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Dual‐Targeting Dual‐Action Platinum(IV) Platform for Enhanced Anticancer Activity and Reduced Nephrotoxicity.
Published in:
Angewandte Chemie, 2019, v. 131, n. 24, p. 8193, doi. 10.1002/ange.201903112
By:
- Babak, Maria V.;
- Zhi, Yang;
- Czarny, Bertrand;
- Toh, Tan Boon;
- Hooi, Lissa;
- Chow, Edward Kai‐Hua;
- Ang, Wee Han;
- Gibson, Dan;
- Pastorin, Giorgia
Publication type:
Article
Frequent upregulation of G9a promotes RelB-dependent proliferation and survival in multiple myeloma.
Published in:
Experimental Hematology & Oncology, 2020, v. 9, n. 1, p. 1, doi. 10.1186/s40164-020-00164-4
By:
- Zhang, Xi Yun;
- Rajagopalan, Deepa;
- Chung, Tae-Hoon;
- Hooi, Lissa;
- Toh, Tan Boon;
- Tian, Johann Shane;
- Rashid, Masturah Bte Mohd Abdul;
- Sahib, Noor Rashidha Bte Meera;
- Gu, Mengjie;
- Lim, Jhin Jieh;
- Wang, Wilson;
- Chng, Wee Joo;
- Jha, Sudhakar;
- Chow, Edward Kai-Hua
Publication type:
Article
Histone‐lysine N‐methyltransferase EHMT2 (G9a) inhibition mitigates tumorigenicity in Myc‐driven liver cancer.
Published in:
Molecular Oncology, 2023, v. 17, n. 11, p. 2275, doi. 10.1002/1878-0261.13417
By:
- Thng, Dexter Kai Hao;
- Hooi, Lissa;
- Toh, Clarissa Chin Min;
- Lim, Jhin Jieh;
- Rajagopalan, Deepa;
- Syariff, Imran Qamar Charles;
- Tan, Zher Min;
- Rashid, Masturah Bte Mohd Abdul;
- Zhou, Lei;
- Kow, Alfred Wei Chieh;
- Bonney, Glenn Kunnath;
- Goh, Brian Kim Poh;
- Kam, Juinn Huar;
- Jha, Sudhakar;
- Dan, Yock Young;
- Chow, Pierce Kah Hoe;
- Toh, Tan Boon;
- Chow, Edward Kai‐Hua
Publication type:
Article
A functional personalised oncology approach against metastatic colorectal cancer in matched patient derived organoids.
Published in:
NPJ Precision Oncology, 2024, v. 8, p. 1, doi. 10.1038/s41698-024-00543-8
By:
- Dexter Kai Hao Thng;
- Hooi, Lissa;
- Siew, Bei En;
- Kai-Yin Lee;
- Ian Jse-Wei Tan;
- Lieske, Bettina;
- Lin, Norman Sihan;
- Chieh Kow, Alfred Wei;
- Shi Wang;
- Mohd Abdul Rashid, Masturah Bte;
- Ang, Chermaine;
- Min Koh, Jasmin Jia;
- Toh, Tan Boon;
- Tan, Ker-Kan;
- Chow, Edward Kai-Hua
Publication type:
Article
Discovery of Broad‐Spectrum Repurposed Drug Combinations Against Carbapenem‐Resistant Enterobacteriaceae (CRE) Through Artificial Intelligence (AI)‐Driven Platform.
Published in:
Advanced Therapeutics, 2024, v. 7, n. 3, p. 1, doi. 10.1002/adtp.202300332
By:
- Li, Ming;
- You, Kui;
- Wang, Peter;
- Hooi, Lissa;
- Chen, Yahua;
- Siah, Anqi;
- Tan, Shi‐Bei;
- Teo, Jeanette;
- Ng, Oon‐Tek;
- Marimuthu, Kalisvar;
- Venkatachalam, Indumathi;
- Blasiak, Agata;
- Chow, Edward Kai‐Hua;
- Ho, Dean;
- Gan, Yunn‐Hwen
Publication type:
Article
Project IDentif.AI: Harnessing Artificial Intelligence to Rapidly Optimize Combination Therapy Development for Infectious Disease Intervention.
