Works by Horton, John R

Results: 46

A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 1, p. 42, doi. 10.1038/nsmb.1939

By:

Estève, Pierre-Olivier;
Yanqi Chang;
Samaranayake, Mala;
Upadhyay, Anup K;
Horton, John R;
Feehery, George R;
Xiaodong Cheng;
Pradhan, Sriharsa

Publication type:

Article

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 1, p. 38, doi. 10.1038/nsmb.1753

By:

Horton, John R.;
Upadhyay, Anup K.;
Qi, Hank H.;
Xing Zhang;
Yang Shi;
Xiaodong Cheng

Publication type:

Article

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 3, p. 312, doi. 10.1038/nsmb.1560

By:

Chang, Yanqi;
Zhang, Xing;
Horton, John R.;
Upadhyay, Anup K.;
Spannhoff, Astrid;
Liu, Jin;
Snyder, James P.;
Bedford, Mark T.;
Cheng, Xiaodong

Publication type:

Article

The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 3, p. 245, doi. 10.1038/nsmb.1384

By:

Collins, Robert E.;
Northrop, Jeffrey P.;
Horton, John R.;
Lee, David Y.;
Xing Zhang;
Stallcup, Michael R.;
Xiaodong Cheng

Publication type:

Article

The State of Infectious Diseases Clinical Trials: A Systematic Review of ClinicalTrials.gov.

Published in:

PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0077086

By:

Goswami, Neela D.;
Pfeiffer, Christopher D.;
Horton, John R.;
Chiswell, Karen;
Tasneem, Asba;
Tsalik, Ephraim L.

Publication type:

Article

Extrauterine Listeriosis in the Gravid Mouse Influences Embryonic Growth and Development.

Published in:

PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0072601

By:

Suyemoto, M. Mitsu;
Hamrick, Terri S.;
Spears, Patricia A.;
Horton, John R.;
Washington, Ida M.;
Havell, Edward A.;
Borst, Luke B.;
Orndorff, Paul E.

Publication type:

Article

Formation of antibiotic, biodegradable polymers by processing with Irgasan DP300R (triclosan) and its inclusion compound with β-cyclodextrin.

Published in:

Journal of Applied Polymer Science, 2001, v. 82, n. 2, p. 300, doi. 10.1002/app.1852

By:

Lu, Jin;
Hill, Marcus A.;
Hood, Miriam;
Greeson, Dale F.;
Horton, John R.;
Orndorff, Paul E.;
Herndon, April S.;
Tonelli, Alan E.

Publication type:

Article

Formation of antibiotic, biodegradable/bioabsorbable polymers by processing with neomycin sulfate and its inclusion compound with β-cyclodextrin.

Published in:

Journal of Applied Polymer Science, 1999, v. 74, n. 4, p. 937, doi. 10.1002/(SICI)1097-4628(19991024)74:4<937::AID-APP20>3.0.CO;2-K

By:

Huang, Lei;
Taylor, Heidi;
Gerber, Michael;
Orndorff, Paul E.;
Horton, John R.;
Tonelli, Alan

Publication type:

Article

Metabolic and cardiorespiratory effects of decreasing lung hyperinflation with budesonide/formoterol in COPD: a randomized, double-crossover, placebo-controlled, multicenter trial.

Published in:

2020

By:

Divo, Miguel J.;
DePietro, Michael R.;
Horton, John R.;
Maguire, Cherie A.;
Celli, Bartolome R.

Publication type:

journal article

The ankyrin repeat domain of Huntingtin interacting protein 14 contains a surface aromatic cage, a potential site for methyl-lysine binding.

Published in:

Proteins, 2009, v. 76, n. 3, p. 772, doi. 10.1002/prot.22452

By:

Gao, Tiyu;
Collins, Robert E.;
Horton, John R.;
Zhang, Xing;
Zhang, Rongguang;
Dhayalan, Arunkumar;
Tamas, Raluca;
Jeltsch, Albert;
Cheng, Xiaodong

Publication type:

Article

Structure of the SANT domain from the Xenopus chromatin remodeling factor ISWI.

