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Lösung des Problems mangelnder oraler Verfügbarkeit cyclischer Hexapeptide: Entwicklung eines selektiven, oral verfügbaren Liganden für das Integrin αvβ3.
Published in:
Angewandte Chemie, 2017, v. 129, n. 51, p. 16624, doi. 10.1002/ange.201709709
By:
- Weinmüller, Michael;
- Rechenmacher, Florian;
- Kiran Marelli, Udaya;
- Reichart, Florian;
- Kapp, Tobias G.;
- Räder, Andreas F. B.;
- Di Leva, Francesco Saverio;
- Marinelli, Luciana;
- Novellino, Ettore;
- Muñoz‐Félix, José M.;
- Hodivala‐Dilke, Kairbaan;
- Schumacher, Adi;
- Fanous, Joseph;
- Gilon, Chaim;
- Hoffman, Amnon;
- Kessler, Horst
Publication type:
Article
"Splitting the matrix": intussusceptive angiogenesis meets MT1‐MMP.
Published in:
EMBO Molecular Medicine, 2020, v. 12, n. 2, p. N.PAG, doi. 10.15252/emmm.201911663
By:
- D'Amico, Gabriela;
- Muñoz‐Félix, José M;
- Pedrosa, Ana Rita;
- Hodivala‐Dilke, Kairbaan M
Publication type:
Article
Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway.
Published in:
EMBO Molecular Medicine, 2020, v. 12, n. 2, p. N.PAG, doi. 10.15252/emmm.201910491
By:
- Wilcz‐Villega, Ewa;
- Carter, Edward;
- Ironside, Alastair;
- Xu, Ruoyan;
- Mataloni, Isabella;
- Holdsworth, Julie;
- Jones, William;
- Moreno Béjar, Rocío;
- Uhlik, Lukas;
- Bentham, Robert B;
- Godinho, Susana A;
- Dalli, Jesmond;
- Grose, Richard;
- Szabadkai, Gyorgy;
- Jones, Louise;
- Hodivala‐Dilke, Kairbaan;
- Bianchi, Katiuscia
Publication type:
Article
Endothelial FAK is required for tumour angiogenesis.
Published in:
EMBO Molecular Medicine, 2016, v. 8, n. 10, p. 1229, doi. 10.15252/emmm.201606907
By:
- Tavora, Bernardo;
- Batista, Silvia;
- Reynolds, Louise E;
- Jadeja, Shalini;
- Robinson, Stephen;
- Kostourou, Vassiliki;
- Hart, Ian;
- Fruttiger, Marcus;
- Parsons, Maddy;
- Hodivala‐Dilke, Kairbaan M
Publication type:
Article
Endothelial FAK is required for tumour angiogenesis.
Published in:
EMBO Molecular Medicine, 2010, v. 2, n. 12, p. 516, doi. 10.1002/emmm.201000106
By:
- Tavora, Bernardo;
- Batista, Silvia;
- Reynolds, Louise E.;
- Jadeja, Shalini;
- Robinson, Stephen;
- Kostourou, Vassiliki;
- Hart, Ian;
- Fruttiger, Marcus;
- Parsons, Maddy;
- Hodivala-Dilke, Kairbaan M.
Publication type:
Article
Overcoming the Lack of Oral Availability of Cyclic Hexapeptides: Design of a Selective and Orally Available Ligand for the Integrin αvβ3.
Published in:
Angewandte Chemie International Edition, 2017, v. 56, n. 51, p. 16405, doi. 10.1002/anie.201709709
By:
- Weinmüller, Michael;
- Rechenmacher, Florian;
- Kiran Marelli, Udaya;
- Reichart, Florian;
- Kapp, Tobias G.;
- Räder, Andreas F. B.;
- Di Leva, Francesco Saverio;
- Marinelli, Luciana;
- Novellino, Ettore;
- Muñoz‐Félix, José M.;
- Hodivala‐Dilke, Kairbaan;
- Schumacher, Adi;
- Fanous, Joseph;
- Gilon, Chaim;
- Hoffman, Amnon;
- Kessler, Horst
Publication type:
Article
Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins.
