Works by Hiroyuki Inuzuka

Results: 42

Expression of milk protein genes is induced directly by exogenous STAT5 without prolactin-mediated signal transduction in transgenic mice.

Published in:

Molecular Reproduction & Development, 1999, v. 54, n. 2, p. 121, doi. 10.1002/(SICI)1098-2795(199910)54:2<121::AID-MRD3>3.0.CO;2-T

By:

Inuzuka, Hiroyuki;
Yamanouchi, Keitaro;
Tachi, Chikashi;
Tojo, Hideaki

Publication type:

Article

SCFβ-TRCP E3 ubiquitin ligase targets the tumor suppressor ZNRF3 for ubiquitination and degradation.

Published in:

Protein & Cell, 2018, v. 9, n. 10, p. 879, doi. 10.1007/s13238-018-0510-2

By:

Ci, Yanpeng;
Li, Xiaoning;
Chen, Maorong;
Zhong, Jiateng;
North, Brian J.;
Inuzuka, Hiroyuki;
He, Xi;
Li, Yu;
Guo, Jianping;
Dai, Xiangpeng

Publication type:

Article

SCFβ‐TrCP ubiquitinates CHK1 in an AMPK‐dependent manner in response to glucose deprivation.

Published in:

Molecular Oncology, 2019, v. 13, n. 2, p. 307, doi. 10.1002/1878-0261.12403

By:

Ma, Ying;
Cui, Danrui;
Xiong, Xiufang;
Inuzuka, Hiroyuki;
Wei, Wenyi;
Sun, Yi;
North, Brian J.;
Zhao, Yongchao

Publication type:

Article

Phosphorylation‐dependent osterix degradation negatively regulates osteoblast differentiation.

Published in:

FASEB Journal, 2020, v. 34, n. 11, p. 14930, doi. 10.1096/fj.202001340R

By:

Hoshikawa, Seira;
Shimizu, Kouhei;
Watahiki, Asami;
Chiba, Mitsuki;
Saito, Kan;
Wei, Wenyi;
Fukumoto, Satoshi;
Inuzuka, Hiroyuki

Publication type:

Article

Azacalix[3]triazines: A Substructure of Triazine‐Based Graphitic Carbon Nitride Featuring Anion‐π Interactions.

Published in:

Angewandte Chemie, 2021, v. 133, n. 30, p. 16513, doi. 10.1002/ange.202104467

By:

Gong, Hao;
Zhang, Cheng;
Ogaki, Takuya;
Inuzuka, Hiroyuki;
Hashizume, Daisuke;
Miyajima, Daigo

Publication type:

Article

A Design Principle for Polar Assemblies with C3‐Sym Bowl‐Shaped π‐Conjugated Molecules.

Published in:

Angewandte Chemie, 2021, v. 133, n. 6, p. 3298, doi. 10.1002/ange.202013333

By:

Zhang, Cheng;
Guo, Yuan;
He, Dan;
Komiya, Jouji;
Watanabe, Go;
Ogaki, Takuya;
Wang, Chengyuan;
Nihonyanagi, Atsuko;
Inuzuka, Hiroyuki;
Gong, Hao;
Yi, Yuanping;
Takimiya, Kazuo;
Hashizume, Daisuke;
Miyajima, Daigo

Publication type:

Article

PROTAC technology for prostate cancer treatment.

Published in:

Acta Materia Medica, 2025, v. 4, n. 1, p. 99, doi. 10.15212/AMM-2024-0075

By:

Wang, Zhen;
Zhang, Dingpeng;
Inuzuka, Hiroyuki;
Wei, Wenyi

Publication type:

Article

Acetylation-dependent regulation of essential iPS-inducing factors: a regulatory crossroad for pluripotency and tumorigenesis.

Published in:

Cancer Medicine, 2014, v. 3, n. 5, p. 1211, doi. 10.1002/cam4.298

By:

Dai, Xiangpeng;
Liu, Pengda;
Lau, Alan W.;
Liu, Yueyong;
Inuzuka, Hiroyuki

Publication type:

Article

Inhibition of CK1ε potentiates the therapeutic efficacy of CDK4/6 inhibitor in breast cancer.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25700-6

By:

Dang, Fabin;
Nie, Li;
Zhou, Jin;
Shimizu, Kouhei;
Chu, Chen;
Wu, Zhong;
Fassl, Anne;
Ke, Shizhong;
Wang, Yuangao;
Zhang, Jinfang;
Zhang, Tao;
Tu, Zhenbo;
Inuzuka, Hiroyuki;
Sicinski, Piotr;
Bass, Adam J.;
Wei, Wenyi

Publication type:

Article

HHIP protein interactions in lung cells provide insight into COPD pathogenesis.

