Works by Hocek, Michal

Results: 98

Synthesis of 2‐Substituted Adenosine Triphosphate Derivatives and their use in Enzymatic Synthesis and Postsynthetic Labelling of RNA.

Published in:

ChemBioChem, 2025, v. 26, n. 12, p. 1, doi. 10.1002/cbic.202500241

By:

Šinkevičiūtė, Ugnė;
Sanchez‐Quirante, Tania;
Rožánková, Samanta;
Poštová Slavětínská, Lenka;
Raindlová, Veronika;
Hocek, Michal

Publication type:

Article

Polymerase Synthesis of Hypermodified DNA Displaying a Combination of Thiol, Hydroxyl, Carboxylate, and Imidazole Functional Groups in the Major Groove.

Published in:

Chemistry - A European Journal, 2025, v. 31, n. 34, p. 1, doi. 10.1002/chem.202501034

By:

Kaiser, Lukáš;
Ondruš, Marek;
Poštová Slavětínská, Lenka;
Raindlová, Veronika;
Hocek, Michal

Publication type:

Article

Polymerase Synthesis of DNA Containing Iodinated Pyrimidine or 7‐Deazapurine Nucleobases and Their Post‐synthetic Modifications through the Suzuki‐Miyaura Cross‐Coupling Reactions.

Published in:

ChemBioChem, 2022, v. 23, n. 3, p. 1, doi. 10.1002/cbic.202100608

By:

Sýkorová, Veronika;
Tichý, Michal;
Hocek, Michal

Publication type:

Article

Oxidative DNA Cleavage with Clip‐Phenanthroline Triplex‐Forming Oligonucleotide Hybrids.

Published in:

ChemBioChem, 2020, v. 21, n. 7, p. 991, doi. 10.1002/cbic.201900670

By:

Panattoni, Alessandro;
El‐Sagheer, Afaf H.;
Brown, Tom;
Kellett, Andrew;
Hocek, Michal

Publication type:

Article

Vicinal Diol‐Tethered Nucleobases as Targets for DNA Redox Labeling with Osmate Complexes.

Published in:

ChemBioChem, 2020, v. 21, n. 1/2, p. 171, doi. 10.1002/cbic.201900388

By:

Havranová‐Vidláková, Pavlína;
Krömer, Matouš;
Sýkorová, Veronika;
Trefulka, Mojmír;
Fojta, Miroslav;
Havran, Luděk;
Hocek, Michal

Publication type:

Article

Polymerase Synthesis and Restriction Enzyme Cleavage of DNA Containing 7-Substituted 7-Deazaguanine Nucleobases.

Published in:

ChemBioChem, 2015, v. 16, n. 15, p. 2225, doi. 10.1002/cbic.201500315

By:

Mačková, Michaela;
Boháčová, Soňa;
Perlíková, Pavla;
Poštová Slavětínská, Lenka;
Hocek, Michal

Publication type:

Article

Polymerase Synthesis of DNAs Bearing Vinyl Groups in the Major Groove and their Cleavage by Restriction Endonucleases.

Published in:

ChemBioChem, 2014, v. 15, n. 15, p. 2306, doi. 10.1002/cbic.201402319

By:

Mačková, Michaela;
Pohl, Radek;
Hocek, Michal

Publication type:

Article

Transient and Switchable (Triethylsilyl)ethynyl Protection of DNA against Cleavage by Restriction Endonucleases.

Published in:

Angewandte Chemie, 2011, v. 123, n. 37, p. 8886, doi. 10.1002/ange.201102898

By:

Kielkowski, Pavel;
Macíčková-Cahová, Hana;
Pohl, Radek;
Hocek, Michal

Publication type:

Article

Direct Polymerase Synthesis of Reactive Aldehyde-Functionalized DNA and Its Conjugation and Staining with Hydrazines.

Published in:

Angewandte Chemie, 2010, v. 122, n. 6, p. 1082, doi. 10.1002/ange.200905556

By:

Raindlová, Veronika;
Pohl, Radek;
Šanda, Miloslav;
Hocek, Michal

Publication type:

Article

Purines Bearing Phenanthroline or Bipyridine Ligands and Their RuII Complexes in Position 8 as Model Compounds for Electrochemical DNA Labelin – Synthesis, Crystal Structure, Electrochemistry, Quantum Chemical Calculations, Cytostatic and Antiviral Activity

Published in:

European Journal of Inorganic Chemistry, 2007, v. 2007, n. 12, p. 1752

By:

Milan Vrábel;
Michal Hocek;
Luděk Havran;
Miroslav Fojta;
Ivan Votruba;
Blanka Klepetářová;
Radek Pohl;
Lubomír Rulíšek;
Lucie Zendlová;
Pavel Hobza;
I-hung Shih;
Eric Mabery;
Richard Mackman

Publication type:

Article

ABNOH‐Linked Nucleotides and DNA for Bioconjugation and Cross‐linking with Tryptophan‐Containing Peptides and Proteins.

