Works by Hofherr, Alexis

Results: 15

Efficient genome editing of differentiated renal epithelial cells.

Published in:

Pflügers Archiv: European Journal of Physiology, 2017, v. 469, n. 2, p. 303, doi. 10.1007/s00424-016-1924-4

By:

Hofherr, Alexis;
Busch, Tilman;
Huber, Nora;
Nold, Andreas;
Bohn, Albert;
Viau, Amandine;
Bienaimé, Frank;
Kuehn, E. Wolfgang;
Arnold, Sebastian;
Köttgen, Michael

Publication type:

Article

A case‐study of model‐informed drug development of a novel PCSK9 anti sense oligonucleotide. Part 1: First time in man to phase II.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 12, p. 1569, doi. 10.1002/psp4.12866

By:

Knöchel, Jane;
Nilsson, Catarina;
Carlsson, Björn;
Wernevik, Linda;
Hofherr, Alexis;
Gennemark, Peter;
Jansson‐Löfmark, Rasmus;
Isaksson, Rikard;
Rydén‐Bergsten, Tina;
Hamrén, Bengt;
Rekić, Dinko

Publication type:

Article

Rapid target validation in a Cas9-inducible hiPSC derived kidney model.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-95986-5

By:

Shamshirgaran, Yasaman;
Jonebring, Anna;
Svensson, Anna;
Leefa, Isabelle;
Bohlooly-Y, Mohammad;
Firth, Mike;
Woollard, Kevin J.;
Hofherr, Alexis;
Rogers, Ian M.;
Hicks, Ryan

Publication type:

Article

Identification of pathological transcription in autosomal dominant polycystic kidney disease epithelia.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-94442-8

By:

Friedrich, Sebastian;
Müller, Hannah;
Riesterer, Caroline;
Schüller, Hannah;
Friedrich, Katja;
Wörner, Carlotta Leonie;
Busch, Tilman;
Viau, Amandine;
Kuehn, E. Wolfgang;
Köttgen, Michael;
Hofherr, Alexis

Publication type:

Article

Drosophila Sperm Swim Backwards in the Female Reproductive Tract and Are Activated via TRPP2 Ion Channels.

Published in:

PLoS ONE, 2011, v. 6, n. 5, p. 1, doi. 10.1371/journal.pone.0020031

By:

Köttgen, Michael;
Hofherr, Alexis;
Weizhe Li;
Chu, Kristy;
Cook, Stacey;
Montell, Craig;
Watnick, Terry

Publication type:

Article

Cilia‐localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney.

Published in:

EMBO Journal, 2018, v. 37, n. 15, p. 1, doi. 10.15252/embj.201798615

By:

Viau, Amandine;
Bienaimé, Frank;
Lukas, Kamile;
Todkar, Abhijeet P.;
Knoll, Manuel;
Yakulov, Toma A.;
Hofherr, Alexis;
Kretz, Oliver;
Helmstädter, Martin;
Reichardt, Wilfried;
Braeg, Simone;
Aschman, Tom;
Merkle, Annette;
Pfeifer, Dietmar;
Dumit, Verónica I.;
Gubler, Marie‐Claire;
Nitschke, Roland;
Huber, Tobias B.;
Terzi, Fabiola;
Dengjel, Jörn

Publication type:

Article

Eomes cannot replace its paralog T-bet during expansion and differentiation of CD8 effector T cells.

Published in:

PLoS Pathogens, 2020, v. 16, n. 9, p. 1, doi. 10.1371/journal.ppat.1008870

By:

Fixemer, Jonas;
Hummel, Jonas F.;
Arnold, Frederic;
Klose, Christoph S. N.;
Hofherr, Alexis;
Weissert, Kristoffer;
Kögl, Tamara;
Köttgen, Michael;
Arnold, Sebastian J.;
Aichele, Peter;
Tanriver, Yakup

Publication type:

Article

Loss of PKD1/polycystin-1 impairs lysosomal activity in a CAPN (calpain)-dependent manner.

