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Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair.
Published in:
eLife, 2018, p. 1, doi. 10.7554/eLife.32692
By:
- Hodel, Karl P.;
- de Borja, Richard;
- Henninger, Erin E.;
- Campbell, Brittany B.;
- Ungerleider, Nathan;
- Light, Nicholas;
- Tong Wu;
- LeCompte, Kimberly G.;
- Goksenin, A. Yasemin;
- Bunnell, Bruce A.;
- Tabori, Uri;
- Shlien, Adam;
- Pursell, Zachary F.
Publication type:
Article
Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.
Published in:
Nature Genetics, 2015, v. 47, n. 3, p. 257, doi. 10.1038/ng.3202
By:
- Shlien, Adam;
- Meier, Bettina;
- Hong, Ye;
- Gartner, Anton;
- Remke, Marc;
- Thakkar, Neha P;
- Pearson, Christopher E;
- Hodel, Karl P;
- Henninger, Erin E;
- Göksenin, A Yasemin;
- Pursell, Zachary F;
- Bakry, Doua;
- Grant, Ronald;
- Nathan, Paul C;
- Alexander, Sarah;
- Charames, George S;
- Druker, Harriet;
- Lerner-Ellis, Jordan;
- Dvir, Rina;
- Elhasid, Ronit
Publication type:
Article
Mouse model and human patient data reveal critical roles for Pten and p53 in suppressing POLE mutant tumor development.
Published in:
NAR Cancer, 2022, v. 4, n. 1, p. 1, doi. 10.1093/narcan/zcac004
By:
- Park, Vivian S.;
- Sun, Meijuan J. S.;
- Frey, Wesley D.;
- Williams, Leonard G.;
- Hodel, Karl P.;
- Strauss, Juliet D.;
- Wellens, Sydney J.;
- Jackson, James G.;
- Pursell, Zachary F.
Publication type:
Article

Found: 3

Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair.

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.

Mouse model and human patient data reveal critical roles for Pten and p53 in suppressing POLE mutant tumor development.