Published in:

Human Molecular Genetics, 2025, v. 34, n. 9, p. 777, doi. 10.1093/hmg/ddaf016

By:

Deritei, Dávid;
Inuzuka, Hiroyuki;
Castaldi, Peter J;
Yun, Jeong Hyun;
Xu, Zhonghui;
Anamika, Wardatul Jannat;
Asara, John M;
Guo, Feng;
Zhou, Xiaobo;
Glass, Kimberly;
Wei, Wenyi;
Silverman, Edwin K

Publication type:

Article

Deficiency of Lipin2 Results in Enhanced NF-κB Signaling and Osteoclast Formation in RAW-D Murine Macrophages.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 6, p. 2893, doi. 10.3390/ijms22062893

By:

Watahiki, Asami;
Hoshikawa, Seira;
Chiba, Mitsuki;
Egusa, Hiroshi;
Fukumoto, Satoshi;
Inuzuka, Hiroyuki;
Knethen, Andreas von;
Kubiak, Jacek Z.

Publication type:

Article

Azacalix[3]triazines: A Substructure of Triazine‐Based Graphitic Carbon Nitride Featuring Anion‐π Interactions.

Published in:

Angewandte Chemie International Edition, 2021, v. 60, n. 30, p. 16377, doi. 10.1002/anie.202104467

By:

Gong, Hao;
Zhang, Cheng;
Ogaki, Takuya;
Inuzuka, Hiroyuki;
Hashizume, Daisuke;
Miyajima, Daigo

Publication type:

Article

A Design Principle for Polar Assemblies with C3‐Sym Bowl‐Shaped π‐Conjugated Molecules.

Published in:

Angewandte Chemie International Edition, 2021, v. 60, n. 6, p. 3261, doi. 10.1002/anie.202013333

By:

Zhang, Cheng;
Guo, Yuan;
He, Dan;
Komiya, Jouji;
Watanabe, Go;
Ogaki, Takuya;
Wang, Chengyuan;
Nihonyanagi, Atsuko;
Inuzuka, Hiroyuki;
Gong, Hao;
Yi, Yuanping;
Takimiya, Kazuo;
Hashizume, Daisuke;
Miyajima, Daigo

Publication type:

Article

Tailoring One‐Dimensional Assemblies of Chiral Bowl‐Shaped Molecules with Diverse Enantiomers and Polar Column Alignments.

Published in:

Angewandte Chemie, 2025, v. 137, n. 20, p. 1, doi. 10.1002/ange.202424162

By:

He, Dan;
Dhara, Barun;
Zhang, Cheng;
Nihonyanagi, Atsuko;
Inuzuka, Hiroyuki;
Hara, Eiju;
Sato, Shunsuke;
Adachi, Kiyohiro;
Watanabe, Go;
Hashizume, Daisuke;
Okuro, Kou;
Miyajima, Daigo

Publication type:

Article

The First‐In‐Class Deubiquitinase‐Targeting Chimera Stabilizes and Activates cGAS.

Published in:

Angewandte Chemie, 2025, v. 137, n. 3, p. 1, doi. 10.1002/ange.202415168

By:

Deng, Zhijie;
Chen, Li;
Qian, Chao;
Liu, Jing;
Wu, Qiong;
Song, Xiangyang;
Xiong, Yan;
Wang, Zhen;
Hu, Xiaoping;
Inuzuka, Hiroyuki;
Zhong, Yue;
Xiang, Yufei;
Lin, Yindan;
Dung Pham, Ngoc;
Shi, Yi;
Wei, Wenyi;
Jin, Jian

Publication type:

Article

The two faces of FBW7 in cancer drug resistance.

Published in:

BioEssays, 2011, v. 33, n. 11, p. 851, doi. 10.1002/bies.201100101

By:

Wang, Zhiwei;
Fukushima, Hidefumi;
Gao, Daming;
Inuzuka, Hiroyuki;
Wan, Lixin;
Lau, Alan W.;
Liu, Pengda;
Wei, Wenyi

Publication type:

Article

Tumor suppressor functions of FBW7 in cancer development and progression

Published in:

FEBS Letters, 2012, v. 586, n. 10, p. 1409, doi. 10.1016/j.febslet.2012.03.017

By:

Wang, Zhiwei;
Inuzuka, Hiroyuki;
Zhong, Jiateng;
Wan, Lixin;
Fukushima, Hidefumi;
Sarkar, Fazlul H.;
Wei, Wenyi

Publication type:

Article

Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells

Published in:

FEBS Letters, 2003, v. 550, n. 1-3, p. 57, doi. 10.1016/S0014-5793(03)00817-2

By:

Ishikawa, Yumi;
Tokumitsu, Hiroshi;
Inuzuka, Hiroyuki;
Murata-Hori, Maki;
Hosoya, Hiroshi;
Kobayashi, Ryoji

Publication type:

Article

DNA Damage Regulates UHRF1 Stability via the SCFβ-TrCP E3 Ligase.

