Works by Hohlfeld, Reinhard

Results: 107

Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination.

Published in:

Acta Neuropathologica Communications, 2014, v. 2, n. 1, p. 1, doi. 10.1186/s40478-014-0168-9

By:

Mohan, Hema;
Friese, Anita;
Albrecht, Stefanie;
Krumbholz, Markus;
Elliott, Christina;
Arthur, Ariel;
Menon, Ramesh;
Farina, Cinthia;
Junker, Andreas;
Stadelmann, Christine;
Barnett, Susan;
Huitinga, Inge;
Wekerle, Hartmut;
Hohlfeld, Reinhard;
Lassmann, Hans;
Kuhlmann, Tanja;
Linington, Chris;
Meinl, Edgar

Publication type:

Article

Ponesimod Compared With Teriflunomide in Patients With Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study: A Randomized Clinical Trial.

Published in:

JAMA Neurology, 2021, v. 78, n. 5, p. 558, doi. 10.1001/jamaneurol.2021.0405

By:

Kappos, Ludwig;
Fox, Robert J.;
Burcklen, Michel;
Freedman, Mark S.;
Havrdová, Eva K.;
Hennessy, Brian;
Hohlfeld, Reinhard;
Lublin, Fred;
Montalban, Xavier;
Pozzilli, Carlo;
Scherz, Tatiana;
D'Ambrosio, Daniele;
Linscheid, Philippe;
Vaclavkova, Andrea;
Pirozek-Lawniczek, Magdalena;
Kracker, Hilke;
Sprenger, Till

Publication type:

Article

Alemtuzumab and Multiple Sclerosis.

Published in:

JAMA Neurology, 2016, v. 73, n. 6, p. 637, doi. 10.1001/jamaneurol.2016.0259

By:

Hohlfeld, Reinhard;
Kümpfel, Tania

Publication type:

Article

The Glycosylation Site of Myelin Oligodendrocyte Glycoprotein Affects Autoantibody Recognition in a Large Proportion of Patients.

Published in:

Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.01189

By:

Marti Fernandez, Iris;
Macrini, Caterina;
Krumbholz, Markus;
Hensbergen, Paul J.;
Hipgrave Ederveen, Agnes L.;
Winklmeier, Stephan;
Vural, Atay;
Kurne, Asli;
Jenne, Dieter;
Kamp, Frits;
Gerdes, Lisa Ann;
Hohlfeld, Reinhard;
Wuhrer, Manfred;
Kümpfel, Tania;
Meinl, Edgar

Publication type:

Article

Cover Picture: Eur. J. Immunol. 8/09.

Published in:

European Journal of Immunology, 2009, v. 39, n. 8, p. n/a, doi. 10.1002/eji.200990045

By:

Hohlfeld, Reinhard

Publication type:

Article

Multiple sclerosis: Human model for EAE?

Published in:

European Journal of Immunology, 2009, v. 39, n. 8, p. 2036, doi. 10.1002/eji.200939545

By:

Hohlfeld, Reinhard

Publication type:

Article

Myasthenia gravis: selective enrichment of antiacetylcholine receptor antibody production in untransformed human B cell cultures.

Published in:

European Journal of Immunology, 1999, v. 29, n. 11, p. 3538, doi. 10.1002/(SICI)1521-4141(199911)29:11<3538::AID-IMMU3538>3.0.CO;2-Y

By:

Padberg, Frank;
Matsuda, Masayuki;
Fenk, Roland;
Patenge, Nadja;
Kubuschok, Boris;
Hohlfeld, Reinhard;
Wekerle, Hartmut;
Spuler, Simone

Publication type:

Article

Human T cell autoimmunity against myelin basic protein: CD4.