Published in:

Proteins, 2007, v. 67, n. 4, p. 1198, doi. 10.1002/prot.21352

By:

Horton, John R.;
Elgar, Stuart J.;
Khan, Seema I.;
Zhang, Xing;
Wade, Paul A.;
Cheng, Xiaodong

Publication type:

Article

Structural basis of allele variation of human thiopurine- S-methyltransferase.

Published in:

Proteins, 2007, v. 67, n. 1, p. 198, doi. 10.1002/prot.21272

By:

Wu, Hong;
Horton, John R.;
Battaile, Kevin;
Allali-Hassani, Abdellah;
Martin, Fernando;
Zeng, Hong;
Loppnau, Peter;
Vedadi, Masoud;
Bochkarev, Alexey;
Plotnikov, Alexander N.;
Cheng, Xiaodong

Publication type:

Article

Comparative Safety and Efficacy of Auranofin and Parenteral Gold Compounds: A Review.

Published in:

Scandinavian Journal of Rheumatology, 1983, v. 12, n. S51, p. 100, doi. 10.3109/03009748309095361

By:

Horton, R. John

Publication type:

Article

Clostridioides difficile specific DNA adenine methyltransferase CamA squeezes and flips adenine out of DNA helix.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23693-w

By:

Zhou, Jujun;
Horton, John R.;
Blumenthal, Robert M.;
Zhang, Xing;
Cheng, Xiaodong

Publication type:

Article

Structure of the bacteriophage T4 DNA adenine methyltransferase.

Published in:

Nature Structural Biology, 2003, v. 10, n. 10, p. 849, doi. 10.1038/nsb973

By:

Yang, Zhe;
Horton, John R;
Zhou, Lan;
Zhang, Xu Jia;
Dong, Aiping;
Zhang, Xing;
Schlagman, Samuel L;
Kossykh, Valeri;
Hattman, Stanley;
Cheng, Xiaodong

Publication type:

Article

Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base.

Published in:

Nature Structural Biology, 1998, v. 5, n. 10, p. 872, doi. 10.1038/2312

By:

O'Gara, Margaret;
Horton, John R.;
Roberts, Richard J.;
Cheng, Xiaodong

Publication type:

Article

KDM5 histone demethylases repress immune response via suppression of STING.

Published in:

PLoS Biology, 2018, v. 16, n. 8, p. 1, doi. 10.1371/journal.pbio.2006134

By:

Wu, Lizhen;
Cao, Jian;
Cai, Wesley L.;
Lang, Sabine M.;
Horton, John R.;
Jansen, Daniel J.;
Liu, Zongzhi Z.;
Chen, Jocelyn F.;
Zhang, Meiling;
Mott, Bryan T.;
Pohida, Katherine;
Rai, Ganesha;
Kales, Stephen C.;
Henderson, Mark J.;
Hu, Xin;
Jadhav, Ajit;
Maloney, David J.;
Simeonov, Anton;
Zhu, Shu;
Iwasaki, Akiko

Publication type:

Article

Structure and mutagenesis of the DNA modification-dependent restriction endonuclease AspBHI.

Published in:

Scientific Reports, 2014, p. 1, doi. 10.1038/srep04246

By:

Horton, John R.;
Nugent, Rebecca L.;
Li, Andrew;
Mabuchi, Megumu Yamada;
Fomenkov, Alexey;
Cohen-Karni, Devora;
Griggs, Rose M.;
Xing Zhang;
Wilson, Geoffrey G.;
Yu Zheng;
Shuang-yong Xu;
Xiaodong Cheng

Publication type:

Article

Structures of CTCF–DNA complexes including all 11 zinc fingers.

