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Inflammatory cytokines can be monitored in exhaled breath particles following segmental and inhalation endotoxin challenge in healthy volunteers.
Published in:
Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-09399-z
By:
- Holz, Olaf;
- Müller, Meike;
- Carstensen, Saskia;
- Olin, Anna-Carin;
- Hohlfeld, Jens M.
Publication type:
Article
Influence of Cell Quality on Inflammatory Biomarkers in COPD Sputum Supernatant.
Published in:
International Journal of COPD, 2021, v. 16, p. 487, doi. 10.2147/COPD.S284938
By:
- Pedersen, Frauke;
- Trinkmann, Frederik;
- Abdo, Mustafa;
- Kirsten, Anne-Marie;
- Rabe, Klaus F;
- Watz, Henrik;
- Baraldo, Simonetta;
- Saetta, Marina;
- Hohlfeld, Jens M;
- Holz, Olaf
Publication type:
Article
Smokers with COPD Show a Shift in Energy and Nitrogen Metabolism at Rest and During Exercise.
Published in:
International Journal of COPD, 2020, v. 15, p. 1, doi. 10.2147/COPD.S217474
By:
- Holz, Olaf;
- DeLuca, David S;
- Roepcke, Stefan;
- Illig, Thomas;
- Weinberger, Klaus M;
- Schudt, Christian;
- Hohlfeld, Jens M
Publication type:
Article
Rating sputum cell quality in clinical trials for asthma and COPD treatment.
Published in:
International Journal of COPD, 2019, v. 14, p. 195, doi. 10.2147/COPD.S188033
By:
- Pedersen, Frauke;
- Zissler, Ulrich M;
- Watz, Henrik;
- Rabe, Klaus F;
- Hohlfeld, Jens M;
- Holz, Olaf
Publication type:
Article
Plasminogen activator inhibitor-1 is elevated in patients with COPD independent of metabolic and cardiovascular function.
Published in:
International Journal of COPD, 2017, v. 12, p. 981, doi. 10.2147/COPD.S128689
By:
- Waschki, Benjamin;
- Watz, Henrik;
- Holz, Olaf;
- Magnussen, Helgo;
- Olejnicka, Beata;
- Welte, Tobias;
- Rabe, Klaus F.;
- Janciauskiene, Sabina
Publication type:
Article
Constant-load exercise decreases the serum concentration of myeloperoxidase in healthy smokers and smokers with COPD.
Published in:
International Journal of COPD, 2015, p. 1393, doi. 10.2147/COPD.S83269
By:
- Holz, Olaf;
- Roepcke, Stefan;
- Watz, Henrik;
- Tegtbur, Uwe;
- Lahu, Gezim;
- Hohlfeld, Jens M.
Publication type:
Article
Constant-load exercise decreases the serum concentration of myeloperoxidase in healthy smokers and smokers with COPD.
Published in:
International Journal of COPD, 2015, v. 10, p. 1393, doi. 10.2147/COPD.S83269
By:
- Holz, Olaf;
- Roepcke, Stefan;
- Watz, Henrik;
- Tegtbur, Uwe;
- Lahu, Gezim;
- Hohlfeld, Jens M.
Publication type:
Article
Raised sputum extracellular DNA confers lung function impairment and poor symptom control in an exacerbation-susceptible phenotype of neutrophilic asthma.
Published in:
2021
By:
- Abdo, Mustafa;
- Uddin, Mohib;
- Goldmann, Torsten;
- Marwitz, Sebastian;
- Bahmer, Thomas;
- Holz, Olaf;
- Kirsten, Anne-Marie;
- Trinkmann, Frederik;
- von Mutius, Erika;
- Kopp, Matthias;
- Hansen, Gesine;
- Rabe, Klaus F.;
- Watz, Henrik;
- Pedersen, Frauke;
- ALLIANCE study group
Publication type:
journal article
Potential prognostic value of biomarkers in lavage, sputum and serum in a five year clinical follow-up of smokers with and without COPD.
Published in:
BMC Pulmonary Medicine, 2014, v. 14, n. 1, p. 1, doi. 10.1186/1471-2466-14-30
By:
- Holz, Olaf;
- Waschki, Benjamin;
- Roepcke, Stefan;
- Watz, Henrik;
- Lauer, Gereon;
- Faulenbach, Cornelia;
- Hohlfeld, Jens M.