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 49, p. 1, doi. 10.1002/chem.202402151

By:

Spampinato, Ambra;
Leone, Denise‐Liu';
Pohl, Radek;
Tarábek, Ján;
Šoltysová, Markéta;
Polák, Marek;
Kádek, Alan;
Sýkorová, Veronika;
Řezáčová, Pavlína;
Hocek, Michal

Publication type:

Article

Glyco‐DNA: Enzymatic Synthesis of Base‐Modified and Hypermodified DNA Displaying up to Four Different Monosaccharide Units in the Major Groove.

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 48, p. 1, doi. 10.1002/chem.202402318

By:

Krömer, Matouš;
Poštová Slavětínská, Lenka;
Hocek, Michal

Publication type:

Article

Glucosylated 5‐Hydroxymethylpyrimidines as Epigenetic DNA Bases Regulating Transcription and Restriction Cleavage.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 31, p. 1, doi. 10.1002/chem.202200911

By:

Chakrapani, Aswathi;
Ruiz‐Larrabeiti, Olatz;
Pohl, Radek;
Svoboda, Martin;
Krásný, Libor;
Hocek, Michal

Publication type:

Article

Glyoxal‐Linked Nucleotides and DNA for Bioconjugations and Crosslinking with Arginine‐Containing Peptides and Proteins.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 14, p. 1, doi. 10.1002/chem.202104208

By:

Leone, Denise‐Liu';
Pohl, Radek;
Hubálek, Martin;
Kadeřábková, Marta;
Krömer, Matouš;
Sýkorová, Veronika;
Hocek, Michal

Publication type:

Article

Acetophenyl‐thienyl‐aniline‐Linked Nucleotide for Construction of Solvatochromic Fluorescence Light‐Up DNA Probes Sensing Protein‐DNA Interactions.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 24, p. 7090, doi. 10.1002/chem.202100575

By:

Güixens‐Gallardo, Pedro;
Hocek, Michal

Publication type:

Article

Real‐time Imaging of Nascent DNA in Live Cells by Monitoring the Fluorescence Lifetime of DNA‐Incorporated Thiazole Orange‐Modified Nucleotides.

Published in:

Angewandte Chemie, 2023, v. 135, n. 38, p. 1, doi. 10.1002/ange.202307548

By:

Kuba, Miroslav;
Khoroshyy, Petro;
Lepšík, Martin;
Kužmová, Erika;
Kodr, David;
Kraus, Tomáš;
Hocek, Michal

Publication type:

Article

Chloroacetamide‐Modified Nucleotide and RNA for Bioconjugations and Cross‐Linking with RNA‐Binding Proteins.

Published in:

Angewandte Chemie, 2023, v. 135, n. 7, p. 1, doi. 10.1002/ange.202213764

By:

Brunderová, Mária;
Krömer, Matouš;
Vlková, Marta;
Hocek, Michal

Publication type:

Article

1,3‐Diketone‐Modified Nucleotides and DNA for Cross‐Linking with Arginine‐Containing Peptides and Proteins.

Published in:

Angewandte Chemie, 2021, v. 133, n. 32, p. 17523, doi. 10.1002/ange.202105126

By:

Leone, Denise‐Liu';
Hubálek, Martin;
Pohl, Radek;
Sýkorová, Veronika;
Hocek, Michal

Publication type:

Article

Squaramate‐Modified Nucleotides and DNA for Specific Cross‐Linking with Lysine‐Containing Peptides and Proteins.

Published in:

Angewandte Chemie, 2019, v. 131, n. 38, p. 13479, doi. 10.1002/ange.201906737

By:

Ivancová, Ivana;
Pohl, Radek;
Hubálek, Martin;
Hocek, Michal

Publication type:

Article

Cleavage of adenine-modified functionalized DNA by type II restriction endonucleases.

Published in:

Nucleic Acids Research, 2009, v. 37, n. 22, p. 7612

By:

Macíčková-Cahová, Hana;
Hocek, Michal

Publication type:

Article

Thienopyrrolo[2, 3‐d]pyrimidines, New Tricyclic Nucleobase Analogues: Synthesis and Biological Activities.