Published in:

European Journal of Immunology, 1993, v. 23, n. 2, p. 530, doi. 10.1002/eji.1830230235

By:

Saruhan-Direskeneli, Güher;
Weber, Frank;
Meinl, Edgar;
Pette, Martin;
Giegerich, Gerhard;
Hinkkanen, Ari;
Epplen, Jörg T.;
Hohlfeld, Reinhard;
Wekerle, Hartmut

Publication type:

Article

Prospects of Transcript Profiling for mRNAs and MicroRNAs Using Formalin-Fixed and Paraffin-Embedded Dissected Autoptic Multiple Sclerosis Lesions.

Published in:

Brain Pathology, 2012, v. 22, n. 5, p. 607, doi. 10.1111/j.1750-3639.2012.00564.x

By:

Eisele, Sylvia;
Krumbholz, Markus;
Fischer, Marie-Therese;
Mohan, Hema;
Junker, Andreas;
Arzberger, Thomas;
Hohlfeld, Reinhard;
Bradl, Monika;
Lassmann, Hans;
Meinl, Edgar

Publication type:

Article

Extracellular Matrix in Multiple Sclerosis Lesions: Fibrillar Collagens, Biglycan and Decorin are Upregulated and Associated with Infiltrating Immune Cells.

Published in:

Brain Pathology, 2010, v. 20, n. 5, p. 966, doi. 10.1111/j.1750-3639.2010.00399.x

By:

Mohan, Hema;
Krumbholz, Markus;
Sharma, Rakhi;
Eisele, Sylvia;
Junker, Andreas;
Sixt, Michael;
Newcombe, Jia;
Wekerle, Hartmut;
Hohlfeld, Reinhard;
Lassmann, Hans;
Meinl, Edgar

Publication type:

Article

CD20+ T Cells as Pathogenic Players and Therapeutic Targets in MS.

Published in:

2021

By:

Meinl, Edgar;
Hohlfeld, Reinhard

Publication type:

journal article

Role of B Cells in Multiple Sclerosis and Related Disorders.

Published in:

Annals of Neurology, 2021, v. 89, n. 1, p. 13, doi. 10.1002/ana.25927

By:

Comi, Giancarlo;
Bar‐Or, Amit;
Lassmann, Hans;
Uccelli, Antonio;
Hartung, Hans‐Peter;
Montalban, Xavier;
Sørensen, Per Solberg;
Hohlfeld, Reinhard;
Hauser, Stephen L.

Publication type:

Article

Abundant glutamic acid decarboxylase (GAD)-reactive B cells in gad-antibody-associated neurological disorders.

Published in:

2019

By:

Thaler, Franziska S.;
Thaller, Anna L.;
Biljecki, Michelle;
Schuh, Elisabeth;
Winklmeier, Stephan;
Mahler, Christoph F.;
Gerhards, Ramona;
Völk, Stefanie;
Schnorfeil, Frauke;
Subklewe, Marion;
Hohlfeld, Reinhard;
Kümpfel, Tania;
Meinl, Edgar

Publication type:

journal article

Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein.

Published in:

2018

By:

Spadaro, Melania;
Winklmeier, Stephan;
Beltrán, Eduardo;
Macrini, Caterina;
Höftberger, Romana;
Schuh, Elisabeth;
Thaler, Franziska S.;
Gerdes, Lisa Ann;
Laurent, Sarah;
Gerhards, Ramona;
Brändle, Simone;
Dornmair, Klaus;
Breithaupt, Constanze;
Krumbholz, Markus;
Moser, Markus;
Krishnamoorthy, Gurumoorthy;
Kamp, Frits;
Jenne, Dieter;
Hohlfeld, Reinhard;
Kümpfel, Tania

Publication type:

journal article

CTLA4 as Immunological Checkpoint in the Development of Multiple Sclerosis.

Published in:

2016

By:

Gerdes, Lisa Ann;
Held, Kathrin;
Beltrán, Eduardo;
Berking, Carola;
Prinz, Jörg C.;
Junker, Andreas;
Tietze, Julia K.;
Ertl‐Wagner, Birgit;
Straube, Andreas;
Kümpfel, Tania;
Dornmair, Klaus;
Hohlfeld, Reinhard

Publication type:

journal article

Cerebrospinal fluid JC virus antibody index for diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy.

