Works matching AU Hirota, Kouji

Results: 63

Monoclonal antibody generation by controlled immunoglobulin gene rearrangements.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-07690-z

By:

Murayama, Akiho;
Matsui, Shin;
Abe, Takuya;
Kanemaki, Masato T.;
Kurosawa, Kohei;
Hirota, Kouji;
Ohta, Kunihiro;
Seo, Hidetaka

Publication type:

Article

ICRF193 potentiates the genotoxicity of etoposide.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-03522-6

By:

Ooka, Masato;
Mitchell, Leah;
Zhao, Jinghua;
Hirota, Kouji;
Huang, Ruili;
Abe, Takuya;
Xia, Menghang

Publication type:

Article

The proteasome factor Bag 101 binds to Rad22 and suppresses homologous recombination.

Published in:

Scientific Reports, 2013, p. 1, doi. 10.1038/srep02022

By:

Yuichiro Saito;
Jun Takeda;
Masahiro Okada;
Junya Kobayashi;
Akihiro Kato;
Kouji Hirota;
Masato Taoka;
Tomohiro Matsumoto;
Kenshi Komatsu;
Toshiaki Isobe

Publication type:

Article

RAD18‐ and BRCA1‐dependent pathways promote cellular tolerance to the nucleoside analog ganciclovir.

Published in:

Genes to Cells, 2024, v. 29, n. 11, p. 935, doi. 10.1111/gtc.13155

By:

Ahmad, Tasnim;
Kawasumi, Ryotaro;
Hirota, Kouji

Publication type:

Article

XRCC1 counteracts poly(ADP ribose)polymerase (PARP) poisons, olaparib and talazoparib, and a clinical alkylating agent, temozolomide, by promoting the removal of trapped PARP1 from broken DNA.

Published in:

Genes to Cells, 2022, v. 27, n. 5, p. 331, doi. 10.1111/gtc.12929

By:

Hirota, Kouji;
Ooka, Masato;
Shimizu, Naoto;
Yamada, Kousei;
Tsuda, Masataka;
Ibrahim, Mahmoud Abdelghany;
Yamada, Shintaro;
Sasanuma, Hiroyuki;
Masutani, Mitsuko;
Takeda, Shunichi

Publication type:

Article

Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides.

Published in:

Cell Cycle, 2016, v. 15, n. 15, p. 1997, doi. 10.1080/15384101.2016.1191711

By:

Kobayashi, Kaori;
Guilliam, Thomas A.;
Tsuda, Masataka;
Yamamoto, Junpei;
Bailey, Laura J.;
Iwai, Shigenori;
Takeda, Shunichi;
Doherty, Aidan J.;
Hirota, Kouji

Publication type:

Article

In-cell Viscosity Measurement Using a Fluorescence Up-conversion Microscope.

Published in:

Chemistry Letters, 2008, v. 37, n. 12, p. 1, doi. 10.1246/cl.2008.1240

By:

Fujino, Tatsuya;
Hirota, Kouji;
Ohta, Kunihiro;
Tahara, Tahei

Publication type:

Article

Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs.

Published in:

Nature, 2008, v. 456, n. 7218, p. 130, doi. 10.1038/nature07348

By:

Hirota, Kouji;
Miyoshi, Tomoichiro;
Kugou, Kazuto;
Hoffman, Charles S.;
Shibata, Takehiko;
Ohta, Kunihiro

Publication type:

Article

lncRNA transcription induces meiotic recombination through chromatin remodelling in fission yeast.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-01798-8

By:

Senmatsu, Satoshi;
Asada, Ryuta;
Oda, Arisa;
Hoffman, Charles S.;
Ohta, Kunihiro;
Hirota, Kouji

Publication type:

Article

GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination.

