Works matching AU Holt, Jeffrey R.

Results: 44

Putting the Pieces Together: the Hair Cell Transduction Complex.

Published in:

JARO - Journal of the Association for Research in Otolaryngology, 2021, v. 22, n. 6, p. 601, doi. 10.1007/s10162-021-00808-0

By:

Holt, Jeffrey R.;
Tobin, Mélanie;
Elferich, Johannes;
Gouaux, Eric;
Ballesteros, Angela;
Yan, Zhiqiang;
Ahmed, Zubair M.;
Nicolson, Teresa

Publication type:

Article

Emerging Gene Therapies for Genetic Hearing Loss.

Published in:

2017

By:

Ahmed, Hena;
Shubina-Oleinik, Olga;
Holt, Jeffrey;
Holt, Jeffrey R

Publication type:

journal article

A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.

Published in:

2010

By:

Asai, Yukako;
Holt, Jeffrey;
Géléoc, Gwenaëlle;
Holt, Jeffrey R;
Géléoc, Gwenaëlle S G

Publication type:

journal article

Differential distribution of stem cells in the auditory and vestibular organs of the inner ear.

Published in:

2007

By:

Oshima, Kazuo;
Grimm, Christian;
Corrales, C.;
Senn, Pascal;
Martinez Monedero, Rodrigo;
Géléoc, Gwenaëlle;
Edge, Albert;
Holt, Jeffrey;
Heller, Stefan;
Grimm, Christian M;
Corrales, C Eduardo;
Géléoc, Gwenaëlle S G;
Holt, Jeffrey R

Publication type:

journal article

Are TMCs the Mechanotransduction Channels of Vertebrate Hair Cells?

Published in:

Journal of Neuroscience, 2016, v. 36, n. 43, p. 10921, doi. 10.1523/JNEUROSCI.1148-16.2016

By:

Corey, David P.;
Holt, Jeffrey R.

Publication type:

Article

TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells.

Published in:

Nature, 2004, v. 432, n. 7018, p. 723, doi. 10.1038/nature03066

By:

Corey, David P.;
García-Añoveros, Jaime;
Holt, Jeffrey R.;
Kwan, Kelvin Y.;
Lin, Shuh-Yow;
Vollrath, Melissa A.;
Amalfitano, Andrea;
Cheung, Eunice L.-M.;
Derfler, Bruce H.;
Duggan, Anne;
Géléoc, Gw&aeacute;naélle S. G.;
Gray, Paul A.;
Hoffman, Matthew P.;
Rehm, Heidi L.;
Tamasauskas, Daniel;
Zhang, Duan-Sun

Publication type:

Article

Dominant-Negative Inhibition of M-Like Potassium Conductances in Hair Cells of the Mouse Inner Ear.

Published in:

Journal of Neuroscience, 2007, v. 27, n. 33, p. 8940, doi. 10.1523/JNEUROSCI.2085-07.2007

By:

Holt, Jeffrey R.;
Stauffer, Eric A.;
Abraham, David;
Géléoc, Gwenaëlle S. G.

Publication type:

Article

The Very Large G-Protein-Coupled Receptor VLGR1: A Component of the Ankle Link Complex Required for the Normal Development of Auditory Hair Bundles.

Published in:

2006

By:

McGee, JoAnn;
Goodyear, Richard J.;
McMillan, D. Randy;
Stauffer, Eric A.;
Holt, Jeffrey R.;
Locke, Kirsten G.;
Birch, David G.;
Legan, P. Kevin;
White, Perrin C.;
Walsh, Edward J.;
Richardson, Guy P.

Publication type:

Abstract

Physical and Functional Interaction between Protocadherin 15 and Myosin VIIa in Mechanosensory Hair Cells.

Published in:

Journal of Neuroscience, 2006, v. 26, n. 7, p. 2060, doi. 10.1523/JNEUROSCI.4251-05.2006

By:

Senften, Mathias;
Schwander, Martin;
Kazmierczak, Piotr;
Lillo, Concepcion;
Jung-Bum Shin;
Hasson, Tama;
Géléoc, Gwenaëlle S. G.;
Gillespie, Peter G.;
Williams, David;
Holt, Jeffrey R.;
Müller, Ulrich

Publication type:

Article

Developmental Acquisition of Voltage-Dependent Conductances and Sensory Signaling in Hair Cells of the Embryonic Mouse Inner Ear.