Published in:

Annals of Neurology, 2014, v. 76, n. 6, p. 792, doi. 10.1002/ana.24153

By:

Warnke, Clemens;
Geldern, Gloria;
Markwerth, Philipp;
Dehmel, Thomas;
Hoepner, Robert;
Gold, Ralf;
Pawlita, Michael;
Kümpfel, Tania;
Mäurer, Mathias;
Stangel, Martin;
Wegner, Florian;
Hohlfeld, Reinhard;
Straeten, Vera;
Limmroth, Volker;
Weber, Thomas;
Hermsen, Derik;
Kleinschnitz, Christoph;
Hartung, Hans‐Peter;
Wattjes, Mike P.;
Svenningson, Anders

Publication type:

Article

Antibody to Aquaporin 4 in the Diagnosis of Neuromyelitis Optica.

Published in:

PLoS Medicine, 2007, v. 4, n. 4, p. e133, doi. 10.1371/journal.pmed.0040133

By:

Paul, Friedemann;
Jarius, Sven;
Aktas, Orhan;
Bluthner, Martin;
Bauer, Oliver;
Appelhans, Heribert;
Franciotta, Diego;
Bergamaschi, Roberto;
Littleton, Edward;
Palace, Jacqueline;
Seelig, Hans-Peter;
Hohlfeld, Reinhard;
Vincent, Angela;
Zipp, Frauke

Publication type:

Article

Charting a global research strategy for progressive MS—An international progressive MS Alliance proposal.

Published in:

Multiple Sclerosis Journal, 2022, v. 28, n. 1, p. 16, doi. 10.1177/13524585211059766

By:

Thompson, Alan J;
Carroll, William;
Ciccarelli, Olga;
Comi, Giancarlo;
Cross, Anne;
Donnelly, Alexis;
Feinstein, Anthony;
Fox, Robert J;
Helme, Anne;
Hohlfeld, Reinhard;
Hyde, Robert;
Kanellis, Pamela;
Landsman, Douglas;
Lubetzki, Catherine;
Marrie, Ruth Ann;
Morahan, Julia;
Montalban, Xavier;
Musch, Bruno;
Rawlings, Sarah;
Salvetti, Marco

Publication type:

Article

Association of smoking but not HLA-DRB1*15:01, APOE or body mass index with brain atrophy in early multiple sclerosis.

Published in:

Multiple Sclerosis Journal, 2019, v. 25, n. 5, p. 661, doi. 10.1177/1352458518763541

By:

Graetz, Christiane;
Gröger, Adriane;
Luessi, Felix;
Salmen, Anke;
Zöller, Daniela;
Schultz, Janine;
Siller, Nelly;
Fleischer, Vinzenz;
Bellenberg, Barbara;
Berthele, Achim;
Biberacher, Viola;
Havla, Joachim;
Hecker, Michael;
Hohlfeld, Reinhard;
Infante-Duarte, Carmen;
Kirschke, Jan S.;
Kümpfel, Tania;
Linker, Ralf;
Paul, Friedemann;
Pfeuffer, Steffen

Publication type:

Article

Recurrence of disease activity during pregnancy after cessation of fingolimod in multiple sclerosis.

Published in:

Multiple Sclerosis Journal, 2018, v. 24, n. 7, p. 991, doi. 10.1177/1352458517731913

By:

Meinl, Ingrid;
Havla, Joachim;
Hohlfeld, Reinhard;
Kümpfel, Tania

Publication type:

Article

Stop inflammation and you stop neurodegeneration in MS – Commentary.

Published in:

Multiple Sclerosis Journal, 2017, v. 23, n. 10, p. 1323, doi. 10.1177/1352458517707587

By:

Hohlfeld, Reinhard

Publication type:

Article

PML risk stratification using anti-JCV antibody index and L-selectin.