Published in:
Nature Medicine, 2002, v. 8, n. 1, p. 27, doi. 10.1038/nm0102-27
By:
- Reynolds, Louise E.;
- Wyder, Lorenza;
- Lively, Julie C.;
- Taverna, Daniela;
- Robinson, Stephen D.;
- Huang, Xiaozhu;
- Sheppard, Dean;
- Hynes, Richard O.;
- Hodivala-Dilke, Kairbaan M.
Publication type:
Article
Elucidating the role of the kinase activity of endothelial cell focal adhesion kinase in angiocrine signalling and tumour growth.
Published in:
Journal of Pathology, 2022, v. 256, n. 2, p. 235, doi. 10.1002/path.5833
By:
- Newport, Emma;
- Pedrosa, Ana Rita;
- Lees, Delphine;
- Dukinfield, Matthew;
- Carter, Edward;
- Gomez‐Escudero, Jesus;
- Casado, Pedro;
- Rajeeve, Vinothini;
- Reynolds, Louise E;
- R Cutillas, Pedro;
- Duffy, Stephen W;
- De Luxán Delgado, Beatriz;
- Hodivala‐Dilke, Kairbaan
Publication type:
Article
Repurposing an anti‐cancer agent for the treatment of hypertrophic heart disease.
Published in:
Journal of Pathology, 2019, v. 249, n. 4, p. 523, doi. 10.1002/path.5340
By:
- Dukinfield, Matthew;
- Maniati, Eleni;
- Reynolds, Louise E;
- Aubdool, Aisah;
- Baliga, Reshma S;
- D'Amico, Gabriela;
- Maiques, Oscar;
- Wang, Jun;
- Bedi, Kenneth C;
- Margulies, Kenneth B;
- Sanz‐Moreno, Victoria;
- Hobbs, Adrian;
- Hodivala‐Dilke, Kairbaan
Publication type:
Article
Focal Adhesion Kinase (FAK) tyrosine 397E mutation restores the vascular leakage defect in endothelium-specific FAK-kinase dead mice.
Published in:
Journal of Pathology, 2017, v. 242, n. 3, p. 358, doi. 10.1002/path.4911
By:
- Alexopoulou, Annika N;
- Lees, Delphine M;
- Bodrug, Natalia;
- Lechertier, Tanguy;
- Fernandez, Isabelle;
- D'Amico, Gabriela;
- Dukinfield, Matthew;
- Batista, Silvia;
- Tavora, Bernardo;
- Serrels, Bryan;
- Hodivala‐Dilke, Kairbaan
Publication type:
Article
alpha3beta1 integrin-controlled Smad7 regulates reepithelialization during wound healing in mice.
Published in:
2008
By:
- Reynolds, Louise E;
- Conti, Francesco J;
- Silva, Rita;
- Robinson, Stephen D;
- Iyer, Vandana;
- Rudling, Rob;
- Cross, Barbara;
- Nye, Emma;
- Hart, Ian R;
- Dipersio, C Michael;
- Hodivala-Dilke, Kairbaan M
Publication type:
journal article
α3β1 integrin--controlled Smad7 regulates reepithelialization during wound healing in mice.
Published in:
Journal of Clinical Investigation, 2008, v. 118, n. 3, p. 965
By:
- Reynolds, Louise E.;
- Conti, Francesco J.;
- Silva, Rita;
- Robinson, Stephen D.;
- Iyer, Vandana;
- Rudling, Rob;
- Cross, Barbara;
- Nye, Emma;
- Hart, Ian R.;
- DiPersio, C. Michael;
- Hodivala-Dilke, Kairbaan M.
Publication type:
Article
Reply to: “Will integrin inhibitors have proangiogenic effects in the clinic?”.