Published in:

Journal of Neuroscience, 2004, v. 24, n. 49, p. 11148, doi. 10.1523/JNEUROSCI.2662-04.2004

By:

Géléoc, Gwenaëlle S. G.;
Risner, Jessica R.;
Holt, Jeffrey R.

Publication type:

Article

Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes.

Published in:

2011

By:

Kawashima, Yoshiyuki;
Géléoc, Gwenaëlle S.G.;
Kurima, Kiyoto;
Labay, Valentina;
Lelli, Andrea;
Asai, Yukako;
Makishima, Tomoko;
Wu, Doris K.;
Della Santina, Charles C.;
Holt, Jeffrey R.;
Griffith, Andrew J.;
Géléoc, Gwenaëlle S G

Publication type:

journal article

Myosin-1 nomenclature.

Published in:

Journal of Cell Biology, 2001, v. 155, n. 5, p. 703, doi. 10.1083/jcb.200110032

By:

Gillespie, Peter G.;
Albanesi, Joseph P.;
Bahler, Martin;
Bement, William M.;
Berg, Jonathan S.;
Burgess, David R.;
Burnside, Beth;
Cheney, Richard E.;
Corey, David P.;
Coudrier, Evelyne;
de Lanerolle, Primal;
Hammer, John A.;
Hasson, Tama;
Holt, Jeffrey R.;
Hudspeth, A.J.;
Ikebe, Mitsuo;
Kendrick-Jones, John;
Korn, Edward D.

Publication type:

Article

Sensory transduction is required for normal development and maturation of cochlear inner hair cell synapses.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.69433

By:

Lee, John;
Kawai, Kosuke;
Holt, Jeffrey R.;
Géléoc, Gwenaëlle S. G.

Publication type:

Article

TMC function, dysfunction, and restoration in mouse vestibular organs.

Published in:

Frontiers in Neurology, 2024, p. 1, doi. 10.3389/fneur.2024.1356614

By:

Ratzan, Evan M.;
Lee, John;
Madison, Margot A.;
Hong Zhu;
Wu Zhou;
Géléoc, Gwenaëlle S. G.;
Holt, Jeffrey R.

Publication type:

Article

Tmc gene therapy restores auditory function in deaf mice.

Published in:

Science Translational Medicine, 2015, v. 7, n. 295, p. 1, doi. 10.1126/scitranslmed.aab1996

By:

Askew, Charles;
Rochat, Cylia;
Pan, Bifeng;
Yukako Asai;
Ahmed, Hena;
Child, Erin;
Schneider, Bernard L.;
Aebischer, Patrick;
Holt, Jeffrey R.

Publication type:

Article

The Mechanosensory Structure of the Hair Cell Requires Clarin-1, a Protein Encoded by Usher Syndrome III Causative Gene.

Published in:

Journal of Neuroscience, 2012, v. 32, n. 28, p. 9485, doi. 10.1523/JNEUROSCI.0311-12.2012

By:

Ruishuang Geng;
Melki, Sami;
Chen, Daniel H.-C.;
Tian, Guilian;
Furness, David N.;
Tomoko Oshima-Takago;
Neef, Jakob;
Moser, Tobias;
Askew, Charles;
Horwitz, Geoff;
Holt, Jeffrey R.;
Yoshikazu Imanishi;
Alagramam, Kumar N.

Publication type:

Article

HCN Channels Expressed in the Inner Ear Are Necessary for Normal Balance Function.

Published in:

Journal of Neuroscience, 2011, v. 31, n. 46, p. 16814, doi. 10.1523/JNEUROSCI.3064-11.2011

By:

Horwitz, Geoffrey C.;
Risner-Janiczek, Jessica R.;
Jones, Sherri M.;
Holt, Jeffrey R.

