Leadlay, Peter F.

Publication type:

Article

Amphetamine Decreases α2C-Adrenoceptor Binding of [11C]ORM-13070: A PET Study in the Primate Brain.

Published in:

International Journal of Neuropsychopharmacology, 2015, v. 18, n. 3, p. 1, doi. 10.1093/ijnp/pyu081

By:

Finnema, Sjoerd J;
Hughes, Zoë A;
Haaparanta-Solin, Merja;
Stepanov, Vladimir;
Nakao, Ryuji;
Varnäs, Katarina;
Varrone, Andrea;
Arponen, Eveliina;
Marjamäki, Päivi;
Pohjanoksa, Katariina;
Vuorilehto, Lauri;
Babalola, Phebian A;
Solin, Olof;
Grimwood, Sarah;
Sallinen, Jukka;
Farde, Lars;
Scheinin, Mika;
Halldin, Christer

Publication type:

Article

5-HT1A receptor antagonism reverses and prevents fluoxetine-induced sexual dysfunction in rats.

Published in:

International Journal of Neuropsychopharmacology, 2009, v. 12, n. 8, p. 1045, doi. 10.1017/S1461145709000406

By:

Rizzo, Stacey J. Sukoff;
Pulicicchio, Claudine;
Malberg, Jessica E.;
Andree, Terrance H.;
Stack, Gary P.;
Hughes, Zoë A.;
Schechter, Lee E.;
Rosenzweig-Lipson, Sharon

Publication type:

Article

A partial noradrenergic lesion induced by DSP-4 increases extracellular noradrenaline concentration in rat frontal cortex: a microdialysis study in vivo.

Published in:

Psychopharmacology, 1998, v. 136, n. 3, p. 299, doi. 10.1007/s002130050569

By:

Hughes, Zoë A.;
Stanford, S. C.

Publication type:

Article

Evidence from microdialysis and synaptosomal studies of rat cortex for noradrenaline uptake sites with different sensitivities to SSRIs.

Published in:

British Journal of Pharmacology, 1998, v. 124, n. 6, p. 1141, doi. 10.1038/sj.bjp.0701947

By:

Hughes, Zoë A.;
Stanford, S. Clare

Publication type:

Article

The location discrimination reversal task in mice is sensitive to deficits in performance caused by aging, pharmacological and other challenges.

Published in:

2018

By:

Graf, Radka;
Longo, Jami L.;
Hughes, Zoë A.

Publication type:

journal article

Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs: in vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-B

Published in:

Psychopharmacology, 2007, v. 192, n. 1, p. 121, doi. 10.1007/s00213-006-0691-x

By:

Hughes, Zoë A.;
Starr, Kathryn R.;
Scott, Claire M.;
Newson, Michael J.;
Sharp, Trevor;
Watson, Jeannette M.;
Hagan, Jim J.;
Dawson, Lee A.

Publication type:

Article

Differential autoreceptor control of extracellular 5-HT in guinea pig and rat: species and regional differences.

Published in:

Psychopharmacology, 2004, v. 172, n. 1, p. 87, doi. 10.1007/s00213-003-1615-7

By:

Hughes, Zoë A.;
Dawson, Lee A.

Publication type:

Article

The BTBR Mouse Model of Autism Spectrum Disorders Has Learning and Attentional Impairments and Alterations in Acetylcholine and Kynurenic Acid in Prefrontal Cortex.

Published in:

PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0062189

By:

McTighe, Stephanie M.;
Neal, Sarah J.;
Lin, Qian;
Hughes, Zoë A.;
Smith, Daniel G.

Publication type:

Article

Intermediates Released from a Polyether-Producing Polyketide Synthase Provide Insight into the Mechanism of Oxidative Cyclization ( This research was supported by the Biotechnology and Biological Sciences Research Council (BBSRC). We gratefully acknowledge the support of a studentship from the BBSRC (to Z.A.H.-T.), the support of I.U.B. through a grant from Glaxo Group Research, Stevenage, UK (to P.F.L. and J.S.), and a grant from Roche Pharmaceuticals (Basel) and an EU Marie Curie Postdoctoral Training Fellowship (to C.B.W.S.). )

Published in:

Angewandte Chemie International Edition, 2003, v. 42, n. 37, p. 4475, doi. 10.1002/anie.200351375

By:

Zoë A. Hughes-Thomas;
Christian B. W. Stark;
Ines U. Böhm;
James Staunton;
Peter F. Leadlay

Publication type:

Article

First-in-Human Evaluation of 18F-PF-06445974, a PET Radioligand That Preferentially Labels Phosphodiesterase-4B.

Published in:

Journal of Nuclear Medicine, 2022, v. 63, n. 12, p. 1919, doi. 10.2967/jnumed.122.263838

By:

Yuichi Wakabayashi;
Stenkrona, Per;
Arakawa, Ryosuke;
Xuefeng Yan;
Van Buskirk, Maia G.;
Jenkins, Madeline D.;
Santamaria, Jose A. Montero;
Maresca, Kevin P.;
Akihiro Takano;
Liow, Jeih-San;
Chappie, Thomas A.;
Varrone, Andrea;
Nag, Sangram;
Lei Zhang;
Hughes, Zoë A.;
Schmidt, Christopher J.;
Doran, Shawn D.;
Mannes, Andrew;
Zanotti-Fregonara, Paolo;
Ooms, Maarten

Publication type:

Article

First-in-human evaluation of 18F-PF-06445974, a PET radioligand that preferentially labels phosphodiesterase-4B.

