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Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations.
Published in:
Acta Neuropathologica Communications, 2020, v. 8, n. 1, p. N.PAG, doi. 10.1186/s40478-020-01037-x
By:
- Huang, Meixiang;
- Modeste, Erica;
- Dammer, Eric;
- Merino, Paola;
- Taylor, Georgia;
- Duong, Duc M.;
- Deng, Qiudong;
- Holler, Christopher J.;
- Gearing, Marla;
- Dickson, Dennis;
- Seyfried, Nicholas T.;
- Kukar, Thomas
Publication type:
Article
ARKD‐104, A Potential Treatment of Frontotemporal Dementia and Other Neurodegenerative Disorders.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 21, p. 1, doi. 10.1002/alz.074362
By:
- Hung, Serena W;
- Hurst, Raymond S.;
- Blain, Jean‐François;
- Holler, Christopher J.;
- Chen, Angela Y.P.;
- Brand, Morgan A.;
- Alves, Anna M;
- Astarita, Giuseppe;
- Gallegos, Richard;
- Greenberg, Gennifer;
- Henry, Shawna;
- Koenig, Gerhard;
- McTighe, Stephanie;
- Peng, Xiaowen;
- Ross, John;
- Thompson, Bonne M;
- Watters, Katherine;
- Wozniak, Mary;
- Lanter, James C.;
- Burnett, Duane A.
Publication type:
Article
Haploinsufficiency of progranulin causes cell type specific impairments in PINK1/Parkin mitophagy.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.064195
By:
- Casey, Jackie M.;
- Melandri, Daniela;
- Arber, Charles;
- Soutar, Marc;
- Holler, Christopher J.;
- Kukar, Thomas;
- Isaacs, Adrian M;
- Rohrer, Jonathan D.;
- Pocock, Jennifer M;
- Plun‐Favreau, Helene;
- Wray, Selina
Publication type:
Article
A Novel In Vivo‐Active Small Molecule Inducer of Progranulin for the Treatment of Frontotemporal Dementia.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 10, p. 1, doi. 10.1002/alz.061924
By:
- Blain, Jean‐François;
- Chen, Angela Y.P.;
- Brand, Morgan A.;
- Lanter, James C.;
- Holler, Christopher J.;
- Brendel, Jerusha K.;
- Koenig, Gerhard;
- Burnett, Duane A.;
- Hurst, Raymond S.
Publication type:
Article
Network analysis of the brain proteome of GRN knockout mice reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations: Developing topics.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.047569
By:
- Kukar, Thomas;
- Huang, Meixiang;
- Modeste, Erica S;
- Dammer, Eric B;
- Holler, Christopher J;
- Deng, Qiudong;
- Taylor, Georgia L;
- Merino, Paola;
- Seyfried, Nicholas T
Publication type:
Article
Haploinsufficiency of progranulin causes impairments in PINK/PARKIN mitophagy: Molecular and cell biology/TDP‐43.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.042104
By:
- Casey, Jackie M.;
- Melandri, Daniela;
- Arber, Charles;
- Soutar, Marc;
- Holler, Christopher J.;
- Kukar, Thomas;
- Isaacs, Adrian M.;
- Rohrer, Jonathan D.;
- Plun‐Favreau, Helene;
- Wray, Selina
Publication type:
Article
BACE1 and BACE2 enzymatic activities in Alzheimer’s disease.
Published in:
Journal of Neurochemistry, 2010, v. 112, n. 4, p. 1045, doi. 10.1111/j.1471-4159.2009.06528.x
By:
- Ahmed, Rachel R.;
- Holler, Christopher J.;
- Webb, Robin L.;
- Feng Li;
- Beckett, Tina L.;
- Murphy, M. Paul
Publication type:
Article
Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.
Published in:
Molecular Neurodegeneration, 2016, v. 11, p. 1, doi. 10.1186/s13024-016-0114-3
By:
- Holler, Christopher J.;
- Taylor, Georgia;
- McEachin, Zachary T.;
- Qiudong Deng;
- Watkins, William J.;
- Hudson, Kathryn;
- Easley, Charles A.;
- Hu, William T.;
- Hales, Chadwick M.;
- Rossoll, Wilfried;
- Bassell, Gary J.;
- Kukar, Thomas
Publication type:
Article
Disulfide bonds and disorder in granulin-3: An unusual handshake between structural stability and plasticity.
Published in:
Protein Science: A Publication of the Protein Society, 2017, v. 26, n. 9, p. 1759, doi. 10.1002/pro.3212
By:
- Ghag, Gaurav;
- Holler, Christopher J.;
- Taylor, Georgia;
- Kukar, Thomas L.;
- Uversky, Vladimir N.;
- Rangachari, Vijayaraghavan
Publication type:
Article
FUS is Phosphorylated by DNA-PK and Accumulates in the Cytoplasm after DNA Damage.
Published in:
Journal of Neuroscience, 2014, v. 34, n. 23, p. 7802, doi. 10.1523/JNEUROSCI.0172-14.2014
By:
- Qiudong Deng;
- Holler, Christopher J.;
- Taylor, Georgia;
- Hudson, Kathryn F.;
- Watkins, William;
- Gearing, Marla;
- Ito, Daisuke;
- Murray, Melissa E.;
- Dickson, Dennis W.;
- Seyfried, Nicholas T.;
- Kukar, Thomas
Publication type:
Article

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