Works by Howell, Brett A.

Results: 25

Quantitative Systems Toxicology Modeling Informed Safe Dose Selection of Emvododstat in Acute Myeloid Leukemia Patients.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 3, p. 525, doi. 10.1002/cpt.3136

By:

Yang, Kyunghee;
Kong, Ronald;
Spiegel, Robert;
Baird, John D.;
O'Keefe, Kylie;
Howell, Brett A.;
Watkins, Paul B.

Publication type:

Article

Assessing Liver Effects of Cannabidiol and Valproate Alone and in Combination Using Quantitative Systems Toxicology.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 5, p. 1006, doi. 10.1002/cpt.3004

By:

Lakhani, Vinal V.;
Generaux, Grant;
Howell, Brett A.;
Longo, Diane M.;
Watkins, Paul B.

Publication type:

Article

Importance of Taylor dispersion in pharmacokinetic and multiple indicator dilution modelling.

Published in:

Mathematical Medicine & Biology: A Journal of the IMA, 2009, v. 26, n. 4, p. 263, doi. 10.1093/imammb/dqp004

By:

Fallon, Marissa S.;
Howell, Brett A.;
Chauhan, Anuj

Publication type:

Article

Prediction of the liver safety profile of a first-in-class myeloperoxidase inhibitor using quantitative systems toxicology modeling.

Published in:

Xenobiotica, 2024, v. 54, n. 7, p. 401, doi. 10.1080/00498254.2024.2361027

By:

Woodhead, Jeffrey L.;
Gebremichael, Yeshi;
Macwan, Joyce;
Qureshi, Irfan A.;
Bertz, Richard;
Wirtz, Victoria;
Howell, Brett A.

Publication type:

Article

Quantitative systems toxicology (QST) reproduces species differences in PF-04895162 liver safety due to combined mitochondrial and bile acid toxicity.

Published in:

Pharmacology Research & Perspectives, 2019, v. 7, n. 6, p. 1, doi. 10.1002/prp2.523

By:

Generaux, Grant;
Lakhani, Vinal V.;
Yuching Yang;
Nadanaciva, Sashi;
Luping Qiu;
Riccardi, Keith;
Li Di;
Howell, Brett A.;
Siler, Scott Q.;
Watkins, Paul B.;
Barton, Hugh A.;
Aleo, Michael D.;
Shoda, Lisl K. M.

Publication type:

Article

The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 11, p. 9692, doi. 10.3390/ijms24119692

By:

Beaudoin, James J.;
Clemens, Lara;
Miedel, Mark T.;
Gough, Albert;
Zaidi, Fatima;
Ramamoorthy, Priya;
Wong, Kari E.;
Sarangarajan, Rangaprasad;
Battista, Christina;
Shoda, Lisl K. M.;
Siler, Scott Q.;
Taylor, D. Lansing;
Howell, Brett A.;
Vernetti, Lawrence A.;
Yang, Kyunghee

Publication type:

Article

In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2012, v. 39, n. 5, p. 527, doi. 10.1007/s10928-012-9266-0

By:

Howell, Brett;
Yang, Yuching;
Kumar, Rukmini;
Woodhead, Jeffrey;
Harrill, Alison;
Clewell, Harvey;
Andersen, Melvin;
Siler, Scott;
Watkins, Paul

Publication type:

Article

Mechanistic Modelling of Drug-Induced Liver Injury: Investigating the Role of Innate Immune Responses.

Published in:

Gene Regulation & Systems Biology, 2017, n. 11, p. 1, doi. 10.1177/1177625017696074

By:

Shoda, Lisl K. M.;
Battista, Christina;
Siler, Scott Q.;
Pisetsky, David S.;
Watkins, Paul B.;
Howell, Brett A.

Publication type:

Article

Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling.

Published in:

Pharmaceutical Research, 2019, v. 36, n. 3, p. 1, doi. 10.1007/s11095-019-2582-y

By:

Woodhead, Jeffrey L.;
Yang, Kyunghee;
Oldach, David;
MacLauchlin, Chris;
Fernandes, Prabhavathi;
Watkins, Paul B.;
Siler, Scott Q.;
Howell, Brett A.