Publication type:

Article

Polycystin-1 Is Required for Stereocilia Structure But Not for Mechanotransduction in Inner Ear Hair Cells.

Published in:

Journal of Neuroscience, 2011, v. 31, n. 34, p. 12251, doi. 10.1523/JNEUROSCI.6531-10.2011

By:

Steigelman, Katherine A.;
Lelli, Andrea;
Xudong Wu;
Jiangang Gao;
Lin, Susan;
Piontek, Klaus;
Wodarczyk, Claas;
Boletta, Alessandra;
Hyunho Kim;
Feng Qian;
Germino, Gregory;
Géléoc, Gwenaélle S. G.;
Holt, Jeffrey R.;
Jian Zuo

Publication type:

Article

Development and Regeneration of Sensory Transduction in Auditory Hair Cells Requires Functional Interaction Between Cadherin-23 and Protocadherin-15.

Published in:

Journal of Neuroscience, 2010, v. 30, n. 34, p. 11259, doi. 10.1523/JNEUROSCI.1949-10.2010

By:

Lelli, Andrea;
Kazmierczak, Piotr;
Kawashima, Yoshiyuki;
Müller, Ulrich;
Holt, Jeffrey R.

Publication type:

Article

Genotype-Phenotype Correlations in TMPRSS3 (DFNB10/DFNB8) with Emphasis on Natural History.

Published in:

Audiology & Neurotology, 2023, v. 28, n. 6, p. 407, doi. 10.1159/000528766

By:

Nisenbaum, Eric;
Yan, Denise;
Shearer, A Eliot;
de Joya, Evan;
Thielhelm, Torin;
Russell, Nicole;
Staecker, Hinrich;
Chen, Zhengyi;
Holt, Jeffrey R.;
Liu, Xuezhong

Publication type:

Article

Viral-mediated gene transfer to study the molecular physiology of the Mammalian inner ear.

Published in:

2002

By:

Holt, Jeffrey R.

Publication type:

journal article

Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.89719

By:

Giese, Arnaud P. J.;
Wei-Hsiang Weng;
Kindt, Katie S.;
Hui Ho Vanessa Chang;
Montgomery, Jonathan S.;
Ratzan, Evan M.;
Beirl, Alisha J.;
Rivera, Roberto Aponte;
Lotthammer, Jeffrey M.;
Walujkar, Sanket;
Foster, Mark P.;
Zobeiri, Omid A.;
Holt, Jeffrey R.;
Riazuddin, Saima;
Cullen, Kathleen E.;
Sotomayor, Marcos;
Ahmed, Zubair M.

Publication type:

Article

Neonatal AAV gene therapy rescues hearing in a mouse model of SYNE4 deafness.

Published in:

EMBO Molecular Medicine, 2021, v. 13, n. 2, p. 1, doi. 10.15252/emmm.202013259

By:

Taiber, Shahar;
Cohen, Roie;
Yizhar‐Barnea, Ofer;
Sprinzak, David;
Holt, Jeffrey R;
Avraham, Karen B

Publication type:

Article

Split otoferlins reunited.

Published in:

EMBO Molecular Medicine, 2019, v. 11, n. 1, p. N.PAG, doi. 10.15252/emmm.201809995

By:

Holt, Jeffrey R;
Geleoc, Gwenaelle SG

Publication type:

Article

Gene Therapy for Deaf Mice Goes Viral.

Published in:

Molecular Therapy, 2012, v. 20, n. 10, p. 1836, doi. 10.1038/mt.2012.196

By:

Holt, Jeffrey R;
Vandenberghe, Luk H

Publication type:

Article

Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-29709-8

By:

Nakanishi, Hiroshi;
Kurima, Kiyoto;
Pan, Bifeng;
Wangemann, Philine;
Fitzgerald, Tracy S.;
Géléoc, Gwenaëlle S.;
Holt, Jeffrey R.;
Griffith, Andrew J.