Published in:

Multiple Sclerosis Journal, 2016, v. 22, n. 8, p. 1048, doi. 10.1177/1352458515607651

By:

Schwab, Nicholas;
Schneider-Hohendorf, Tilman;
Pignolet, Béatrice;
Spadaro, Michela;
Görlich, Dennis;
Meinl, Ingrid;
Windhagen, Susanne;
Tackenberg, Björn;
Breuer, Johanna;
Cantó, Ester;
Kümpfel, Tania;
Hohlfeld, Reinhard;
Siffrin, Volker;
Luessi, Felix;
Posevitz-Fejfár, Anita;
Montalban, Xavier;
Meuth, Sven G.;
Zipp, Frauke;
Gold, Ralf;
Du Pasquier, Renaud A.

Publication type:

Article

Natalizumab exerts a suppressive effect on surrogates of B cell function in blood and CSF.

Published in:

Multiple Sclerosis Journal, 2015, v. 21, n. 8, p. 1036, doi. 10.1177/1352458514556296

By:

Warnke, Clemens;
Stettner, Mark;
Lehmensiek, Vera;
Dehmel, Thomas;
Mausberg, Anne K.;
Von Geldern, Gloria;
Gold, Ralf;
Kümpfel, Tania;
Hohlfeld, Reinhard;
Mäurer, Mathias;
Stangel, Martin;
Straeten, Vera;
Limmroth, Volker;
Weber, Thomas;
Kleinschnitz, Christoph;
Wattjes, Mike P.;
Svenningsson, Anders;
Olsson, Tomas;
Hartung, Hans-Peter;
Hermsen, Derik

Publication type:

Article

Predictors for multiple sclerosis relapses after switching from natalizumab to fingolimod.

Published in:

Multiple Sclerosis Journal, 2014, v. 20, n. 13, p. 1714, doi. 10.1177/1352458514533398

By:

Hoepner, Robert;
Havla, Joachim;
Eienbröker, Christian;
Tackenberg, Björn;
Hellwig, Kerstin;
Meinl, Ingrid;
Hohlfeld, Reinhard;
Gold, Ralf;
Kümpfel, Tania;
Kleiter, Ingo

Publication type:

Article

Non-specific alterations of craniocervical venous drainage in multiple sclerosis revealed by cardiac-gated phase-contrast MRI.

Published in:

Multiple Sclerosis Journal, 2012, v. 18, n. 7, p. 1000, doi. 10.1177/1352458511432742

By:

Ertl-Wagner, Birgit;
Koerte, Inga;
Kümpfel, Tania;
Blaschek, Astrid;
Laubender, Ruediger P;
Schick, Max;
Steffinger, Denise;
Kaufmann, David;
Heinen, Florian;
Reiser, Maximilian;
Alperin, Noam;
Hohlfeld, Reinhard

Publication type:

Article

Revised McDonald criteria: The persisting importance of cerebrospinal fluid analysis.

Published in:

Annals of Neurology, 2011, v. 70, n. 3, p. 520, doi. 10.1002/ana.22508

By:

Tumani, Hayrettin;
Deisenhammer, Florian;
Giovannoni, Gavin;
Gold, Ralf;
Hartung, Hans-Peter;
Hemmer, Bernhard;
Hohlfeld, Reinhard;
Otto, Markus;
Stangel, Martin;
Wildemann, Brigitte;
Zettl, Uwe K.

Publication type:

Article

Zero tolerance (to acetylcholine receptor) and ways to overcome it.

Published in:

Annals of Neurology, 2010, v. 67, n. 4, p. 422, doi. 10.1002/ana.22025

By:

Wekerle, Hartmut;
Hohlfeld, Reinhard

Publication type:

Article

Reply.

Published in:

Annals of Neurology, 2006, v. 60, n. 4, p. 487

By:

Edgar Meinl;
Markus Krumbholz;
Reinhard Hohlfeld

Publication type:

Article

Book review.

Published in:

Annals of Neurology, 2006, v. 60, n. 3, p. 384

By:

Reinhard Hohlfeld

Publication type:

Article

B lineage cells in the inflammatory central nervous system environment: Migration, maintenance, local antibody production, and therapeutic modulation.

