Works by Horswill, Alexander R.

Results: 58

New approaches for treating staphylococcal biofilm infections.

Published in:

Annals of the New York Academy of Sciences, 2011, v. 1241, n. 1, p. 104, doi. 10.1111/j.1749-6632.2011.06281.x

By:

Kiedrowski, Megan R.;
Horswill, Alexander R.

Publication type:

Article

Staphylococcus aureus biofilms: recent developments in biofilm dispersal.

Published in:

Frontiers in Cellular & Infection Microbiology, 2014, p. 1, doi. 10.3389/fcimb.2014.00178

By:

Lister, Jessica L.;
Horswill, Alexander R.

Publication type:

Article

Methionine Sulfoxide Reductases Protect against Oxidative Stress in Staphylococcus aureus Encountering Exogenous Oxidants and Human Neutrophils.

Published in:

Journal of Innate Immunity, 2014, v. 6, n. 3, p. 353, doi. 10.1159/000355915

By:

Pang, Yun Yun;
Schwartz, Jamie;
Bloomberg, Sarah;
Boyd, Jeffrey M.;
Horswill, alexander R.;
Nauseef, William M.

Publication type:

Article

The Role of Innate Immunity in Promoting SaeR/S-Mediated Virulence in Staphylococcus aureus.

Published in:

Journal of Innate Immunity, 2014, v. 6, n. 1, p. 21, doi. 10.1159/000351200

By:

Zurek, Oliwia W.;
Nygaard, Tyler K.;
Watkins, Robert L.;
Pallister, Kyler B.;
Torres, Victor J.;
Horswill, alexander R.;
Voyich, Jovanka M.

Publication type:

Article

agr-Dependent Interactions of Staphylococcus aureus USA300 with Human Polymorphonuclear Neutrophils.

Published in:

Journal of Innate Immunity, 2010, v. 2, n. 6, p. 546, doi. 10.1159/000319855

By:

Pang, Yun Yun;
Schwartz, Jamie;
Thoendel, Matthew;
Ackermann, Laynez W.;
Horswill, Alexander R.;
Nauseef, William M.

Publication type:

Article

Nuclease Expression by Staphylococcus aureus Facilitates Escape from Neutrophil Extracellular Traps.

Published in:

Journal of Innate Immunity, 2010, v. 2, n. 6, p. 576, doi. 10.1159/000319909

By:

Berends, Evelien T.M.;
Horswill, Alexander R.;
Haste, Nina M.;
Monestier, Marc;
Nizet, Victor;
von Köckritz-Blickwede, Maren

Publication type:

Article

Biofilm dispersal of community-associated methicillin-resistant Staphylococcus aureus on orthopedic implant material.

Published in:

Journal of Orthopaedic Research, 2010, v. 28, n. 1, p. 55, doi. 10.1002/jor.20943

By:

Lauderdale, Katherine J.;
Malone, Cheryl L.;
Boles, Blaise R.;
Morcuende, Jose;
Horswill, Alexander R.

Publication type:

Article

Overcoming pH defenses on the skin to establish infections.

Published in:

PLoS Pathogens, 2022, v. 18, n. 5, p. 1, doi. 10.1371/journal.ppat.1010512

By:

Costa, Flavia G.;
Horswill, Alexander R.

Publication type:

Article

Intracellular Environment and agr System Affect Colony Size Heterogeneity of Staphylococcus aureus.

Published in:

Frontiers in Microbiology, 2020, v. 11, p. 1, doi. 10.3389/fmicb.2020.01415

By:

Häffner, Nicola;
Bär, Julian;
Dengler Haunreiter, Vanina;
Mairpady Shambat, Srikanth;
Seidl, Kati;
Crosby, Heidi A.;
Horswill, Alexander R.;
Zinkernagel, Annelies S.

Publication type:

Article

A role for type I signal peptidase in Staphylococcus aureus quorum sensing.

