Works by Hohlfeld, Reinhard

Results: 106

Mitochondrial DNA Variation and Heteroplasmy in Monozygotic Twins Clinically Discordant for Multiple Sclerosis.
Published in:
Human Mutation, 2016, v. 37, n. 8, p. 765, doi. 10.1002/humu.23003
By:
- Souren, Nicole Y.P.;
- Gerdes, Lisa A.;
- Kümpfel, Tania;
- Lutsik, Pavlo;
- Klopstock, Thomas;
- Hohlfeld, Reinhard;
- Walter, Jörn
Publication type:
Article
Autoimmune human T lymphocytes specific for acetylcholine receptor.
Published in:
Nature, 1984, v. 310, n. 5974, p. 244, doi. 10.1038/310244a0
By:
- Hohlfeld, Reinhard;
- Toyka, Klaus V.;
- Heininger, Kurt;
- Grosse-Wilde, Hans;
- Kalies, Inge
Publication type:
Article
Progress in understanding inflammatory and autoimmune diseases of the central nervous system.
Published in:
2009
By:
- Hohlfeld, Reinhard;
- Kappos, Ludwig
Publication type:
Editorial
Novel approaches for identifying target antigens of autoreactive human B and T cells.
Published in:
Seminars in Immunopathology, 2009, v. 31, n. 4, p. 467, doi. 10.1007/s00281-009-0179-y
By:
- Dornmair, Klaus;
- Meinl, Edgar;
- Hohlfeld, Reinhard
Publication type:
Article
Optical coherence tomography in myelin-oligodendrocyte-glycoprotein antibody-seropositive patients: a longitudinal study.
Published in:
2019
By:
- Oertel, Frederike C.;
- Outteryck, Olivier;
- Knier, Benjamin;
- Zimmermann, Hanna;
- Borisow, Nadja;
- Bellmann-Strobl, Judith;
- Blaschek, Astrid;
- Jarius, Sven;
- Reindl, Markus;
- Ruprecht, Klemens;
- Meinl, Edgar;
- Hohlfeld, Reinhard;
- Paul, Friedemann;
- Brandt, Alexander U.;
- Kümpfel, Tania;
- Havla, Joachim
Publication type:
journal article
Ponesimod Compared With Teriflunomide in Patients With Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study: A Randomized Clinical Trial.
Published in:
JAMA Neurology, 2021, v. 78, n. 5, p. 558, doi. 10.1001/jamaneurol.2021.0405
By:
- Kappos, Ludwig;
- Fox, Robert J.;
- Burcklen, Michel;
- Freedman, Mark S.;
- Havrdová, Eva K.;
- Hennessy, Brian;
- Hohlfeld, Reinhard;
- Lublin, Fred;
- Montalban, Xavier;
- Pozzilli, Carlo;
- Scherz, Tatiana;
- D'Ambrosio, Daniele;
- Linscheid, Philippe;
- Vaclavkova, Andrea;
- Pirozek-Lawniczek, Magdalena;
- Kracker, Hilke;
- Sprenger, Till
Publication type:
Article
Managing Risks with Immune Therapies in Multiple Sclerosis.
Published in:
2019
By:
- Förster, Moritz;
- Küry, Patrick;
- Aktas, Orhan;
- Warnke, Clemens;
- Havla, Joachim;
- Hohlfeld, Reinhard;
- Mares, Jan;
- Hartung, Hans-Peter;
- Kremer, David
Publication type:
journal article
Review: Progress in the treatment of myasthenia gravis.
Published in:
Therapeutic Advances in Neurological Disorders, 2008, v. 1, n. 2, p. 99, doi. 10.1177/1756285608093888
By:
- Gold, Ralf;
- Hohlfeld, Reinhard;
- Toyka, Klaus V.
Publication type:
Article
Transplantation of Myasthenia Gravis Thymus to SCID Micea.
Published in:
Annals of the New York Academy of Sciences, 1993, v. 681, n. 1, p. 66, doi. 10.1111/j.1749-6632.1993.tb22870.x
By:
- SCHÖNBECK, SIMONE;
- PADBERG, FRANK;
- MARX, ALEXANDER;
- HOHLFELD, REINHARD;
- WEKERLE, HARTMUT
Publication type:
Article
Glatiramer acetate in the treatment of multiple sclerosis: emerging concepts regarding its mechanism of action.