Published in:

Nucleic Acids Research, 2010, v. 38, n. 15, p. 5059, doi. 10.1093/nar/gkq271

By:

Takizawa, Yoshimasa;
Qing, Yong;
Takaku, Motoki;
Ishida, Takako;
Morozumi, Yuichi;
Tsujita, Takashi;
Kogame, Toshiaki;
Hirota, Kouji;
Takahashi, Masayuki;
Shibata, Takehiko;
Kurumizaka, Hitoshi;
Takeda, Shunichi

Publication type:

Article

Structural and functional analyses of the DMC1-M200V polymorphism found in the human population.

Published in:

Nucleic Acids Research, 2008, v. 36, n. 12, p. 4181, doi. 10.1093/nar/gkn362

By:

Hikiba, Juri;
Hirota, Kouji;
Kagawa, Wataru;
Ikawa, Shukuko;
Kinebuchi, Takashi;
Sakane, Isao;
Takizawa, Yoshimasa;
Yokoyama, Shigeyuki;
Mandon-Pépin, Béatrice;
Nicolas, Alain;
Shibata, Takehiko;
Ohta, Kunihiro;
Kurumizaka, Hitoshi

Publication type:

Article

Fission yeast global repressors regulate the specificity of chromatin alteration in response to distinct environmental stresses.

Published in:

Nucleic Acids Research, 2004, v. 32, n. 2, p. 855, doi. 10.1093/nar/gkh251

By:

Hirota, Kouji;
Hasemi, Tomoko;
Yamada, Takatomi;
Mizuno, Ken‐ich;
Hoffman, Charles S.;
Shibata, Takehiko;
Ohta, Kunihiro

Publication type:

Article

Participation of TDP1 in the repair of formaldehyde-induced DNA-protein cross-links in chicken DT40 cells.

Published in:

PLoS ONE, 2020, v. 15, n. 6, p. 1, doi. 10.1371/journal.pone.0234859

By:

Nakano, Toshiaki;
Shoulkamy, Mahmoud I.;
Tsuda, Masataka;
Sasanuma, Hiroyuki;
Hirota, Kouji;
Takata, Minoru;
Masunaga, Shin-ichiro;
Takeda, Shunichi;
Ide, Hiroshi;
Bessho, Tadayoshi;
Tano, Keizo

Publication type:

Article

The Epistatic Relationship between BRCA2 and the Other RAD51 Mediators in Homologous Recombination.

Published in:

PLoS Genetics, 2011, v. 7, n. 7, p. 1, doi. 10.1371/journal.pgen.1002148

By:

Yong Qing;
Yamazoe, Mitsuyoshi;
Hirota, Kouji;
Dejsuphong, Donniphat;
Sakai, Wataru;
Yamamoto, Kimiyo N.;
Bishop, Douglas K.;
XiaoHua Wu;
Takeda, Shunichi

Publication type:

Article

Application of neural network-based image analysis to detect sister chromatid cohesion defects.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-28742-6

By:

Ikemoto, Daiki;
Taniguchi, Tomoya;
Hirota, Kouji;
Nishikawa, Kiyoshi;
Okubo, Kan;
Abe, Takuya

Publication type:

Article

DNA Damage Tolerance Mechanisms Revealed from the Analysis of Immunoglobulin V Gene Diversification in Avian DT40 Cells.

Published in:

Genes, 2018, v. 9, n. 12, p. 614, doi. 10.3390/genes9120614

By:

Abe, Takuya;
Branzei, Dana;
Hirota, Kouji

Publication type:

Article

Transcription of mRNA-type long non-coding RNAs (mlonRNAs) disrupts chromatin array.

Published in:

Communicative & Integrative Biology, 2009, v. 2, n. 1, p. 25, doi. 10.4161/cib.2.1.7378

By:

Hirota, Kouji;
Ohta, Kunihiro

Publication type:

Article

Chromatin remodeler ALC1 prevents replication-fork collapse by slowing fork progression.

Published in:

PLoS ONE, 2018, v. 13, n. 2, p. 1, doi. 10.1371/journal.pone.0192421

By:

Ooka, Masato;
Abe, Takuya;
Cho, Kosai;
Koike, Kaoru;
Takeda, Shunichi;
Hirota, Kouji

Publication type:

Article

Essential roles of Snf21, a Swi2/Snf2 family chromatin remodeler, in fission yeast mitosis.

