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Connecting Hydroxychloroquine In Vitro Antiviral Activity to In Vivo Concentration for Prediction of Antiviral Effect: A Critical Step in Treating Patients With Coronavirus Disease 2019.
- Published in:
- Clinical Infectious Diseases, 2020, v. 71, n. 12, p. 3232, doi. 10.1093/cid/ciaa623
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- Publication type:
- Article
Drug-metabolizing enzymes: Evidence for clinical utility of pharmacogenomic tests
- Published in:
- 2005
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- Publication type:
- Editorial
The Effect of Echinacea (Echinacea purpurea Root) on Cytochrome P450 Activity in Vivo<sup>*</sup>.
- Published in:
- Clinical Pharmacology & Therapeutics, 2004, v. 75, n. 1, p. 89, doi. 10.1016/j.clpt.2003.09.013
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- Publication type:
- Article
Drug Interactions with Herbal Products and Grapefruit Juice: A Conference Report<sup>*</sup>.
- Published in:
- Clinical Pharmacology & Therapeutics, 2004, v. 75, n. 1, p. 1, doi. 10.1016/j.clpt.2003.07.002
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- Publication type:
- Article
The interaction between St John's wort and an oral contraceptive<sup>*</sup>.
- Published in:
- Clinical Pharmacology & Therapeutics, 2003, v. 74, n. 6, p. 525, doi. 10.1016/j.clpt.2003.08.009
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- Publication type:
- Article
Effect of St John's wort on the pharmacokinetics of fexofenadine<sup>*</sup>.
- Published in:
- Clinical Pharmacology & Therapeutics, 2002, v. 71, n. 6, p. 414, doi. 10.1067/mcp.2002.124080
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- Publication type:
- Article
The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity<sup>*</sup>.
- Published in:
- Clinical Pharmacology & Therapeutics, 2001, v. 70, n. 4, p. 317, doi. 10.1016/S0009-9236(01)00127-8
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- Publication type:
- Article
Optimizing drug development: Strategies to assess drug metabolism/transporter interaction potential-toward a consensus<sup>*</sup>.
- Published in:
- Clinical Pharmacology & Therapeutics, 2001, v. 70, n. 2, p. 103, doi. 10.1067/mcp.2001.116891
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- Publication type:
- Article
A sensitive high performance liquid chromatography microassay for bemoradan, a novel cardiotonic agent, in plasma/serum using a semi-automatic liquid/solid extraction sample preparation system-AASP®.
- Published in:
- Biomedical Chromatography, 1990, v. 4, n. 2, p. 52, doi. 10.1002/bmc.1130040203
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- Publication type:
- Article
Metformin Disrupts Bile Acid Efflux by Repressing Bile Salt Export Pump Expression.
- Published in:
- Pharmaceutical Research, 2020, v. 37, n. 2, p. 1, doi. 10.1007/s11095-019-2753-x
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- Publication type:
- Article
Predicting Nonlinear Pharmacokinetics of Omeprazole Enantiomers and Racemic Drug Using Physiologically Based Pharmacokinetic Modeling and Simulation: Application to Predict Drug/Genetic Interactions.
- Published in:
- Pharmaceutical Research, 2014, v. 31, n. 8, p. 1919, doi. 10.1007/s11095-013-1293-z
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- Publication type:
- Article
Utility of a physiologically-based pharmacokinetic (PBPK) modeling approach to quantitatively predict a complex drug-drug-disease interaction scenario for rivaroxaban during the drug review process: implications for clinical practice.
- Published in:
- Biopharmaceutics & Drug Disposition, 2012, v. 33, n. 2, p. 99, doi. 10.1002/bdd.1771
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- Publication type:
- Article
PBPK as a tool in regulatory review.
- Published in:
- Biopharmaceutics & Drug Disposition, 2012, v. 33, n. 2, p. 51, doi. 10.1002/bdd.1777
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- Publication type:
- Article
A pharmacokinetic evaluation of HIV protease inhibitors, cyclic ureas, in rats and dogs.
- Published in:
- Biopharmaceutics & Drug Disposition, 1994, v. 15, n. 7, p. 535, doi. 10.1002/bdd.2510150702
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- Publication type:
- Article
Simultaneous monitoring of bemoradan pharmacokinetics and hemodynamics in mongrel dogs.
- Published in:
- Biopharmaceutics & Drug Disposition, 1992, v. 13, n. 7, p. 539, doi. 10.1002/bdd.2510130707
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- Publication type:
- Article
Clinical pharmacokinetics of etintidine.