Published in:
2011
By:
- Lalive PH;
- Neuhaus O;
- Benkhoucha M;
- Burger D;
- Hohlfeld R;
- Zamvil SS;
- Weber MS;
- Lalive, Patrice H;
- Neuhaus, Oliver;
- Benkhoucha, Mahdia;
- Burger, Danielle;
- Hohlfeld, Reinhard;
- Zamvil, Scott S;
- Weber, Martin S
Publication type:
journal article
Interdisciplinary Risk Management in the Treatment of Multiple Sclerosis.
Published in:
Deutsches Ärzteblatt International, 2016, v. 113, n. 51/52, p. 879, doi. 10.3238/arztebl.2016.0879
By:
- Havla, Joachim;
- Warnke, Clemens;
- Derfuss, Tobias;
- Kappos, Ludwig;
- Hartung, Hans-Peter;
- Hohlfeld, Reinhard
Publication type:
Article
Effector mechanisms in myasthenia gravis: End-plate function after passive transfer of IgG, Fab, and F(ab′)2 hybrid molecules.
Published in:
Muscle & Nerve, 1986, v. 9, n. 4, p. 306, doi. 10.1002/mus.880090404
By:
- Sterz, Raimund;
- Hohlfeld, Reinhard;
- Rajki, Klara;
- Kaul, Martin;
- Heininger, Kurt;
- Peper, Klaus;
- Toyka, Klaus V.
Publication type:
Article
Experimental myasthenia: Lack of correlation between the autoantibody titer and the reduction of acetylcholine-controlled ionic channels measured at functioning endplates.
Published in:
Muscle & Nerve, 1983, v. 6, n. 2, p. 160, doi. 10.1002/mus.880060213
By:
- Hohlfeld, Reinhard;
- Sterz, Raimund;
- Kalies, Inge;
- Wekerle, Hartmut;
- Peper, Klaus
Publication type:
Article
Prospects of Transcript Profiling for mRNAs and MicroRNAs Using Formalin-Fixed and Paraffin-Embedded Dissected Autoptic Multiple Sclerosis Lesions.
Published in:
Brain Pathology, 2012, v. 22, n. 5, p. 607, doi. 10.1111/j.1750-3639.2012.00564.x
By:
- Eisele, Sylvia;
- Krumbholz, Markus;
- Fischer, Marie-Therese;
- Mohan, Hema;
- Junker, Andreas;
- Arzberger, Thomas;
- Hohlfeld, Reinhard;
- Bradl, Monika;
- Lassmann, Hans;
- Meinl, Edgar
Publication type:
Article
Extracellular Matrix in Multiple Sclerosis Lesions: Fibrillar Collagens, Biglycan and Decorin are Upregulated and Associated with Infiltrating Immune Cells.
Published in:
Brain Pathology, 2010, v. 20, n. 5, p. 966, doi. 10.1111/j.1750-3639.2010.00399.x
By:
- Mohan, Hema;
- Krumbholz, Markus;
- Sharma, Rakhi;
- Eisele, Sylvia;
- Junker, Andreas;
- Sixt, Michael;
- Newcombe, Jia;
- Wekerle, Hartmut;
- Hohlfeld, Reinhard;
- Lassmann, Hans;
- Meinl, Edgar
Publication type:
Article
Pro-inflammatory pattern of IgG1 Fc glycosylation in multiple sclerosis cerebrospinal fluid.
Published in:
2015
By:
- Wuhrer, Manfred;
- Selman, Maurice H. J.;
- McDonnell, Liam A.;
- Kümpfel, Tania;
- Derfuss, Tobias;
- Khademi, Mohsen;
- Olsson, Tomas;
- Hohlfeld, Reinhard;
- Meinl, Edgar;
- Krumbholz, Markus
Publication type:
journal article
Fingolimod induces neuroprotective factors in human astrocytes.