Published in:

ChemistrySelect, 2018, v. 3, n. 31, p. 9144, doi. 10.1002/slct.201802190

By:

Tichý, Michal;
Smoleń, Sabina;
Deingruber, Tomáš;
Džubák, Petr;
Pohl, Radek;
Slavětínská, Lenka Poštová;
Hajdúch, Marián;
Hocek, Michal

Publication type:

Article

Transient and Switchable (Triethylsilyl)ethynyl Protection of DNA against Cleavage by Restriction Endonucleases.

Published in:

Angewandte Chemie International Edition, 2011, v. 50, n. 37, p. 8727, doi. 10.1002/anie.201102898

By:

Kielkowski, Pavel;
Macíčková-Cahová, Hana;
Pohl, Radek;
Hocek, Michal

Publication type:

Article

Direct Polymerase Synthesis of Reactive Aldehyde-Functionalized DNA and Its Conjugation and Staining with Hydrazines.

Published in:

Angewandte Chemie International Edition, 2010, v. 49, n. 6, p. 1064, doi. 10.1002/anie.200905556

By:

Raindlová, Veronika;
Pohl, Radek;
Šanda, Miloslav;
Hocek, Michal

Publication type:

Article

Aminophenyl- and Nitrophenyl-Labeled Nucleoside Triphosphates: Synthesis, Enzymatic Incorporation, and Electrochemical Detection.

Published in:

Angewandte Chemie International Edition, 2008, v. 47, n. 11, p. 2059, doi. 10.1002/anie.200705088

By:

Cahová, Hana;
Havran, Luděk;
Brázdilová, Petra;
Pivoňková, Hana;
Pohl, Radek;
Fojta, Miroslav;
Hocek, Michal

Publication type:

Article

Covalent Analogues of Nucleobase-Pairs.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2003, v. 22, n. 5-8, p. 775, doi. 10.1081/NCN-120022632

By:

Hocek, Michal;
Dvořák, Dalimil;
Havelková, Martina

Publication type:

Article

Cover Feature: Institute Feature: IOCB Prague (Eur. J. Org. Chem. 37/2018).

Published in:

European Journal of Organic Chemistry, 2018, v. 2018, n. 37, p. 5075, doi. 10.1002/ejoc.201801330

By:

Hocek, Michal;
Hostomský, Zdeněk

Publication type:

Article

Front Cover: Institute Feature: IOCB Prague (Eur. J. Org. Chem. 37/2018).

Published in:

European Journal of Organic Chemistry, 2018, v. 2018, n. 37, p. 5074, doi. 10.1002/ejoc.201801329

By:

Hocek, Michal;
Hostomský, Zdeněk

Publication type:

Article

Isomeric Naphtho‐Fused 7‐Deazapurine Nucleosides and Nucleotides: Synthesis, Biological Activity, Photophysical Properties and Enzymatic Incorporation to Nucleic Acids.

Published in:

European Journal of Organic Chemistry, 2018, v. 2018, n. 37, p. 5092, doi. 10.1002/ejoc.201800165

By:

Ghosh, Ketaki;
Perlíková, Pavla;
Havlíček, Vojtěch;
Yang, Chao;
Pohl, Radek;
Tloušťová, Eva;
Hodek, Jan;
Gurská, Soňa;
Džubák, Petr;
Hajdúch, Marián;
Hocek, Michal

Publication type:

Article

Modification of Pyrrolo[2,3- d]pyrimidines by C-H Borylation Followed by Cross-Coupling or Other Transformations: Synthesis of 6,8-Disubstituted 7-Deazapurine Bases.

Published in:

European Journal of Organic Chemistry, 2015, v. 2015, n. 36, p. 7943, doi. 10.1002/ejoc.201501177

By:

Klečka, Martin;
Poštová Slavětínská, Lenka;
Hocek, Michal

Publication type:

Article

Synthesis of Benzene and Pyridine 2′- C-Methyl- C-ribonucleosides and -nucleotides.

Published in:

European Journal of Organic Chemistry, 2015, v. 2015, n. 36, p. 7962, doi. 10.1002/ejoc.201501219

By:

Tokarenko, Anna;
Poštová Slavětínská, Lenka;
Klepetářová, Blanka;
Hocek, Michal

Publication type:

Article

Chemoselective Synthesis of 4,5-Diarylpyrrolo[2,3- d]pyrimidines (6,7-Diaryl-7-deazapurines) by Consecutive Suzuki and Liebeskind-Srogl Cross-Couplings.