Published in:

Autophagy, 2021, v. 17, n. 9, p. 2384, doi. 10.1080/15548627.2020.1826716

By:

Peintner, Lukas;
Venkatraman, Anusha;
Waeldin, Astrid;
Hofherr, Alexis;
Busch, Tilman;
Voronov, Alexander;
Viau, Amandine;
Kuehn, E. Wolfgang;
Köttgen, Michael;
Borner, Christoph

Publication type:

Article

Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicle Production and Trafficking.

Published in:

Biology (2079-7737), 2022, v. 11, n. 5, p. 709, doi. 10.3390/biology11050709

By:

Kumar, Prashant;
Zadjali, Fahad;
Yao, Ying;
Köttgen, Michael;
Hofherr, Alexis;
Gross, Kenneth W.;
Mehta, Darshan;
Bissler, John J.

Publication type:

Article

The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism.

Published in:

PLoS Biology, 2018, v. 16, n. 8, p. 1, doi. 10.1371/journal.pbio.2005651

By:

Hofherr, Alexis;
Seger, Claudia;
Fitzpatrick, Fiona;
Busch, Tilman;
Michel, Elisabeth;
Luan, Jingting;
Osterried, Lea;
Linden, Frieder;
Kramer-Zucker, Albrecht;
Wakimoto, Barbara;
Schütze, Conny;
Wiedemann, Nils;
Artati, Anna;
Adamski, Jerzy;
Walz, Gerd;
Kunji, Edmund R. S.;
Montell, Craig;
Watnick, Terry;
Köttgen, Michael

Publication type:

Article

Population pharmacokinetics of a novel PCSK9 antisense oligonucleotide.

Published in:

British Journal of Clinical Pharmacology, 2024, v. 90, n. 6, p. 1503, doi. 10.1111/bcp.16046

By:

Clewe, Oskar;
Rekić, Dinko;
Quartino, Angelica L.;
Carlsson, Björn;
Higashimori, Mitsuo;
Wernevik, Linda;
Hofherr, Alexis;
Rydén‐Bergsten, Tina;
Nilsson, Catarina;
Knöchel, Jane

Publication type:

Article

The role of the co‐chaperone DNAJB11 in polycystic kidney disease: Molecular mechanisms and cellular origin of cyst formation.

Published in:

FASEB Journal, 2024, v. 38, n. 21, p. 1, doi. 10.1096/fj.202401763R

By:

Busch, Tilman;
Neubauer, Björn;
Schmitt, Lars;
Cascante, Isabel;
Knoblich, Luise;
Wegehaupt, Oliver;
Schöler, Felix;
Tholen, Stefan;
Hofherr, Alexis;
Schell, Christoph;
Schilling, Oliver;
Westermann, Lukas;
Köttgen, Michael

Publication type:

Article

Wildtype heterogeneity contributes to clonal variability in genome edited cells.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-22885-8

By:

Westermann, Lukas;
Li, Yong;
Göcmen, Burulca;
Niedermoser, Matthias;
Rhein, Kilian;
Jahn, Johannes;
Cascante, Isabel;
Schöler, Felix;
Moser, Niklas;
Neubauer, Björn;
Hofherr, Alexis;
Behrens, Yvonne Lisa;
Göhring, Gudrun;
Köttgen, Anna;
Köttgen, Michael;
Busch, Tilman

Publication type:

Article

Targeting inflammation for the treatment of Diabetic Kidney Disease: a five-compartment mechanistic model.

Published in:

2022

By:

Hofherr, Alexis;
Williams, Julie;
Gan, Li-Ming;
Söderberg, Magnus;
Hansen, Pernille B. L.;
Woollard, Kevin J.

Publication type:

journal article

Roxadustat and Oral Iron Absorption in Chinese Patients with Anemia of Chronic Kidney Disease: A Randomized, Open-Label, Phase 4 Study (ALTAI).

Published in:

Advances in Therapy, 2024, v. 41, n. 3, p. 1168, doi. 10.1007/s12325-023-02741-5

By:

Wu, Haiting;
Cheng, Hong;
Wang, Caili;
Yao, Li;
Qin, Shuguang;
Zuo, Li;
Hu, Zhao;
Zhang, Chun;
Wu, Yiqing;
Hofherr, Alexis;
Mohan, Katie;
Rush, Stephen;
Li, Xuemei

Publication type:

Article