Published in:
2015
By:
- Hoffmann, Franziska S.;
- Hofereiter, Johann;
- Rübsamen, Heike;
- Melms, Johannes;
- Schwarz, Sigrid;
- Faber, Hans;
- Weber, Peter;
- Pütz, Benno;
- Loleit, Verena;
- Weber, Frank;
- Hohlfeld, Reinhard;
- Meinl, Edgar;
- Krumbholz, Markus
Publication type:
journal article
Stimulation of Autoimmune Helper T Lymphocytes from Patients with Myasthenia Gravis with Synthetic Peptides of the Acetylcholine Receptor Alpha Subunita.
Published in:
Annals of the New York Academy of Sciences, 1988, v. 540, n. 1, p. 511, doi. 10.1111/j.1749-6632.1988.tb27154.x
By:
- HOHLFELD, REINHARD;
- TOYKA, KLAUS V.;
- MINER, LUCINDA L.;
- CONTI-TRONCONI, BIANCA M.
Publication type:
Article
Acetylcholine Receptor-Specific Human T-Lymphocyte Linesa.
Published in:
Annals of the New York Academy of Sciences, 1987, v. 505, n. 1, p. 27, doi. 10.1111/j.1749-6632.1987.tb51280.x
By:
- HOHLFELD, REINHARD;
- TOYKA, KLAUS V.;
- MICHELS, MARCO;
- HEININGER, KURT;
- CONTI-TRONCONI, BIANCA;
- TZARTOS, SOCRATES J.
Publication type:
Article
In Vitro Propagation of Acetylcholine Receptor-Specific Human T Lymphocytes with Autologous Epstein-Barr Virus-Transformed B Lymphocytesa.
Published in:
Annals of the New York Academy of Sciences, 1987, v. 505, n. 1, p. 693, doi. 10.1111/j.1749-6632.1987.tb51340.x
By:
- HOHLFELD, REINHARD;
- MICHELS, MARCO;
- TESCH, HANS;
- FAHSBENDER, ANDREA;
- HEININGER, KURT;
- CONTI-TRONCONI, BIANCA;
- TOYKA, KLAUS V.
Publication type:
Article
IN VITRO SELECTION OF RAT AUTOIMMUNE HELPER T-LYMPHOCYTES SPECIFIC FOR ACETYLCHOLINE RECEPTOR (AChR).
Published in:
Annals of the New York Academy of Sciences, 1981, v. 377, n. 1, p. 831, doi. 10.1111/j.1749-6632.1981.tb33789.x
By:
- Hohlfeld, Reinhard;
- Kalies, Inge;
- Ketelsen, Uwe-Peter;
- Kalden, Jochen R.;
- Wekerle, Hartmut
Publication type:
Article
Twin study identifies early immunological and metabolic dysregulation of CD8+ T cells in multiple sclerosis.
Published in:
Science Immunology, 2024, v. 9, n. 99, p. 1, doi. 10.1126/sciimmunol.adj8094
By:
- Kavaka, Vladyslav;
- Mutschler, Luisa;
- de la Rosa del Val, Clara;
- Eglseer, Klara;
- Gómez Martínez, Ana M.;
- Flierl-Hecht, Andrea;
- Ertl-Wagner, Birgit;
- Keeser, Daniel;
- Mortazavi, Martin;
- Seelos, Klaus;
- Zimmermann, Hanna;
- Haas, Jürgen;
- Wildemann, Brigitte;
- Kümpfel, Tania;
- Dornmair, Klaus;
- Korn, Thomas;
- Hohlfeld, Reinhard;
- Kerschensteiner, Martin;
- Gerdes, Lisa Ann;
- Beltrán, Eduardo
Publication type:
Article
Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination.
Published in:
Acta Neuropathologica Communications, 2014, v. 2, n. 1, p. 1, doi. 10.1186/s40478-014-0168-9
By:
- Mohan, Hema;
- Friese, Anita;
- Albrecht, Stefanie;
- Krumbholz, Markus;
- Elliott, Christina;
- Arthur, Ariel;
- Menon, Ramesh;
- Farina, Cinthia;
- Junker, Andreas;
- Stadelmann, Christine;
- Barnett, Susan;
- Huitinga, Inge;
- Wekerle, Hartmut;
- Hohlfeld, Reinhard;
- Lassmann, Hans;
- Kuhlmann, Tanja;
- Linington, Chris;
- Meinl, Edgar
Publication type:
Article
Charting a global research strategy for progressive MS—An international progressive MS Alliance proposal.