Published in:
Advanced Therapeutics, 2020, v. 3, n. 7, p. 1, doi. 10.1002/adtp.202000034
By:
- Abdulla, Aynur;
- Wang, Boqian;
- Qian, Feng;
- Kee, Theodore;
- Blasiak, Agata;
- Ong, Yoong Hun;
- Hooi, Lissa;
- Parekh, Falgunee;
- Soriano, Rafael;
- Olinger, Gene G.;
- Keppo, Jussi;
- Hardesty, Chris L.;
- Chow, Edward K.;
- Ho, Dean;
- Ding, Xianting
Publication type:
Article
Splice-switch oligonucleotide-based combinatorial platform prioritizes synthetic lethal targets CHK1 and BRD4 against MYC-driven hepatocellular carcinoma.
Published in:
Bioengineering & Translational Medicine, 2023, v. 8, n. 1, p. 1, doi. 10.1002/btm2.10363
By:
- Kai Hao Thng, Dexter;
- Tan Boon Toh;
- Pigini, Paolo;
- Hooi, Lissa;
- Yock Young Dan;
- Kah-Hoe Chow, Pierce;
- Bonney, Glenn Kunnath;
- Abdul Rashid, Masturah Bte Mohd;
- Guccione, Ernesto;
- Keng Boon Wee, Dave;
- Kai-Hua Chow, Edward
Publication type:
Article
IDentif.AI: Rapidly optimizing combination therapy design against severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐Cov‐2) with digital drug development.
Published in:
Bioengineering & Translational Medicine, 2021, v. 6, n. 1, p. 1, doi. 10.1002/btm2.10196
By:
- Blasiak, Agata;
- Lim, Jhin Jieh;
- Seah, Shirley Gek Kheng;
- Kee, Theodore;
- Remus, Alexandria;
- Chye, De Hoe;
- Wong, Pui San;
- Hooi, Lissa;
- Truong, Anh T. L.;
- Le, Nguyen;
- Chan, Conrad E. Z.;
- Desai, Rishi;
- Ding, Xianting;
- Hanson, Brendon J.;
- Chow, Edward Kai‐Hua;
- Ho, Dean
Publication type:
Article
Optimizing drug combinations against multiple myeloma using a quadratic phenotypic optimization platform (QPOP).
Published in:
Science Translational Medicine, 2018, v. 10, n. 453, p. 1, doi. 10.1126/scitranslmed.aan0941
By:
- Rashid, Masturah Bte Mohd Abdul;
- Toh, Tan Boon;
- Hooi, Lissa;
- Silva, Aleidy;
- Zhang, Yanzhou;
- Tan, Pei Fang;
- Teh, Ai Ling;
- Karnani, Neerja;
- Jha, Sudhakar;
- Ho, Chih-Ming;
- Chng, Wee Joo;
- Ho, Dean;
- Chow, Edward Kai-Hua
Publication type:
Article
Dual‐Targeting Dual‐Action Platinum(IV) Platform for Enhanced Anticancer Activity and Reduced Nephrotoxicity.
Published in:
Angewandte Chemie International Edition, 2019, v. 58, n. 24, p. 8109, doi. 10.1002/anie.201903112
By:
- Babak, Maria V.;
- Zhi, Yang;
- Czarny, Bertrand;
- Toh, Tan Boon;
- Hooi, Lissa;
- Chow, Edward Kai‐Hua;
- Ang, Wee Han;
- Gibson, Dan;
- Pastorin, Giorgia
Publication type:
Article
The IDentif.AI-x pandemic readiness platform: Rapid prioritization of optimized COVID-19 combination therapy regimens.