Published in:
2009
By:
- Reynolds, Andrew R.;
- Hodivala-Dilke, Kairbaan M.
Publication type:
Letter
Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors.
Published in:
Nature Medicine, 2009, v. 15, n. 4, p. 392, doi. 10.1038/nm.1941
By:
- Reynolds, Andrew R.;
- Hart, Ian R.;
- Watson, Alan R.;
- Welti, Jonathan C.;
- Silva, Rita G.;
- Robinson, Stephen D.;
- Da Violante, Georges;
- Gourlaouen, Morgane;
- Salih, Mishal;
- Jones, Matt C.;
- Jones, Dylan T.;
- Saunders, Garry;
- Kostourou, Vassiliki;
- Perron-Sierra, Françoise;
- Norman, Jim C.;
- Tucker, Gordon C.;
- Hodivala-Dilke, Kairbaan M.
Publication type:
Article
Focal adhesion kinase and tumour angiogenesis.
Published in:
Journal of Pathology, 2012, v. 226, n. 2, p. 404, doi. 10.1002/path.3018
By:
- Lechertier, Tanguy;
- Hodivala-Dilke, Kairbaan
Publication type:
Article
Deficiency of bone marrow β3-integrin enhances non-functional neovascularization.
Published in:
Journal of Pathology, 2010, v. 220, n. 4, p. 435, doi. 10.1002/path.2660
By:
- Watson, Alan R;
- Pitchford, Simon C;
- Reynolds, Louise E;
- Direkze, Natalie;
- Brittan, Mairi;
- Alison, Malcolm R;
- Rankin, Sara;
- Wright, Nicholas A;
- Hodivala-Dilke, Kairbaan M
Publication type:
Article
Genetic ablation of the alpha 6-integrin subunit in Tie1Cre mice enhances tumour angiogenesis.
Published in:
Journal of Pathology, 2010, v. 220, n. 3, p. 370, doi. 10.1002/path.2654
By:
- Germain, Mitchel;
- De Arcangelis, Adèle;
- Robinson, Stephen D;
- Baker, Marianne;
- Tavora, Bernardo;
- D'Amico, Gabriela;
- Silva, Rita;
- Kostourou, Vassiliki;
- Reynolds, Louise E;
- Watson, Alan;
- Jones, J Louise;
- Georges-Labouesse, Elisabeth;
- Hodivala-Dilke, Kairbaan
Publication type:
Article
Bone marrow contributes to renal parenchymal turnover and regeneration.
Published in:
Journal of Pathology, 2001, v. 195, n. 2, p. 229, doi. 10.1002/path.976
By:
- Poulsom, Richard;
- Forbes, Stuart J.;
- Hodivala-Dilke, Kairbaan;
- Ryan, Eoin;
- Wyles, Susannah;
- Navaratnarasah, Sobana;
- Jeffery, Rosemary;
- Hunt, Toby;
- Alison, Malcolm;
- Cook, Terence;
- Pusey, Charles;
- Wright, Nicholas A.
Publication type:
Article
Author Correction: Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth.
Published in:
2023
By:
- Lechertier, Tanguy;
- Reynolds, Louise E.;
- Kim, Hyojin;
- Pedrosa, Ana Rita;
- Gómez-Escudero, Jesús;
- Muñoz-Félix, José M.;
- Batista, Silvia;
- Dukinfield, Matthew;
- Demircioglu, Fevzi;
- Wong, Ping Pui;
- Matchett, Kylie P.;
- Henderson, Neil C.;
- D'Amico, Gabriela;
- Parsons, Maddy;
- Harwood, Catherine;
- Meier, Pascal;
- Hodivala-Dilke, Kairbaan M.