Published in:

Molecular Microbiology, 2007, v. 65, n. 3, p. 780, doi. 10.1111/j.1365-2958.2007.05830.x

By:

Kavanaugh, Jeffrey S.;
Thoendel, Matthew;
Horswill, Alexander R.

Publication type:

Article

Correction: Investigation of synovial fluid induced Staphylococcus aureus aggregate development and its impact on surface attachment and biofilm formation.

Published in:

2020

By:

Pestrak, Matthew J.;
Gupta, Tripti Thapa;
Dusane, Devendra H.;
Guzior, Doug V.;
Staats, Amelia;
Harro, Jan;
Horswill, Alexander R.;
Stoodley, Paul

Publication type:

Correction Notice

Investigation of synovial fluid induced Staphylococcus aureus aggregate development and its impact on surface attachment and biofilm formation.

Published in:

PLoS ONE, 2020, v. 15, n. 4, p. 1, doi. 10.1371/journal.pone.0231791

By:

Pestrak, Matthew J.;
Gupta, Tripti Thapa;
Dusane, Devendra H.;
Guzior, Doug V.;
Staats, Amelia;
Harro, Jan;
Horswill, Alexander R.;
Stoodley, Paul

Publication type:

Article

Neutrophil‐derived extracellular vesicles modulate the phenotype of naïve human neutrophils.

Published in:

Journal of Leukocyte Biology, 2021, v. 110, n. 5, p. 917, doi. 10.1002/JLB.3AB0520-339RR

By:

Amjadi, Maya F.;
Avner, Benjamin S.;
Greenlee‐Wacker, Mallary C.;
Horswill, Alexander R.;
Nauseef, William M.

Publication type:

Article

Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease.

Published in:

Protein Science: A Publication of the Protein Society, 2007, v. 16, n. 8, p. 1535, doi. 10.1110/ps.072933007

By:

Cheng, Lin;
Naumann, Todd A.;
Horswill, Alexander R.;
Hong, Sue-Jean;
Venters, Bryan J.;
Tomsho, John W.;
Benkovic, Stephen J.;
Keiler, Kenneth C.

Publication type:

Article

Staphylococcus aureus adhesion in endovascular infections is controlled by the ArlRS–MgrA signaling cascade.

Published in:

PLoS Pathogens, 2019, v. 15, n. 5, p. 1, doi. 10.1371/journal.ppat.1007800

By:

Kwiecinski, Jakub M.;
Crosby, Heidi A.;
Valotteau, Claire;
Hippensteel, Joseph A.;
Nayak, Manasa K.;
Chauhan, Anil K.;
Schmidt, Eric P.;
Dufrêne, Yves F.;
Horswill, Alexander R.

Publication type:

Article

The effect of the chemical, biological, and physical environment on quorum sensing in structured microbial communities.

Published in:

Analytical & Bioanalytical Chemistry, 2007, v. 387, n. 2, p. 371, doi. 10.1007/s00216-006-0720-y

By:

Horswill, Alexander R.;
Stoodley, Paul;
Stewart, Philip S.;
Parsek, Matthew R.

Publication type:

Article

Castaneroxy A From the Leaves of Castanea sativa Inhibits Virulence in Staphylococcus aureus.

Published in:

Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.640179

By:

Salam, Akram M.;
Porras, Gina;
Cho, Young-Saeng K.;
Brown, Morgan M.;
Risener, Caitlin J.;
Marquez, Lewis;
Lyles, James T.;
Bacsa, John;
Horswill, Alexander R.;
Quave, Cassandra L.

Publication type:

Article

Flipping the switch: tools for detecting small molecule inhibitors of staphylococcal virulence.

Published in:

Frontiers in Microbiology, 2014, v. 5, p. 1, doi. 10.3389/fmicb.2014.00706

By:

Quave, Cassandra L.;
Horswill, Alexander R.

Publication type:

Article

Cyclic Peptides, a Chemical Genetics Tool for Biologists.