Published in:
NPJ Digital Medicine, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s41746-022-00627-4
By:
- Blasiak, Agata;
- Truong, Anh T. L.;
- Remus, Alexandria;
- Hooi, Lissa;
- Seah, Shirley Gek Kheng;
- Wang, Peter;
- Chye, De Hoe;
- Lim, Angeline Pei Chiew;
- Ng, Kim Tien;
- Teo, Swee Teng;
- Tan, Yee-Joo;
- Allen, David Michael;
- Chai, Louis Yi Ann;
- Chng, Wee Joo;
- Lin, Raymond T. P.;
- Lye, David C. B.;
- Wong, John Eu-Li;
- Tan, Gek-Yen Gladys;
- Chan, Conrad En Zuo;
- Chow, Edward Kai-Hua
Publication type:
Article
Addressing antimicrobial resistance with the IDentif.AI platform: Rapidly optimizing clinically actionable combination therapy regimens against nontuberculous mycobacteria.
Published in:
Theranostics, 2022, v. 12, n. 16, p. 6848, doi. 10.7150/thno.73078
By:
- Mukherjee, Devika;
- Peter Wang;
- Hooi, Lissa;
- Sandhu, Vedant;
- Kui You;
- Blasiak, Agata;
- Kai-Hua Chow, Edward;
- Dean Ho;
- Pui Lai Rachel Ee
Publication type:
Article
Rational drug combination design in patient-derived avatars reveals effective inhibition of hepatocellular carcinoma with proteasome and CDK inhibitors.
Published in:
Journal of Experimental & Clinical Cancer Research (17569966), 2022, v. 41, n. 1, p. 1, doi. 10.1186/s13046-022-02436-9
By:
- Lim, Jhin Jieh;
- Hooi, Lissa;
- Dan, Yock Young;
- Bonney, Glenn K.;
- Zhou, Lei;
- Chow, Pierce K.-H.;
- Chee, Cheng Ean;
- Toh, Tan Boon;
- Chow, Edward K.-H.
Publication type:
Article
Photodynamic Therapy: A Flexi‐PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy (Adv. Mater. 29/2020).
Published in:
Advanced Materials, 2020, v. 32, n. 29, p. 1, doi. 10.1002/adma.202070219
By:
- Teh, Daniel Boon Loong;
- Bansal, Akshaya;
- Chai, Chou;
- Toh, Tan Boon;
- Tucker, Robert Alan Jappy;
- Gammad, Gil Gerald Lasam;
- Yeo, Yanzhuang;
- Lei, Zhendong;
- Zheng, Xiang;
- Yang, Fengyuan;
- Ho, John S.;
- Bolem, Nagarjun;
- Wu, Bing Cheng;
- Gnanasammandhan, Muthu Kumar;
- Hooi, Lissa;
- Dawe, Gavin Stewart;
- Libedinsky, Camilo;
- Ong, Wei‐Yi;
- Halliwell, Barry;
- Chow, Edward Kai‐Hua
Publication type:
Article
A Flexi‐PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy.
Published in:
Advanced Materials, 2020, v. 32, n. 29, p. 1, doi. 10.1002/adma.202001459
By:
- Teh, Daniel Boon Loong;
- Bansal, Akshaya;
- Chai, Chou;
- Toh, Tan Boon;
- Tucker, Robert Alan Jappy;
- Gammad, Gil Gerald Lasam;
- Yeo, Yanzhuang;
- Lei, Zhendong;
- Zheng, Xiang;
- Yang, Fengyuan;
- Ho, John S.;
- Bolem, Nagarjun;
- Wu, Bing Cheng;
- Gnanasammandhan, Muthu Kumar;
- Hooi, Lissa;
- Dawe, Gavin Stewart;
- Libedinsky, Camilo;
- Ong, Wei‐Yi;
- Halliwell, Barry;
- Chow, Edward Kai‐Hua
Publication type:
Article

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