Published in:

Nucleic Acids Research, 2023, v. 51, n. 16, p. 8447, doi. 10.1093/nar/gkad594

By:

Yang, Jie;
Horton, John R;
Liu, Bin;
Corces, Victor G;
Blumenthal, Robert M;
Zhang, Xing;
Cheng, Xiaodong

Publication type:

Article

Allosteric autoregulation of DNA binding via a DNA-mimicking protein domain: a biophysical study of ZNF410–DNA interaction using small angle X-ray scattering.

Published in:

Nucleic Acids Research, 2023, v. 51, n. 4, p. 1674, doi. 10.1093/nar/gkac1274

By:

Kaur, Gundeep;
Ren, Ren;
Hammel, Michal;
Horton, John R;
Yang, Jie;
Cao, Yu;
He, Chenxi;
Lan, Fei;
Lan, Xianjiang;
Blobel, Gerd A;
Blumenthal, Robert M;
Zhang, Xing;
Cheng, Xiaodong

Publication type:

Article

Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions.

Published in:

Nucleic Acids Research, 2021, v. 49, n. 20, p. 11629, doi. 10.1093/nar/gkab460

By:

Yu, Dan;
Horton, John R;
Yang, Jie;
Hajian, Taraneh;
Vedadi, Masoud;
Sagum, Cari A;
Bedford, Mark T;
Blumenthal, Robert M;
Zhang, Xing;
Cheng, Xiaodong

Publication type:

Article

Preferential CEBP binding to T:G mismatches and increased C-to-T human somatic mutations.

Published in:

Nucleic Acids Research, 2021, v. 49, n. 9, p. 5084, doi. 10.1093/nar/gkab276

By:

Yang, Jie;
Horton, John R;
Akdemir, Kadir C;
Li, Jia;
Huang, Yun;
Kumar, Janani;
Blumenthal, Robert M;
Zhang, Xing;
Cheng, Xiaodong

Publication type:

Article

Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 18, p. 10329, doi. 10.1093/nar/gkaa604

By:

Woodcock, Clayton B;
Horton, John R;
Zhou, Jujun;
Bedford, Mark T;
Blumenthal, Robert M;
Zhang, Xing;
Cheng, Xiaodong

Publication type:

Article

Beta class amino methyltransferases from bacteria to humans: evolution and structural consequences.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 18, p. 10034, doi. 10.1093/nar/gkaa446

By:

Woodcock, Clayton B;
Horton, John R;
Zhang, Xing;
Blumenthal, Robert M;
Cheng, Xiaodong

Publication type:

Article

Structure of HhaI endonuclease with cognate DNA at an atomic resolution of 1.0 Å.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 3, p. 1466, doi. 10.1093/nar/gkz1195

By:

Horton, John R;
Yang, Jie;
Zhang, Xing;
Petronzio, Theresa;
Fomenkov, Alexey;
Wilson, Geoffrey G;
Roberts, Richard J;
Cheng, Xiaodong

Publication type:

Article

Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine.

Published in:

Nucleic Acids Research, 2019, v. 47, n. 16, p. 8375, doi. 10.1093/nar/gkz381

By:

Yang, Jie;
Horton, John R;
Li, Jia;
Huang, Yun;
Zhang, Xing;
Blumenthal, Robert M;
Cheng, Xiaodong

Publication type:

Article

Structural basis of specific DNA binding by the transcription factor ZBTB24.

Published in:

Nucleic Acids Research, 2019, v. 47, n. 16, p. 8388, doi. 10.1093/nar/gkz557

By:

Ren, Ren;
Hardikar, Swanand;
Horton, John R;
Lu, Yue;
Zeng, Yang;
Singh, Anup K;
Lin, Kevin;
Coletta, Luis Della;
Shen, Jianjun;
Lin Kong, Celine Shuet;
Hashimoto, Hideharu;
Zhang, Xing;
Chen, Taiping;
Cheng, Xiaodong

Publication type:

Article

Structural basis for effects of CpA modifications on C/EBPβ binding of DNA.