Published in:

Cell Cycle, 2005, v. 4, n. 4, p. 552, doi. 10.4161/cc.4.4.1585

By:

Horswill, Alexander R.;
Benkovic, Stephen J.

Publication type:

Article

An 18 kDa Scaffold Protein Is Critical for Staphylococcus epidermidis Biofilm Formation.

Published in:

PLoS Pathogens, 2015, v. 11, n. 3, p. 1, doi. 10.1371/journal.ppat.1004735

By:

Decker, Rahel;
Burdelski, Christoph;
Zobiak, Melanie;
Büttner, Henning;
Franke, Gefion;
Christner, Martin;
Saß, Katharina;
Zobiak, Bernd;
Henke, Hanae A.;
Horswill, Alexander R.;
Bischoff, Markus;
Bur, Stephanie;
Hartmann, Torsten;
Schaeffer, Carolyn R.;
Fey, Paul D.;
Rohde, Holger

Publication type:

Article

Selective Chemical Inhibition of agr Quorum Sensing in Staphylococcus aureus Promotes Host Defense with Minimal Impact on Resistance.

Published in:

PLoS Pathogens, 2014, v. 10, n. 6, p. 1, doi. 10.1371/journal.ppat.1004174

By:

Sully, Erin K.;
Malachowa, Natalia;
Elmore, Bradley O.;
Alexander, Susan M.;
Femling, Jon K.;
Gray, Brian M.;
DeLeo, Frank R.;
Otto, Michael;
Cheung, Ambrose L.;
Edwards, Bruce S.;
Sklar, Larry A.;
Horswill, Alexander R.;
Hall, Pamela R.;
Gresham, Hattie D.

Publication type:

Article

The Staphylococcus aureus ArlRS Two-Component System Is a Novel Regulator of Agglutination and Pathogenesis.

Published in:

PLoS Pathogens, 2013, v. 9, n. 12, p. 1, doi. 10.1371/journal.ppat.1003819

By:

Walker, Jennifer N.;
Crosby, Heidi A.;
Spaulding, Adam R.;
Salgado-Pabón, Wilmara;
Malone, Cheryl L.;
Rosenthal, Carolyn B.;
Schlievert, Patrick M.;
Boyd, Jeffrey M.;
Horswill, Alexander R.

Publication type:

Article

Nox2 Modification of LDL Is Essential for Optimal Apolipoprotein B-mediated Control of agr Type III Staphylococcus aureus Quorum-sensing.

Published in:

PLoS Pathogens, 2013, v. 9, n. 2, p. 1, doi. 10.1371/journal.ppat.1003166

By:

Hall, Pamela R.;
Elmore, Bradley O.;
Spang, Cynthia H.;
Alexander, Susan M.;
Manifold-Wheeler, Brett C.;
Castleman, Moriah J.;
Daly, Seth M.;
Peterson, M. Michal;
Sully, Erin K.;
Femling, Jon K.;
Otto, Michael;
Horswill, Alexander R.;
Timmins, Graham S.;
Gresham, Hattie D.

Publication type:

Article

agr-Mediated Dispersal of Staphylococcus aureus Biofilms.

Published in:

PLoS Pathogens, 2008, v. 4, n. 4, p. 1, doi. 10.1371/journal.ppat.1000052

By:

Boles, Blaise R.;
Horswill, Alexander R.

Publication type:

Article

The Staphylococcus aureus ArlRS two‐component system regulates virulence factor expression through MgrA.

Published in:

Molecular Microbiology, 2020, v. 113, n. 1, p. 103, doi. 10.1111/mmi.14404

By:

Crosby, Heidi A.;
Tiwari, Nitija;
Kwiecinski, Jakub M.;
Xu, Zhen;
Dykstra, Allison;
Jenul, Christian;
Fuentes, Ernesto J.;
Horswill, Alexander R.

Publication type:

Article

The metalloprotease Sep A governs processing of accumulation-associated protein and shapes intercellular adhesive surface properties in S taphylococcus epidermidis.