- Published in:
- Biopharmaceutics & Drug Disposition, 1988, v. 9, n. 5, p. 477, doi. 10.1002/bod.2510090506
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- Publication type:
- Article
Pharmacokinetics and bioavailability of etintidine in beagle dogs: Effects of routes of administration, doses, dosage forms, and chronic dosing.
- Published in:
- Biopharmaceutics & Drug Disposition, 1988, v. 9, n. 1, p. 71, doi. 10.1002/bod.2510090108
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- Publication type:
- Article
Etintidine-theophylline interaction study in humans.
- Published in:
- Biopharmaceutics & Drug Disposition, 1987, v. 8, n. 6, p. 561, doi. 10.1002/bdd.2510080607
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- Publication type:
- Article
Pharmacokinetics of drugs in blood I. Unusual distribution of gentamicin.
- Published in:
- Biopharmaceutics & Drug Disposition, 1981, v. 2, n. 1, p. 89, doi. 10.1002/bdd.2510020110
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- Publication type:
- Article
Dosing Recommendations for Pediatric Patients With Renal Impairment.
- Published in:
- Journal of Clinical Pharmacology, 2020, v. 60, n. 12, p. 1551, doi. 10.1002/jcph.1676
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- Publication type:
- Article
Application of PBPK Modeling and Simulation for Regulatory Decision Making and Its Impact on US Prescribing Information: An Update on the 2018‐2019 Submissions to the US FDA's Office of Clinical Pharmacology.
- Published in:
- Journal of Clinical Pharmacology, 2020, v. 60, p. S160, doi. 10.1002/jcph.1767
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- Publication type:
- Article
Application of PBPK Modeling and Simulation for Regulatory Decision Making and Its Impact on US Prescribing Information: An Update on the 2018‐2019 Submissions to the US FDA's Office of Clinical Pharmacology.
- Published in:
- Journal of Clinical Pharmacology, 2020, v. 60, p. S160, doi. 10.1002/jcph.1767
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- Publication type:
- Article
Incorporating Ontogeny in Physiologically Based Pharmacokinetic Modeling to Improve Pediatric Drug Development: What We Know About Developmental Changes in Membrane Transporters.
- Published in:
- Journal of Clinical Pharmacology, 2019, v. 59, p. S56, doi. 10.1002/jcph.1489
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- Publication type:
- Article
Incorporating Ontogeny in Physiologically Based Pharmacokinetic Modeling to Improve Pediatric Drug Development: What We Know About Developmental Changes in Membrane Transporters.
- Published in:
- Journal of Clinical Pharmacology, 2019, v. 59, p. S56, doi. 10.1002/jcph.1489
- By:
- Publication type:
- Article
Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential—towards a consensus.
- Published in:
- British Journal of Clinical Pharmacology, 2001, v. 52, n. 1, p. 107, doi. 10.1046/j.0306-5251.2001.Temp.1441.x
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- Publication type:
- Article
Impact of Organ Impairment on the Pharmacokinetics of Therapeutic Peptides and Proteins.
- Published in:
- AAPS Journal, 2023, v. 25, n. 4, p. 1, doi. 10.1208/s12248-023-00819-0
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- Publication type:
- Article
Clinical Pharmacology Regulatory Sciences in Drug Development and Precision Medicine: Current Status and Emerging Trends.
- Published in:
- AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00563-3
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- Publication type:
- Article
Systematic Review of Device Parameters and Design of Studies Bridging Biologic-Device Combination Products Using Prefilled Syringes and Autoinjectors.
- Published in:
- AAPS Journal, 2020, v. 22, n. 2, p. 1, doi. 10.1208/s12248-020-0433-8
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- Publication type:
- Article
AAPS Workshop Report: Strategies to Address Therapeutic Protein-Drug Interactions during Clinical Development.
- Published in:
- 2011
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- Publication type:
- Report
Predicting Drug–Drug Interactions: An FDA Perspective.
- Published in:
- AAPS Journal, 2009, v. 11, n. 2, p. 300, doi. 10.1208/s12248-009-9106-3
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- Publication type:
- Article
Towards Quantitation of the Effects of Renal Impairment and Probenecid Inhibition on Kidney Uptake and Efflux Transporters, Using Physiologically Based Pharmacokinetic Modelling and Simulations.
- Published in:
- Clinical Pharmacokinetics, 2014, v. 53, n. 3, p. 283, doi. 10.1007/s40262-013-0117-y
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- Publication type:
- Article
CYP-mediated therapeutic protein-drug interactions: clinical findings, proposed mechanisms and regulatory implications.
- Published in:
- 2010
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- Publication type:
- journal article
In Memoriam Arthur J. Atkinson, Jr. (1938–2024).