Publication type:
Article
Potential prognostic value of biomarkers in lavage, sputum and serum in a five year clinical follow-up of smokers with and without COPD.
Published in:
2014
By:
- Holz, Olaf;
- Waschki, Benjamin;
- Roepcke, Stefan;
- Watz, Henrik;
- Lauer, Gereon;
- Faulenbach, Cornelia;
- Hohlfeld, Jens M
Publication type:
journal article
Low-dose endotoxin inhalation in healthy volunteers - a challenge model for early clinical drug development.
Published in:
BMC Pulmonary Medicine, 2013, v. 13, n. 1, p. 1, doi. 10.1186/1471-2466-13-19
By:
- Janssen, Ole;
- Schaumann, Frank;
- Holz, Olaf;
- Lavae-Mokhtari, Bianca;
- Welker, Lutz;
- Winkler, Carla;
- Biller, Heike;
- Krug, Norbert;
- Hohlfeld, Jens M.
Publication type:
Article
Low-dose endotoxin inhalation in healthy volunteers--a challenge model for early clinical drug development.
Published in:
2013
By:
- Janssen, Ole;
- Schaumann, Frank;
- Holz, Olaf;
- Lavae-Mokhtari, Bianca;
- Welker, Lutz;
- Winkler, Carla;
- Biller, Heike;
- Krug, Norbert;
- Hohlfeld, Jens M
Publication type:
journal article
Assessing airway inflammation in clinical practice - experience with spontaneous sputum analysis.
Published in:
2008
By:
- Holz O;
- Seiler T;
- Karmeier A;
- Fraedrich J;
- Leiner H;
- Magnussen H;
- Jörres RA;
- Welker L;
- Holz, Olaf;
- Seiler, Tanja;
- Karmeier, Andreas;
- Fraedrich, Jan;
- Leiner, Helmut;
- Magnussen, Helgo;
- Jörres, Rudolf A;
- Welker, Lutz
Publication type:
journal article
Assessing airway inflammation in clinical practice -- experience with spontaneous sputum analysis.
Published in:
BMC Pulmonary Medicine, 2008, v. 8, p. 1, doi. 10.1186/1471-2466-8-5
By:
- Holz, Olaf;
- Seiler, Tanja;
- Karmeier, Andreas;
- Fraedrich, Jan;
- Leiner, Helmut;
- Magnussen, Helgo;
- Jörres, Rudolf A.;
- Welker, Lutz
Publication type:
Article
Impact of endobronchial allergen provocation on macrophage phenotype in asthmatics.
Published in:
BMC Immunology, 2014, v. 15, n. 1, p. 1, doi. 10.1186/1471-2172-15-12
By:
- Winkler, Carla;
- Witte, Lena;
- Moraw, Natali;
- Faulenbach, Conny;
- Müller, Meike;
- Holz, Olaf;
- Schaumann, Frank;
- Hohlfeld, Jens M.
Publication type:
Article
Repeatability of and Relationship between Potential COPD Biomarkers in Bronchoalveolar Lavage, Bronchial Biopsies, Serum, and Induced Sputum.
Published in:
PLoS ONE, 2012, v. 7, n. 10, p. 1, doi. 10.1371/journal.pone.0046207
By:
- Röpcke, Stefan;
- Holz, Olaf;
- Lauer, Gereon;
- Müller, Meike;
- Rittinghausen, Susanne;
- Ernst, Peter;
- Lahu, Gezim;
- Elmlinger, Martin;
- Krug, Norbert;
- Hohlfeld, Jens M.
Publication type:
Article
Systemic Biomarkers of Neutrophilic Inflammation, Tissue Injury and Repair in COPD Patients with Differing Levels of Disease Severity.
Published in:
PLoS ONE, 2012, v. 7, n. 6, p. 1, doi. 10.1371/journal.pone.0038629
By:
- Cockayne, Debra A.;
- Cheng, Donavan T.;
- Waschki, Benjamin;
- Sridhar, Sriram;
- Ravindran, Palanikumar;
- Hilton, Holly;
- Kourteva, Galina;
- Bitter, Hans;
- Pillai, Sreekumar G.;
- Visvanathan, Sudha;
- Müller, Kai-Christian;
- Holz, Olaf;
- Magnussen, Helgo;
- Watz, Henrik;
- Fine, Jay S.