Published in:
Multiple Sclerosis Journal, 2022, v. 28, n. 1, p. 16, doi. 10.1177/13524585211059766
By:
- Thompson, Alan J;
- Carroll, William;
- Ciccarelli, Olga;
- Comi, Giancarlo;
- Cross, Anne;
- Donnelly, Alexis;
- Feinstein, Anthony;
- Fox, Robert J;
- Helme, Anne;
- Hohlfeld, Reinhard;
- Hyde, Robert;
- Kanellis, Pamela;
- Landsman, Douglas;
- Lubetzki, Catherine;
- Marrie, Ruth Ann;
- Morahan, Julia;
- Montalban, Xavier;
- Musch, Bruno;
- Rawlings, Sarah;
- Salvetti, Marco
Publication type:
Article
Association of smoking but not HLA-DRB1*15:01, APOE or body mass index with brain atrophy in early multiple sclerosis.
Published in:
Multiple Sclerosis Journal, 2019, v. 25, n. 5, p. 661, doi. 10.1177/1352458518763541
By:
- Graetz, Christiane;
- Gröger, Adriane;
- Luessi, Felix;
- Salmen, Anke;
- Zöller, Daniela;
- Schultz, Janine;
- Siller, Nelly;
- Fleischer, Vinzenz;
- Bellenberg, Barbara;
- Berthele, Achim;
- Biberacher, Viola;
- Havla, Joachim;
- Hecker, Michael;
- Hohlfeld, Reinhard;
- Infante-Duarte, Carmen;
- Kirschke, Jan S.;
- Kümpfel, Tania;
- Linker, Ralf;
- Paul, Friedemann;
- Pfeuffer, Steffen
Publication type:
Article
γ-secretase directly sheds the survival receptor BCMA from plasma cells.
Published in:
Nature Communications, 2015, v. 6, n. 6, p. 7333, doi. 10.1038/ncomms8333
By:
- Laurent, Sarah A.;
- Hoffmann, Franziska S.;
- Kuhn, Peer-Hendrik;
- Cheng, Qingyu;
- Chu, Yuanyuan;
- Schmidt-Supprian, Marc;
- Hauck, Stefanie M.;
- Schuh, Elisabeth;
- Krumbholz, Markus;
- Rübsamen, Heike;
- Wanngren, Johanna;
- Khademi, Mohsen;
- Olsson, Tomas;
- Alexander, Tobias;
- Hiepe, Falk;
- Pfister, Hans-Walter;
- Weber, Frank;
- Jenne, Dieter;
- Wekerle, Hartmut;
- Hohlfeld, Reinhard
Publication type:
Article
CD20+ T Cells as Pathogenic Players and Therapeutic Targets in MS.
Published in:
2021
By:
- Meinl, Edgar;
- Hohlfeld, Reinhard
Publication type:
journal article
Role of B Cells in Multiple Sclerosis and Related Disorders.
Published in:
Annals of Neurology, 2021, v. 89, n. 1, p. 13, doi. 10.1002/ana.25927
By:
- Comi, Giancarlo;
- Bar‐Or, Amit;
- Lassmann, Hans;
- Uccelli, Antonio;
- Hartung, Hans‐Peter;
- Montalban, Xavier;
- Sørensen, Per Solberg;
- Hohlfeld, Reinhard;
- Hauser, Stephen L.
Publication type:
Article
Abundant glutamic acid decarboxylase (GAD)-reactive B cells in gad-antibody-associated neurological disorders.
Published in:
2019
By:
- Thaler, Franziska S.;
- Thaller, Anna L.;
- Biljecki, Michelle;
- Schuh, Elisabeth;
- Winklmeier, Stephan;
- Mahler, Christoph F.;
- Gerhards, Ramona;
- Völk, Stefanie;
- Schnorfeil, Frauke;
- Subklewe, Marion;
- Hohlfeld, Reinhard;
- Kümpfel, Tania;
- Meinl, Edgar
Publication type:
journal article
Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein.