Published in:

European Journal of Organic Chemistry, 2014, v. 2014, n. 32, p. 7203, doi. 10.1002/ejoc.201402882

By:

Krömer, Matouš;
Klečka, Martin;
Slavětínská, Lenka;
Klepetářová, Blanka;
Hocek, Michal

Publication type:

Article

Synthesis of Substituted Benzyl Homo- C-Ribonucleosides and -Nucleotides as Carba Analogues of Phosphoribosylanthranilate.

Published in:

European Journal of Organic Chemistry, 2012, v. 2012, n. 26, p. 4969, doi. 10.1002/ejoc.201200819

By:

Kubelka, Tomáš;
Slavětínská, Lenka;
Hocek, Michal

Publication type:

Article

Synthesis of 6-Substituted 2(1 H)-Pyridon-3-yl C-2′-Deoxyribonucleosides.

Published in:

European Journal of Organic Chemistry, 2012, v. 2012, n. 9, p. 1759, doi. 10.1002/ejoc.201101662

By:

Chapuis, Hubert;
Kubelka, Tomáš;
Joubert, Nicolas;
Pohl, Radek;
Hocek, Michal

Publication type:

Article

Real‐time Imaging of Nascent DNA in Live Cells by Monitoring the Fluorescence Lifetime of DNA‐Incorporated Thiazole Orange‐Modified Nucleotides.

Published in:

Angewandte Chemie International Edition, 2023, v. 62, n. 38, p. 1, doi. 10.1002/anie.202307548

By:

Kuba, Miroslav;
Khoroshyy, Petro;
Lepšík, Martin;
Kužmová, Erika;
Kodr, David;
Kraus, Tomáš;
Hocek, Michal

Publication type:

Article

Chloroacetamide‐Modified Nucleotide and RNA for Bioconjugations and Cross‐Linking with RNA‐Binding Proteins.

Published in:

Angewandte Chemie International Edition, 2023, v. 62, n. 7, p. 1, doi. 10.1002/anie.202213764

By:

Brunderová, Mária;
Krömer, Matouš;
Vlková, Marta;
Hocek, Michal

Publication type:

Article

1,3‐Diketone‐Modified Nucleotides and DNA for Cross‐Linking with Arginine‐Containing Peptides and Proteins.

Published in:

Angewandte Chemie International Edition, 2021, v. 60, n. 32, p. 17383, doi. 10.1002/anie.202105126

By:

Leone, Denise‐Liu';
Hubálek, Martin;
Pohl, Radek;
Sýkorová, Veronika;
Hocek, Michal

Publication type:

Article

Squaramate‐Modified Nucleotides and DNA for Specific Cross‐Linking with Lysine‐Containing Peptides and Proteins.

Published in:

Angewandte Chemie International Edition, 2019, v. 58, n. 38, p. 13345, doi. 10.1002/anie.201906737

By:

Ivancová, Ivana;
Pohl, Radek;
Hubálek, Martin;
Hocek, Michal

Publication type:

Article

The selection of a hydrophobic 7-phenylbutyl-7-deazaadenine-modified DNA aptamer with high binding affinity for the Heat Shock Protein 70.

Published in:

Communications Chemistry, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42004-023-00862-0

By:

Mulholland, Catherine;
Jestřábová, Ivana;
Sett, Arghya;
Ondruš, Marek;
Sýkorová, Veronika;
Manzanares, C. Lorena;
Šimončík, Oliver;
Muller, Petr;
Hocek, Michal

Publication type:

Article

Addendum: Expedient production of site specifically nucleobase-labelled or hypermodified RNA with engineered thermophilic DNA polymerases.

Published in:

2024

By:

Brunderová, Mária;
Havlíček, Vojtěch;
Matyašovský, Ján;
Pohl, Radek;
Poštová Slavětínská, Lenka;
Krömer, Matouš;
Hocek, Michal

Publication type:

Correction Notice

Expedient production of site specifically nucleobase-labelled or hypermodified RNA with engineered thermophilic DNA polymerases.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-47444-9

By:

Brunderová, Mária;
Havlíček, Vojtěch;
Matyašovský, Ján;
Pohl, Radek;
Poštová Slavětínská, Lenka;
Krömer, Matouš;
Hocek, Michal

Publication type:

Article

Synthesis and Cytotoxic and Antiviral Activity Profiling of All‐Four Isomeric Series of Pyrido‐Fused 7‐Deazapurine Ribonucleosides.