Publication type:

Article

Linking physiology to toxicity using DILIsym<sup>®</sup>, a mechanistic mathematical model of drug-induced liver injury.

Published in:

Biopharmaceutics & Drug Disposition, 2014, v. 35, n. 1, p. 33, doi. 10.1002/bdd.1878

By:

Shoda, Lisl K. M.;
Woodhead, Jeffrey L.;
Siler, Scott Q.;
Watkins, Paul B.;
Howell, Brett A.

Publication type:

Article

Variable responses of karst springs to recharge in the Middle Atlas region of Morocco.

Published in:

Hydrogeology Journal, 2019, v. 27, n. 5, p. 1693, doi. 10.1007/s10040-019-01945-w

By:

Howell, Brett A.;
Fryar, Alan E.;
Benaabidate, Lahcen;
Bouchaou, Lhoussaine;
Farhaoui, Mohamed

Publication type:

Article

Modeling drug- and chemical- induced hepatotoxicity with systems biology approaches.

Published in:

Frontiers in Physiology, 2012, v. 3, p. 1, doi. 10.3389/fphys.2012.00462

By:

Bhattacharya, Sudin;
Shoda, Lisl K. M.;
Zhang, Qiang;
Woods, Courtney G.;
Howell, Brett A.;
Siler, Scott Q.;
Woodhead, Jeffrey L.;
Yang, Yuching;
McMullen, Patrick;
Watkins, Paul B.;
Andersen, Melvin E.

Publication type:

Article

Reclaiming Lost Territory: the Response of Owyhee Harvester Ants to Forager Intrusions by Neighboring Colonies.

Published in:

Journal of Insect Behavior, 2015, v. 28, n. 6, p. 722, doi. 10.1007/s10905-015-9538-9

By:

Howell, Brett;
Robertson, Ian

Publication type:

Article

Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072.

Published in:

Archives of Toxicology, 2017, v. 91, n. 11, p. 3647, doi. 10.1007/s00204-017-1994-x

By:

Paech, Franziska;
Messner, Simon;
Spickermann, Jochen;
Wind, Mathias;
Schmitt-Hoffmann, Anne-Hortense;
Witschi, Anne;
Howell, Brett;
Church, Rachel;
Woodhead, Jeff;
Engelhardt, Marc;
Krähenbühl, Stephan;
Maurer, Martina

Publication type:

Article

Comparing the Liver Safety Profiles of 4 Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling.

Published in:

Toxicological Sciences, 2022, v. 188, n. 1, p. 108, doi. 10.1093/toxsci/kfac051

By:

Woodhead, Jeffrey L;
Siler, Scott Q;
Howell, Brett A;
Watkins, Paul B;
Conway, Charles

Publication type:

Article

Assessing Effects of BHV-0223 40 mg Zydis Sublingual Formulation and Riluzole 50 mg Oral Tablet on Liver Function Test Parameters Utilizing DILIsym.

Published in:

Toxicological Sciences, 2020, v. 175, n. 2, p. 292, doi. 10.1093/toxsci/kfaa019

By:

Longo, Diane M;
Shoda, Lisl K M;
Howell, Brett A;
Coric, Vladimir;
Berman, Robert M;
Qureshi, Irfan A

Publication type:

Article

Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 458, doi. 10.1093/toxsci/kfy253

By:

Longo, Diane M;
Woodhead, Jeffrey L;
Walker, Paul;
Herédi-Szabó, Krisztina;
Mogyorósi, Károly;
Wolenski, Francis S;
Dragan, Yvonne P;
Mosedale, Merrie;
Siler, Scott Q;
Watkins, Paul B;
Howell, Brett A

Publication type:

Article

Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity.

Published in:

Toxicological Sciences, 2018, v. 166, n. 1, p. 123, doi. 10.1093/toxsci/kfy191

By:

Battista, Christina;
Yang, Kyunghee;
Stahl, Simone H;
Mettetal, Jerome T;
Watkins, Paul B;
Siler, Scott Q;
Howell, Brett A

Publication type:

Article

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors.