Published in:

Molecular Microbiology, 2017, v. 103, n. 5, p. 860, doi. 10.1111/mmi.13594

By:

Paharik, Alexandra E.;
Kotasinska, Marta;
Both, Anna;
Hoang, Tra‐My N.;
Büttner, Henning;
Roy, Paroma;
Fey, Paul D.;
Horswill, Alexander R.;
Rohde, Holger

Publication type:

Article

Rot is a key regulator of S taphylococcus aureus biofilm formation.

Published in:

Molecular Microbiology, 2015, v. 96, n. 2, p. 388, doi. 10.1111/mmi.12943

By:

Mootz, Joe M.;
Benson, Meredith A.;
Heim, Cortney E.;
Crosby, Heidi A.;
Kavanaugh, Jeffrey S.;
Dunman, Paul M.;
Kielian, Tammy;
Torres, Victor J.;
Horswill, Alexander R.

Publication type:

Article

Random mutagenesis and topology analysis of the autoinducing peptide biosynthesis proteins in Staphylococcus aureus.

Published in:

Molecular Microbiology, 2013, v. 87, n. 2, p. 318, doi. 10.1111/mmi.12100

By:

Thoendel, Matthew;
Horswill, Alexander R.

Publication type:

Article

sarA-mediated repression of protease production plays a key role in the pathogenesis of Staphylococcus aureus USA300 isolates.

Published in:

Molecular Microbiology, 2012, v. 86, n. 5, p. 1183, doi. 10.1111/mmi.12048

By:

Zielinska, Agnieszka K.;
Beenken, Karen E.;
Mrak, Lara N.;
Spencer, Horace J.;
Post, Ginell R.;
Skinner, Robert A.;
Tackett, Alan J.;
Horswill, Alexander R.;
Smeltzer, Mark S.

Publication type:

Article

Staphylococcus aureus regulates the expression and production of the staphylococcal superantigen-like secreted proteins in a Rot-dependent manner.

Published in:

Molecular Microbiology, 2011, v. 81, n. 3, p. 659, doi. 10.1111/j.1365-2958.2011.07720.x

By:

Benson, Meredith A.;
Lilo, Sarit;
Wasserman, Gregory A.;
Thoendel, Matthew;
Smith, Amanda;
Horswill, Alexander R.;
Fraser, John;
Novick, Richard P.;
Shopsin, Bo;
Torres, Victor J.

Publication type:

Article

Staphylococcus aureus SspA (V8 protease): New skin pathogenesis insights into an old enzyme.

Published in:

PLoS Pathogens, 2025, v. 21, n. 4, p. 1, doi. 10.1371/journal.ppat.1013048

By:

Thorstenson, John C.;
Horswill, Alexander R.

Publication type:

Article

Biofilm formation by Staphylococcus aureus clinical isolates correlates with the infection type.

Published in:

2019

By:

Kwiecinski, Jakub M.;
Jacobsson, Gunnar;
Horswill, Alexander R.;
Josefsson, Elisabet;
Jin, Tao

Publication type:

Report

Development of an in vitro colonization model to investigate Staphylococcus aureus interactions with airway epithelia.

Published in:

Cellular Microbiology, 2016, v. 18, n. 5, p. 720, doi. 10.1111/cmi.12543

By:

Kiedrowski, Megan R.;
Paharik, Alexandra E.;
Ackermann, Laynez W.;
Shelton, Annie U.;
Singh, Sachinkumar B.;
Starner, Timothy D.;
Horswill, Alexander R.

Publication type:

Article

Noninvasive imaging of Staphylococcus aureus infections with a nuclease-activated probe.