Published in:

Genes & Genetic Systems, 2008, v. 83, n. 5, p. 361, doi. 10.1266/ggs.83.361

By:

Yamada, Kentaro;
Hirota, Kouji;
Mizuno, Ken-ichi;
Shibata, Takehiko;
Ohta, Kunihiro

Publication type:

Article

Differential micronucleus frequency in isogenic human cells deficient in DNA repair pathways is a valuable indicator for evaluating genotoxic agents and their genotoxic mechanisms.

Published in:

Environmental & Molecular Mutagenesis, 2018, v. 59, n. 6, p. 529, doi. 10.1002/em.22201

By:

Saha, Liton Kumar;
Kim, Sujin;
Kang, Habyeong;
Akter, Salma;
Choi, Kyungho;
Sakuma, Tetsushi;
Yamamoto, Takashi;
Sasanuma, Hiroyuki;
Hirota, Kouji;
Nakamura, Jun;
Honma, Masamitsu;
Takeda, Shunichi;
Dertinger, S.

Publication type:

Article

Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines.

Published in:

Environmental & Molecular Mutagenesis, 2011, v. 52, n. 7, p. 547, doi. 10.1002/em.20656

By:

Yamamoto, Kimiyo N.;
Hirota, Kouji;
Kono, Koichi;
Takeda, Shunichi;
Sakamuru, Srilatha;
Xia, Menghang;
Huang, Ruili;
Austin, Christopher P.;
Witt, Kristine L.;
Tice, Raymond R.

Publication type:

Article

Role of TDP2 in the repair of DNA damage induced by the radiomimetic drug Bleomycin.

Published in:

Genes & Environment, 2025, v. 47, n. 1, p. 1, doi. 10.1186/s41021-025-00329-9

By:

Shimizu, Naoto;
Izawa, Kazuki;
Washif, Mubasshir;
Morozumi, Ryosuke;
Hirota, Kouji;
Tsuda, Masataka

Publication type:

Article

Histone Chaperone Asf1 Is Required for the Establishment of Repressive Chromatin in Schizosaccharomyces pombe fbp1Gene Repression.

Published in:

Molecular & Cellular Biology, 2018, v. 38, n. 18, p. 1, doi. 10.1128/MCB.00194-18

By:

Umeda, Miki;
Chiaki Tsunekawa;
Satoshi Senmatsu;
Ryuta Asada;
Takuya Abe;
Kunihiro Ohta;
Hoffman, Charles S.;
Kouji Hirota

Publication type:

Article

Antagonistic Controls of Chromatin and mRNA Start Site Selection by Tup Family Corepressors and the CCAAT-Binding Factor.

Published in:

Molecular & Cellular Biology, 2015, v. 35, n. 5, p. 847, doi. 10.1128/MCB.00924-14

By:

Ryuta Asada;
Naomichi Takemata;
Hoffman, Charles S.;
Kunihiro Ohta;
Kouji Hirota

Publication type:

Article

The USP1/UAF1 Complex Promotes Double-Strand Break Repair through Homologous Recombination.

Published in:

2011

By:

Murai, Junko;
Yang, Kailin;
Dejsuphong, Donniphat;
Hirota, Kouji;
Takeda, Shunichi;
D'Andrea, Alan D.

Publication type:

Abstract

A novel genotoxicity assay of carbon nanotubes using functional macrophage receptor with collagenous structure (MARCO)-expressing chicken B lymphocytes.

Published in:

Archives of Toxicology, 2014, v. 88, n. 1, p. 145, doi. 10.1007/s00204-013-1084-7

By:

Mohiuddin;
Keka, Islam;
Evans, Terry;
Hirota, Kouji;
Shimizu, Hiroyasu;
Kono, Koichi;
Takeda, Shunichi;
Hirano, Seishiro

Publication type:

Article

DNA polymerases ν and φ are required for efficient immunoglobulin V gene diversification in chicken.