Publication type:
Correction Notice
Stromal Claudin14-Heterozygosity, but Not Deletion, Increases Tumour Blood Leakage without Affecting Tumour Growth
Published in:
PLoS ONE, 2013, v. 8, n. 5, p. 1, doi. 10.1371/journal.pone.0062516
By:
- Baker, Marianne;
- Reynolds, Louise E.;
- Robinson, Stephen D.;
- Lees, Delphine M.;
- Parsons, Maddy;
- Elia, George;
- Hodivala-Dilke, Kairbaan
Publication type:
Article
Gene Expression Analysis in Human Breast Cancer Associated Blood Vessels.
Published in:
PLoS ONE, 2012, v. 7, n. 10, p. 1, doi. 10.1371/journal.pone.0044294
By:
- Jones, Dylan T.;
- Lechertier, Tanguy;
- Mitter, Richard;
- Herbert, John M. J.;
- Bicknell, Roy;
- Jones, J. Louise;
- Ji-Liang Li;
- Buffa, Francesca;
- Harris, Adrian L.;
- Hodivala-Dilke, Kairbaan
Publication type:
Article
Endothelial-Rac1 Is Not Required for Tumor Angiogenesis unless αvβ3-Integrin Is Absent.
Published in:
PLoS ONE, 2010, v. 5, n. 3, p. 1, doi. 10.1371/journal.pone.0009766
By:
- D'Amico, Gabriela;
- Robinson, Stephen D.;
- Germain, Mitchel;
- Reynolds, Louise E.;
- Thomas, Gareth J.;
- Elia, George;
- Saunders, Garry;
- Fruttiger, Marcus;
- Tybulewicz, Victor;
- Mavria, Georgia;
- Hodivala-Dilke, Kairbaan M.
Publication type:
Article
C-type natriuretic peptide co-ordinates cardiac structure and function.
Published in:
European Heart Journal, 2020, v. 41, n. 9, p. 1006, doi. 10.1093/eurheartj/ehz093
By:
- Moyes, Amie J;
- Chu, Sandy M;
- Aubdool, Aisah A;
- Dukinfield, Matthew S;
- Margulies, Kenneth B;
- Bedi, Kenneth C;
- Hodivala-Dilke, Kairbaan;
- Baliga, Reshma S;
- Hobbs, Adrian J
Publication type:
Article
Single-cell transcriptome analyses reveal novel targets modulating cardiac neovascularization by resident endothelial cells following myocardial infarction.
Published in:
European Heart Journal, 2019, v. 40, n. 30, p. 2507, doi. 10.1093/eurheartj/ehz305
By:
- Li, Ziwen;
- Solomonidis, Emmanouil G;
- Meloni, Marco;
- Taylor, Richard S;
- Duffin, Rodger;
- Dobie, Ross;
- Magalhaes, Marlene S;
- Henderson, Beth E P;
- Louwe, Pieter A;
- D'Amico, Gabriela;
- Hodivala-Dilke, Kairbaan M;
- Shah, Ajay M;
- Mills, Nicholas L;
- Simons, Benjamin D;
- Gray, Gillian A;
- Henderson, Neil C;
- Baker, Andrew H;
- Brittan, Mairi
Publication type:
Article
Improved Immunotherapy Efficacy by Vascular Modulation.
Published in:
Cancers, 2021, v. 13, n. 20, p. 5207, doi. 10.3390/cancers13205207
By:
- Newport, Emma L.;
- Pedrosa, Ana Rita;
- Njegic, Alexandra;
- Hodivala-Dilke, Kairbaan M.;
- Muñoz-Félix, José M.
Publication type:
Article
Abundance of Microvascular Endothelial Cells Is Associated with Response to Chemotherapy and Prognosis in Colorectal Cancer.
Published in:
Cancers, 2021, v. 13, n. 6, p. 1477, doi. 10.3390/cancers13061477
By:
- Oshi, Masanori;
- Huyser, Michelle R.;
- Le, Lan;
- Tokumaru, Yoshihisa;
- Yan, Li;
- Matsuyama, Ryusei;
- Endo, Itaru;
- Takabe, Kazuaki;
- Hodivala-Dilke, Kairbaan;
- Munoz-Felix, Jose M.