Published in:

Nucleic Acids Research, 2019, v. 47, n. 4, p. 1774, doi. 10.1093/nar/gky1264

By:

Yang, Jie;
Horton, John R;
Wang, Dongxue;
Ren, Ren;
Li, Jia;
Sun, Deqiang;
Huang, Yun;
Zhang, Xing;
Blumenthal, Robert M;
Cheng, Xiaodong

Publication type:

Article

Role for first zinc finger of WT1 in DNA sequence specificity: Denys--Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites.

Published in:

Nucleic Acids Research, 2018, v. 46, n. 8, p. 3864, doi. 10.1093/nar/gkx1274

By:

Wang, Dongxue;
Horton, John R;
Zheng, Yu;
Blumenthal, Robert M;
Zhang, Xing;
Cheng, Xiaodong

Publication type:

Article

Amyloid-like assembly of the low complexity domain of yeast Nab3.

Published in:

Prion, 2015, v. 9, n. 1, p. 34, doi. 10.1080/19336896.2014.997618

By:

O'Rourke, Thomas W;
Loya, Travis J;
Head, PamelaSara E;
Horton, John R;
Reines, Daniel

Publication type:

Article

The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix.

Published in:

Nature, 2008, v. 455, n. 7214, p. 826, doi. 10.1038/nature07280

By:

Hashimoto, Hideharu;
Horton, John R.;
Xing Zhang;
Bostick, Magnolia;
Jacobsen, Steven E.;
Xiaodong Cheng

Publication type:

Article

Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression.

Published in:

Nature, 2007, v. 448, n. 7154, p. 718, doi. 10.1038/nature06034

By:

Fei Lan;
Collins, Robert E.;
De Cegli, Rossella;
Alpatov, Roman;
Horton, John R.;
Xiaobing Shi;
Gozani, Or;
Xiaodong Cheng;
Yang Shi

Publication type:

Article

Caught in the act: visualization of an intermediate in the DNA base-flipping pathway induced by HhaI methyltransferase.

Published in:

Nucleic Acids Research, 2004, v. 32, n. 13, p. 3877, doi. 10.1093/nar/gkh701

By:

Horton, John R.;
Ratner, Gary;
Banavali, Nilesh K.;
Huang, Niu;
Choi, Yongseok;
Maier, Martin A.;
Marquez, Victor E.;
MacKerell, Alexander D.;
Cheng, Xiaodong

Publication type:

Article

The cell cycle-regulated DNA adenine methyltransferase CcrM opens a bubble at its DNA recognition site.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-12498-7

By:

Horton, John R.;
Woodcock, Clayton B.;
Opot, Sifa B.;
Reich, Norbert O.;
Zhang, Xing;
Cheng, Xiaodong

Publication type:

Article

Structural basis for the target specificity of actin histidine methyltransferase SETD3.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-11554-6

By:

Dai, Shaobo;
Horton, John R.;
Woodcock, Clayton B.;
Wilkinson, Alex W.;
Xing Zhang;
Gozani, Or;
Xiaodong Cheng

Publication type:

Article

Methyl-dependent and spatial-specific DNA recognition by the orthologous transcription factors human AP-1 and Epstein-Barr virus Zta.

Published in:

Nucleic Acids Research, 2017, v. 45, n. 5, p. 2503, doi. 10.1093/nar/gkx057

By:

Samuel Hong;
Dongxue Wang;
Horton, John R.;
Xing Zhang;
Speck, Samuel H.;
Blumenthal, Robert M.;
Xiaodong Cheng

Publication type:

Article

Structures of Escherichia coli DNA adenine methyltransferase (Dam) in complex with a non-GATC sequence: potential implications for methylation-independent transcriptional repression.

Published in:

Nucleic Acids Research, 2015, v. 43, n. 8, p. 4296, doi. 10.1093/nar/gkv251

By:

Horton, John R.;
Xing Zhang;
Blumenthal, Robert M.;
Xiaodong Cheng

Publication type:

Article

Modification-dependent restriction endonuclease, MspJI, flips 5-methylcytosine out of the DNA helix.