Published in:

Molecular & Cellular Biology, 2013, v. 33, n. 6, p. 1139, doi. 10.1128/MCB.01191-12

By:

Hao Chen;
Honghui Ma;
Inuzuka, Hiroyuki;
Jianbo Diao;
Fei Lan;
Yujiang Geno Shi;
Wenyi Wei;
Yang Shi

Publication type:

Article

Targeting the PARylation-Dependent Ubiquitination Signaling Pathway for Cancer Therapies.

Published in:

2025

By:

Huang, Daoyuan;
Wang, Jingchao;
Chen, Li;
Jiang, Weiwei;
Inuzuka, Hiroyuki;
Simon, David K.;
Wei, Wenyi

Publication type:

Literature Review

SCFβ-TRCP promotes cell growth by targeting PR-Set7/Set8 for degradation.

Published in:

Nature Communications, 2015, v. 6, n. 12, p. 10185, doi. 10.1038/ncomms10185

By:

Wang, Zhiwei;
Dai, Xiangpeng;
Zhong, Jiateng;
Inuzuka, Hiroyuki;
Wan, Lixin;
Li, Xiaoning;
Wang, Lixia;
Ye, Xiantao;
Sun, Liankun;
Gao, Daming;
Zou, Lee;
Wei, Wenyi

Publication type:

Article

Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets.

Published in:

Oncogene, 2003, v. 22, n. 35, p. 5525, doi. 10.1038/sj.onc.1206853

By:

Ohira, Miki;
Morohashi, Aiko;
Inuzuka, Hiroyuki;
Shishikura, Tomotane;
Kawamoto, Takemasa;
Kageyama, Hajime;
Nakamura, Yohko;
Isogai, Eriko;
Takayasu, Hajime;
Sakiyama, Shigeru;
Suzuki, Yutaka;
Sugano, Sumio;
Goto, Takeshi;
Sato, Shuji;
Nakagawara, Akira

Publication type:

Article

SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage.

Published in:

Nucleic Acids Research, 2016, v. 44, n. 18, p. 8855, doi. 10.1093/nar/gkw748

By:

Xuehui Hong;
Wenyu Liu1;
Ruipeng Song;
Shah, Jamie J.;
Xing Feng;
Chi Kwan Tsang;
Morgan, Katherine M.;
Bunting, Samuel F.;
Hiroyuki Inuzuka;
Zheng, X. F. Steven;
Zhiyuan Shen;
Sabaawy, Hatem E.;
LianXin Liu;
Pine, Sharon R.

Publication type:

Article

SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06038-y

By:

Huang, Li-Yu;
Zhao, Junjie;
Chen, Hao;
Wan, Lixin;
Inuzuka, Hiroyuki;
Guo, Jianping;
Fu, Xuhong;
Zhai, Yangyang;
Lu, Zhaoning;
Wang, Xuefei;
Han, Ze-Guang;
Sun, Yihong;
Wei, Wenyi

Publication type:

Article

The role of calcium/calmodulin-dependent protein kinase cascade in glucose upregulation of insulin gene expression.

Published in:

2004

By:

Yu, Xiao;
Murao, Koji;
Sayo, Yoshitaka;
Imachi, Hitomi;
Cao, Wen M.;
Ohtsuka, Shouji;
Niimi, Michio;
Tokumitsu, Hiroshi;
Inuzuka, Hiroyuki;
Wong, Norman C.W.;
Kobayashi, Ryoji;
Ishida, Toshihiko

Publication type:

journal article

Loss of UCHL1 Leads to Enhanced Mouse Osteoclast Formation.

Published in:

Journal of Cellular Physiology, 2025, v. 240, n. 4, p. 1, doi. 10.1002/jcp.70032

By:

Chiba, Mitsuki;
Hoshikawa, Seira;
Shimizu, Kouhei;
Fujita, Hiromi;
Wada, Keiji;
Yamada, Aya;
Saito, Kan;
Inuzuka, Hiroyuki;
Fukumoto, Satoshi

Publication type:

Article

Roles of F-box proteins in cancer.