Publication type:
Article
Prostaglandin E2 Receptor 4 (EP4) as a Therapeutic Target to Impede Breast Cancer-Associated Angiogenesis and Lymphangiogenesis.
Published in:
Cancers, 2021, v. 13, n. 5, p. 942, doi. 10.3390/cancers13050942
By:
- De Paz Linares, Guillermo Antonio;
- Opperman, Reid Morgan;
- Majumder, Mousumi;
- Lala, Peeyush K.;
- Hodivala-Dilke, Kairbaan;
- Munoz-Felix, Jose M.
Publication type:
Article
Effects of senescence on the tumour microenvironment and response to therapy.
Published in:
FEBS Journal, 2024, v. 291, n. 11, p. 2306, doi. 10.1111/febs.16984
By:
- Reynolds, Louise E.;
- Maallin, Seynab;
- Haston, Scott;
- Martinez‐Barbera, Juan Pedro;
- Hodivala‐Dilke, Kairbaan M.;
- Pedrosa, Ana‐Rita
Publication type:
Article
Haematopoietic focal adhesion kinase deficiency alters haematopoietic homeostasis to drive tumour metastasis.
Published in:
Nature Communications, 2014, v. 5, n. 10, p. 5054, doi. 10.1038/ncomms6054
By:
- Batista, Silvia;
- Maniati, Eleni;
- Reynolds, Louise E.;
- Tavora, Bernardo;
- Lees, Delphine M.;
- Fernandez, Isabelle;
- Elia, George;
- Casanovas, Oriol;
- Celso, Cristina Lo;
- Hagemann, Thorsten;
- Hodivala-Dilke, Kairbaan
Publication type:
Article
FAK-heterozygous mice display enhanced tumour angiogenesis.
Published in:
Nature Communications, 2013, v. 4, n. 6, p. 2020, doi. 10.1038/ncomms3020
By:
- Kostourou, Vassiliki;
- Lechertier, Tanguy;
- Reynolds, Louise E.;
- Lees, Delphine M.;
- Baker, Marianne;
- Jones, Dylan T.;
- Tavora, Bernardo;
- Ramjaun, Antoine R.;
- Birdsey, Graeme M.;
- Robinson, Stephen D.;
- Parsons, Maddy;
- Randi, Anna M.;
- Hart, Ian R.;
- Hodivala-Dilke, Kairbaan
Publication type:
Article
αvβ3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration.
Published in:
Journal of Cell Biology, 2010, v. 189, n. 2, p. 369, doi. 10.1083/jcb.200912014
By:
- Worth, Daniel C.;
- Hodivala-Dilke, Kairbaan;
- Robinson, Stephen D.;
- King, Samantha J.;
- Morton, Penny E.;
- Gertler, Frank B.;
- Humphries, Martin J.;
- Parsons, Maddy
Publication type:
Article
Contribution of ADAMTS1 as a tumor suppressor gene in human breast carcinoma. Linking its tumor inhibitory properties to its proteolytic activity on nidogen-1 and nidogen-2.
Published in:
International Journal of Cancer, 2013, v. 133, n. 10, p. 2315, doi. 10.1002/ijc.28271
By:
- Martino‐Echarri, Estefanía;
- Fernández‐Rodríguez, Rubén;
- Rodríguez‐Baena, Francisco Javier;
- Barrientos‐Durán, Antonio;
- Torres‐Collado, Antoni X.;
- Carmen Plaza‐Calonge, María;
- Amador‐Cubero, Suyapa;
- Cortés, Javier;
- Reynolds, Louise E.;
- Hodivala‐Dilke, Kairbaan M.;
- Rodríguez‐Manzaneque, Juan Carlos
Publication type:
Article
Integrins in angiogenesis: multitalented molecules in a balancing act.
Published in:
Cell & Tissue Research, 2003, v. 314, n. 1, p. 131, doi. 10.1007/s00441-003-0774-5
By:
- Hodivala-Dilke, Kairbaan M.;
- Reynolds, Andrew R.;
- Reynolds, Louise E.