Published in:

Journal of Cell Biology, 2010, v. 189, n. 7, p. 1117, doi. 10.1083/jcb.200912012

By:

Kohzaki, Masaoki;
Nishihara, Kana;
Hirota, Kouji;
Sonoda, Eiichiro;
Yoshimura, Michio;
Ekino, Shigeo;
Butler, John E.;
Watanabe, Masami;
Halazonetis, Thanos D.;
Takeda, Shunichi

Publication type:

Article

lncRNA transcriptional initiation induces chromatin remodeling within a limited range in the fission yeast fbp1 promoter.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-018-36049-0

By:

Senmatsu, Satoshi;
Asada, Ryuta;
Abe, Takuya;
Hoffman, Charles S.;
Ohta, Kunihiro;
Hirota, Kouji

Publication type:

Article

Regulation Mechanisms of Meiotic Recombination Revealed from the Analysis of a Fission Yeast Recombination Hotspot ade6-M26.

Published in:

Biomolecules (2218-273X), 2022, v. 12, n. 12, p. 1761, doi. 10.3390/biom12121761

By:

Hirota, Kouji

Publication type:

Article

Molecular mechanisms of avian immunoglobulin gene diversification and prospect for industrial applications.

Published in:

Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1453833

By:

Hidetaka Seo;
Kouji Hirota;
Kunihiro Ohta

Publication type:

Article

PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching.

Published in:

PLoS ONE, 2019, v. 14, n. 3, p. 1, doi. 10.1371/journal.pone.0213383

By:

Tsuda, Masataka;
Ogawa, Saki;
Ooka, Masato;
Kobayashi, Kaori;
Hirota, Kouji;
Wakasugi, Mitsuo;
Matsunaga, Tsukasa;
Sakuma, Tetsushi;
Yamamoto, Takashi;
Chikuma, Shunsuke;
Sasanuma, Hiroyuki;
Debatisse, Michelle;
Doherty, Aidan J.;
Fuchs, Robert P.;
Takeda, Shunichi

Publication type:

Article

Homology recognition without double-stranded DNA-strand separation in D-loop formation by RecA.

Published in:

Nucleic Acids Research, 2024, v. 52, n. 5, p. 2565, doi. 10.1093/nar/gkad1260

By:

Shibata, Takehiko;
Ikawa, Shukuko;
Iwasaki, Wakana;
Sasanuma, Hiroyuki;
Masai, Hisao;
Hirota, Kouji

Publication type:

Article

The proofreading exonuclease of leading-strand DNA polymerase epsilon prevents replication fork collapse at broken template strands.

Published in:

Nucleic Acids Research, 2023, v. 52, n. 22, p. 12288, doi. 10.1093/nar/gkad999

By:

Ahmad, Tasnim;
Kawasumi, Ryotaro;
Taniguchi, Tomoya;
Abe, Takuya;
Terada, Kazuhiro;
Tsuda, Masataka;
Shimizu, Naoto;
Tsurimoto, Toshiki;
Takeda, Shunichi;
Hirota, Kouji

Publication type:

Article

Landscape of the complete RNA chemical modifications in the human 80S ribosome.

Published in:

Nucleic Acids Research, 2018, v. 46, n. 18, p. 9289, doi. 10.1093/nar/gky811

By:

Taoka, Masato;
Nobe, Yuko;
Yamaki, Yuka;
Sato, Ko;
Ishikawa, Hideaki;
Izumikawa, Keiichi;
Yamauchi, Yoshio;
Hirota, Kouji;
Nakayama, Hiroshi;
Takahashi, Nobuhiro

Publication type:

Article

Recruitment and delivery of the fission yeast Rst2 transcription factor via a local genome structure counteracts repression by Tup1-family corepressors.