Published in:
2018
By:
- Spadaro, Melania;
- Winklmeier, Stephan;
- Beltrán, Eduardo;
- Macrini, Caterina;
- Höftberger, Romana;
- Schuh, Elisabeth;
- Thaler, Franziska S.;
- Gerdes, Lisa Ann;
- Laurent, Sarah;
- Gerhards, Ramona;
- Brändle, Simone;
- Dornmair, Klaus;
- Breithaupt, Constanze;
- Krumbholz, Markus;
- Moser, Markus;
- Krishnamoorthy, Gurumoorthy;
- Kamp, Frits;
- Jenne, Dieter;
- Hohlfeld, Reinhard;
- Kümpfel, Tania
Publication type:
journal article
CTLA4 as Immunological Checkpoint in the Development of Multiple Sclerosis.
Published in:
2016
By:
- Gerdes, Lisa Ann;
- Held, Kathrin;
- Beltrán, Eduardo;
- Berking, Carola;
- Prinz, Jörg C.;
- Junker, Andreas;
- Tietze, Julia K.;
- Ertl‐Wagner, Birgit;
- Straube, Andreas;
- Kümpfel, Tania;
- Dornmair, Klaus;
- Hohlfeld, Reinhard
Publication type:
journal article
Cerebrospinal fluid JC virus antibody index for diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy.
Published in:
Annals of Neurology, 2014, v. 76, n. 6, p. 792, doi. 10.1002/ana.24153
By:
- Warnke, Clemens;
- Geldern, Gloria;
- Markwerth, Philipp;
- Dehmel, Thomas;
- Hoepner, Robert;
- Gold, Ralf;
- Pawlita, Michael;
- Kümpfel, Tania;
- Mäurer, Mathias;
- Stangel, Martin;
- Wegner, Florian;
- Hohlfeld, Reinhard;
- Straeten, Vera;
- Limmroth, Volker;
- Weber, Thomas;
- Hermsen, Derik;
- Kleinschnitz, Christoph;
- Hartung, Hans‐Peter;
- Wattjes, Mike P.;
- Svenningson, Anders
Publication type:
Article
Revised McDonald criteria: The persisting importance of cerebrospinal fluid analysis.
Published in:
Annals of Neurology, 2011, v. 70, n. 3, p. 520, doi. 10.1002/ana.22508
By:
- Tumani, Hayrettin;
- Deisenhammer, Florian;
- Giovannoni, Gavin;
- Gold, Ralf;
- Hartung, Hans-Peter;
- Hemmer, Bernhard;
- Hohlfeld, Reinhard;
- Otto, Markus;
- Stangel, Martin;
- Wildemann, Brigitte;
- Zettl, Uwe K.
Publication type:
Article
Zero tolerance (to acetylcholine receptor) and ways to overcome it.
Published in:
Annals of Neurology, 2010, v. 67, n. 4, p. 422, doi. 10.1002/ana.22025
By:
- Wekerle, Hartmut;
- Hohlfeld, Reinhard
Publication type:
Article
Reply.
Published in:
Annals of Neurology, 2006, v. 60, n. 4, p. 487
By:
- Edgar Meinl;
- Markus Krumbholz;
- Reinhard Hohlfeld
Publication type:
Article
Book review.
Published in:
Annals of Neurology, 2006, v. 60, n. 3, p. 384
By:
- Reinhard Hohlfeld
Publication type:
Article
B lineage cells in the inflammatory central nervous system environment: Migration, maintenance, local antibody production, and therapeutic modulation.
Published in:
Annals of Neurology, 2006, v. 59, n. 6, p. 880
By:
- Edgar Meinl;
- Markus Krumbholz;
- Reinhard Hohlfeld
Publication type:
Article
The ups and downs of multiple sclerosis therapeutics.
Published in:
Annals of Neurology, 2001, v. 49, n. 3, p. 281, doi. 10.1002/ana.61
By:
- Hohlfeld, Reinhard;
- Wiendl, Heinz
Publication type:
Article
Intrathecal antibody (IgG) production against human herpesvirus type 6 occurs in about 20% of multiple sclerosis patients and might be linked to a polyspecific B–cell response.