Publication type:
Article
Effect of Acute Ozone Induced Airway Inflammation on Human Sympathetic Nerve Traffic: A Randomized, Placebo Controlled, Crossover Study.
Published in:
PLoS ONE, 2011, v. 6, n. 4, p. 1, doi. 10.1371/journal.pone.0018737
By:
- Tank, Jens;
- Biller, Heike;
- Heusser, Karsten;
- Holz, Olaf;
- Diedrich, André;
- Framke, Theodor;
- Koch, Armin;
- Grosshennig, Anika;
- Koch, Wolfgang;
- Krug, Norbert;
- Jordan, Jens;
- Hohlfeld, Jens M.
Publication type:
Article
Disease Progression and Changes in Physical Activity in Patients with Chronic Obstructive Pulmonary Disease.
Published in:
2015
By:
- Waschki, Benjamin;
- Kirsten, Anne M;
- Holz, Olaf;
- Mueller, Kai-Christian;
- Schaper, Miriam;
- Sack, Anna-Lena;
- Meyer, Thorsten;
- Rabe, Klaus F;
- Magnussen, Helgo;
- Watz, Henrik
Publication type:
Journal Article
Disease Progression and Changes in Physical Activity in Patients with Chronic Obstructive Pulmonary Disease.
Published in:
American Journal of Respiratory & Critical Care Medicine, 2015, v. 192, n. 3, p. 295, doi. 10.1164/rccm.201501-0081OC
By:
- Waschki, Benjamin;
- Kirsten, Anne M.;
- Holz, Olaf;
- Mueller, Kai-Christian;
- Schaper, Miriam;
- Sack, Anna-Lena;
- Meyer, Thorsten;
- Rabe, Klaus F.;
- Magnussen, Helgo;
- Watz, Henrik
Publication type:
Article
Comprehensive characterisation of pulmonary and serum surfactant protein D in COPD.
Published in:
Respiratory Research, 2011, v. 12, n. 3, p. 1, doi. 10.1186/1465-9921-12-29
By:
- Winkler, Carla;
- Atochina^Vasserman, Elena N.;
- Holz, Olaf;
- Beers, Michael F.;
- Erpenbeck, Veit J.;
- Krug, Norbert;
- Roepcke, Stefan;
- Lauer, Gereon;
- Elmlinger, Martin;
- Hohlfeld, Jens M.
Publication type:
Article
Comprehensive characterisation of pulmonary and serum surfactant protein D in COPD.
Published in:
Respiratory Research, 2011, v. 12, n. 1, p. 29, doi. 10.1186/1465-9921-12-29
By:
- Winkler, Carla;
- Atochina-Vasserman, Elena N.;
- Holz, Olaf;
- Beers, Michael F.;
- Erpenbeck, Veit J.;
- Krug, Norbert;
- Roepcke, Stefan;
- Lauer, Gereon;
- Elmlinger, Martin;
- Hohlfeld, Jens M.
Publication type:
Article
Noninvasive Monitoring of the Response of Human Lungs to Low‐Dose Lipopolysaccharide Inhalation Challenge Using MRI: A Feasibility Study.
Published in:
Journal of Magnetic Resonance Imaging, 2020, v. 51, n. 6, p. spcone, doi. 10.1002/jmri.27000
By:
- Kern, Agilo L.;
- Biller, Heike;
- Klimeš, Filip;
- Voskrebenzev, Andreas;
- Gutberlet, Marcel;
- Renne, Julius;
- Müller, Meike;
- Holz, Olaf;
- Wacker, Frank;
- Hohlfeld, Jens M.;
- Vogel‐Claussen, Jens
Publication type:
Article
Noninvasive Monitoring of the Response of Human Lungs to Low-Dose Lipopolysaccharide Inhalation Challenge Using MRI: A Feasibility Study.