Published in:

Nature Medicine, 2014, v. 20, n. 3, p. 301, doi. 10.1038/nm.3460

By:

Hernandez, Frank J;
Huang, Lingyan;
Olson, Michael E;
Powers, Kristy M;
Hernandez, Luiza I;
Meyerholz, David K;
Thedens, Daniel R;
Behlke, Mark A;
Horswill, Alexander R;
McNamara, James O

Publication type:

Article

Cathepsin G Degrades Staphylococcus aureus Biofilms.

Published in:

2021

By:

Kavanaugh, Jeffrey S;
Leidal, Kevin G;
Nauseef, William M;
Horswill, Alexander R

Publication type:

journal article

Staphylococcus aureus Staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis.

Published in:

EMBO Journal, 2012, v. 31, n. 17, p. 3607, doi. 10.1038/emboj.2012.212

By:

Laarman, Alexander J;
Mijnheer, Gerdien;
Mootz, Joe M;
van Rooijen, Willemien J M;
Ruyken, Maartje;
Malone, Cheryl L;
Heezius, Erik C;
Ward, Richard;
Milligan, Graeme;
van Strijp, Jos A G;
de Haas, Carla J C;
Horswill, Alexander R;
van Kessel, Kok P M;
Rooijakkers, Suzan H M

Publication type:

Article

The Staphylococcus aureus CamS lipoprotein is a repressor of toxin production that shapes host-pathogen interaction.

Published in:

PLoS Biology, 2024, v. 22, n. 1, p. 1, doi. 10.1371/journal.pbio.3002451

By:

Schilcher, Katrin;
Severn, Morgan M.;
Jenul, Christian;
Avina, Young-Saeng C.;
Keogh, Rebecca A.;
Horswill, Alexander R.

Publication type:

Article

Short chain fatty acids produced by Cutibacterium acnes inhibit biofilm formation by Staphylococcus epidermidis.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-77790-9

By:

Nakamura, Kouki;
O'Neill, Alan M.;
Williams, Michael R.;
Cau, Laura;
Nakatsuji, Teruaki;
Horswill, Alexander R.;
Gallo, Richard L.

Publication type:

Article

Triterpenoid acids isolated from Schinus terebinthifolia fruits reduce Staphylococcus aureus virulence and abate dermonecrosis.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-65080-3

By:

Tang, Huaqiao;
Porras, Gina;
Brown, Morgan M.;
Chassagne, Francois;
Lyles, James T.;
Bacsa, John;
Horswill, Alexander R.;
Quave, Cassandra L.

Publication type:

Article

Corrigendum: Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice.

Published in:

2019

By:

Tian, Xiaoli;
Hellman, Judith;
Horswill, Alexander R.;
Crosby, Heidi A.;
Francis, Kevin P.;
Prakash, Arun

Publication type:

Correction Notice

Coinfection with Leishmania major and Staphylococcus aureus enhances the pathologic responses to both microbes through a pathway involving IL-17A.

Published in:

PLoS Neglected Tropical Diseases, 2019, v. 13, n. 5, p. 1, doi. 10.1371/journal.pntd.0007247

By:

Borbón, Tiffany Y.;
Scorza, Breanna M.;
Clay, Gwendolyn M.;
Lima Nobre de Queiroz, Fellipe;
Sariol, Alan J.;
Bowen, Jayden L.;
Chen, Yani;
Zhanbolat, Bayan;
Parlet, Corey P.;
Valadares, Diogo G.;
Cassel, Suzanne L.;
Nauseef, William M.;
Horswill, Alexander R.;
Sutterwala, Fayyaz S.;
Wilson, Mary E.

Publication type:

Article

Castanea sativa (European Chestnut) Leaf Extracts Rich in Ursene and Oleanene Derivatives Block Staphylococcus aureus Virulence and Pathogenesis without Detectable Resistance.

Published in:

PLoS ONE, 2015, v. 10, n. 8, p. 1, doi. 10.1371/journal.pone.0136486

By:

Quave, Cassandra L.;
Lyles, James T.;
Kavanaugh, Jeffery S.;
Nelson, Kate;
Parlet, Corey P.;
Crosby, Heidi A.;
Heilmann, Kristopher P.;
Horswill, Alexander R.