Published in:

Annals of Neurology, 2006, v. 59, n. 6, p. 880

By:

Edgar Meinl;
Markus Krumbholz;
Reinhard Hohlfeld

Publication type:

Article

The ups and downs of multiple sclerosis therapeutics.

Published in:

Annals of Neurology, 2001, v. 49, n. 3, p. 281, doi. 10.1002/ana.61

By:

Hohlfeld, Reinhard;
Wiendl, Heinz

Publication type:

Article

Muscle fibers in inflammatory myopathies and cultured myoblasts express the nonclassical major histocompatibility antigen HLA-G.

Published in:

Annals of Neurology, 2000, v. 48, n. 4, p. 679, doi. 10.1002/1531-8249(200010)48:4<679::AID-ANA19>3.0.CO;2-V

By:

Wiendl, Heinz;
Behrens, Lueder;
Maier, Sabine;
Johnson, Margaret A.;
Weiss, Elisabeth H.;
Hohlfeld, Reinhard

Publication type:

Article

Genetic control of multiple sclerosis: Increased production of lymphotoxin and tumor necrosis factor-α by HLA-DR2+ T cells.

Published in:

Annals of Neurology, 1995, v. 38, n. 5, p. 723, doi. 10.1002/ana.410380506

By:

Zipp, Frauke;
Weber, Frank;
Huber, Susanne;
Sotgiu, Stefano;
Czlonkowska, Anna;
Holler, Ernst;
Albert, Ekkehard;
Weiss, Elisabeth H.;
Wekerle, Hartmut;
Hohlfeld, Reinhard

Publication type:

Article

Expression of 65-kd heat shock proteins in the inflammatory myopathies.

Published in:

Annals of Neurology, 1992, v. 32, n. 6, p. 821, doi. 10.1002/ana.410320619

By:

Hohlfeld, Reinhard;
Engel, Andrew G.

Publication type:

Article

Coculture with autologous myotubes of cytotoxic T cells isolated from muscle in inflammatory myopathies.

Published in:

Annals of Neurology, 1991, v. 29, n. 5, p. 498, doi. 10.1002/ana.410290509

By:

Hohlfeld, Reinhard;
Engel, Andrew G.

Publication type:

Article

Neurological autoimmune disease and the trimolecular complex of T-lymphocytes.

Published in:

Annals of Neurology, 1989, v. 25, n. 6, p. 531, doi. 10.1002/ana.410250602

By:

Hohlfeld, Reinhard

Publication type:

Article

Intrathecal antibody (IgG) production against human herpesvirus type 6 occurs in about 20% of multiple sclerosis patients and might be linked to a polyspecific B–cell response.

Published in:

Journal of Neurology, 2005, v. 252, n. 8, p. 968, doi. 10.1007/s00415-005-0794-z

By:

Derfuss, Tobias;
Hohlfeld, Reinhard;
Meinl, Edgar

Publication type:

Article

Immunological assay for assessing the efficacy of glatiramer acetate (Copaxone) in multiple sclerosis : A pilot study.

Published in:

Journal of Neurology, 2002, v. 249, n. 11, p. 1587, doi. 10.1007/s00415-002-0904-0

By:

Farina, Cinthia;
Wagenpfeil, Stefan;
Hohlfeld, Reinhard

Publication type:

Article

How promising is hematopoetic stem cell transplantation in multiple sclerosis?

Published in:

2002

By:

Hohlfeld, Reinhard

Publication type:

Editorial

IN VITRO SELECTION OF RAT AUTOIMMUNE HELPER T-LYMPHOCYTES SPECIFIC FOR ACETYLCHOLINE RECEPTOR (AChR).

Published in:

Annals of the New York Academy of Sciences, 1981, v. 377, n. 1, p. 831, doi. 10.1111/j.1749-6632.1981.tb33789.x

By:

Hohlfeld, Reinhard;
Kalies, Inge;
Ketelsen, Uwe-Peter;
Kalden, Jochen R.;
Wekerle, Hartmut

Publication type:

Article

Effector mechanisms in myasthenia gravis: End-plate function after passive transfer of IgG, Fab, and F(ab′)2 hybrid molecules.