Published in:
2020
By:
- Kern, Agilo L.;
- Biller, Heike;
- Klimeš, Filip;
- Voskrebenzev, Andreas;
- Gutberlet, Marcel;
- Renne, Julius;
- Müller, Meike;
- Holz, Olaf;
- Wacker, Frank;
- Hohlfeld, Jens M.;
- Vogel‐Claussen, Jens;
- Vogel-Claussen, Jens
Publication type:
journal article
Anti-inflammatory effects of budesonide in human lung fibroblasts are independent of histone deacetylase 2.
Published in:
Journal of Inflammation Research, 2013, v. 6, p. 109, doi. 10.2147/JIR.S43736
By:
- Xingqi Wang;
- Nelson, Amy;
- Weiler, Zachary M.;
- Patil, Amol;
- Tadashi Sato;
- Nobuhiro Kanaji;
- Masanori Nakanishi;
- Michalsk, Joel;
- Farid, Maha;
- Basma, Hesham;
- LeVan, Tricia D.;
- Miller-Larsson, Anna;
- Wieslander, Elisabet;
- Muller, Kai-Christian;
- Holz, Olaf;
- Magnussen, Helgo;
- Rabe, Klaus F.;
- Xiangde Liu;
- Rennard, Stephen I.
Publication type:
Article
Quantitative analysis of endotoxin‐induced inflammation in human lung cells by Chipcytometry.
Published in:
Cytometry. Part A, 2021, v. 99, n. 10, p. 967, doi. 10.1002/cyto.a.24352
By:
- Carstensen, Saskia;
- Holz, Olaf;
- Hohlfeld, Jens M.;
- Müller, Meike
Publication type:
Article
Oncostatin M Modulates Fibroblast Function via Signal Transducers and Activators of Transcription Proteins-3.
Published in:
American Journal of Respiratory Cell & Molecular Biology, 2013, v. 49, n. 4, p. 582, doi. 10.1165/rcmb.2012-0460OC
By:
- Nagahama, Kumi Yoneda;
- Togo, Shinsaku;
- Holz, Olaf;
- Magnussen, Helgo;
- Xiangde Liu;
- Seyama, Kuniaki3;
- Takahashi, Kazuhisa;
- Rennard, Stephen I.
Publication type:
Article
Attenuation of Inhibitory Prostaglandin E2 Signaling in Human Lung Fibroblasts Is Mediated by Phosphodiesterase 4.
Published in:
American Journal of Respiratory Cell & Molecular Biology, 2012, v. 47, n. 6, p. 729, doi. 10.1165/rcmb.2012-0057OC
By:
- Michalski, Joel;
- Nobuhiro Kanaji;
- Xiangde Liu;
- Nogel, Steve;
- Xingqi Wang;
- Basma, Hesham;
- Nakanishi, Masanori;
- Tadashi Sato;
- Yoko Gunji;
- Fahrid, Maha;
- Nelson, Amy;
- Muller, Kai-Christian;
- Holz, Olaf;
- Magnussen, Helgo;
- Rabe, Klaus F.;
- Toews, Myron L.;
- Rennard, Stephen I.
Publication type:
Article
Prostaglandin E<sub>2</sub> Stimulates the Production of Vascular Endothelial Growth Factor through the E-Prostanoid-2 Receptor in Cultured Human Lung Fibroblasts.
Published in:
American Journal of Respiratory Cell & Molecular Biology, 2012, v. 46, n. 2, p. 217, doi. 10.1165/rcmb.2010-0115OC
By:
- Nakanishi, Masanori;
- Sato, Tadashi;
- Yingji Li;
- Nelson, Amy J.;
- Farid, Maha;
- Michalski, Joel;
- Kanaji, Nobuhiro;
- Xingqi Wang;
- Basma, Hesham;
- Patil, Amol;
- Goraya, Jadvinder;
- Xiangde Liu;
- Shinsaku Togo;
- Toews, Myron L.;
- Holz, Olaf;
- Muller, Kai-Christian;
- Magnussen, Helgo;
- Rennard, Stephen I.
Publication type:
Article
Spatial Interactions between Dendritic Cells and Sensory Nerves in Allergic Airway Inflammation.