Published in:

Journal of Nuclear Medicine, 2022, v. 63, n. 10, p. 1, doi. 10.2967/jnumed.122.263838

By:

Yuichi Wakabayashi;
Stenkrona, Per;
Ryosuke Arakawa;
Xuefeng Yan;
Van Buskirk, Maia G.;
Jenkins, Madeline D.;
Montero Santamaria, Jose A.;
Maresca, Kevin P.;
Akihiro Takano;
Liow, Jeih-San;
Chappie, Thomas A.;
Varrone, Andrea;
Nag, Sangram;
Lei Zhang;
Hughes, Zoë A;
Schmidt, Christopher J.;
Doran, Shawn D.;
Mannes, Andrew;
Zanotti-Fregonara, Paolo;
Ooms, Maarten

Publication type:

Article

First-in-human evaluation of 18F-PF-06445974, a PET radioligand that preferentially labels phosphodiesterase-4B.

Published in:

Journal of Nuclear Medicine, 2022, v. 63, n. 9, p. 1, doi. 10.2967/jnumed.122.263838

By:

Wakabayashi, Yuichi;
Stenkrona, Per;
Arakawa, Ryosuke;
Xuefeng Yan;
Van Buskirk, Maia G.;
Jenkins, Madeline D.;
Montero Santamaria, Jose A.;
Maresca, Kevin P.;
Takano, Akihiro;
Liow, Jeih-San;
Chappie, Thomas A.;
Varrone, Andrea;
Nag, Sangram;
Lei Zhang;
Hughes, Zoë A;
Schmidt, Christopher J.;
Doran, Shawn D.;
Mannes, Andrew;
Zanotti-Fregonara, Paolo;
Ooms, Maarten

Publication type:

Article

First-in-human evaluation of 18F-PF-06445974, a PET radioligand that preferentially labels phosphodiesterase-4B.

Published in:

Journal of Nuclear Medicine, 2022, v. 63, n. 7, p. 1, doi. 10.2967/jnumed.122.263838

By:

Yuichi Wakabayashi;
Stenkrona, Per;
Ryosuke Arakawa;
Xuefeng Yan;
Van Buskirk, Maia G.;
Jenkins, Madeline D.;
Montero Santamaria, Jose A.;
Maresca, Kevin P.;
Akihiro Takano;
Jeih-San Liow;
Chappie, Thomas A.;
Varrone, Andrea;
Sangram Nag;
Lei Zhang;
Hughes, Zoë A;
Schmidt, Christopher J.;
Doran, Shawn D.;
Mannes, Andrew;
Zanotti-Fregonara, Paolo;
Ooms, Maarten

Publication type:

Article

Works by Hughes, Zoë A

Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor.

PDE4B as a microglia target to reduce neuroinflammation.

The novel persistent sodium current inhibitor PRAX‐562 has potent anticonvulsant activity with improved protective index relative to standard of care sodium channel blockers.

Evidence that a Novel Thioesterase is Responsible for Polyketide Chain Release during Biosynthesis of the Polyether Ionophore Monensin.

Translational Pharmacology of PRAX‐944, a Novel T‐Type Calcium Channel Blocker in Development for the Treatment of Essential Tremor.

Prefrontal Cortical Kappa Opioid Receptors Attenuate Responses to Amygdala Inputs.

Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization.

Amphetamine Decreases α2C-Adrenoceptor Binding of [11C]ORM-13070: A PET Study in the Primate Brain.

5-HT<sub>1A</sub> receptor antagonism reverses and prevents fluoxetine-induced sexual dysfunction in rats.

A partial noradrenergic lesion induced by DSP-4 increases extracellular noradrenaline concentration in rat frontal cortex: a microdialysis study in vivo.

Evidence from microdialysis and synaptosomal studies of rat cortex for noradrenaline uptake sites with different sensitivities to SSRIs.

The location discrimination reversal task in mice is sensitive to deficits in performance caused by aging, pharmacological and other challenges.

Simultaneous blockade of 5-HT<sub>1A/B</sub> receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs: in vivo characterization of the novel 5-HT<sub>1A/B</sub> receptor antagonist/5-HT transport inhibitor SB-649915-B

Differential autoreceptor control of extracellular 5-HT in guinea pig and rat: species and regional differences.

The BTBR Mouse Model of Autism Spectrum Disorders Has Learning and Attentional Impairments and Alterations in Acetylcholine and Kynurenic Acid in Prefrontal Cortex.

First-in-Human Evaluation of <sup>18</sup>F-PF-06445974, a PET Radioligand That Preferentially Labels Phosphodiesterase-4B.

First-in-human evaluation of <sup>18</sup>F-PF-06445974, a PET radioligand that preferentially labels phosphodiesterase-4B.

First-in-human evaluation of <sup>18</sup>F-PF-06445974, a PET radioligand that preferentially labels phosphodiesterase-4B.

First-in-human evaluation of <sup>18</sup>F-PF-06445974, a PET radioligand that preferentially labels phosphodiesterase-4B.