Published in:

Nucleic Acids Research, 2017, v. 45, n. 16, p. 9361, doi. 10.1093/nar/gkx555

By:

Asada, Ryuta;
Miki Umeda;
Akira Adachi;
Satoshi Senmatsu;
Takuya Abe;
Hiroshi Iwasaki;
Kunihiro Ohta;
Hoffman, Charles S.;
Kouji Hirota

Publication type:

Article

Human CTF18-RFC clamp-loader complexed with non-synthesising DNA polymerase ε efficiently loads the PCNA sliding clamp.

Published in:

Nucleic Acids Research, 2017, v. 45, n. 8, p. 4550, doi. 10.1093/nar/gkx096

By:

Ryo Fujisawa;
Eiji Ohashi;
Kouji Hirota;
Toshiki Tsurimoto

Publication type:

Article

In vivo evidence for translesion synthesis by the replicative DNA polymerase δ.

Published in:

Nucleic Acids Research, 2016, v. 44, n. 15, p. 7242, doi. 10.1093/nar/gkw439

By:

Kouji Hirota;
Masataka Tsuda;
Mohiuddin;
Toshiki Tsurimoto;
Cohen, Isadora S.;
Livneh, Zvi;
Kaori Kobayashi;
Takeo Narita;
Kana Nishihara;
Junko Murai;
Shigenori Iwai;
Guilbaud, Guillaume;
Sale, Julian E.;
Shunichi Takeda

Publication type:

Article

Local potentiation of stress-responsive genes by upstream noncoding transcription.

Published in:

Nucleic Acids Research, 2016, v. 44, n. 11, p. 5174, doi. 10.1093/nar/gkw142

By:

Naomichi Takemata;
Arisa Oda;
Takatomi Yamada;
Galipon, Josephine;
Tomoichiro Miyoshi;
Yutaka Suzuki;
Sumio Sugano;
Hoffman, Charles S.;
Kouji Hirota;
Kunihiro Ohta

Publication type:

Article

The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ.

Published in:

Nucleic Acids Research, 2015, v. 43, n. 3, p. 1671, doi. 10.1093/nar/gkv023

By:

Hirota, Kouji;
Yoshikiyo, Kazunori;
Guilbaud, Guillaume;
Tsurimoto, Toshiki;
Murai, Junko;
Tsuda, Masataka;
Phillips, Lara G.;
Narita, Takeo;
Nishihara, Kana;
Kobayashi, Kaori;
Yamada, Kouich;
Nakamura, Jun;
Pommier, Yves;
Lehmann, Alan;
Sale, Julian E.;
Takeda, Shunichi

Publication type:

Article

AND-1 fork protection function prevents fork resection and is essential for proliferation.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-05586-7

By:

Abe, Takuya;
Kawasumi, Ryotaro;
Giannattasio, Michele;
Dusi, Sabrina;
Yoshimoto, Yui;
Miyata, Keiji;
Umemura, Koyuki;
Hirota, Kouji;
Branzei, Dana

Publication type:

Article

Relationship between globus sensation and esophageal clearance.

Published in:

Acta Oto-Laryngologica, 2010, v. 130, n. 1, p. 138, doi. 10.3109/00016480902962766

By:

Adachi, Jin;
Ohmae, Yukio;
Karaho, Takehiro;
Tanabe, Tetsuya;
Mizokami, Daisuke;
Hirota, Kouji;
Tomifuji, Masayuki;
Kurita, Akihiro;
Matsunobu, Takeshi;
Shiotani, Akihiro

Publication type:

Article

Metabolic stress-induced long ncRNA transcription governs the formation of meiotic DNA breaks in the fission yeast fbp1 gene.

Published in:

PLoS ONE, 2024, v. 19, n. 1, p. 1, doi. 10.1371/journal.pone.0294191

By:

Tsuruta, Yusuke;
Senmatsu, Satoshi;
Oe, Hana;
Hoffman, Charles S.;
Hirota, Kouji

Publication type:

Article

Roles of histone acetylation and chromatin remodeling factor in a meiotic recombination hotspot.