Publication type:

Article

Staphylococcus aureus Nuc2 Is a Functional, Surface-Attached Extracellular Nuclease.

Published in:

PLoS ONE, 2014, v. 9, n. 4, p. 1, doi. 10.1371/journal.pone.0095574

By:

Kiedrowski, Megan R.;
Crosby, Heidi A.;
Hernandez, Frank J.;
Malone, Cheryl L.;
McNamara II, James O.;
Horswill, Alexander R.

Publication type:

Article

Staphylococcus aureus sarA Regulates Inflammation and Colonization during Central Nervous System Biofilm Formation.

Published in:

PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0084089

By:

Snowden, Jessica N.;
Beaver, Matt;
Beenken, Karen;
Smeltzer, Mark;
Horswill, Alexander R.;
Kielian, Tammy

Publication type:

Article

Transcriptome Analysis of Acetyl-Homoserine Lactone-Based Quorum Sensing Regulation in Yersinia pestis.

Published in:

PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0062337

By:

LaRock, Christopher N.;
Yu, Jing;
Horswill, Alexander R.;
Parsek, Matthew R.;
Minion, F. Chris

Publication type:

Article

Alpha-Toxin Induces Programmed Cell Death of Human T cells, B cells, and Monocytes during USA300 Infection.

Published in:

PLoS ONE, 2012, v. 7, n. 5, p. 1, doi. 10.1371/journal.pone.0036532

By:

Nygaard, Tyler K.;
Pallister, Kyler B.;
DuMont, Ashley L.;
DeWald, Mark;
Watkins, Robert L.;
Pallister, Erik Q.;
Malone, Cheryl;
Griffith, Shannon;
Horswill, Alexander R.;
Torres, Victor J.;
Voyich, Jovanka M.

Publication type:

Article

Nuclease Modulates Biofilm Formation in Community- Associated Methicillin-Resistant Staphylococcus aureus.

Published in:

PLoS ONE, 2011, v. 6, n. 11, p. 1, doi. 10.1371/journal.pone.0026714

By:

Kiedrowski, Megan R.;
Kavanaugh, Jeffrey S.;
Malone, Cheryl L.;
Mootz, Joe M.;
Voyich, Jovanka M.;
Smeltzer, Mark S.;
Bayles, Kenneth W.;
Horswill, Alexander R.

Publication type:

Article

Epistatic Relationships between sarA and agr in Staphylococcus aureus Biofilm Formation.

Published in:

PLoS ONE, 2010, v. 5, n. 5, p. 1, doi. 10.1371/journal.pone.0010790

By:

Beenken, Karen E.;
Mrak, Lara N.;
Griffin, Linda M.;
Zielinska, Agnieszka K.;
Shaw, Lindsey N.;
Rice, Kelly C.;
Horswill, Alexander R.;
Bayles, Kenneth W.;
Smeltzer, Mark S.

Publication type:

Article

Identification of Genes Involved in Polysaccharide-Independent Staphylococcus aureus Biofilm Formation.

Published in:

PLoS ONE, 2010, v. 5, n. 4, p. 1, doi. 10.1371/journal.pone.0010146

By:

Boles, Blaise R.;
Thoendel, Matthew;
Roth, Aleeza J.;
Horswill, Alexander R.

Publication type:

Article

Modulation of eDNA Release and Degradation Affects Staphylococcus aureus Biofilm Maturation.

Published in:

PLoS ONE, 2009, v. 4, n. 6, p. 1, doi. 10.1371/journal.pone.0005822

By:

Mann, Ethan E.;
Rice, Kelly C.;
Boles, Blaise R.;
Endres, Jennifer L.;
Ranjit, Dev;
Chandramohan, Lakshmi;
Tsang, Laura H.;
Smeltzer, Mark S.;
Horswill, Alexander R.;
Bayles, Kenneth W.

Publication type:

Article