Published in:
American Journal of Respiratory Cell & Molecular Biology, 2007, v. 37, n. 5, p. 553, doi. 10.1165/rcmb.2007-0087OC
By:
- Veres, Tibor Z.;
- Rochlitzer, Sabine;
- Shevchenko, Marina;
- Fuchs, Barbara;
- Prenzler, Frauke;
- Nassenstein, Christina;
- Fischer, Axel;
- Welker, Lutz;
- Holz, Olaf;
- Müller, Meike;
- Krug, Norbert;
- Braun, Armin
Publication type:
Article
Efficacy and safety of inhaled calcium lactate PUR118 in the ozone challenge model - a clinical trial.
Published in:
BMC Pharmacology & Toxicology, 2015, v. 16, n. 1, p. 1, doi. 10.1186/s40360-015-0021-1
By:
- Holz, Olaf;
- Biller, H.;
- Mueller, M.;
- Kane, K.;
- Rosano, M.;
- Hanrahan, J.;
- Hava, D. L.;
- Hohlfeld, J. M.
Publication type:
Article
Longitudinal measurement of airway inflammation over one year in children and adults with intermittent asthma.
Published in:
BMC Research Notes, 2014, v. 7, n. 1, p. 813, doi. 10.1186/1756-0500-7-925
By:
- Pedersen, Frauke;
- Holz, Olaf;
- Kanniess, Frank;
- Zielen, Stefan;
- Schulze, Johannes;
- Gillissen, Adrian;
- von Berg, Andrea;
- Berdel, Dietrich;
- Beier, Jutta;
- Beeh, Kai;
- Schnoor, Maike;
- Magnussen, Helgo
Publication type:
Article
Analysis of Human Breath by Millimeter-Wave/Terahertz Spectroscopy.
Published in:
Sensors (14248220), 2019, v. 19, n. 12, p. 2719, doi. 10.3390/s19122719
By:
- Rothbart, Nick;
- Holz, Olaf;
- Koczulla, Rembert;
- Schmalz, Klaus;
- Hübers, Heinz-Wilhelm
Publication type:
Article
3D-printed mouthpiece adapter for sampling exhaled breath in medical applications.
Published in:
3D Printing in Medicine, 2022, v. 8, n. 1, p. 1, doi. 10.1186/s41205-022-00150-y
By:
- Pham, Y Lan;
- Beauchamp, Jonathan;
- Clement, Alexander;
- Wiegandt, Felix;
- Holz, Olaf
Publication type:
Article
Diagnostic outcome of two different CT-guided fine needle biopsy procedures.
Published in:
Diagnostic Pathology, 2007, v. 2, p. 31, doi. 10.1186/1746-1596-2-31
By:
- Welker, Lutz;
- Akkan, Reyhan;
- Holz, Olaf;
- Schultz, Holger;
- Magnussen, Helgo
Publication type:
Article
Reduced miR-146a Increases Prostaglandin E<sub>2</sub> in Chronic Obstructive Pulmonary Disease Fibroblasts.
Published in:
American Journal of Respiratory & Critical Care Medicine, 2010, v. 182, n. 8, p. 1020, doi. 10.1164/rccm.201001-0055OC
By:
- Sato, Tadashi;
- Xiangde Liu;
- Nelson, Amy;
- Nakanishi, Masanori;
- Kanaji, Nobuhiro;
- Xingqi Wang;
- Miok Kim;
- Yingji Li;
- Jianhong Sun;
- Michalski, Joel;
- Patil, Amol;
- Basma, Hesham;
- Holz, Olaf;
- Magnussen, Helgo;
- Rennard, Stephen I.
Publication type:
Article
Lung fibroblast repair functions in patients with chronic obstructive pulmonary disease are altered by multiple mechanisms.
Published in:
2008
By:
- Togo S;
- Holz O;
- Liu X;
- Sugiura H;
- Kamio K;
- Wang X;
- Kawasaki S;
- Ahn Y;
- Fredriksson K;
- Skold CM;
- Mueller KC;
- Branscheid D;
- Welker L;
- Watz H;
- Magnussen H;
- Rennard SI;
- Togo, Shinsaku;
- Holz, Olaf;
- Liu, Xiangde;
- Sugiura, Hisatoshi
Publication type:
journal article
Association of Tumor Necrosis Factor-α Polymorphisms and Ozone-induced Change in Lung Function.