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 57, p. 13002, doi. 10.1002/chem.202001124

By:

Veselovská, Lucia;
Kudlová, Natálie;
Gurská, Soňa;
Lišková, Barbora;
Medvedíková, Martina;
Hodek, Ondřej;
Tloušťová, Eva;
Milisavljevic, Nemanja;
Tichý, Michal;
Perlíková, Pavla;
Mertlíková‐Kaiserová, Helena;
Trylčová, Jana;
Pohl, Radek;
Klepetářová, Blanka;
Džubák, Petr;
Hajdúch, Marián;
Hocek, Michal

Publication type:

Article

Cover Feature: Nucleotide‐Bearing Benzylidene‐Tetrahydroxanthylium Near‐IR Fluorophore for Sensing DNA Replication, Secondary Structures and Interactions (Chem. Eur. J. 52/2020).

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 52, p. 11911, doi. 10.1002/chem.202003781

By:

Kuba, Miroslav;
Kraus, Tomáš;
Pohl, Radek;
Hocek, Michal

Publication type:

Article

Nucleotide‐Bearing Benzylidene‐Tetrahydroxanthylium Near‐IR Fluorophore for Sensing DNA Replication, Secondary Structures and Interactions.

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 52, p. 11950, doi. 10.1002/chem.202003192

By:

Kuba, Miroslav;
Kraus, Tomáš;
Pohl, Radek;
Hocek, Michal

Publication type:

Article

Cover Feature: Tuning of Oxidation Potential of Ferrocene for Ratiometric Redox Labeling and Coding of Nucleotides and DNA (Chem. Eur. J. 6/2020).

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 6, p. 1162, doi. 10.1002/chem.201905443

By:

Simonova, Anna;
Magriñá, Ivan;
Sýkorová, Veronika;
Pohl, Radek;
Ortiz, Mayreli;
Havran, Luděk;
Fojta, Miroslav;
O'Sullivan, Ciara K.;
Hocek, Michal

Publication type:

Article

Tuning of Oxidation Potential of Ferrocene for Ratiometric Redox Labeling and Coding of Nucleotides and DNA.

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 6, p. 1286, doi. 10.1002/chem.201904700

By:

Simonova, Anna;
Magriñá, Ivan;
Sýkorová, Veronika;
Pohl, Radek;
Ortiz, Mayreli;
Havran, Luděk;
Fojta, Miroslav;
O'Sullivan, Ciara K.;
Hocek, Michal

Publication type:

Article

2‐Allyl‐ and Propargylamino‐dATPs for Site‐Specific Enzymatic Introduction of a Single Modification in the Minor Groove of DNA.

Published in:

Chemistry - A European Journal, 2018, v. 24, n. 56, p. 14938, doi. 10.1002/chem.201803973

By:

Matyašovský, Ján;
Pohl, Radek;
Hocek, Michal

Publication type:

Article

Cover Feature: Synthesis of Dihydroxyalkynyl and Dihydroxyalkyl Nucleotides as Building Blocks or Precursors for Introduction of Diol or Aldehyde Groups to DNA for Bioconjugations (Chem. Eur. J. 46/2018).

Published in:

Chemistry - A European Journal, 2018, v. 24, n. 46, p. 11804, doi. 10.1002/chem.201803253

By:

Krömer, Matouš;
Bártová, Kateřina;
Raindlová, Veronika;
Hocek, Michal

Publication type:

Article

Synthesis of Dihydroxyalkynyl and Dihydroxyalkyl Nucleotides as Building Blocks or Precursors for Introduction of Diol or Aldehyde Groups to DNA for Bioconjugations.

Published in:

Chemistry - A European Journal, 2018, v. 24, n. 46, p. 11890, doi. 10.1002/chem.201802282

By:

Krömer, Matouš;
Bártová, Kateřina;
Raindlová, Veronika;
Hocek, Michal

Publication type:

Article

Turning Off Transcription with Bacterial RNA Polymerase through CuAAC Click Reactions of DNA Containing 5‐Ethynyluracil.

Published in:

Chemistry - A European Journal, 2018, v. 24, n. 33, p. 8311, doi. 10.1002/chem.201801757

By:

Slavíčková, Michaela;
Janoušková, Martina;
Šimonová, Anna;
Cahová, Hana;
Kambová, Milada;
Šanderová, Hana;
Krásný, Libor;
Hocek, Michal

Publication type:

Article

Synthesis of Nucleosides through Direct Glycosylation of Nucleobases with 5- O-Monoprotected or 5-Modified Ribose: Improved Protocol, Scope, and Mechanism.

Published in:

Chemistry - A European Journal, 2017, v. 23, n. 16, p. 3910, doi. 10.1002/chem.201604955

By:

Downey, A. Michael;
Pohl, Radek;
Roithová, Jana;
Hocek, Michal

Publication type:

Article