Publication type:

Article

Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-28958-x

By:

Asai, Yukako;
Pan, Bifeng;
Nist-Lund, Carl;
Galvin, Alice;
Lukashkin, Andrei N.;
Lukashkina, Victoria A.;
Chen, Tianwen;
Zhou, Wu;
Zhu, Hong;
Russell, Ian J.;
Holt, Jeffrey R.;
Géléoc, Gwenaelle S. G.

Publication type:

Article

Optimized AAV Vectors for TMC1 Gene Therapy in a Humanized Mouse Model of DFNB7/11.

Published in:

Biomolecules (2218-273X), 2022, v. 12, n. 7, p. N.PAG, doi. 10.3390/biom12070914

By:

Marcovich, Irina;
Baer, Nicholas K.;
Shubina-Oleinik, Olga;
Eclov, Rachel;
Beard, Clayton W.;
Holt, Jeffrey R.

Publication type:

Article

Efficient Viral Transduction in Fetal and Adult Human Inner Ear Explants with AAV9-PHP.B Vectors.

Published in:

Biomolecules (2218-273X), 2022, v. 12, n. 6, p. 816, doi. 10.3390/biom12060816

By:

van Beelen, Edward S. A.;
van der Valk, Wouter H.;
Verhagen, Thijs O.;
de Groot, John C. M. J.;
Madison, Margot A.;
Shadmanfar, Wijs;
Hensen, Erik F.;
Jansen, Jeroen C.;
van Benthem, Peter Paul G.;
Holt, Jeffrey R.;
Locher, Heiko

Publication type:

Article

Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells.

Published in:

Nature Communications, 2016, v. 7, n. 5, p. 11508, doi. 10.1038/ncomms11508

By:

Liu, Xiao-Ping;
Koehler, Karl R.;
Mikosz, Andrew M.;
Hashino, Eri;
Holt, Jeffrey R.

Publication type:

Article

Gene Transfer in Human Vestibular Epithelia and the Prospects for Inner Ear Gene Therapy.

Published in:

Laryngoscope, 2008, v. 118, n. 5, p. 821, doi. 10.1097/MLG.0b013e318164d0aa

By:

Kesser, Bradley W.;
Hashisaki, George T.;
Holt, Jeffrey R.

Publication type:

Article

Developmental acquisition of sensory transduction in hair cells of the mouse inner ear.

Published in:

Nature Neuroscience, 2003, v. 6, n. 10, p. 1019, doi. 10.1038/nn1120

By:

Géléoc, Gwénaëlle S.G.;
Holt, Jeffrey R.

Publication type:

Article

HCN Channels Are Not Required for Mechanotransduction in Sensory Hair Cells of the Mouse Inner Ear.

Published in:

PLoS ONE, 2010, v. 5, n. 1, p. 1, doi. 10.1371/journal.pone.0008627

By:

Horwitz, Geoffrey C.;
Lelli, Andrea;
Géléoc, Gwenaëlle S. G.;
Holt, Jeffrey R.

Publication type:

Article

Stimulus Processing by Type II Hair Cells in the Mouse Utricle.

Published in:

Annals of the New York Academy of Sciences, 1999, v. 871, n. 1, p. 15, doi. 10.1111/j.1749-6632.1999.tb09172.x

By:

HOLT, JEFFREY R.;
VOLLRATH, MELISSA A.;
EATOCK, RUTH ANNE

Publication type:

Article

Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing in adult mice.

Published in:

Science Translational Medicine, 2023, v. 15, n. 702, p. 1, doi. 10.1126/scitranslmed.abq3916

By:

Mathiesen, Barbara K.;
Miyakoshi, Leo M.;
Cederroth, Christopher R.;
Tserga, Evangelia;
Versteegh, Corstiaen;
Bork, Peter A. R.;
Hauglund, Natalie L.;
Gomolka, Ryszard Stefan;
Mori, Yuki;
Edvall, Niklas K.;
Rouse, Stephanie;
Møllgård, Kjeld;
Holt, Jeffrey R.;
Nedergaard, Maiken;
Canlon, Barbara

Publication type:

Article

In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness.