Published in:
Journal of Neurology, 2005, v. 252, n. 8, p. 968, doi. 10.1007/s00415-005-0794-z
By:
- Derfuss, Tobias;
- Hohlfeld, Reinhard;
- Meinl, Edgar
Publication type:
Article
Immunological assay for assessing the efficacy of glatiramer acetate (Copaxone) in multiple sclerosis : A pilot study.
Published in:
Journal of Neurology, 2002, v. 249, n. 11, p. 1587, doi. 10.1007/s00415-002-0904-0
By:
- Farina, Cinthia;
- Wagenpfeil, Stefan;
- Hohlfeld, Reinhard
Publication type:
Article
How promising is hematopoetic stem cell transplantation in multiple sclerosis?
Published in:
2002
By:
- Hohlfeld, Reinhard
Publication type:
Editorial
Alemtuzumab and Multiple Sclerosis.
Published in:
JAMA Neurology, 2016, v. 73, n. 6, p. 637, doi. 10.1001/jamaneurol.2016.0259
By:
- Hohlfeld, Reinhard;
- Kümpfel, Tania
Publication type:
Article
β-Amyloid: Enemy or Remedy?
Published in:
Science Translational Medicine, 2012, v. 4, n. 145, p. 1, doi. 10.1126/scitranslmed.3004586
By:
- Hohlfeld, Reinhard;
- Wekerle, Hartmut
Publication type:
Article
Finding cures for neurological diseases.
Published in:
Brain: A Journal of Neurology, 2022, v. 145, n. 11, p. 4138, doi. 10.1093/brain/awac282
By:
- Hohlfeld, Reinhard
Publication type:
Article
Features of MOG required for recognition by patients with MOG antibody-associated disorders.
Published in:
2021
By:
- Macrini, Caterina;
- Gerhards, Ramona;
- Winklmeier, Stephan;
- Bergmann, Lena;
- Mader, Simone;
- Spadaro, Melania;
- Vural, Atay;
- Smolle, Michaela;
- Hohlfeld, Reinhard;
- Kümpfel, Tania;
- Lichtenthaler, Stefan F;
- Franquelim, Henri G;
- Jenne, Dieter;
- Meinl, Edgar
Publication type:
journal article
Tissue-resident CD8+ memory T cells in multiple sclerosis.
Published in:
2021
By:
- Hohlfeld, Reinhard;
- Beltran, Eduardo;
- Gerdes, Lisa Ann;
- Dornmair, Klaus
Publication type:
Letter
Immune dysbalance in childhood multiple sclerosis: a 'chicken or the egg' conundrum.
Published in:
2019
By:
- Hohlfeld, Reinhard
Publication type:
journal article
Cytotoxic T cells go awry in inclusion body myositis.
Published in:
2016
By:
- Hohlfeld, Reinhard;
- Schulze-Koops, Hendrik
Publication type:
journal article
Muscle fibers in inflammatory myopathies and cultured myoblasts express the nonclassical major histocompatibility antigen HLA-G.
Published in:
Annals of Neurology, 2000, v. 48, n. 4, p. 679, doi. 10.1002/1531-8249(200010)48:4<679::AID-ANA19>3.0.CO;2-V
By:
- Wiendl, Heinz;
- Behrens, Lueder;
- Maier, Sabine;
- Johnson, Margaret A.;
- Weiss, Elisabeth H.;
- Hohlfeld, Reinhard
Publication type:
Article
Genetic control of multiple sclerosis: Increased production of lymphotoxin and tumor necrosis factor-α by HLA-DR2+ T cells.
Published in:
Annals of Neurology, 1995, v. 38, n. 5, p. 723, doi. 10.1002/ana.410380506
By:
- Zipp, Frauke;
- Weber, Frank;
- Huber, Susanne;
- Sotgiu, Stefano;
- Czlonkowska, Anna;
- Holler, Ernst;
- Albert, Ekkehard;
- Weiss, Elisabeth H.;
- Wekerle, Hartmut;
- Hohlfeld, Reinhard
Publication type:
Article