- Published in:
- Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 1, p. 20, doi. 10.1002/cpt.3300
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- Publication type:
- Article
Using Machine Learning to Determine a Suitable Patient Population for Anakinra for the Treatment of COVID‐19 Under the Emergency Use Authorization.
- Published in:
- Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 4, p. 890, doi. 10.1002/cpt.3191
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- Publication type:
- Article
Clinical Pharmacology Approaches to Support Approval of New Routes of Administration for Therapeutic Proteins.
- Published in:
- Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 3, p. 440, doi. 10.1002/cpt.3178
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- Publication type:
- Article
Pharmacokinetics‐Bridging Between Autoinjectors and Prefilled Syringes for Subcutaneous Injection: Case Examples Revealing a Knowledge Gap.
- Published in:
- Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 3, p. 404, doi. 10.1002/cpt.3145
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- Publication type:
- Article
The Association Between Baseline Hepatic or Renal Function and Clinical Outcomes for Patients With Non‐Small Cell Lung Cancer Treated With a PD‐1/PD‐L1 Blocking Antibody Using Real‐World and Trial Data.
- Published in:
- Clinical Pharmacology & Therapeutics, 2023, v. 113, n. 5, p. 1139, doi. 10.1002/cpt.2874
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- Publication type:
- Article
Landscape Analysis of the Application of Artificial Intelligence and Machine Learning in Regulatory Submissions for Drug Development From 2016 to 2021.
- Published in:
- Clinical Pharmacology & Therapeutics, 2023, v. 113, n. 4, p. 771, doi. 10.1002/cpt.2668
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- Publication type:
- Article
Model‐Based Approach to Selecting Pegfilgrastim Dose for Pharmacokinetic and Pharmacodynamic Similarity Studies in Biosimilar Development.
- Published in:
- Clinical Pharmacology & Therapeutics, 2023, v. 113, n. 1, p. 62, doi. 10.1002/cpt.2722
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- Publication type:
- Article
More Than Pharmacokinetics: Transporters in Clinical Pharmacology.
- Published in:
- Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 3, p. 423, doi. 10.1002/cpt.2710
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- Publication type:
- Article
Current Perspective on Residual Knowledge Gaps in the Assessment of Transporter‐Mediated Drug Interactions.
- Published in:
- Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 3, p. 450, doi. 10.1002/cpt.2671
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- Publication type:
- Article
Roadmap to 2030 for Drug Evaluation in Older Adults.
- Published in:
- Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 2, p. 210, doi. 10.1002/cpt.2452
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- Publication type:
- Article
Toward Bridging Unmet Medical Need in Early Alzheimer's Disease: An Evaluation of Beta‐Amyloid (Aβ) Plaque Burden as a Potential Drug Development Tool.
- Published in:
- Clinical Pharmacology & Therapeutics, 2022, v. 111, n. 4, p. 728, doi. 10.1002/cpt.2536
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- Publication type:
- Article
Cannabis for Medical Use: Clinical Pharmacology Perspectives on Scientific and Regulatory Challenges.
- Published in:
- Clinical Pharmacology & Therapeutics, 2022, v. 111, n. 4, p. 732, doi. 10.1002/cpt.2470
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- Publication type:
- Article
Do Inhibitory Metabolites Impact DDI Risk Assessment? Analysis of in vitro and in vivo Data from NDA Reviews Between 2013 and 2018.
- Published in:
- Clinical Pharmacology & Therapeutics, 2021, v. 110, n. 2, p. 452, doi. 10.1002/cpt.2259
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- Publication type:
- Article
Evaluating Patients With Impaired Renal Function During Drug Development: Highlights From the 2019 US FDA Pharmaceutical Science and Clinical Pharmacology Advisory Committee Meeting.
- Published in:
- Clinical Pharmacology & Therapeutics, 2021, v. 110, n. 2, p. 285, doi. 10.1002/cpt.2151
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- Publication type:
- Article
Regulatory Efforts to Facilitate Evaluation and Clinical Management of Drug‐Drug Interaction Risks.
- Published in:
- Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 1, p. 42, doi. 10.1002/cpt.1984
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- Publication type:
- Article
Application of Machine Learning in Drug Development and Regulation: Current Status and Future Potential.
- Published in:
- Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 726, doi. 10.1002/cpt.1771
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- Publication type:
- Article
Expanding Precompetitive Multisector Collaborations to Advance Drug Development and Pharmacogenomics.
- Published in:
- Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 1, p. 96, doi. 10.1002/cpt.1691
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- Publication type:
- Article
A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization.
- Published in:
- Clinical Pharmacology & Therapeutics, 2019, v. 106, n. 5, p. 1083, doi. 10.1002/cpt.1516
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- Publication type:
- Article