Publication type:
Article
Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy.
Published in:
Nature, 2014, v. 514, n. 7520, p. 112, doi. 10.1038/nature13541
By:
- Tavora, Bernardo;
- Alexopoulou, Annika;
- Hodivala-Dilke, Kairbaan M.;
- Reynolds, Louise E.;
- Batista, Silvia;
- Demircioglu, Fevzi;
- Fernandez, Isabelle;
- Lechertier, Tanguy;
- Lees, Delphine M.;
- Wong, Ping-Pui;
- Elia, George;
- Clear, Andrew;
- Gribben, John G.;
- Ledoux, Adeline;
- Hunter, Jill;
- Perkins, Neil
Publication type:
Article
Association of Low Tumor Endothelial Cell pY397–Focal Adhesion Kinase Expression With Survival in Patients With Neoadjuvant-Treated Locally Advanced Breast Cancer.
Published in:
JAMA Network Open, 2020, v. 3, n. 10, p. e2019304, doi. 10.1001/jamanetworkopen.2020.19304
By:
- Roy-Luzarraga, Marina;
- Abdel-Fatah, Tarek;
- Reynolds, Louise E.;
- Clear, Andrew;
- Taylor, Joseph G.;
- Gribben, John G.;
- Chan, Stephen;
- Jones, Louise;
- Hodivala-Dilke, Kairbaan
Publication type:
Article
Acute, but not constitutive, loss of endothelial β3-integrin inhibits tumour growth and angiogenesis.
Published in:
BMC Proceedings, 2013, v. 7, n. Suppl 2, p. 1, doi. 10.1186/1753-6561-7-S2-O7
By:
- Steri, Veronica;
- Ellison, Tim;
- Weilbaecher, Katherine;
- Hodivala-Dilke, Kairbaan;
- Robinson, Stephen D.
Publication type:
Article
Tumour-associated endothelial-FAK correlated with molecular sub-type and prognostic factors in invasive breast cancer.
Published in:
BMC Cancer, 2014, v. 14, p. 1, doi. 10.1186/1471-2407-14-237
By:
- Alexopoulou, Annika N.;
- Ho-Yen, Colan M.;
- Papalazarou, Vassilis;
- Elia, George;
- Jones, J. Louise;
- Hodivala-Dilke, Kairbaan
Publication type:
Article
Tumour-associated endothelial-FAK correlated with molecular sub-type and prognostic factors in invasive breast cancer.
Published in:
BMC Cancer, 2014, v. 14, n. 1, p. 1, doi. 10.1186/1471-2407-14-237
By:
- Alexopoulou, Annika N.;
- Ho-Yen, Colan M.;
- Papalazarou, Vassilis;
- Elia, George;
- Jones, J. Louise;
- Hodivala-Dilke, Kairbaan
Publication type:
Article
Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16618-6
By:
- Lechertier, Tanguy;
- Reynolds, Louise E.;
- Kim, Hyojin;
- Pedrosa, Ana Rita;
- Gómez-Escudero, Jesús;
- Muñoz-Félix, José M.;
- Batista, Silvia;
- Dukinfield, Matthew;
- Demircioglu, Fevzi;
- Wong, Ping Pui;
- Matchett, Kylie P.;
- Henderson, Neil C.;
- D'Amico, Gabriela;
- Parsons, Maddy;
- Harwood, Catherine;
- Meier, Pascal;
- Hodivala-Dilke, Kairbaan M.
Publication type:
Article
Tumour-associated endothelial-FAK correlated with molecular sub-type and prognostic factors in invasive breast cancer.
Published in:
2014
By:
- Alexopoulou, Annika N;
- Ho-Yen, Colan M;
- Papalazarou, Vassilis;
- Elia, George;
- Jones, J Louise;
- Hodivala-Dilke, Kairbaan
Publication type:
journal article

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