Published in:

Science Translational Medicine, 2020, v. 12, n. 546, p. 1, doi. 10.1126/scitranslmed.aay9101

By:

Yeh, Wei-Hsi;
Shubina-Oleinik, Olga;
Levy, Jonathan M.;
Pan, Bifeng;
Newby, Gregory A.;
Wornow, Michael;
Burt, Rachel;
Chen, Jonathan C.;
Holt, Jeffrey R.;
Liu, David R.

Publication type:

Article

Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice.

Published in:

Human Molecular Genetics, 2014, v. 23, n. 9, p. 2374, doi. 10.1093/hmg/ddt629

By:

Zou, Junhuang;
Zheng, Tihua;
Ren, Chongyu;
Askew, Charles;
Liu, Xiao-Ping;
Pan, Bifeng;
Holt, Jeffrey R.;
Wang, Yong;
Yang, Jun

Publication type:

Article

Publisher Correction: Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-018-08264-w

By:

Nist-Lund, Carl A.;
Pan, Bifeng;
Patterson, Amy;
Asai, Yukako;
Chen, Tianwen;
Zhou, Wu;
Zhu, Hong;
Romero, Sandra;
Resnik, Jennifer;
Polley, Daniel B.;
Géléoc, Gwenaelle S.;
Holt, Jeffrey R.

Publication type:

Article

Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-018-08264-w

By:

Nist-Lund, Carl A.;
Pan, Bifeng;
Patterson, Amy;
Asai, Yukako;
Chen, Tianwen;
Zhou, Wu;
Zhu, Hong;
Romero, Sandra;
Resnik, Jennifer;
Polley, Daniel B.;
Géléoc, Gwenaelle S.;
Holt, Jeffrey R.

Publication type:

Article

Publisher Correction: Continuous evolution of base editors with expanded target compatibility and improved activity.

Published in:

2019

By:

Thuronyi, Benjamin W.;
Koblan, Luke W.;
Levy, Jonathan M.;
Yeh, Wei-Hsi;
Zheng, Christine;
Newby, Gregory A.;
Wilson, Christopher;
Bhaumik, Mantu;
Shubina-Oleinik, Olga;
Holt, Jeffrey R.;
Liu, David R.

Publication type:

Correction Notice

Continuous evolution of base editors with expanded target compatibility and improved activity.

Published in:

Nature Biotechnology, 2019, v. 37, n. 9, p. 1070, doi. 10.1038/s41587-019-0193-0

By:

Thuronyi, Benjamin W.;
Koblan, Luke W.;
Levy, Jonathan M.;
Yeh, Wei-Hsi;
Zheng, Christine;
Newby, Gregory A.;
Wilson, Christopher;
Bhaumik, Mantu;
Shubina-Oleinik, Olga;
Holt, Jeffrey R.;
Liu, David R.

Publication type:

Article

Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells.

Published in:

Nature Biotechnology, 2017, v. 35, n. 6, p. 583, doi. 10.1038/nbt.3840

By:

Koehler, Karl R;
Nie, Jing;
Longworth-Mills, Emma;
Liu, Xiao-Ping;
Lee, Jiyoon;
Holt, Jeffrey R;
Hashino, Eri

Publication type:

Article

A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear.

Published in:

Nature Biotechnology, 2017, v. 35, n. 3, p. 280, doi. 10.1038/nbt.3781

By:

Landegger, Lukas D;
Pan, Bifeng;
Askew, Charles;
Wassmer, Sarah J;
Gluck, Sarah D;
Galvin, Alice;
Taylor, Ruth;
Forge, Andrew;
Stankovic, Konstantina M;
Holt, Jeffrey R;
Vandenberghe, Luk H

Publication type:

Article

Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c.

Published in:

Nature Biotechnology, 2017, v. 35, n. 3, p. 264, doi. 10.1038/nbt.3801

By:

Pan, Bifeng;
Askew, Charles;
Galvin, Alice;
Heman-Ackah, Selena;
Asai, Yukako;
Indzhykulian, Artur A;
Jodelka, Francine M;
Hastings, Michelle L;
Lentz, Jennifer J;
Vandenberghe, Luk H;
Holt, Jeffrey R;
Géléoc, Gwenaëlle S

Publication type:

Article