Published in:

Nature Reviews Cancer, 2014, v. 14, n. 4, p. 233, doi. 10.1038/nrc3700

By:

Wang, Zhiwei;
Liu, Pengda;
Inuzuka, Hiroyuki;
Wei, Wenyi

Publication type:

Article

Cyclin C is a haploinsufficient tumour suppressor.

Published in:

Nature Cell Biology, 2014, v. 16, n. 11, p. 1080, doi. 10.1038/ncb3046

By:

Li, Na;
Fassl, Anne;
Chick, Joel;
Inuzuka, Hiroyuki;
Li, Xiaoyu;
Mansour, Marc R.;
Liu, Lijun;
Wang, Haizhen;
King, Bryan;
Shaik, Shavali;
Gutierrez, Alejandro;
Ordureau, Alban;
Otto, Tobias;
Kreslavsky, Taras;
Baitsch, Lukas;
Bury, Leah;
Meyer, Clifford A.;
Ke, Nan;
Mulry, Kristin A.;
Kluk, Michael J.

Publication type:

Article

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.

Published in:

Nature Cell Biology, 2013, v. 15, n. 11, p. 1340, doi. 10.1038/ncb2860

By:

Liu, Pengda;
Gan, Wenjian;
Inuzuka, Hiroyuki;
Lazorchak, Adam S.;
Gao, Daming;
Arojo, Omotooke;
Liu, Dou;
Wan, Lixin;
Zhai, Bo;
Yu, Yonghao;
Yuan, Min;
Kim, Byeong Mo;
Shaik, Shavali;
Menon, Suchithra;
Gygi, Steven P.;
Lee, Tae Ho;
Asara, John M.;
Manning, Brendan D.;
Blenis, John;
Su, Bing

Publication type:

Article

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction.

Published in:

Nature Cell Biology, 2009, v. 11, n. 4, p. 397, doi. 10.1038/ncb1847

By:

Gao, Daming;
Inuzuka, Hiroyuki;
Tseng, Alan;
Chin, Rebecca Y.;
Toker, Alex;
Wei, Wenyi

Publication type:

Article

Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors.

Published in:

Science Signaling, 2018, v. 11, n. 521, p. 1, doi. 10.1126/scisignal.aao3810

By:

Clement, Emilie;
Inuzuka, Hiroyuki;
Nihira, Naoe T.;
Wei, Wenyi;
Toker, Alex

Publication type:

Article

Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function.

Published in:

Science Signaling, 2017, v. 10, n. 466, p. 1, doi. 10.1126/scisignal.aai8026

By:

Nihira, Naoe T.;
Kohei Ogura;
Kouhei Shimizu;
North, Brian J.;
Jinfang Zhang;
Daming Gao;
Hiroyuki Inuzuka;
Wenyi Wei

Publication type:

Article

Regulation of APCCdh1 E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7.

Published in:

Cell Research, 2013, v. 23, n. 7, p. 947, doi. 10.1038/cr.2013.67

By:

Lau, Alan W;
Inuzuka, Hiroyuki;
Fukushima, Hidefumi;
Wan, Lixin;
Liu, Pengda;
Gao, Daming;
Sun, Yi;
Wei, Wenyi

Publication type:

Article

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.

Published in:

Nature, 2014, v. 508, n. 7497, p. 541, doi. 10.1038/nature13079

By:

Liu, Pengda;
Begley, Michael;
Michowski, Wojciech;
Inuzuka, Hiroyuki;
Ginzberg, Miriam;
Gao, Daming;
Tsou, Peiling;
Gan, Wenjian;
Papa, Antonella;
Kim, Byeong Mo;
Wan, Lixin;
Singh, Amrik;
Zhai, Bo;
Yuan, Min;
Wang, Zhiwei;
Gygi, Steven P.;
Lee, Tae Ho;
Lu, Kun-Ping;
Toker, Alex;
Pandolfi, Pier Paolo

Publication type:

Article

SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.

Published in:

Nature, 2011, v. 471, n. 7336, p. 104, doi. 10.1038/nature09732

By:

Inuzuka, Hiroyuki;
Shaik, Shavali;
Onoyama, Ichiro;
Daming Gao;
Tseng, Alan;
Maser, Richard S.;
Bo Zhai;
Lixin Wan;
Gutierrez, Alejandro;
Lau, Alan W.;
Yonghong Xiao;
Christie, Amanda L.;
Aster, Jon;
Settleman, Jeffrey;
Gygi, Steven P.;
Kung, Andrew L.;
Look, Thomas;
Nakayama, Keiichi I.;
DePinho, Ronald A.;
Wenyi Wei

Publication type:

Article

USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice.