Published in:

EMBO Journal, 2004, v. 23, n. 8, p. 1792, doi. 10.1038/sj.emboj.7600138

By:

Yamada, Takatomi;
Mizuno, Ken-ichi;
Hirota, Kouji;
Ning Kon;
Wahls, Wayne P.;
Hartsuiker, Edgar;
Murofushi, Hiromu;
Shibata, Takehiko;
Ohta, Kunihiro

Publication type:

Article

high-throughput 384-well CometChip platform reveals a role for 3-methyladenine in the cellular response to etoposide-induced DNA damage.

Published in:

NAR Genomics & Bioinformatics, 2022, v. 4, n. 3, p. 1, doi. 10.1093/nargab/lqac065

By:

Li, Jianfeng;
Beiser, Alison;
Dey, Nupur B;
Takeda, Shunichi;
Saha, Liton Kumar;
Hirota, Kouji;
Parker, L Lynette;
Carter, Mariah;
Arrieta, Martha I;
Sobol, Robert W

Publication type:

Article

Relative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell lines.

Published in:

Genes to Cells, 2015, v. 20, n. 12, p. 1059, doi. 10.1111/gtc.12310

By:

Hoa, Nguyen Ngoc;
Akagawa, Remi;
Yamasaki, Tomomi;
Hirota, Kouji;
Sasa, Kentaro;
Natsume, Toyoaki;
Kobayashi, Junya;
Sakuma, Tetsushi;
Yamamoto, Takashi;
Komatsu, Kenshi;
Kanemaki, Masato T.;
Pommier, Yves;
Takeda, Shunichi;
Sasanuma, Hiroyuki

Publication type:

Article

SUMO-targeted ubiquitin ligase RNF4 plays a critical role in preventing chromosome loss.

Published in:

Genes to Cells, 2014, v. 19, n. 10, p. 743, doi. 10.1111/gtc.12173

By:

Hirota, Kouji;
Tsuda, Masataka;
Murai, Junko;
Takagi, Tokiyo;
Keka, Islam Shamima;
Narita, Takeo;
Fujita, Mari;
Sasanuma, Hiroyuki;
Kobayashi, Junya;
Takeda, Shunichi

Publication type:

Article

Human replicative DNA polymerase δ can bypass T-T (6-4) ultraviolet photoproducts on template strands.

Published in:

Genes to Cells, 2010, v. 15, n. 12, p. 1228, doi. 10.1111/j.1365-2443.2010.01457.x

By:

Narita, Takeo;
Tsurimoto, Toshiki;
Yamamoto, Junpei;
Nishihara, Kana;
Ogawa, Kaori;
Ohashi, Eiji;
Evans, Terry;
Iwai, Shigenori;
Takeda, Shunichi;
Hirota, Kouji

Publication type:

Article

Functional analysis of the C-terminal cytoplasmic region of the M-factor receptor in fission yeast.

Published in:

Genes to Cells, 2001, v. 6, n. 3, p. 201, doi. 10.1046/j.1365-2443.2001.00415.x

By:

Hirota, Kouji;
Tanaka, Kayoko;
Watanabe, Yoshinori;
Yamamoto, Masayuki

Publication type:

Article

Development of a Targeted Flip-in System in Avian DT40 Cells.

Published in:

PLoS ONE, 2015, v. 10, n. 3, p. 1, doi. 10.1371/journal.pone.0122006

By:

Kobayashi, Kaori;
Fujii, Toshihiko;
Asada, Ryuta;
Ooka, Masato;
Hirota, Kouji

Publication type:

Article

RNase MRP Cleaves Pre-tRNA<sup>Ser-Met</sup> in the tRNA Maturation Pathway.

Published in:

PLoS ONE, 2014, v. 9, n. 11, p. 1, doi. 10.1371/journal.pone.0112488

By:

Saito, Yuichiro;
Takeda, Jun;
Adachi, Kousuke;
Nobe, Yuko;
Kobayashi, Junya;
Hirota, Kouji;
Oliveira, Douglas V.;
Taoka, Masato;
Isobe, Toshiaki

Publication type:

Article