Published in:

Toxicological Sciences, 2017, v. 155, n. 1, p. 61, doi. 10.1093/toxsci/kfw193

By:

Woodhead, Jeffrey L.;
Brock, William J.;
Roth, Sharin E.;
Shoaf, Susan E.;
Brouwer, Kim L. R.;
Church, Rachel;
Grammatopoulos, Tom N.;
Stiles, Linsey;
Siler, Scott Q.;
Howell, Brett A.;
Mosedale, Merrie;
Watkins, Paul B.;
Shoda, Lisl K. M.

Publication type:

Article

Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling.

Published in:

CTS: Clinical & Translational Science, 2018, v. 11, n. 5, p. 498, doi. 10.1111/cts.12560

By:

Woodhead, Jeffrey L.;
Paech, Franziska;
Maurer, Martina;
Engelhardt, Marc;
Schmitt‐Hoffmann, Anne H.;
Spickermann, Jochen;
Messner, Simon;
Wind, Mathias;
Witschi, Anne‐Therese;
Krähenbühl, Stephan;
Siler, Scott Q.;
Watkins, Paul B.;
Howell, Brett A.

Publication type:

Article

Mechanistic investigation of liver injury induced by BMS-932481, an experimental ɣ-secretase modulator.

Published in:

Toxicological Sciences, 2023, v. 194, n. 2, p. 235, doi. 10.1093/toxsci/kfad057

By:

Zhuo, Xiaoliang;
Howell, Brett A;
Shen, Hong;
Woodhead, Jeffrey L;
Mosure, Kathy;
Zhang, Yueping;
Scialis, Renato J;
Iyer, Ramaswamy;
Sun, Yongnian;
Boy, Kenneth M;
Lentz, Kimberley A;
Denton, R Rex;
Soars, Matthew G;
Johnson, Benjamin M;
Humphreys, W Griffith

Publication type:

Article

Investigating bile acid-mediated cholestatic drug-induced liver injury using a mechanistic model of multidrug resistance protein 3 (MDR3) inhibition.

Published in:

Frontiers in Pharmacology, 2023, v. 14, p. 1, doi. 10.3389/fphar.2022.1085621

By:

Beaudoin, James J.;
Yang, Kyunghee;
Adiwidjaja, Jeffry;
Taneja, Guncha;
Watkins, Paul B.;
Siler, Scott Q.;
Howell, Brett A.;
Woodhead, Jeffrey L.

Publication type:

Article

Bioactivation and reactivity research advances – 2023 year in review.

Published in:

Drug Metabolism Reviews, 2024, v. 56, n. 3, p. 247, doi. 10.1080/03602532.2024.2376023

By:

Wang, Shuai;
Argikar, Upendra A.;
Chatzopoulou, Maria;
Cho, Sungjoon;
Crouch, Rachel D.;
Dhaware, Deepika;
Gu, Ting-Jia;
Heck, Carley J. S.;
Johnson, Kevin M.;
Kalgutkar, Amit S.;
Liu, Joyce;
Ma, Bin;
Miller, Grover P.;
Rowley, Jessica A.;
Seneviratne, Herana Kamal;
Zhang, Donglu;
Khojasteh, S. Cyrus;
McGill, M. R.;
Zhuo, Xiaoliang;
Howell, Brett A.

Publication type:

Article

Modeling and Simulation of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended‐Release and Immediate‐Release Formulations in Healthy Adults Using the Quantitative Systems Toxicology Software Platform DILIsym.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2025, v. 14, n. 4, p. 681, doi. 10.1002/psp4.13304

By:

Beaudoin, James J.;
Yang, Kyunghee;
Howell, Brett A.;
Kenz, Zackary;
Lakhani, Vinal V.;
Woodhead, Jeffrey L.;
Lai, John C. K.;
Gelotte, Cathy K.;
Sista, Sury;
Atillasoy, Evren

Publication type:

Article

Current and Emerging Detoxification Therapies for Critical Care.

Published in:

Materials (1996-1944), 2010, v. 3, n. 4, p. 2483, doi. 10.3390/ma3042483

By:

Howell, Brett A.;
Chauhan, Anuj

Publication type:

Article