Published in:

Nucleic Acids Research, 2014, v. 42, n. 19, p. 12092, doi. 10.1093/nar/gku871

By:

Horton, John R.;
Wang, Hua;
Mabuchi, Megumu Yamada;
Zhang, Xing;
Roberts, Richard J.;
Zheng, Yu;
Wilson, Geoffrey G.;
Cheng, Xiaodong

Publication type:

Article

Structure of 5-hydroxymethylcytosine-specific restriction enzyme, AbaSI, in complex with DNA.

Published in:

Nucleic Acids Research, 2014, v. 42, n. 12, p. 7947, doi. 10.1093/nar/gku497

By:

Horton, John R.;
Borgaro, Janine G.;
Griggs, Rose M.;
Quimby, Aine;
Guan, Shengxi;
Zhang, Xing;
Wilson, Geoffrey G.;
Zheng, Yu;
Zhu, Zhenyu;
Cheng, Xiaodong

Publication type:

Article

Structure and cleavage activity of the tetrameric MspJI DNA modification-dependent restriction endonuclease.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 19, p. 9763, doi. 10.1093/nar/gks719

By:

Horton, John R.;
Mabuchi, Megumu Yamada;
Cohen-Karni, Devora;
Zhang, Xing;
Griggs, Rose M.;
Samaranayake, Mala;
Roberts, Richard J.;
Zheng, Yu;
Cheng, Xiaodong

Publication type:

Article

Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling.

Published in:

Nucleic Acids Research, 2011, v. 39, n. 15, p. 6380, doi. 10.1093/nar/gkr256

By:

Chang, Yanqi;
Levy, Dan;
Horton, John R.;
Peng, Junmin;
Zhang, Xing;
Gozani, Or;
Cheng, Xiaodong

Publication type:

Article

DNA nicking by HinP1I endonuclease: bending, base flipping and minor groove expansion.

Published in:

Nucleic Acids Research, 2006, v. 34, n. 3, p. 939, doi. 10.1093/nar/gkj484

By:

Horton, John R.;
Zhang, Xing;
Maunus, Robert;
Yang, Zhe;
Wilson, Geoffrey G.;
Roberts, Richard J.;
Cheng, Xiaodong

Publication type:

Article

Structure of HinP1I endonuclease reveals a striking similarity to the monomeric restriction enzyme MspI.

Published in:

Nucleic Acids Research, 2005, v. 33, n. 6, p. 1892, doi. 10.1093/nar/gki337

By:

Yang, Zhe;
Horton, John R.;
Maunus, Robert;
Wilson, Geoffrey G.;
Roberts, Richard J.;
Cheng, Xiaodong

Publication type:

Article

Repurposing epigenetic inhibitors to target the Clostridioides difficile-specific DNA adenine methyltransferase and sporulation regulator CamA.

Published in:

Epigenetics, 2022, v. 17, n. 9, p. 970, doi. 10.1080/15592294.2021.1976910

By:

Zhou, Jujun;
Horton, John R.;
Yu, Dan;
Ren, Ren;
Blumenthal, Robert M.;
Zhang, Xing;
Cheng, Xiaodong

Publication type:

Article

A cross-sectional analysis of HIV and hepatitis C clinical trials 2007 to 2010: the relationship between industry sponsorship and randomized study design.

Published in:

Trials, 2014, v. 15, n. 1, p. 1, doi. 10.1186/1745-6215-15-31

By:

Goswami, Neela D.;
Tsalik, Ephraim L.;
Naggie, Susanna;
Miller, William C.;
Horton, John R.;
Pfeiffer, Christopher D.;
Hicks, Charles B.

Publication type:

Article

A cross-sectional analysis of HIV and hepatitis C clinical trials 2007 to 2010: the relationship between industry sponsorship and randomized study design.

Published in:

2014

By:

Goswami, Neela D;
Tsalik, Ephraim L;
Naggie, Susanna;
Miller, William C;
Horton, John R;
Pfeiffer, Christopher D;
Hicks, Charles B

Publication type:

journal article