Published in:

Muscle & Nerve, 1986, v. 9, n. 4, p. 306, doi. 10.1002/mus.880090404

By:

Sterz, Raimund;
Hohlfeld, Reinhard;
Rajki, Klara;
Kaul, Martin;
Heininger, Kurt;
Peper, Klaus;
Toyka, Klaus V.

Publication type:

Article

Experimental myasthenia: Lack of correlation between the autoantibody titer and the reduction of acetylcholine-controlled ionic channels measured at functioning endplates.

Published in:

Muscle & Nerve, 1983, v. 6, n. 2, p. 160, doi. 10.1002/mus.880060213

By:

Hohlfeld, Reinhard;
Sterz, Raimund;
Kalies, Inge;
Wekerle, Hartmut;
Peper, Klaus

Publication type:

Article

Glatiramer acetate in the treatment of multiple sclerosis: emerging concepts regarding its mechanism of action.

Published in:

2011

By:

Lalive PH;
Neuhaus O;
Benkhoucha M;
Burger D;
Hohlfeld R;
Zamvil SS;
Weber MS;
Lalive, Patrice H;
Neuhaus, Oliver;
Benkhoucha, Mahdia;
Burger, Danielle;
Hohlfeld, Reinhard;
Zamvil, Scott S;
Weber, Martin S

Publication type:

journal article

DNA methylation signatures of monozygotic twins clinically discordant for multiple sclerosis.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-09984-3

By:

Souren, Nicole Y.;
Gerdes, Lisa A.;
Lutsik, Pavlo;
Gasparoni, Gilles;
Beltrán, Eduardo;
Salhab, Abdulrahman;
Kümpfel, Tania;
Weichenhan, Dieter;
Plass, Christoph;
Hohlfeld, Reinhard;
Walter, Jörn

Publication type:

Article

Immune dysbalance in childhood multiple sclerosis: a 'chicken or the egg' conundrum.

Published in:

2019

By:

Hohlfeld, Reinhard

Publication type:

journal article

Cytotoxic T cells go awry in inclusion body myositis.

Published in:

2016

By:

Hohlfeld, Reinhard;
Schulze-Koops, Hendrik

Publication type:

journal article

Intrathecal somatic hypermutation of IgM in multiple sclerosis and neuroinflammation.

Published in:

Brain: A Journal of Neurology, 2014, v. 137, n. 10, p. 2703, doi. 10.1093/brain/awu205

By:

Beltrán, Eduardo;
Obermeier, Birgit;
Moser, Markus;
Coret, Francisco;
Simó-Castelló, María;
Boscá, Isabel;
Pérez-Miralles, Francisco;
Villar, Luisa M.;
Senel, Makbule;
Tumani, Hayrettin;
Hohlfeld, Reinhard;
Casanova, Bonaventura;
Dornmair, Klaus

Publication type:

Article

Update on sporadic inclusion body myositis.

Published in:

Brain: A Journal of Neurology, 2011, v. 134, n. 11, p. 3141, doi. 10.1093/brain/awr258

By:

Hohlfeld, Reinhard

Publication type:

Article

Beneficial brain autoimmunity?

Published in:

Brain: A Journal of Neurology, 2010, v. 133, n. 8, p. 2182, doi. 10.1093/brain/awq206

By:

Wekerle, Hartmut;
Hohlfeld, Reinhard

Publication type:

Article

MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47.

Published in:

Brain: A Journal of Neurology, 2009, v. 132, n. 12, p. 3342, doi. 10.1093/brain/awp300

By:

Junker, Andreas;
Krumbholz, Markus;
Eisele, Sylvia;
Mohan, Hema;
Augstein, Florian;
Bittner, Robert;
Lassmann, Hans;
Wekerle, Hartmut;
Hohlfeld, Reinhard;
Meinl, Edgar

Publication type:

Article