Published in:

Science Translational Medicine, 2023, v. 15, n. 725, p. 1, doi. 10.1126/scitranslmed.adh7668

By:

Dang, Fabin;
Bai, Lei;
Dong, Jiazhen;
Hu, Xiaoping;
Wang, Jingchao;
Paulo, Joao A.;
Xiong, Yan;
Liang, Xiaowei;
Sun, Yishuang;
Chen, Yuncai;
Guo, Ming;
Wang, Xin;
Huang, Zhixiang;
Inuzuka, Hiroyuki;
Chen, Li;
Chu, Chen;
Liu, Jianping;
Zhang, Tao;
Rezaeian, Abdol-Hossein;
Liu, Jing

Publication type:

Article

The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis.

Published in:

Science Signaling, 2017, v. 10, n. 460, p. 1, doi. 10.1126/scisignal.aah4117

By:

Kouhei Shimizu;
Hidefumi Fukushima;
Kohei Ogura;
Lien, Evan C.;
Nihira, Naoe Taira;
Jinfang Zhang;
North, Brian J.;
Guo, Ailan;
Katsuyuki Nagashima;
Tadashi Nakagawa;
Seira Hoshikawa;
Asami Watahiki;
Koji Okabe;
Aya Yamada;
Toker, Alex;
Asara, John M.;
Fukumoto, Satoshi;
Nakayama, Keiichi I.;
Nakayama, Keiko;
Hiroyuki Inuzuka

Publication type:

Article

Transcriptional regulation of nuclear orphan receptor, NOR-1, by Ca2+/calmodulin-dependent protein kinase cascade

Published in:

FEBS Letters, 2002, v. 522, n. 1-3, p. 88, doi. 10.1016/S0014-5793(02)02890-9

By:

Inuzuka, Hiroyuki;
Tokumitsu, Hiroshi;
Ohkura, Naganari;
Kobayashi, Ryoji

Publication type:

Article

Molecular Subtypes and Targeted Therapeutic Strategies in Small Cell Lung Cancer: Advances, Challenges, and Future Perspectives.

Published in:

Molecules, 2025, v. 30, n. 8, p. 1731, doi. 10.3390/molecules30081731

By:

Huang, Daoyuan;
Wang, Jingchao;
Chen, Li;
Jiang, Weiwei;
Inuzuka, Hiroyuki;
Simon, David K.;
Wei, Wenyi

Publication type:

Article

Emerging roles of the FBW7 tumour suppressor in stem cell differentiation.

Published in:

EMBO Reports, 2012, v. 13, n. 1, p. 36, doi. 10.1038/embor.2011.231

By:

Wang, Zhiwei;
Inuzuka, Hiroyuki;
Fukushima, Hidefumi;
Wan, Lixin;
Gao, Daming;
Shaik, Shavali;
Sarkar, Fazlul H;
Wei, Wenyi

Publication type:

Article

Tailoring One‐Dimensional Assemblies of Chiral Bowl‐Shaped Molecules with Diverse Enantiomers and Polar Column Alignments.

Published in:

Angewandte Chemie International Edition, 2025, v. 64, n. 20, p. 1, doi. 10.1002/anie.202424162

By:

He, Dan;
Dhara, Barun;
Zhang, Cheng;
Nihonyanagi, Atsuko;
Inuzuka, Hiroyuki;
Hara, Eiju;
Sato, Shunsuke;
Adachi, Kiyohiro;
Watanabe, Go;
Hashizume, Daisuke;
Okuro, Kou;
Miyajima, Daigo

Publication type:

Article

The First‐In‐Class Deubiquitinase‐Targeting Chimera Stabilizes and Activates cGAS.

Published in:

Angewandte Chemie International Edition, 2025, v. 64, n. 3, p. 1, doi. 10.1002/anie.202415168

By:

Deng, Zhijie;
Chen, Li;
Qian, Chao;
Liu, Jing;
Wu, Qiong;
Song, Xiangyang;
Xiong, Yan;
Wang, Zhen;
Hu, Xiaoping;
Inuzuka, Hiroyuki;
Zhong, Yue;
Xiang, Yufei;
Lin, Yindan;
Dung Pham, Ngoc;
Shi, Yi;
Wei, Wenyi;
Jin, Jian

Publication type:

Article