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Targeting inflammation for the treatment of Diabetic Kidney Disease: a five-compartment mechanistic model.
Published in:
2022
By:
- Hofherr, Alexis;
- Williams, Julie;
- Gan, Li-Ming;
- Söderberg, Magnus;
- Hansen, Pernille B. L.;
- Woollard, Kevin J.
Publication type:
journal article
Wildtype heterogeneity contributes to clonal variability in genome edited cells.
Published in:
Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-22885-8
By:
- Westermann, Lukas;
- Li, Yong;
- Göcmen, Burulca;
- Niedermoser, Matthias;
- Rhein, Kilian;
- Jahn, Johannes;
- Cascante, Isabel;
- Schöler, Felix;
- Moser, Niklas;
- Neubauer, Björn;
- Hofherr, Alexis;
- Behrens, Yvonne Lisa;
- Göhring, Gudrun;
- Köttgen, Anna;
- Köttgen, Michael;
- Busch, Tilman
Publication type:
Article
The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism.
Published in:
PLoS Biology, 2018, v. 16, n. 8, p. 1, doi. 10.1371/journal.pbio.2005651
By:
- Hofherr, Alexis;
- Seger, Claudia;
- Fitzpatrick, Fiona;
- Busch, Tilman;
- Michel, Elisabeth;
- Luan, Jingting;
- Osterried, Lea;
- Linden, Frieder;
- Kramer-Zucker, Albrecht;
- Wakimoto, Barbara;
- Schütze, Conny;
- Wiedemann, Nils;
- Artati, Anna;
- Adamski, Jerzy;
- Walz, Gerd;
- Kunji, Edmund R. S.;
- Montell, Craig;
- Watnick, Terry;
- Köttgen, Michael
Publication type:
Article
Drosophila Sperm Swim Backwards in the Female Reproductive Tract and Are Activated via TRPP2 Ion Channels.
Published in:
PLoS ONE, 2011, v. 6, n. 5, p. 1, doi. 10.1371/journal.pone.0020031
By:
- Köttgen, Michael;
- Hofherr, Alexis;
- Weizhe Li;
- Chu, Kristy;
- Cook, Stacey;
- Montell, Craig;
- Watnick, Terry
Publication type:
Article
Population pharmacokinetics of a novel PCSK9 antisense oligonucleotide.
Published in:
British Journal of Clinical Pharmacology, 2024, v. 90, n. 6, p. 1503, doi. 10.1111/bcp.16046
By:
- Clewe, Oskar;
- Rekić, Dinko;
- Quartino, Angelica L.;
- Carlsson, Björn;
- Higashimori, Mitsuo;
- Wernevik, Linda;
- Hofherr, Alexis;
- Rydén‐Bergsten, Tina;
- Nilsson, Catarina;
- Knöchel, Jane
Publication type:
Article
Cilia‐localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney.
Published in:
EMBO Journal, 2018, v. 37, n. 15, p. 1, doi. 10.15252/embj.201798615
By:
- Viau, Amandine;
- Bienaimé, Frank;
- Lukas, Kamile;
- Todkar, Abhijeet P.;
- Knoll, Manuel;
- Yakulov, Toma A.;
- Hofherr, Alexis;
- Kretz, Oliver;
- Helmstädter, Martin;
- Reichardt, Wilfried;
- Braeg, Simone;
- Aschman, Tom;
- Merkle, Annette;
- Pfeifer, Dietmar;
- Dumit, Verónica I.;
- Gubler, Marie‐Claire;
- Nitschke, Roland;
- Huber, Tobias B.;
- Terzi, Fabiola;
- Dengjel, Jörn
Publication type:
Article
Efficient genome editing of differentiated renal epithelial cells.
Published in:
Pflügers Archiv: European Journal of Physiology, 2017, v. 469, n. 2, p. 303, doi. 10.1007/s00424-016-1924-4
By:
- Hofherr, Alexis;
- Busch, Tilman;
- Huber, Nora;
- Nold, Andreas;
- Bohn, Albert;
- Viau, Amandine;
- Bienaimé, Frank;
- Kuehn, E. Wolfgang;
- Arnold, Sebastian;
- Köttgen, Michael
Publication type:
Article
A case‐study of model‐informed drug development of a novel PCSK9 anti sense oligonucleotide. Part 1: First time in man to phase II.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 12, p. 1569, doi. 10.1002/psp4.12866
By:
- Knöchel, Jane;
- Nilsson, Catarina;
- Carlsson, Björn;
- Wernevik, Linda;
- Hofherr, Alexis;
- Gennemark, Peter;
- Jansson‐Löfmark, Rasmus;
- Isaksson, Rikard;
- Rydén‐Bergsten, Tina;
- Hamrén, Bengt;
- Rekić, Dinko
Publication type:
Article
Rapid target validation in a Cas9-inducible hiPSC derived kidney model.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-95986-5
By:
- Shamshirgaran, Yasaman;
- Jonebring, Anna;
- Svensson, Anna;
- Leefa, Isabelle;
- Bohlooly-Y, Mohammad;
- Firth, Mike;
- Woollard, Kevin J.;
- Hofherr, Alexis;
- Rogers, Ian M.;
- Hicks, Ryan
Publication type:
Article
Identification of pathological transcription in autosomal dominant polycystic kidney disease epithelia.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-94442-8
By:
- Friedrich, Sebastian;
- Müller, Hannah;
- Riesterer, Caroline;
- Schüller, Hannah;
- Friedrich, Katja;
- Wörner, Carlotta Leonie;
- Busch, Tilman;
- Viau, Amandine;
- Kuehn, E. Wolfgang;
- Köttgen, Michael;
- Hofherr, Alexis
Publication type:
Article
Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicle Production and Trafficking.
Published in:
Biology (2079-7737), 2022, v. 11, n. 5, p. 709, doi. 10.3390/biology11050709
By:
- Kumar, Prashant;
- Zadjali, Fahad;
- Yao, Ying;
- Köttgen, Michael;
- Hofherr, Alexis;
- Gross, Kenneth W.;
- Mehta, Darshan;
- Bissler, John J.
Publication type:
Article
Roxadustat and Oral Iron Absorption in Chinese Patients with Anemia of Chronic Kidney Disease: A Randomized, Open-Label, Phase 4 Study (ALTAI).
Published in:
Advances in Therapy, 2024, v. 41, n. 3, p. 1168, doi. 10.1007/s12325-023-02741-5
By:
- Wu, Haiting;
- Cheng, Hong;
- Wang, Caili;
- Yao, Li;
- Qin, Shuguang;
- Zuo, Li;
- Hu, Zhao;
- Zhang, Chun;
- Wu, Yiqing;
- Hofherr, Alexis;
- Mohan, Katie;
- Rush, Stephen;
- Li, Xuemei
Publication type:
Article
Eomes cannot replace its paralog T-bet during expansion and differentiation of CD8 effector T cells.
Published in:
PLoS Pathogens, 2020, v. 16, n. 9, p. 1, doi. 10.1371/journal.ppat.1008870
By:
- Fixemer, Jonas;
- Hummel, Jonas F.;
- Arnold, Frederic;
- Klose, Christoph S. N.;
- Hofherr, Alexis;
- Weissert, Kristoffer;
- Kögl, Tamara;
- Köttgen, Michael;
- Arnold, Sebastian J.;
- Aichele, Peter;
- Tanriver, Yakup
Publication type:
Article

Found: 13