Published in:
American Journal of Respiratory & Critical Care Medicine, 2005, v. 171, n. 2, p. 171, doi. 10.1164/rccm.200402-194OC
By:
- Yang, Ian A.;
- Holz, Olaf;
- Jörres, Rudolf A.;
- Magnussen, Helgo;
- Barton, Sheila J.;
- Rodríguez, Santiago;
- Cakebread, Julie A.;
- Holloway, John W.;
- Holgate, Stephen T.
Publication type:
Article
Association of tumour necrosis factor-α polymorphisms and ozone-induced change in lung function.
Published in:
American Journal of Respiratory & Critical Care Medicine, 2005, v. 171, n. 2, p. 20, doi. 10.1164/rccm.200402-194oc
By:
- Yang, Ian A.;
- Holz, Olaf;
- Jörres, Rudolf A.;
- Magnussen, Helgo;
- Barton, Sheila J.;
- Rodríguez, Santiago;
- Cakebread, Julie A.;
- Holloway, John W.;
- Holgate, Stephen T.
Publication type:
Article
Lung pharmacokinetics of inhaled and systemic drugs: A clinical evaluation.
Published in:
2021
By:
- Sadiq, Muhammad Waqas;
- Holz, Olaf;
- Ellinghusen, Birthe D.;
- Faulenbach, Cornelia;
- Müller, Meike;
- Badorrek, Philipp;
- Eriksson, Ulf G.;
- Fridén, Markus;
- Stomilovic, Stina;
- Lundqvist, Anders J.;
- Hohlfeld, Jens M.
Publication type:
journal article
Validation of the Human Ozone Challenge Model as a Tool for Assessing Anti-Inflammatory Drugs in Early Development.
Published in:
Journal of Clinical Pharmacology, 2005, v. 45, n. 5, p. 498, doi. 10.1177/0091270004273527
By:
- Holz, Olaf;
- Tal-Singer, Ruth;
- Kanniess, Frank;
- Simpson, Kathy J.;
- Gibson, Anthony;
- Vessey, Rupert S. J.;
- Janicki, Stanislawa;
- Magnussen, Helgo;
- Jörres, Rudolf A.;
- Richter, Kai
Publication type:
Article
Ultrafine particles and ozone perturb norepinephrine clearance rather than centrally generated sympathetic activity in humans.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-40343-w
By:
- Heusser, Karsten;
- Tank, Jens;
- Holz, Olaf;
- May, Marcus;
- Brinkmann, Julia;
- Engeli, Stefan;
- Diedrich, André;
- Framke, Theodor;
- Koch, Armin;
- Großhennig, Anika;
- Jan Danser, A. H.;
- Sweep, Fred C. G. J.;
- Schindler, Christoph;
- Schwarz, Katharina;
- Krug, Norbert;
- Jordan, Jens;
- Hohlfeld, Jens M.
Publication type:
Article
Exhaled breath particles as a novel tool to study lipid composition of epithelial lining fluid from the distal lung.
Published in:
BMC Pulmonary Medicine, 2023, v. 23, n. 1, p. 1, doi. 10.1186/s12890-023-02718-8
By:
- Larsson, Per;
- Holz, Olaf;
- Koster, Grielof;
- Postle, Anthony;
- Olin, Anna-Carin;
- Hohlfeld, Jens M.
Publication type:
Article
Reduced microRNA-503 expression augments lung fibroblast VEGF production in chronic obstructive pulmonary disease.
Published in:
PLoS ONE, 2017, v. 12, n. 9, p. 1, doi. 10.1371/journal.pone.0184039
By:
- Ikari, Jun;
- Nelson, Amy J.;
- Obaid, Jannah;
- Giron-Martinez, Alvaro;
- Ikari, Kumiko;
- Makino, Fumihiko;
- Iwasawa, Shunichiro;
- Gunji, Yoko;
- Farid, Maha;
- Wang, Xingqi;
- Basma, Hesham;
- Demeo, Dawn;
- Feghali-Bostwick, Carol;
- Holz, Olaf;
- Rabe, Klaus;
- Liu, Xiangde;
- Rennard, Stephen I.
Publication type:
Article

Found: 44